Germ cell neoplasia in situ - Revision history

Michael at 04:41, 22 March 2016

2016-03-22T04:41:34Z

← Older revision		Revision as of 04:41, 22 March 2016
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	\| Width =		\| Width =
	\| Caption = GCNIS (left of image). [[H&E stain]].		\| Caption = GCNIS (left of image). [[H&E stain]].
	\| Synonyms =		\| Synonyms = intratubular germ cell neoplasia (old term)
	\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule		\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule
	\| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular non-seminoma)		\| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular non-seminoma)

Michael: tweak

2016-03-16T00:43:13Z

tweak

← Older revision		Revision as of 00:43, 16 March 2016
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	\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule		\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule
	\| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular non-seminoma)		\| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular non-seminoma)
	\| LMDDx = [[seminoma]], [[embryonal carcinoma]], Sertoli cell-only syndrome		\| LMDDx = [[seminoma]], [[embryonal carcinoma]], Sertoli cell-only syndrome, [[mixed germ cell tumour]]
	\| Stains =		\| Stains =
	\| IHC = OCT4, PLAP +ve, D2-40 +ve		\| IHC = OCT4, PLAP +ve, D2-40 +ve
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	*[[Seminoma]] - especially intratubular predominant growth pattern.		*[[Seminoma]] - especially intratubular predominant growth pattern.
	*[[Embryonal carcinoma]].		*[[Embryonal carcinoma]].
			*[[Mixed germ cell tumour]].

	===Images===		===Images===

Michael at 00:41, 16 March 2016

2016-03-16T00:41:47Z

← Older revision		Revision as of 00:41, 16 March 2016
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	\| Synonyms =		\| Synonyms =
	\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule		\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule
	\| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular ~~embyronal carcinoma~~)		\| Subtypes = undifferentiated, differentiated (intratubular seminoma, intratubular non-seminoma)
	\| LMDDx = [[seminoma]], [[embryonal carcinoma]], Sertoli cell-only syndrome		\| LMDDx = [[seminoma]], [[embryonal carcinoma]], Sertoli cell-only syndrome
	\| Stains =		\| Stains =

Michael: /* General */

2016-03-16T00:40:28Z

General

← Older revision		Revision as of 00:40, 16 March 2016
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	Classification:<ref name=pmid11900581/>		Classification:<ref name=pmid11900581/>
	*Undifferentiated ~~ITGCN~~.		*Undifferentiated GCNIS.
	*Differentiated ~~ITGCN~~.<ref name=pmid17592271>{{Cite journal \| last1 = Lau \| first1 = SK. \| last2 = Weiss \| first2 = LM. \| last3 = Chu \| first3 = PG. \| title = Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 7 \| pages = 1045-9 \| month = Jul \| year = 2007 \| doi = 10.1097/PAS.0b013e31802b8712 \| PMID = 17592271 }}</ref>		*Differentiated GCNIS.<ref name=pmid17592271>{{Cite journal \| last1 = Lau \| first1 = SK. \| last2 = Weiss \| first2 = LM. \| last3 = Chu \| first3 = PG. \| title = Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors. \| journal = Am J Surg Pathol \| volume = 31 \| issue = 7 \| pages = 1045-9 \| month = Jul \| year = 2007 \| doi = 10.1097/PAS.0b013e31802b8712 \| PMID = 17592271 }}</ref>
	**''Intratubular embryonal carcinoma''.
	**''Intratubular seminoma.''		**''Intratubular seminoma.''
			**''Intratubular non-seminoma''.

	Treatment:		Treatment:

Michael: update term

2016-03-15T23:10:27Z

update term

← Older revision		Revision as of 23:10, 15 March 2016
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	\| Image = Intratubular germ cell neoplasia - 2 - very high mag.jpg		\| Image = Intratubular germ cell neoplasia - 2 - very high mag.jpg
	\| Width =		\| Width =
	\| Caption = ~~ITGCN~~ (left of image). [[H&E stain]].		\| Caption = GCNIS (left of image). [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule		\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule
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	*Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''.		*Not all germ cell tumours (GCTs) arise from ''intratubular germ cell neoplasia''.

	The following testicular GCTs do not arise from ~~ITGCN~~:		The following testicular GCTs do not arise from GCNIS:
	*[[Spermatocytic ~~seminoma~~]].<ref>{{cite journal \|author=Müller J, Skakkebaek NE, Parkinson MC \|title=The spermatocytic seminoma: views on pathogenesis \|journal=Int. J. Androl. \|volume=10 \|issue=1 \|pages=147–56 \|year=1987 \|month=February \|pmid=3583416 \|doi= \|url=}}</ref>		*[[Spermatocytic tumour]].<ref name=pmid2837162>{{cite journal \|author=Müller J, Skakkebaek NE, Parkinson MC \|title=The spermatocytic seminoma: views on pathogenesis \|journal=Int. J. Androl. \|volume=10 \|issue=1 \|pages=147–56 \|year=1987 \|month=February \|pmid=3583416 \|doi= \|url=}}</ref>
	*[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal \|author=Manivel JC, Simonton S, Wold LE, Dehner LP \|title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study \|journal=Arch. Pathol. Lab. Med. \|volume=112 \|issue=6 \|pages=641–5 \|year=1988 \|month=June \|pmid=2837162 \|doi= \|url=}}</ref>		*[[Yolk sac tumour]]s (endodermal sinus tumour).<ref>{{cite journal \|author=Manivel JC, Simonton S, Wold LE, Dehner LP \|title=Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. A histochemical and immunohistochemical study \|journal=Arch. Pathol. Lab. Med. \|volume=112 \|issue=6 \|pages=641–5 \|year=1988 \|month=June \|pmid=2837162 \|doi= \|url=}}</ref>
	*Teratoma.{{Fact}}		*Teratoma.{{Fact}}
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	====Case 1====		====Case 1====
	<gallery>		<gallery>
	Image: Intratubular germ cell neoplasia - intermed mag.jpg \| ITGCN - intermed. mag.		Image: Intratubular germ cell neoplasia - intermed mag.jpg \| GCNIS (ITGCN) - intermed. mag.
	Image: Intratubular germ cell neoplasia - high mag.jpg \| ITGCN - high mag.		Image: Intratubular germ cell neoplasia - high mag.jpg \| GCNIS (ITGCN) - high mag.
	Image: Intratubular germ cell neoplasia - very high mag.jpg \| ITGCN - very high mag.		Image: Intratubular germ cell neoplasia - very high mag.jpg \| GCNIS (ITGCN) - very high mag.
	Image: Intratubular germ cell neoplasia - 2 - very high mag.jpg \| ITGCN - very high mag.		Image: Intratubular germ cell neoplasia - 2 - very high mag.jpg \| GCNIS (ITGCN) - very high mag.
	</gallery>		</gallery>
	====Case 2====		====Case 2====
	<gallery>		<gallery>
	Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg \| ITGCN - cropped. (WC/Nephron)		Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg \| GCNIS (ITGCN) - cropped. (WC/Nephron)
	Image:Intratubular_germ_cell_neoplasia_high_mag.jpg \| ITGCN. (WC/Nephron)		Image:Intratubular_germ_cell_neoplasia_high_mag.jpg \| GCNIS (ITGCN). (WC/Nephron)
	</gallery>		</gallery>
	====Case 3====		====Case 3====
	<gallery>		<gallery>
	Image: ITGCN and Sertoli cells only -- intermed mag.jpg \| ITGCN & SCO - intermed. mag.		Image: ITGCN and Sertoli cells only -- intermed mag.jpg \| GCNIS (ITGCN) & SCO - intermed. mag.
	Image: ITGCN and Sertoli cells only -- high mag.jpg \| ITGCN & SCO - high mag.		Image: ITGCN and Sertoli cells only -- high mag.jpg \| GCNIS (ITGCN) & SCO - high mag.

	Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg \| ITGCN & SCO - intermed. mag.		Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg \| GCNIS (ITGCN) & SCO - intermed. mag.
	Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg \| ITGCN & SCO - high mag.		Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg \| GCNIS (ITGCN) & SCO - high mag.
	Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg \| ITGCN & SCO - very high mag.		Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg \| GCNIS (ITGCN) & SCO - very high mag.
	</gallery>		</gallery>
	====www====		====www====
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	==IHC==		==IHC==
	===ISUP consensus===		===ISUP consensus===
	ITGCN versus atypical intratubular germ cells:<ref name=pmid25025364>{{Cite journal \| last1 = Amin \| first1 = MB. \| last2 = Epstein \| first2 = JI. \| last3 = Ulbright \| first3 = TM. \| last4 = Humphrey \| first4 = PA. \| last5 = Egevad \| first5 = L. \| last6 = Montironi \| first6 = R. \| last7 = Grignon \| first7 = D. \| last8 = Trpkov \| first8 = K. \| last9 = Lopez-Beltran \| first9 = A. \| title = Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the international society of urological pathology consensus conference. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 8 \| pages = 1017-22 \| month = Aug \| year = 2014 \| doi = 10.1097/PAS.0000000000000254 \| PMID = 25025364 }}</ref>		GCNIS (ITGCN) versus atypical intratubular germ cells:<ref name=pmid25025364>{{Cite journal \| last1 = Amin \| first1 = MB. \| last2 = Epstein \| first2 = JI. \| last3 = Ulbright \| first3 = TM. \| last4 = Humphrey \| first4 = PA. \| last5 = Egevad \| first5 = L. \| last6 = Montironi \| first6 = R. \| last7 = Grignon \| first7 = D. \| last8 = Trpkov \| first8 = K. \| last9 = Lopez-Beltran \| first9 = A. \| title = Best practices recommendations in the application of immunohistochemistry in urologic pathology: report from the international society of urological pathology consensus conference. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 8 \| pages = 1017-22 \| month = Aug \| year = 2014 \| doi = 10.1097/PAS.0000000000000254 \| PMID = 25025364 }}</ref>
	*OCT4 +ve.		*OCT4 +ve.

	Alternates:		Alternates:
	*[[PLAP]] +ve.<ref>{{Cite journal \| last1 = Schreiber \| first1 = L. \| last2 = Lifschitz-Mercer \| first2 = B. \| last3 = Paz \| first3 = G. \| last4 = Yavetz \| first4 = H. \| last5 = Elliott \| first5 = DJ. \| last6 = Kula \| first6 = K. \| last7 = Slowikowska-Hilczer \| first7 = J. \| last8 = Maymon \| first8 = BB. \| title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. \| journal = Int J Surg Pathol \| volume = 11 \| issue = 1 \| pages = 17-20 \| month = Jan \| year = 2003 \| doi = \| PMID = 12598912 }}</ref>		*[[PLAP]] +ve.<ref name=pmid12598912>{{Cite journal \| last1 = Schreiber \| first1 = L. \| last2 = Lifschitz-Mercer \| first2 = B. \| last3 = Paz \| first3 = G. \| last4 = Yavetz \| first4 = H. \| last5 = Elliott \| first5 = DJ. \| last6 = Kula \| first6 = K. \| last7 = Slowikowska-Hilczer \| first7 = J. \| last8 = Maymon \| first8 = BB. \| title = Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis. \| journal = Int J Surg Pathol \| volume = 11 \| issue = 1 \| pages = 17-20 \| month = Jan \| year = 2003 \| doi = \| PMID = 12598912 }}</ref>
	*D2-40 +ve.		*D2-40 +ve.

Michael: rename entity + ref

2016-03-15T23:02:45Z

rename entity + ref

← Older revision		Revision as of 23:02, 15 March 2016
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	\| Tx = radiotherapy (?)		\| Tx = radiotherapy (?)
	}}		}}
	'''~~Intratubular germ~~ cell neoplasia''', abbreviated '''~~ITGCN~~''', is a premalignant lesion of the [[testis]].		'''Germ cell neoplasia in situ''', abbreviated '''GCNIS''', is a premalignant lesion of the [[testis]].

	It ~~is also~~ known as '''testicular intraepithelial neoplasia'''.<ref name=pmid23293116 >{{Cite journal \| last1 = Dieckmann \| first1 = KP. \| last2 = Wilken \| first2 = S. \| last3 = Loy \| first3 = V. \| last4 = Matthies \| first4 = C. \| last5 = Kleinschmidt \| first5 = K. \| last6 = Bedke \| first6 = J. \| last7 = Martinschek \| first7 = A. \| last8 = Souchon \| first8 = R. \| last9 = Pichlmeier \| first9 = U. \| title = Treatment of testicular intraepithelial neoplasia (intratubular germ cell neoplasia unspecified) with local radiotherapy or with platinum-based chemotherapy: a survey of the German Testicular Cancer Study Group. \| journal = Ann Oncol \| volume = 24 \| issue = 5 \| pages = 1332-7 \| month = May \| year = 2013 \| doi = 10.1093/annonc/mds628 \| PMID = 23293116 }}</ref>		It was previously known previously known as '''intratubular germ cell neoplasia''' (abbreviated '''ITGCN''') and '''testicular intraepithelial neoplasia'''.<ref name=pmid23293116 >{{Cite journal \| last1 = Dieckmann \| first1 = KP. \| last2 = Wilken \| first2 = S. \| last3 = Loy \| first3 = V. \| last4 = Matthies \| first4 = C. \| last5 = Kleinschmidt \| first5 = K. \| last6 = Bedke \| first6 = J. \| last7 = Martinschek \| first7 = A. \| last8 = Souchon \| first8 = R. \| last9 = Pichlmeier \| first9 = U. \| title = Treatment of testicular intraepithelial neoplasia (intratubular germ cell neoplasia unspecified) with local radiotherapy or with platinum-based chemotherapy: a survey of the German Testicular Cancer Study Group. \| journal = Ann Oncol \| volume = 24 \| issue = 5 \| pages = 1332-7 \| month = May \| year = 2013 \| doi = 10.1093/annonc/mds628 \| PMID = 23293116 }}</ref><ref name=pmid26918959>{{Cite journal \| last1 = Berney \| first1 = DM. \| last2 = Looijenga \| first2 = L. \| last3 = Idrees \| first3 = M. \| last4 = Oosterhuis \| first4 = JW. \| last5 = Rajpert-De Meyts \| first5 = E. \| last6 = Ulbright \| first6 = TM. \| last7 = Skakkebaek \| first7 = NE. \| title = Germ Cell Neoplasia In Situ (GCNIS). Evolution of the Current Nomenclature for Testicular Pre-invasive Germ Cell Malignancy. \| journal = Histopathology \| volume = \| issue = \| pages = \| month = Feb \| year = 2016 \| doi = 10.1111/his.12958 \| PMID = 26918959 }}</ref>

	==General==		==General==

Michael: Michael moved page Intratubular germ cell neoplasia to Germ cell neoplasia in situ: new WHO term

2016-03-15T22:58:50Z

Michael moved page Intratubular germ cell neoplasia to Germ cell neoplasia in situ: new WHO term

← Older revision	Revision as of 22:58, 15 March 2016
(No difference)

Michael: /* Images */

2015-12-24T03:22:27Z

Images

← Older revision		Revision as of 03:22, 24 December 2015
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image: Intratubular germ cell neoplasia - intermed mag.jpg \| ITGCN - intermed. mag.		Image: Intratubular germ cell neoplasia - intermed mag.jpg \| ITGCN - intermed. mag.
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	Image: Intratubular germ cell neoplasia - 2 - very high mag.jpg \| ITGCN - very high mag.		Image: Intratubular germ cell neoplasia - 2 - very high mag.jpg \| ITGCN - very high mag.
	</gallery>		</gallery>
			====Case 2====
	<gallery>		<gallery>
	Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg \| ITGCN - cropped. (WC/Nephron)		Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg \| ITGCN - cropped. (WC/Nephron)
	Image:Intratubular_germ_cell_neoplasia_high_mag.jpg \| ITGCN. (WC/Nephron)		Image:Intratubular_germ_cell_neoplasia_high_mag.jpg \| ITGCN. (WC/Nephron)
	</gallery>		</gallery>
	www:		====Case 3====
			<gallery>
			Image: ITGCN and Sertoli cells only -- intermed mag.jpg \| ITGCN & SCO - intermed. mag.
			Image: ITGCN and Sertoli cells only -- high mag.jpg \| ITGCN & SCO - high mag.

			Image: ITGCN and Sertoli cells only - PLAP -- intermed mag.jpg \| ITGCN & SCO - intermed. mag.
			Image: ITGCN and Sertoli cells only - PLAP -- high mag.jpg \| ITGCN & SCO - high mag.
			Image: ITGCN and Sertoli cells only - PLAP -- very high mag.jpg \| ITGCN & SCO - very high mag.
			</gallery>
			====www====
	*[http://www.webpathology.com/image.asp?case=30&n=1 ITGCN (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=30&n=1 ITGCN (webpathology.com)].
	*[http://www.archivesofpathology.org/na101/home/literatum/publisher/pinnacle/journals/content/arpa/2002/15432165-126.4/0003-9985%282002%29126%3C0487%3Aiec%3E2.0.co%3B2/production/images/large/i1543-2165-126-4-487-f01.jpeg Intratubular embryonal carcinoma (archivesofpathology.org)].<ref name=pmid11900581/>		*[http://www.archivesofpathology.org/na101/home/literatum/publisher/pinnacle/journals/content/arpa/2002/15432165-126.4/0003-9985%282002%29126%3C0487%3Aiec%3E2.0.co%3B2/production/images/large/i1543-2165-126-4-487-f01.jpeg Intratubular embryonal carcinoma (archivesofpathology.org)].<ref name=pmid11900581/>

Michael: /* Microscopic */

2015-10-05T04:13:19Z

Microscopic

← Older revision		Revision as of 04:13, 5 October 2015
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	DDx:		DDx:
	*Sertoli cell-only syndrome - Sertoli cells also have nucleoli, wind swept appearance.<ref>URL: [http://www.webpathology.com/image.asp?n=3&Case=28 http://www.webpathology.com/image.asp?n=3&Case=28]. Accessed on: 25 March 2013.</ref>		*Sertoli cell-only syndrome - Sertoli cells also have nucleoli, wind swept appearance.<ref>URL: [http://www.webpathology.com/image.asp?n=3&Case=28 http://www.webpathology.com/image.asp?n=3&Case=28]. Accessed on: 25 March 2013.</ref>
	*[[Seminoma]].		*[[Seminoma]] - especially intratubular predominant growth pattern.
	*[[Embryonal carcinoma]].		*[[Embryonal carcinoma]].

Michael at 13:51, 21 July 2015

2015-07-21T13:51:19Z

← Older revision		Revision as of 13:51, 21 July 2015
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	\| Image = Intratubular germ cell neoplasia - 2 - very high mag.jpg		\| Image = Intratubular germ cell neoplasia - 2 - very high mag.jpg
	\| Width =		\| Width =
	\| Caption = ITGCN. [[H&E stain]].		\| Caption = ITGCN (left of image). [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule		\| Micro = "large" round or polygonal nuclei, prominent nucleoli, clear cytoplasm, +/-cells (completely) fill the tubule