Gestational trophoblastic disease - Revision history

Michael at 22:07, 7 December 2023

2023-12-07T22:07:30Z

← Older revision		Revision as of 22:07, 7 December 2023
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	Submitted as "Retained Products of Conception":		Submitted as "Retained Products of Conception":
	- Small and large chorionic villi with cisterns, suggestive of hydropic abortus, see comment.		- Small and large chorionic villi with cisterns, suggestive of hydropic abortus, see comment.
	- Benign ~~scant~~ decidual tissue present.		- Benign decidual tissue present.
	- Negative for evidence of fetal tissue in sampled tissue, see comment.		- Negative for evidence of fetal tissue in sampled tissue, see comment.

Michael at 22:00, 7 December 2023

2023-12-07T22:00:06Z

← Older revision		Revision as of 22:00, 7 December 2023
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	*Molar pregnancy.		*Molar pregnancy.

			===Sign out===
	<pre>		<pre>
	Submitted as "Retained Products of Conception":		Submitted as "Retained Products of Conception":

Michael: +hydropic abortus

2023-12-07T21:59:28Z

+hydropic abortus

← Older revision		Revision as of 21:59, 7 December 2023
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	===Molecular===		===Molecular===
	*The type of mole can be determined by [[cytogenetics]].<ref>[http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf]</ref>		*The type of mole can be determined by [[cytogenetics]].<ref>[http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf http://jcp.bmjjournals.com/cgi/reprint/51/6/438.pdf]</ref>

			==Hydropic abortus==
			===General===
			*May be seen in the context of a previously detected fetal heart beat.

			===Microsopic===
			Features:
			*Enlarged chorionic villi with some cisterns.

			DDx:<ref>{{cite journal \|authors=Rios-Doria E, Pennington KP, Reiter DJ, Parker EU \|title=Diagnostic challenges in differentiating between hydropic abortus, and complete and partial hydatidiform molar pregnancies in early gestation \|journal=Int J Gynecol Cancer \|volume=33 \|issue=9 \|pages=1482–1484 \|date=September 2023 \|pmid=37268312 \|doi=10.1136/ijgc-2022-004104 \|url=}}</ref>
			*Molar pregnancy.

			<pre>
			Submitted as "Retained Products of Conception":
			- Small and large chorionic villi with cisterns, suggestive of hydropic abortus, see comment.
			- Benign scant decidual tissue present.
			- Negative for evidence of fetal tissue in sampled tissue, see comment.

			Comment:
			Imaging previously described a gestational sac and a fetal heart beat.
			</pre>

	==Partial hydatidiform mole==		==Partial hydatidiform mole==

Michael: remove broken link

2023-10-20T01:34:24Z

remove broken link

← Older revision		Revision as of 01:34, 20 October 2023
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	Images:		Images:
	*[http://www.webpathology.com/image.asp?case=589&n=2 ETT (webpathology.com)].<ref name=webp_ett/>		*[http://www.webpathology.com/image.asp?case=589&n=2 ETT (webpathology.com)].<ref name=webp_ett/>
	*[http://www.gfmer.ch/selected_images_v2/detail_list.php?cat1=12&cat3=861&stype=d ETT - several images (gfmer.ch)].

	===IHC===		===IHC===

Michael: +cate

2019-12-11T17:56:02Z

+cate

← Older revision		Revision as of 17:56, 11 December 2019
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	[[Category:Gynecologic pathology]]		[[Category:Gynecologic pathology]]
			[[Category:Gestational trophoblastic disease]]

Brigitte: /* Gross */

2018-05-10T15:11:04Z

Gross

← Older revision		Revision as of 15:11, 10 May 2018
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	Image:		Image:
	*[http://www.nature.com/modpathol/journal/v19/n1/fig_tab/3800485f1.html#figure-title ETT (nature.com)].<ref name=pmid16258513/>

	===Microscopic===		===Microscopic===

Michael at 13:10, 30 June 2017

2017-06-30T13:10:23Z

← Older revision		Revision as of 13:10, 30 June 2017
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	\|}		\|}
	Note:		Note:
	* ‡ The amount of Ki-67 staining varies considerably based on what one reads. Chen ''at al.''<ref>{{Cite journal \| last1 = Chen \| first1 = Y. \| last2 = Shen \| first2 = D. \| last3 = Gu \| first3 = Y. \| last4 = Zhong \| first4 = P. \| last5 = Xie \| first5 = J. \| last6 = Song \| first6 = Q. \| title = The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion. \| journal = Wien Klin Wochenschr \| volume = 124 \| issue = 5-6 \| pages = 184-7 \| month = Mar \| year = 2012 \| doi = 10.1007/s00508-011-0119-4 \| PMID = 22218717 }}</ref> suggest 25% versus 5% for partial mole versus hydropic abortus.		* ‡ The amount of [[Ki-67]] staining varies considerably based on what one reads. Chen ''at al.''<ref>{{Cite journal \| last1 = Chen \| first1 = Y. \| last2 = Shen \| first2 = D. \| last3 = Gu \| first3 = Y. \| last4 = Zhong \| first4 = P. \| last5 = Xie \| first5 = J. \| last6 = Song \| first6 = Q. \| title = The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion. \| journal = Wien Klin Wochenschr \| volume = 124 \| issue = 5-6 \| pages = 184-7 \| month = Mar \| year = 2012 \| doi = 10.1007/s00508-011-0119-4 \| PMID = 22218717 }}</ref> suggest 25% versus 5% for partial mole versus hydropic abortus.

	====Mole versus normal====		====Mole versus normal====

Michael at 13:51, 14 October 2016

2016-10-14T13:51:21Z

← Older revision		Revision as of 13:51, 14 October 2016
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	====Non-molar versus partial versus complete - short version====		====Non-molar versus partial versus complete - short version====
	Features:<ref name=pmid8157742>{{Cite journal \| last1 = Howat \| first1 = AJ. \| last2 = Beck \| first2 = S. \| last3 = Fox \| first3 = H. \| last4 = Harris \| first4 = SC. \| last5 = Hill \| first5 = AS. \| last6 = Nicholson \| first6 = CM. \| last7 = Williams \| first7 = RA. \| title = Can histopathologists reliably diagnose molar pregnancy? \| journal = J Clin Pathol \| volume = 46 \| issue = 7 \| pages = 599-602 \| month = Jul \| year = 1993 \| doi = \| PMID = 8157742 }}</ref>		Features:<ref name=pmid8157742>{{Cite journal \| last1 = Howat \| first1 = AJ. \| last2 = Beck \| first2 = S. \| last3 = Fox \| first3 = H. \| last4 = Harris \| first4 = SC. \| last5 = Hill \| first5 = AS. \| last6 = Nicholson \| first6 = CM. \| last7 = Williams \| first7 = RA. \| title = Can histopathologists reliably diagnose molar pregnancy? \| journal = J Clin Pathol \| volume = 46 \| issue = 7 \| pages = 599-602 \| month = Jul \| year = 1993 \| doi = \| PMID = 8157742 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC501384/?page=3 }}</ref>
	*Non-molar pregnancy: polar proliferation of trophoblastic tissue.		*Non-molar pregnancy: polar proliferation of trophoblastic tissue.
	*Partial mole: Norwegian fjord periphery, circumferential or multifocal trophoblastic proliferation, fetal parts.		*Partial mole: Norwegian fjord periphery, circumferential or multifocal trophoblastic proliferation, fetal parts.

Michael: /* Most common */

2015-03-31T05:59:50Z

Most common

← Older revision		Revision as of 05:59, 31 March 2015
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	\| beta-hCG +ve		\| beta-hCG +ve
	\| ?		\| ?
	\| [~~http~~:~~//www~~.~~webpathology~~.~~com/image.asp?case=36&n=1 choriocarcinoma~~ (~~webpathology.com~~)]		\| [[Image:Choriocarcinoma_-2-_very_high_mag.jpg\|thumb\|center\|120px\|Choriocarcinoma. (WC)]]
	\|-		\|-
	\|}		\|}

Michael at 05:57, 31 March 2015

2015-03-31T05:57:22Z

← Older revision		Revision as of 05:57, 31 March 2015
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	'''Gestational trophoblastic disease''' (GTD) includes [[choriocarcinoma]] and hydatidiform moles.		'''Gestational trophoblastic disease''' (abbreviated '''GTD'''), also '''gestational trophoblastic neoplasia''' (abbreviated '''GTN'''), includes [[choriocarcinoma]] and hydatidiform moles.

	=Overview=		=Overview=