Hereditary renal cell carcinoma - Revision history

Michael: add edit that lost

2025-04-24T16:49:30Z

add edit that lost

← Older revision		Revision as of 16:49, 24 April 2025
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	===Suspected - young patient===		===Suspected - young patient===
	<pre>		<pre>
	The patient is eligible for genetic testing via Cancer Care Ontario's Hereditary Cancer Testing program, as they are less than age 45 years at the time of the diagnosis.		The patient should be eligible for genetic testing via Cancer Care Ontario's Hereditary Cancer Testing program, as they are less than age 45 years at the time of the diagnosis.
			https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources
			https://www.cancercareontario.ca/en/guidelines-advice/types-of-cancer/70161
			</pre>
			===Family history===
			<pre>
			The patient should be eligible for genetic testing via Cancer Care Ontario's Hereditary Cancer Testing program, due to the family history.
	https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources		https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources
	https://www.cancercareontario.ca/en/guidelines-advice/types-of-cancer/70161		https://www.cancercareontario.ca/en/guidelines-advice/types-of-cancer/70161

Michael at 16:30, 28 February 2025

2025-02-28T16:30:44Z

← Older revision		Revision as of 16:30, 28 February 2025
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	Others:		Others:
	* Hereditary papillary carcinoma (TFE3 related translocations).<ref name=omim314310>{{OMIM\|314310}}</ref>		* Hereditary papillary carcinoma (TFE3 related translocations).<ref name=omim314310>{{OMIM\|314310}}</ref>
	* BAP1 ~~associated with~~ clear cell RCC.<ref name=pmid37941648>{{cite journal \|authors=Lee J, Thuzar M, DiPoto-Brahmbhatt AC, Chaudoir C, Tanner A, Fazili T, Yu X, Constantinescu M, Yeh YA \|title=Clear cell renal cell carcinoma with BAP1 mutation: a report of two cases \|journal=Am J Clin Exp Urol \|volume=11 \|issue=5 \|pages=429–434 \|date=2023 \|pmid=37941648 \|pmc=10628621 \|doi= \|url=}}</ref>		* Small number of BAP1 mutation described in the context of clear cell RCC.<ref name=pmid37941648>{{cite journal \|authors=Lee J, Thuzar M, DiPoto-Brahmbhatt AC, Chaudoir C, Tanner A, Fazili T, Yu X, Constantinescu M, Yeh YA \|title=Clear cell renal cell carcinoma with BAP1 mutation: a report of two cases \|journal=Am J Clin Exp Urol \|volume=11 \|issue=5 \|pages=429–434 \|date=2023 \|pmid=37941648 \|pmc=10628621 \|doi= \|url=}}</ref>

	Notes:<br>		Notes:<br>

Michael at 16:29, 28 February 2025

2025-02-28T16:29:55Z

← Older revision		Revision as of 16:29, 28 February 2025
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	Others:		Others:
	* Hereditary papillary carcinoma (TFE3 related translocations).<ref name=omim314310>{{OMIM\|314310}}</ref>		* Hereditary papillary carcinoma (TFE3 related translocations).<ref name=omim314310>{{OMIM\|314310}}</ref>
			* BAP1 associated with clear cell RCC.<ref name=pmid37941648>{{cite journal \|authors=Lee J, Thuzar M, DiPoto-Brahmbhatt AC, Chaudoir C, Tanner A, Fazili T, Yu X, Constantinescu M, Yeh YA \|title=Clear cell renal cell carcinoma with BAP1 mutation: a report of two cases \|journal=Am J Clin Exp Urol \|volume=11 \|issue=5 \|pages=429–434 \|date=2023 \|pmid=37941648 \|pmc=10628621 \|doi= \|url=}}</ref>

	Notes:<br>		Notes:<br>

Michael at 19:56, 25 November 2024

2024-11-25T19:56:12Z

← Older revision		Revision as of 19:56, 25 November 2024
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	<pre>		<pre>
	The patient is eligible for genetic testing via Cancer Care Ontario's Hereditary Cancer Testing program, as they are less than age 45 years at the time of the diagnosis.		The patient is eligible for genetic testing via Cancer Care Ontario's Hereditary Cancer Testing program, as they are less than age 45 years at the time of the diagnosis.
	https://www.cancercareontario.ca/~~sites~~/~~ccocancercare~~/~~files~~/guidelines/~~full~~/~~HCTEligibilityCriteriaV3_0.pdf~~		https://www.cancercareontario.ca/en/guidelines-advice/treatment-modality/pathology-laboratory-testing/genetic-testing-resources
			https://www.cancercareontario.ca/en/guidelines-advice/types-of-cancer/70161
	</pre>		</pre>

Michael at 21:39, 15 August 2024

2024-08-15T21:39:34Z

← Older revision		Revision as of 21:39, 15 August 2024
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	**Familial:		**Familial:
	***Trisomy 7 - contains MET gene.<ref>{{OMIM\|164860}}</ref>		***Trisomy 7 - contains MET gene.<ref>{{OMIM\|164860}}</ref>

			==Sign out==
			===Suspected - young patient===
			<pre>
			The patient is eligible for genetic testing via Cancer Care Ontario's Hereditary Cancer Testing program, as they are less than age 45 years at the time of the diagnosis.
			https://www.cancercareontario.ca/sites/ccocancercare/files/guidelines/full/HCTEligibilityCriteriaV3_0.pdf
			</pre>

	==See also==		==See also==

Michael at 21:38, 15 August 2024

2024-08-15T21:38:24Z

← Older revision		Revision as of 21:38, 15 August 2024
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	'''Hereditary renal cell carcinoma''' is relatively uncommon.		'''Hereditary renal cell carcinoma''' is relatively uncommon.

			==General==
	The classics - which are ''all'' autosomal dominant:<ref name=Ref_PBoD1016>{{Ref PBoD\|1016}}</ref>		The classics - which are ''all'' autosomal dominant:<ref name=Ref_PBoD1016>{{Ref PBoD\|1016}}</ref>
	# [[Von Hippel-Lindau syndrome]].		# [[Von Hippel-Lindau syndrome]].
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	*A total of ten hereditary renal cancer syndromes have been described. In eight of the ten the gene is known.<ref name=pmid20817385>{{Cite journal \| last1 = Verine \| first1 = J. \| last2 = Pluvinage \| first2 = A. \| last3 = Bousquet \| first3 = G. \| last4 = Lehmann-Che \| first4 = J. \| last5 = de Bazelaire \| first5 = C. \| last6 = Soufir \| first6 = N. \| last7 = Mongiat-Artus \| first7 = P. \| title = Hereditary renal cancer syndromes: an update of a systematic review. \| journal = Eur Urol \| volume = 58 \| issue = 5 \| pages = 701-10 \| month = Nov \| year = 2010 \| doi = 10.1016/j.eururo.2010.08.031 \| PMID = 20817385 }}</ref>		*A total of ten hereditary renal cancer syndromes have been described. In eight of the ten the gene is known.<ref name=pmid20817385>{{Cite journal \| last1 = Verine \| first1 = J. \| last2 = Pluvinage \| first2 = A. \| last3 = Bousquet \| first3 = G. \| last4 = Lehmann-Che \| first4 = J. \| last5 = de Bazelaire \| first5 = C. \| last6 = Soufir \| first6 = N. \| last7 = Mongiat-Artus \| first7 = P. \| title = Hereditary renal cancer syndromes: an update of a systematic review. \| journal = Eur Urol \| volume = 58 \| issue = 5 \| pages = 701-10 \| month = Nov \| year = 2010 \| doi = 10.1016/j.eururo.2010.08.031 \| PMID = 20817385 }}</ref>

	===Molecular===		==Molecular==
	Recurrent molecular changes in RCC:		Recurrent molecular changes in RCC:
	*Clear cell RCC:		*Clear cell RCC:

Michael: Removed redirect to Kidney tumours#Hereditary renal cell carcinoma

2024-08-15T21:36:25Z

Removed redirect to Kidney tumours#Hereditary renal cell carcinoma

← Older revision		Revision as of 21:36, 15 August 2024
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	#~~redirect~~ [[~~Kidney_tumours~~#~~Hereditary_renal_cell_carcinoma~~]]		'''Hereditary renal cell carcinoma''' is relatively uncommon.

			The classics - which are ''all'' autosomal dominant:<ref name=Ref_PBoD1016>{{Ref PBoD\|1016}}</ref>
			# [[Von Hippel-Lindau syndrome]].
			#* VHL gene mutation.
			#* Clear cell RCC.
			# Hereditary [[clear cell renal cell carcinoma]].
			#* VHL gene mutation.
			# Hereditary [[papillary renal cell carcinoma]].
			#* MET proto-oncogene mutation.
			#* PaRCC type 1.<ref name=Ref_WMSP290>{{Ref WMSP\|290}}</ref>
			# [[Hereditary leiomyomatosis and renal cell cancer]]:<ref name=Ref_WMSP290>{{Ref WMSP\|290}}</ref>
			#* FH (fumarate hydratase) gene mutation.<ref name=omim136850>{{OMIM\|136850}}</ref>
			#* PaRCC type 2.
			#* Benign [[leiomyoma]]s skin/[[uterine leiomyoma\|uterus]].
			#* Uterine [[leiomyosarcoma]].
			# [[Birt–Hogg–Dubé syndrome]]:<ref name=Ref_WMSP290>{{Ref WMSP\|290}}</ref>
			#* FLCN (folliculin) gene mutation.<ref name=omim135150>{{OMIM\|135150}}</ref>
			#* Skin lesions (fibrofolliculoma, trichodiscoma, [[acrochordon]]).
			#* ChRCC most common, other types seen (e.g. [[renal oncocytoma\|oncocytoma]]).
			#* Variable penetrance (autosomal dominant).

			Others:
			* Hereditary papillary carcinoma (TFE3 related translocations).<ref name=omim314310>{{OMIM\|314310}}</ref>

			Notes:<br>
			*A total of ten hereditary renal cancer syndromes have been described. In eight of the ten the gene is known.<ref name=pmid20817385>{{Cite journal \| last1 = Verine \| first1 = J. \| last2 = Pluvinage \| first2 = A. \| last3 = Bousquet \| first3 = G. \| last4 = Lehmann-Che \| first4 = J. \| last5 = de Bazelaire \| first5 = C. \| last6 = Soufir \| first6 = N. \| last7 = Mongiat-Artus \| first7 = P. \| title = Hereditary renal cancer syndromes: an update of a systematic review. \| journal = Eur Urol \| volume = 58 \| issue = 5 \| pages = 701-10 \| month = Nov \| year = 2010 \| doi = 10.1016/j.eururo.2010.08.031 \| PMID = 20817385 }}</ref>

			===Molecular===
			Recurrent molecular changes in RCC:
			*Clear cell RCC:
			**Loss of 3p - contains the VHL gene.
			*Papillary RCC:
			**Sporadic:
			***Trisomy 7, 16, 17.
			***Loss of Y.
			**Familial:
			***Trisomy 7 - contains MET gene.<ref>{{OMIM\|164860}}</ref>

			==See also==
			*[[Kidney tumours]].

			==References==
			{{Reflist\|2}}

			[[Category:Kidney tumours]]

Michael: redirect

2013-01-07T15:28:17Z

redirect

New page

#redirect [[Kidney_tumours#Hereditary_renal_cell_carcinoma]]