Graves' disease - Revision history

Michael at 12:43, 21 April 2016

2016-04-21T12:43:31Z

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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross = "beefy-red" appearance, enlarged		\| Gross = "beefy-red" appearance, enlarged, +/-white nodules
	\| Grossing =		\| Grossing =
	\| Staging =		\| Staging =

Michael: /* Gross */

2016-04-21T12:43:07Z

Gross

← Older revision		Revision as of 12:43, 21 April 2016
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	==Gross==		==Gross==
	Features:<ref>{{Ref EP\|30}}</ref>		Features:
	*Enlarged 50-150 g.		*Classic appearance:<ref name=Ref_EP30>{{Ref EP\|30}}</ref>
	*"Beefy-red" appearance, looks like raw beef.		**Enlarged 50-150 g.
			**"Beefy-red" appearance, looks like raw beef.
			*May have scattered white nodules (lymphocytes).

	==Microscopic==		==Microscopic==

Michael: /* Images */

2016-04-05T21:07:31Z

Images

← Older revision		Revision as of 21:07, 5 April 2016
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	*[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves' disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref>		*[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves' disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref>
	*[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves' disease & normal thyroid (yale.edu)].		*[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves' disease & normal thyroid (yale.edu)].

			==Sign out==
			===History provided===
			<pre>
			Total Thyroid, Total Thyroidectomy:
			- Lymphocytic thyroiditis compatible with Graves' disease.
			- One benign lymph node (0/1).
			- NEGATIVE for malignancy.
			</pre>

	==See also==		==See also==

Michael: /* Microscopic */

2016-04-05T21:02:54Z

Microscopic

← Older revision		Revision as of 21:02, 5 April 2016
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	*Classic:		*Classic:
	**Hypercellular		**Hypercellular
	**Patchy lymphocytes.		**Patchy lymphocytes.<ref name=pmid6129766>{{Cite journal \| last1 = Leövey \| first1 = A. \| last2 = Bakó \| first2 = G. \| last3 = Sztojka \| first3 = I. \| last4 = Bordán \| first4 = L. \| last5 = Szabó \| first5 = T. \| last6 = Kálmán \| first6 = K. \| last7 = Balázs \| first7 = C. \| title = The pathogenetic connection between Graves' disease and chronic lymphocytic thyroiditis. (The role and incidence of thyroid stimulating antibodies). \| journal = Acta Med Acad Sci Hung \| volume = 39 \| issue = 1-2 \| pages = 1-6 \| month = \| year = 1982 \| doi = \| PMID = 6129766 }}</ref>
	**Little colloid.		**Little colloid.
	*Scalloping of colloid; colloid has undulating border.		*Scalloping of colloid; colloid has undulating border.
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	DDx:		DDx:
	*[[Papillary thyroid carcinoma]].		*[[Papillary thyroid carcinoma]].
			*[[Lymphocytic thyroiditis]].

	===Images===		===Images===

Michael at 04:25, 12 December 2015

2015-12-12T04:25:52Z

← Older revision		Revision as of 04:25, 12 December 2015
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs = exophthalmos		\| Signs = exophthalmos, signs of hyperthyroidism (tremor, muscle wasting, weight loss, tachycardia, sweating)
	\| Symptoms =		\| Symptoms = symptoms of hyperthyroidism (palpitations, fatigue, restlessness, oligomenorrhea, amenorrhea, intolerance to heart, diarrhea, irritability)
	\| Prevalence = uncommon		\| Prevalence = uncommon
	\| Bloodwork = TSH-receptor antibody - required		\| Bloodwork = TSH-receptor antibody - required

Michael: /* General */

2015-12-12T04:23:15Z

General

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	*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal \| last1 = Massart \| first1 = C. \| last2 = Gibassier \| first2 = J. \| last3 = d'Herbomez \| first3 = M. \| title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. \| journal = Clin Chim Acta \| volume = 407 \| issue = 1-2 \| pages = 62-6 \| month = Sep \| year = 2009 \| doi = 10.1016/j.cca.2009.06.033 \| PMID = 19576193 }}</ref>		*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal \| last1 = Massart \| first1 = C. \| last2 = Gibassier \| first2 = J. \| last3 = d'Herbomez \| first3 = M. \| title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. \| journal = Clin Chim Acta \| volume = 407 \| issue = 1-2 \| pages = 62-6 \| month = Sep \| year = 2009 \| doi = 10.1016/j.cca.2009.06.033 \| PMID = 19576193 }}</ref>
	*+/-Exophthalmos (bulging eyes).		*+/-Exophthalmos (bulging eyes).

			===Hyperthyroidism===
			Mnemonic ''hyperTHYROIDISM'':<ref name=Ref_TN2006_E24>{{Ref TN2006\|E24}}</ref><ref>URL: [http://www.prep4usmle.com/forum/thread/6731/2/ http://www.prep4usmle.com/forum/thread/6731/2/]. Accessed on: 1 May 2012.</ref>
			*Tremor.
			*Heart rate elevated, palpitations.
			*Yawn (fatigue).
			*Restlessness.
			*Oligomenorrhea, amenorrhea.
			*Intolerance to heat.
			*Diarrhea.
			*Irritable.
			*Sweating.
			*Muscle wasting/weight loss.

	==Gross==		==Gross==

Michael: /* See also */

2015-12-12T03:46:13Z

Michael at 02:38, 12 December 2015

2015-12-12T02:38:53Z

← Older revision		Revision as of 02:38, 12 December 2015
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	\| Caption = Graves' disease. [[H&E stain]]. (WC)		\| Caption = Graves' disease. [[H&E stain]]. (WC)
	\| Synonyms =		\| Synonyms =
	\| Micro = hypercellular appearance with patchy lymphocytes, little colloid that is scalloped,		\| Micro = hypercellular appearance with patchy lymphocytes, little colloid that is scalloped, +/-nuclear clearing, +/-papillae
	+/-nuclear clearing, +/-papillae
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[papillary thyroid carcinoma]]		\| LMDDx = [[papillary thyroid carcinoma]]

Michael: /* Microscopic */

2015-12-12T02:38:26Z

Microscopic

← Older revision		Revision as of 02:38, 12 December 2015
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	*Usually has an unimpressive appearance... as it is treated, i.e. history is important.		*Usually has an unimpressive appearance... as it is treated, i.e. history is important.
	*Nuclear clearing and papillae are usu. diffuse in Graves' disease - unlike in papillary thyroid carcinoma.		*Nuclear clearing and papillae are usu. diffuse in Graves' disease - unlike in papillary thyroid carcinoma.

			DDx:
			*[[Papillary thyroid carcinoma]].

	===Images===		===Images===

Michael at 02:37, 12 December 2015

2015-12-12T02:37:57Z

← Older revision		Revision as of 02:37, 12 December 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Graves disease -- low mag.jpg
			\| Width =
			\| Caption = Graves' disease. [[H&E stain]]. (WC)
			\| Synonyms =
			\| Micro = hypercellular appearance with patchy lymphocytes, little colloid that is scalloped,
			+/-nuclear clearing, +/-papillae
			\| Subtypes =
			\| LMDDx = [[papillary thyroid carcinoma]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = "beefy-red" appearance, enlarged
			\| Grossing =
			\| Staging =
			\| Site = [[thyroid gland]]
			\| Assdx = [[papillary thyroid carcinoma]]
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = exophthalmos
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork = TSH-receptor antibody - required
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism.		'''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism.

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	Clinical:		Clinical:
	*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal \| last1 = Massart \| first1 = C. \| last2 = Gibassier \| first2 = J. \| last3 = d'Herbomez \| first3 = M. \| title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. \| journal = Clin Chim Acta \| volume = 407 \| issue = 1-2 \| pages = 62-6 \| month = Sep \| year = 2009 \| doi = 10.1016/j.cca.2009.06.033 \| PMID = 19576193 }}</ref>		*TSH-receptor antibody +ve.<ref name=pmid19576193>{{Cite journal \| last1 = Massart \| first1 = C. \| last2 = Gibassier \| first2 = J. \| last3 = d'Herbomez \| first3 = M. \| title = Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. \| journal = Clin Chim Acta \| volume = 407 \| issue = 1-2 \| pages = 62-6 \| month = Sep \| year = 2009 \| doi = 10.1016/j.cca.2009.06.033 \| PMID = 19576193 }}</ref>
			*+/-Exophthalmos (bulging eyes).

	==Gross==		==Gross==

← Older revision		Revision as of 03:46, 12 December 2015
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	==See also==		==See also==
	*[[Thyroid gland]].		*[[Thyroid gland]].
			*[[Hashimoto's thyroiditis]].

	==References==		==References==