https://librepathology.org/w/index.php?action=history&feed=atom&title=H3F3A 2026-05-11T14:13:30Z Revision history for this page on the wiki MediaWiki 1.36.3 https://librepathology.org/w/index.php?title=H3F3A&diff=43784&oldid=prev 2016-04-18T14:00:28Z

<p>K27M antibody</p> <p><b>New page</b></p><div>[[File:K27M_mutant_diffuse_glioma_of_the_midline.jpg|thumb|right|250px|K27M staining in a diffuse glioma of the midline.]]<br /> '''H3F3A (K27M)''', often abbreviated '''K27M''' or '''H3.3 K27M''' is a mutation-specific antibody detecting the K27M mutation in tumor nuclei.&lt;ref&gt;{{Cite journal | last1 = Venneti | first1 = S. | last2 = Santi | first2 = M. | last3 = Felicella | first3 = MM. | last4 = Yarilin | first4 = D. | last5 = Phillips | first5 = JJ. | last6 = Sullivan | first6 = LM. | last7 = Martinez | first7 = D. | last8 = Perry | first8 = A. | last9 = Lewis | first9 = PW. | title = A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas. | journal = Acta Neuropathol | volume = 128 | issue = 5 | pages = 743-53 | month = Nov | year = 2014 | doi = 10.1007/s00401-014-1338-3 | PMID = 25200322 }}<br /> <br /> &lt;/ref&gt;<br /> <br /> ==Positive staining==<br /> *Nuclear<br /> **Approx 30% of pediatric glioma.<br /> **Approx 80% of diffuse intrinsic pontine glioma (DIPG).<br /> <br /> Note:<br /> *The antibody does not detect other H3F3A mutations (ie. G34V or G34R).<br /> <br /> ==Normal tissues==<br /> *Absent<br /> <br /> ==See also==<br /> *[[Immunohistochemistry]].<br /> <br /> ==References==<br /> {{Reflist|1}}<br /> <br /> [[Category:Immunohistochemistry]]<br /> [[Category:Neuropathology]]</div>

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