Giant cell cystitis - Revision history

Michael: /* General */

2016-12-07T14:12:59Z

General

← Older revision		Revision as of 14:12, 7 December 2016
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	==General==		==General==
	*Considered a common benign finding; ''not'' a clinical entity.<ref name=Ref_Amin2_6>{{Ref Amin\|2:6}}</ref>		*Considered a common benign finding; ''not'' a clinical entity.<ref name=Ref_Amin2_6>{{Ref Amin\|2:6}}</ref>
	*Reported in up to 1/3 of bladders at autopsy.<ref>{{Cite journal \| last1 = Wells \| first1 = HG \| last2 = \| first2 = \| title = Giant cells in cystitis \| journal = Arch Pathol \| volume = 26 \| issue = \| pages = 32-43 \| month = \| year = 1938 \| doi = \| PMID = \| PMC = \| url = }}</ref>		*Reported in up to 1/3 of bladders at [[autopsy]].<ref>{{Cite journal \| last1 = Wells \| first1 = HG \| last2 = \| first2 = \| title = Giant cells in cystitis \| journal = Arch Pathol \| volume = 26 \| issue = \| pages = 32-43 \| month = \| year = 1938 \| doi = \| PMID = \| PMC = \| url = }}</ref>

	==Microscopic==		==Microscopic==

Michael: +images

2016-12-07T14:00:38Z

+images

← Older revision		Revision as of 14:00, 7 December 2016
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			[[Image:Bladder with benign large mesenchymal cells -- high mag.jpg\|thumb\|right\|300px\|Urinary bladder with benign large mesenchymal cells - so-called "giant cell cystitis". [[H&E stain]].]]
	'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.		'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.

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	*[[Sarcoma]] of the bladder or metastatic sarcoma - typically more cellular.<ref name=Ref_Amin2_6/>		*[[Sarcoma]] of the bladder or metastatic sarcoma - typically more cellular.<ref name=Ref_Amin2_6/>
	*Sarcomatoid change in [[urothelial carcinoma]].		*Sarcomatoid change in [[urothelial carcinoma]].

			===Images===
			<gallery>
			Image: Bladder with benign large mesenchymal cells -- very low mag.jpg \| GCC - very low mag. (WC)
			Image: Bladder with benign large mesenchymal cells -- low mag.jpg \| GCC - low mag. (WC)
			Image: Bladder with benign large mesenchymal cells -- intermed mag.jpg \| GCC - intermed. mag. (WC)
			Image: Bladder with benign large mesenchymal cells -- high mag.jpg \| GCC - high mag. (WC)

			Image: Bladder with benign large mesenchymal cells - alt -- intermed mag.jpg \| GCC - intermed. mag. (WC)
			Image: Bladder with benign large mesenchymal cells - alt -- high mag.jpg \| GCC - high mag. (WC)
			Image: Bladder with benign large mesenchymal cells - alt -- very high mag.jpg \| GCC - very high mag. (WC)
			Image: Bladder with benign large mesenchymal cells -- very high mag.jpg \| GCC - very high mag. (WC)
			</gallery>

	==Sign out==		==Sign out==

Michael: /* See also */

2016-11-02T21:42:22Z

Michael: /* Microscopic */

2016-11-02T21:41:30Z

Microscopic

← Older revision		Revision as of 21:41, 2 November 2016
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	*Scattered atypical mesenchymal cells - mononuclear or multinucleated - '''key feature'''.		*Scattered atypical mesenchymal cells - mononuclear or multinucleated - '''key feature'''.
	*+/-Nuclear hyperchromasia and/or lobulation.		*+/-Nuclear hyperchromasia and/or lobulation.
	*~~Absence~~ of ~~apparent~~ mitotic activity.		*Minimal/absence of mitotic activity.

	Note:		Note:

Michael: /* Microscopic */

2016-11-02T21:40:48Z

Microscopic

← Older revision		Revision as of 21:40, 2 November 2016
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	==Microscopic==		==Microscopic==
	Features:<ref name=Ref_Uropath305>{{Ref Uropath\|305}}</ref>		Features:<ref name=Ref_Uropath305>{{Ref Uropath\|305}}</ref>
	*Scattered atypical mesenchymal cells - mononuclear or multinucleated.		*Scattered atypical mesenchymal cells - mononuclear or multinucleated - '''key feature'''.
	*+/-Nuclear hyperchromasia and/or lobulation.		*+/-Nuclear hyperchromasia and/or lobulation.
	*Absence of apparent mitotic activity.		*Absence of apparent mitotic activity.

Michael at 21:40, 2 November 2016

2016-11-02T21:40:30Z

← Older revision		Revision as of 21:40, 2 November 2016
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	*+/-Nuclear hyperchromasia and/or lobulation.		*+/-Nuclear hyperchromasia and/or lobulation.
	*Absence of apparent mitotic activity.		*Absence of apparent mitotic activity.

			Note:
			*Inflammation may be present or absent; "giant cell cystitis" is a misnomer.

	DDx:		DDx:
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	- NEGATIVE for significant proliferative activity and NEGATIVE for significant inflammation.		- NEGATIVE for significant proliferative activity and NEGATIVE for significant inflammation.
	- NEGATIVE for dysplasia and NEGATIVE for malignancy.		- NEGATIVE for dysplasia and NEGATIVE for malignancy.

	~~Comment:~~
	~~The large mesenchymal cells are a benign change that is referred to~~
	~~as "giant cell cystitis" and may be seen with or without inflammation.~~
	</pre>		</pre>

Michael at 21:37, 2 November 2016

2016-11-02T21:37:47Z

← Older revision		Revision as of 21:37, 2 November 2016
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	'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.		'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.

	''Giant cell cystitis'' is considered a misnomer as may be seen in an otherwise normal bladder that lacks significant inflammation.<ref name=pmid20196670>{{Cite journal \| last1 = Hameed \| first1 = O. \| last2 = Humphrey \| first2 = PA. \| title = Pseudoneoplastic mimics of prostate and bladder carcinomas. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 3 \| pages = 427-43 \| month = Mar \| year = 2010 \| doi = 10.1043/1543-2165-134.3.427 \| PMID = 20196670 }}</ref>		''Giant cell cystitis'' is considered a misnomer as it may be seen in an otherwise normal bladder that lacks significant inflammation.<ref name=pmid20196670>{{Cite journal \| last1 = Hameed \| first1 = O. \| last2 = Humphrey \| first2 = PA. \| title = Pseudoneoplastic mimics of prostate and bladder carcinomas. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 3 \| pages = 427-43 \| month = Mar \| year = 2010 \| doi = 10.1043/1543-2165-134.3.427 \| PMID = 20196670 }}</ref>

	==General==		==General==

Michael at 21:37, 2 November 2016

2016-11-02T21:37:34Z

← Older revision		Revision as of 21:37, 2 November 2016
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	'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.		'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.

	''Giant cell cystitis'' is considered a misnomer as may be seen in an otherwise normal bladder.<ref name=pmid20196670>{{Cite journal \| last1 = Hameed \| first1 = O. \| last2 = Humphrey \| first2 = PA. \| title = Pseudoneoplastic mimics of prostate and bladder carcinomas. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 3 \| pages = 427-43 \| month = Mar \| year = 2010 \| doi = 10.1043/1543-2165-134.3.427 \| PMID = 20196670 }}</ref>		''Giant cell cystitis'' is considered a misnomer as may be seen in an otherwise normal bladder that lacks significant inflammation.<ref name=pmid20196670>{{Cite journal \| last1 = Hameed \| first1 = O. \| last2 = Humphrey \| first2 = PA. \| title = Pseudoneoplastic mimics of prostate and bladder carcinomas. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 3 \| pages = 427-43 \| month = Mar \| year = 2010 \| doi = 10.1043/1543-2165-134.3.427 \| PMID = 20196670 }}</ref>

	==General==		==General==

Michael at 21:32, 2 November 2016

2016-11-02T21:32:53Z

← Older revision		Revision as of 21:32, 2 November 2016
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	'''Giant cell cystitis''' is term used for a benign change of ~~the~~ mesenchymal cells of the [[urinary bladder]] lamina propria.		'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria.

	''Giant cell cystitis'' is considered a misnomer as may be seen in an otherwise normal bladder.<ref name=pmid20196670>{{Cite journal \| last1 = Hameed \| first1 = O. \| last2 = Humphrey \| first2 = PA. \| title = Pseudoneoplastic mimics of prostate and bladder carcinomas. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 3 \| pages = 427-43 \| month = Mar \| year = 2010 \| doi = 10.1043/1543-2165-134.3.427 \| PMID = 20196670 }}</ref>		''Giant cell cystitis'' is considered a misnomer as may be seen in an otherwise normal bladder.<ref name=pmid20196670>{{Cite journal \| last1 = Hameed \| first1 = O. \| last2 = Humphrey \| first2 = PA. \| title = Pseudoneoplastic mimics of prostate and bladder carcinomas. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 3 \| pages = 427-43 \| month = Mar \| year = 2010 \| doi = 10.1043/1543-2165-134.3.427 \| PMID = 20196670 }}</ref>

Michael: /* General */

2016-11-02T21:31:46Z

General

← Older revision		Revision as of 21:31, 2 November 2016
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	==General==		==General==
	*Considered a common benign finding; ''not'' a clinical entity.<ref name=Ref_Amin2_6>{{Ref Amin\|2:6}}</ref>		*Considered a common benign finding; ''not'' a clinical entity.<ref name=Ref_Amin2_6>{{Ref Amin\|2:6}}</ref>
			*Reported in up to 1/3 of bladders at autopsy.<ref>{{Cite journal \| last1 = Wells \| first1 = HG \| last2 = \| first2 = \| title = Giant cells in cystitis \| journal = Arch Pathol \| volume = 26 \| issue = \| pages = 32-43 \| month = \| year = 1938 \| doi = \| PMID = \| PMC = \| url = }}</ref>

	==Microscopic==		==Microscopic==

← Older revision		Revision as of 21:42, 2 November 2016
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	==See also==		==See also==
	*[[Radiation cystitis]].		*[[Radiation cystitis]].
			*[[Giant cells]].

	==References==		==References==