Gallbladder carcinoma - Revision history

Michael at 14:43, 15 August 2024

2024-08-15T14:43:15Z

← Older revision		Revision as of 14:43, 15 August 2024
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	\| IF =		\| IF =
	\| Gross = lesion - usually fundus of gallbladder		\| Gross = lesion - usually fundus of gallbladder
	\| Grossing =		\| Grossing = [[gallbladder grossing]]
	\| Site = [[gallbladder]]		\| Site = [[gallbladder]]
	\| Assdx = [[chronic cholecystitis]], [[gallstones]], [[primary sclerosing cholangitis]], [[intestinal metaplasia of the gallbladder]]		\| Assdx = [[chronic cholecystitis]], [[gallstones]], [[primary sclerosing cholangitis]], [[intestinal metaplasia of the gallbladder]]

Mitchell: /* Images */ added a case

2017-01-03T15:32:22Z

Images: added a case

← Older revision		Revision as of 15:32, 3 January 2017
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F1/ Mimics of GB carcinoma (nih.gov)].<ref name=pmid22284391>{{Cite journal \| last1 = Giang \| first1 = TH. \| last2 = Ngoc \| first2 = TT. \| last3 = Hassell \| first3 = LA. \| title = Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma. \| journal = Diagn Pathol \| volume = 7 \| issue = \| pages = 10 \| month = \| year = 2012 \| doi = 10.1186/1746-1596-7-10 \| PMID = 22284391 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F1/ Mimics of GB carcinoma (nih.gov)].<ref name=pmid22284391>{{Cite journal \| last1 = Giang \| first1 = TH. \| last2 = Ngoc \| first2 = TT. \| last3 = Hassell \| first3 = LA. \| title = Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma. \| journal = Diagn Pathol \| volume = 7 \| issue = \| pages = 10 \| month = \| year = 2012 \| doi = 10.1186/1746-1596-7-10 \| PMID = 22284391 }}</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F2/ Dysplasia in RA sinuses (nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F2/ Dysplasia in RA sinuses (nih.gov)].
			[[File:5 42027008799505 sl 1.png\| Moderately differentiated adenocarcinoma of gallbladder]]
			[[File:5 42027008799505 sl 2.png\| Moderately differentiated adenocarcinoma of gallbladder]]
			[[File:5 42027008799505 sl 3.png\| Moderately differentiated adenocarcinoma of gallbladder]]
			[[File:5 42027008799505 sl 4.png\| Moderately differentiated adenocarcinoma of gallbladder]]
			[[File:5 42027008799505 sl 5.png\| Moderately differentiated adenocarcinoma of gallbladder]]
			[[File:5 42027008799505 sl 6.png\| Moderately differentiated adenocarcinoma of gallbladder]]<br>
			Moderately differentiated adenocarcinoma of gallbladder in a 59 year old man. A. Tumor bounds cystic duct. B. Cystic duct at left shows high grade dysplasia. At right lie acini and nests of round and sometimes spindled cancerous nuclei. Overall most of the tumor was in tubules/acini, meaning the lesion is moderately differentiated. C. Region with Rokitansky-Aschoff sinuses showing high grade dysplasia and foci of intestinal metaplasia, with some nests likely being invasive cancer. D. Tumorous involvement of cystic duct lymph node. E. Bizarrely shaped cancerous groups. F. invasion of liver by neoplastic acini.

	==IHC==		==IHC==

Michael: touch

2015-06-11T05:12:44Z

touch

← Older revision		Revision as of 05:12, 11 June 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Gallbladder adenocarcinoma (2) histopathology.jpg		\| Image = Gallbladder adenocarcinoma (2) histopathology.jpg
	\| Width =		\| Width =
	\| Caption = Gallbladder adenocarcinoma. [[H&E stain]].		\| Caption = Gallbladder adenocarcinoma. [[H&E stain]].

Michael: /* Images */ touch

2015-06-10T13:24:25Z

Images: touch

← Older revision		Revision as of 13:24, 10 June 2015
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	Image:Gallbladder adenocarcinoma (3) lymphatic invasion histopathology.jpg \| GB carcinoma - LVI. (WC)		Image:Gallbladder adenocarcinoma (3) lymphatic invasion histopathology.jpg \| GB carcinoma - LVI. (WC)
	</gallery>		</gallery>
	www:		www:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F1/ Mimics of GB carcinoma (nih.gov)].<ref name=pmid22284391>{{Cite journal \| last1 = Giang \| first1 = TH. \| last2 = Ngoc \| first2 = TT. \| last3 = Hassell \| first3 = LA. \| title = Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma. \| journal = Diagn Pathol \| volume = 7 \| issue = \| pages = 10 \| month = \| year = 2012 \| doi = 10.1186/1746-1596-7-10 \| PMID = 22284391 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F1/ Mimics of GB carcinoma (nih.gov)].<ref name=pmid22284391>{{Cite journal \| last1 = Giang \| first1 = TH. \| last2 = Ngoc \| first2 = TT. \| last3 = Hassell \| first3 = LA. \| title = Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma. \| journal = Diagn Pathol \| volume = 7 \| issue = \| pages = 10 \| month = \| year = 2012 \| doi = 10.1186/1746-1596-7-10 \| PMID = 22284391 }}</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F2/ Dysplasia in RA sinuses (nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F2/ Dysplasia in RA sinuses (nih.gov)].

Michael: touch

2015-06-10T13:17:54Z

touch

← Older revision		Revision as of 13:17, 10 June 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Gallbladder adenocarcinoma (2) histopathology.jpg		\| Image = Gallbladder adenocarcinoma (2) histopathology.jpg
	\| Width =		\| Width =
	\| Caption = Gallbladder adenocarcinoma. [[H&E stain]].		\| Caption = Gallbladder adenocarcinoma. [[H&E stain]].

Michael: /* IHC */ fix

2014-03-13T09:17:56Z

IHC: fix

← Older revision		Revision as of 09:17, 13 March 2014
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	==IHC==		==IHC==
	Features - conventional:<ref name=pmid23106580>{{Cite journal \| last1 = Dursun \| first1 = N. \| last2 = Escalona \| first2 = OT. \| last3 = Roa \| first3 = JC. \| last4 = Basturk \| first4 = O. \| last5 = Bagci \| first5 = P. \| last6 = Cakir \| first6 = A. \| last7 = Cheng \| first7 = J. \| last8 = Sarmiento \| first8 = J. \| last9 = Losada \| first9 = H. \| title = Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 11 \| pages = 1347-58 \| month = Nov \| year = 2012 \| doi = 10.5858/arpa.2011-0447-OA \| PMID = 23106580 }}</ref>		Features - conventional:<ref name=pmid23106580>{{Cite journal \| last1 = Dursun \| first1 = N. \| last2 = Escalona \| first2 = OT. \| last3 = Roa \| first3 = JC. \| last4 = Basturk \| first4 = O. \| last5 = Bagci \| first5 = P. \| last6 = Cakir \| first6 = A. \| last7 = Cheng \| first7 = J. \| last8 = Sarmiento \| first8 = J. \| last9 = Losada \| first9 = H. \| title = Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 11 \| pages = 1347-58 \| month = Nov \| year = 2012 \| doi = 10.5858/arpa.2011-0447-OA \| PMID = 23106580 }}</ref>
	*CK7 +ve (7 of 8 cases.		*CK7 +ve (7 of 8 cases).
	*CK20 -ve (7 of 8 cases).		*CK20 -ve (7 of 8 cases).
	*CDX2 -ve (8 of 8 cases).		*CDX2 -ve (8 of 8 cases).

Michael: /* Microscopic */

2014-01-08T20:48:22Z

Microscopic

← Older revision		Revision as of 20:48, 8 January 2014
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	*[[metastasis\|Metastatic carcinoma]].		*[[metastasis\|Metastatic carcinoma]].
	**[[Cholangiocarcinoma]].		**[[Cholangiocarcinoma]].
			*[[Chronic cholecystitis]] with glands extending deep into the wall.

	===Images===		===Images===
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	Image:Gallbladder adenocarcinoma (3) lymphatic invasion histopathology.jpg \| GB carcinoma - LVI. (WC)		Image:Gallbladder adenocarcinoma (3) lymphatic invasion histopathology.jpg \| GB carcinoma - LVI. (WC)
	</gallery>		</gallery>
			www:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F1/ Mimics of GB carcinoma (nih.gov)].<ref name=pmid22284391>{{Cite journal \| last1 = Giang \| first1 = TH. \| last2 = Ngoc \| first2 = TT. \| last3 = Hassell \| first3 = LA. \| title = Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma. \| journal = Diagn Pathol \| volume = 7 \| issue = \| pages = 10 \| month = \| year = 2012 \| doi = 10.1186/1746-1596-7-10 \| PMID = 22284391 }}</ref>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285085/figure/F2/ Dysplasia in RA sinuses (nih.gov)].

	==IHC==		==IHC==

Michael at 02:49, 17 December 2013

2013-12-17T02:49:47Z

← Older revision		Revision as of 02:49, 17 December 2013
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	\| Micro = atypical epithelium usually gland forming, may be bland with an infiltrative growth pattern		\| Micro = atypical epithelium usually gland forming, may be bland with an infiltrative growth pattern
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[adenomyoma of the gallbladder]], [[metastasis\|metastatic carcinoma]] (e.g. [[cholangiocarcinoma]])		\| LMDDx = [[adenomyoma of the gallbladder]], [[metastasis\|metastatic carcinoma]] (e.g. [[cholangiocarcinoma]]), [[gallbladder adenoma]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, CK20 -ve, CDX2 -ve		\| IHC = CK7 +ve, CK20 -ve, CDX2 -ve
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	\| Grossing =		\| Grossing =
	\| Site = [[gallbladder]]		\| Site = [[gallbladder]]
	\| Assdx = [[chronic cholecystitis]], [[gallstones]], [[primary sclerosing cholangitis]]		\| Assdx = [[chronic cholecystitis]], [[gallstones]], [[primary sclerosing cholangitis]], [[intestinal metaplasia of the gallbladder]]
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
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	DDx:		DDx:
	*[[Adenomyoma of the gallbladder]].		*[[Adenomyoma of the gallbladder]].
			*[[Gallbladder adenoma]].
	*[[metastasis\|Metastatic carcinoma]].		*[[metastasis\|Metastatic carcinoma]].
	**[[Cholangiocarcinoma]].		**[[Cholangiocarcinoma]].

Michael at 02:47, 17 December 2013

2013-12-17T02:47:51Z

← Older revision		Revision as of 02:47, 17 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Gallbladder adenocarcinoma (2) histopathology.jpg
			\| Width =
			\| Caption = Gallbladder adenocarcinoma. [[H&E stain]].
			\| Micro = atypical epithelium usually gland forming, may be bland with an infiltrative growth pattern
			\| Subtypes =
			\| LMDDx = [[adenomyoma of the gallbladder]], [[metastasis\|metastatic carcinoma]] (e.g. [[cholangiocarcinoma]])
			\| Stains =
			\| IHC = CK7 +ve, CK20 -ve, CDX2 -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = lesion - usually fundus of gallbladder
			\| Grossing =
			\| Site = [[gallbladder]]
			\| Assdx = [[chronic cholecystitis]], [[gallstones]], [[primary sclerosing cholangitis]]
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			}}
	'''Gallbladder carcinoma''' is a malignant epithelial neoplasm arising from the [[gallbladder]]. Most gallbladder carcinomas are [[adenocarcinoma]]s.		'''Gallbladder carcinoma''' is a malignant epithelial neoplasm arising from the [[gallbladder]]. Most gallbladder carcinomas are [[adenocarcinoma]]s.

Michael at 02:43, 17 December 2013

2013-12-17T02:43:05Z

← Older revision		Revision as of 02:43, 17 December 2013
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	*May be very subtle, i.e. difficult to differentiate from normal glands.		*May be very subtle, i.e. difficult to differentiate from normal glands.
	**"Deep glands" that look bland shouldn't immediately be dismissed as benign.		**"Deep glands" that look bland shouldn't immediately be dismissed as benign.

			Subtypes:
			*[[Mucinous carcinoma]].<ref name=pmid23106580/>

	DDx:		DDx:
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	Image:Gallbladder adenocarcinoma (3) lymphatic invasion histopathology.jpg \| GB carcinoma - LVI. (WC)		Image:Gallbladder adenocarcinoma (3) lymphatic invasion histopathology.jpg \| GB carcinoma - LVI. (WC)
	</gallery>		</gallery>

			==IHC==
			Features - conventional:<ref name=pmid23106580>{{Cite journal \| last1 = Dursun \| first1 = N. \| last2 = Escalona \| first2 = OT. \| last3 = Roa \| first3 = JC. \| last4 = Basturk \| first4 = O. \| last5 = Bagci \| first5 = P. \| last6 = Cakir \| first6 = A. \| last7 = Cheng \| first7 = J. \| last8 = Sarmiento \| first8 = J. \| last9 = Losada \| first9 = H. \| title = Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 11 \| pages = 1347-58 \| month = Nov \| year = 2012 \| doi = 10.5858/arpa.2011-0447-OA \| PMID = 23106580 }}</ref>
			*CK7 +ve (7 of 8 cases.
			*CK20 -ve (7 of 8 cases).
			*CDX2 -ve (8 of 8 cases).

	==See also==		==See also==