Gastroesophageal reflux disease - Revision history

Michael: /* Gross */

2016-04-14T19:27:24Z

Gross

← Older revision		Revision as of 19:27, 14 April 2016
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	\|-		\|-
	\|}		\|}
			Note:
			*Correlation with histology is poor; mucosal breaks are seen rarely.<ref name=pmid20659145>{{Cite journal \| last1 = Genta \| first1 = RM. \| last2 = Spechler \| first2 = SJ. \| last3 = Kielhorn \| first3 = AF. \| title = The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology. \| journal = Dis Esophagus \| volume = 24 \| issue = 1 \| pages = 10-7 \| month = Jan \| year = 2011 \| doi = 10.1111/j.1442-2050.2010.01092.x \| PMID = 20659145 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* Gross */

2016-04-14T19:24:01Z

Gross

← Older revision		Revision as of 19:24, 14 April 2016
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	Note:		Note:
	*Many be graded using ''Savary-Miller classification''.		*Many be graded using ''Savary-Miller classification'' or ''Los Angeles classification''.<ref name=pmid20659145>{{Cite journal \| last1 = Genta \| first1 = RM. \| last2 = Spechler \| first2 = SJ. \| last3 = Kielhorn \| first3 = AF. \| title = The Los Angeles and Savary-Miller systems for grading esophagitis: utilization and correlation with histology. \| journal = Dis Esophagus \| volume = 24 \| issue = 1 \| pages = 10-7 \| month = Jan \| year = 2011 \| doi = 10.1111/j.1442-2050.2010.01092.x \| PMID = 20659145 }}</ref>

	Images:		Images:
	*[http://www.gastrohep.com/images/image.asp?id=171 Savary-Miller classification - endoscopic images (gastrohep.com)].		*[http://www.gastrohep.com/images/image.asp?id=171 Savary-Miller classification - endoscopic images (gastrohep.com)].

			===Los Angeles classification for GERD===
			Features:<ref>URL: [http://www.sciencedirect.com/science/article/pii/S2212097113700463 http://www.sciencedirect.com/science/article/pii/S2212097113700463]. Accessed on: 14 April 2015</ref>
			{\| class="wikitable sortable"
			! Classification
			! Description
			\|-
			\| A
			\| mucosal break <=5 mm, not beyond the tops of two (adjacent) mucosal folds
			\|-
			\| B
			\| mucosal break >5 mm, not beyond the tops of two (adjacent) mucosal folds
			\|-
			\| C
			\| mucosa break beyond the tops of two mucosal folds but <75% of the esophageal circumference
			\|-
			\| D
			\| mucosal break >=75% of the esophageal circumference
			\|-
			\|}

	==Microscopic==		==Microscopic==

Michael at 15:56, 23 November 2015

2015-11-23T15:56:35Z

← Older revision		Revision as of 15:56, 23 November 2015
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	www:		www:
	*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-6-815-f03&doi=10.1043%2F1543-2165-134.6.815 EE versus GERD (archivesofpathology.org)].<ref name=pmid20524860>{{Cite journal \| last1 = Genevay \| first1 = M. \| last2 = Rubbia-Brandt \| first2 = L. \| last3 = Rougemont \| first3 = AL. \| title = Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 6 \| pages = 815-25 \| month = Jun \| year = 2010 \| doi = 10.1043/1543-2165-134.6.815 \| PMID = 20524860 }}</ref>		*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-6-815-f03&doi=10.1043%2F1543-2165-134.6.815 EE versus GERD (archivesofpathology.org)].<ref name=pmid20524860>{{Cite journal \| last1 = Genevay \| first1 = M. \| last2 = Rubbia-Brandt \| first2 = L. \| last3 = Rougemont \| first3 = AL. \| title = Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 6 \| pages = 815-25 \| month = Jun \| year = 2010 \| doi = 10.1043/1543-2165-134.6.815 \| PMID = 20524860 }}</ref>

			==Stains==
			*[[Oil red O stain]] +ve in macrophages from [[bronchoalveolar lavage]] specimens.<ref name=pmid20466562>{{Cite journal \| last1 = Hopkins \| first1 = PM. \| last2 = Kermeen \| first2 = F. \| last3 = Duhig \| first3 = E. \| last4 = Fletcher \| first4 = L. \| last5 = Gradwell \| first5 = J. \| last6 = Whitfield \| first6 = L. \| last7 = Godinez \| first7 = C. \| last8 = Musk \| first8 = M. \| last9 = Chambers \| first9 = D. \| title = Oil red O stain of alveolar macrophages is an effective screening test for gastroesophageal reflux disease in lung transplant recipients. \| journal = J Heart Lung Transplant \| volume = 29 \| issue = 8 \| pages = 859-64 \| month = Aug \| year = 2010 \| doi = 10.1016/j.healun.2010.03.015 \| PMID = 20466562 }}</ref>

	==Sign out==		==Sign out==

Michael: /* See also */

2015-05-16T10:18:36Z

Michael: touch

2015-02-28T18:56:01Z

touch

← Older revision		Revision as of 18:56, 28 February 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Gastroesophageal reflux disease -- intermed mag.jpg		\| Image = Gastroesophageal reflux disease -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption = [[Micrograph]] showing histology compatible with gastroesophageal reflux disease. [[H&E stain]].		\| Caption = [[Micrograph]] showing histology compatible with gastroesophageal reflux disease. [[H&E stain]].

Michael at 20:25, 17 June 2014

2014-06-17T20:25:27Z

← Older revision		Revision as of 20:25, 17 June 2014
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	\| Caption = [[Micrograph]] showing histology compatible with gastroesophageal reflux disease. [[H&E stain]].		\| Caption = [[Micrograph]] showing histology compatible with gastroesophageal reflux disease. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = basal cell hyperplasia (> 3 cells thick or >15% of epithelial thickness), papillae elongated (papillae reach into the top 1/3 of the epithelial layer), inflammation, esp. eosinophils, lymphocytes with convoluted nuclei ("squiggle cells"), +/-intraepithelial edema, +/-~~Apoptotic~~ cells		\| Micro = basal cell hyperplasia (> 3 cells thick or >15% of epithelial thickness), papillae elongated (papillae reach into the top 1/3 of the epithelial layer), inflammation, esp. eosinophils, lymphocytes with convoluted nuclei ("squiggle cells"), +/-intraepithelial edema, +/-apoptotic cells, +/-glycogenation
	\| Subtypes =		\| Subtypes =
	\| LMDDx = intestinal metaplasia ([[Barrett's esophagus]]), [[eosinophilic esophagitis]], [[acute esophagitis]]		\| LMDDx = intestinal metaplasia ([[Barrett's esophagus]]), [[eosinophilic esophagitis]], [[acute esophagitis]]

Michael: /* Microscopic */

2014-06-14T03:07:18Z

Microscopic

← Older revision		Revision as of 03:07, 14 June 2014
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	#+/-Intraepithelial edema.		#+/-Intraepithelial edema.
	#+/-Apoptotic cells.<ref name=pmid9926792>{{cite journal \|author=Wetscher GJ, Schwelberger H, Unger A, ''et al.'' \|title=Reflux-induced apoptosis of the esophageal mucosa is inhibited in Barrett's epithelium \|journal=Am. J. Surg. \|volume=176 \|issue=6 \|pages=569–73 \|year=1998 \|month=December \|pmid=9926792 \|doi= \|url=}}</ref>		#+/-Apoptotic cells.<ref name=pmid9926792>{{cite journal \|author=Wetscher GJ, Schwelberger H, Unger A, ''et al.'' \|title=Reflux-induced apoptosis of the esophageal mucosa is inhibited in Barrett's epithelium \|journal=Am. J. Surg. \|volume=176 \|issue=6 \|pages=569–73 \|year=1998 \|month=December \|pmid=9926792 \|doi= \|url=}}</ref>
	#+/-Glycogen - cytoplasm cleared (white).		#+/-Glycogen - cytoplasm cleared (white).<ref name=pmid8409304>{{cite journal \|author=Vadva MD, Triadafilopoulos G \|title=Glycogenic acanthosis of the esophagus and gastroesophageal reflux \|journal=J. Clin. Gastroenterol. \|volume=17 \|issue=1 \|pages=79–83 \|year=1993 \|month=July \|pmid=8409304 \|doi= \|url=}}</ref>

	Notes:		Notes:

Michael: /* Microscopic */

2014-06-14T03:02:54Z

Microscopic

← Older revision		Revision as of 03:02, 14 June 2014
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	#+/-Intraepithelial edema.		#+/-Intraepithelial edema.
	#+/-Apoptotic cells.<ref name=pmid9926792>{{cite journal \|author=Wetscher GJ, Schwelberger H, Unger A, ''et al.'' \|title=Reflux-induced apoptosis of the esophageal mucosa is inhibited in Barrett's epithelium \|journal=Am. J. Surg. \|volume=176 \|issue=6 \|pages=569–73 \|year=1998 \|month=December \|pmid=9926792 \|doi= \|url=}}</ref>		#+/-Apoptotic cells.<ref name=pmid9926792>{{cite journal \|author=Wetscher GJ, Schwelberger H, Unger A, ''et al.'' \|title=Reflux-induced apoptosis of the esophageal mucosa is inhibited in Barrett's epithelium \|journal=Am. J. Surg. \|volume=176 \|issue=6 \|pages=569–73 \|year=1998 \|month=December \|pmid=9926792 \|doi= \|url=}}</ref>
			#+/-Glycogen - cytoplasm cleared (white).

	Notes:		Notes:
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	*[[Barrett's esophagus]] - intestinal metaplasia may be minimal.		*[[Barrett's esophagus]] - intestinal metaplasia may be minimal.

	Images:		===Images===
			<gallery>
			Image: Gastroesophageal reflux disease -- low mag.jpg \| GERD - low mag.
			Image: Gastroesophageal reflux disease -- intermed mag.jpg \| GERD - intermed. mag.
			Image: Gastroesophageal reflux disease -- high mag.jpg \| GERD - high mag.

			Image: Gastroesophageal reflux disease - glycogen -- intermed mag.jpg \| GERD - intermed. mag.
			Image: Gastroesophageal reflux disease - glycogen -- high mag.jpg \| GERD - high mag.
			Image: Gastroesophageal reflux disease - glycogen -- very high mag.jpg \| GERD - high mag.
			</gallery>
			www:
	*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-6-815-f03&doi=10.1043%2F1543-2165-134.6.815 EE versus GERD (archivesofpathology.org)].<ref name=pmid20524860>{{Cite journal \| last1 = Genevay \| first1 = M. \| last2 = Rubbia-Brandt \| first2 = L. \| last3 = Rougemont \| first3 = AL. \| title = Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 6 \| pages = 815-25 \| month = Jun \| year = 2010 \| doi = 10.1043/1543-2165-134.6.815 \| PMID = 20524860 }}</ref>		*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-134-6-815-f03&doi=10.1043%2F1543-2165-134.6.815 EE versus GERD (archivesofpathology.org)].<ref name=pmid20524860>{{Cite journal \| last1 = Genevay \| first1 = M. \| last2 = Rubbia-Brandt \| first2 = L. \| last3 = Rougemont \| first3 = AL. \| title = Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 6 \| pages = 815-25 \| month = Jun \| year = 2010 \| doi = 10.1043/1543-2165-134.6.815 \| PMID = 20524860 }}</ref>

Michael at 02:59, 14 June 2014

2014-06-14T02:59:11Z

← Older revision		Revision as of 02:59, 14 June 2014
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Gastroesophageal reflux disease -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = [[Micrograph]] showing histology compatible with gastroesophageal reflux disease. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = basal cell hyperplasia (> 3 cells thick or >15% of epithelial thickness), papillae elongated (papillae reach into the top 1/3 of the epithelial layer), inflammation, esp. eosinophils, lymphocytes with convoluted nuclei ("squiggle cells"), +/-intraepithelial edema, +/-Apoptotic cells		\| Micro = basal cell hyperplasia (> 3 cells thick or >15% of epithelial thickness), papillae elongated (papillae reach into the top 1/3 of the epithelial layer), inflammation, esp. eosinophils, lymphocytes with convoluted nuclei ("squiggle cells"), +/-intraepithelial edema, +/-Apoptotic cells

Michael at 18:45, 31 January 2014

2014-01-31T18:45:36Z

← Older revision		Revision as of 18:45, 31 January 2014
Line 5:		Line 5:
	\| Caption =		\| Caption =
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = basal cell hyperplasia (> 3 cells thick or >15% of epithelial thickness), papillae elongated (papillae reach into the top 1/3 of the epithelial layer), inflammation, esp. eosinophils, lymphocytes with convoluted nuclei ("squiggle cells"), +/-intraepithelial edema, +/-Apoptotic cells
	\| Subtypes =		\| Subtypes =
	\| LMDDx = intestinal metaplasia ([[Barrett's esophagus]]), [[eosinophilic esophagitis]], [[acute esophagitis]]		\| LMDDx = intestinal metaplasia ([[Barrett's esophagus]]), [[eosinophilic esophagitis]], [[acute esophagitis]]

← Older revision		Revision as of 10:18, 16 May 2015
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	*[[Barrett's esophagus]].		*[[Barrett's esophagus]].
	*[[PPI effect]].		*[[PPI effect]].
			*[[Glycogenic acanthosis of the esophagus]].

	==References==		==References==