High-grade papillary urothelial carcinoma - Revision history

Michael at 01:43, 22 February 2017

2017-02-22T01:43:08Z

← Older revision		Revision as of 01:43, 22 February 2017
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	\| LMDDx = [[low-grade papillary urothelial carcinoma]], [[urothelial carcinoma in situ]], [[squamous cell carcinoma]]		\| LMDDx = [[low-grade papillary urothelial carcinoma]], [[urothelial carcinoma in situ]], [[squamous cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = Ki-67 high (>35% of cells)		\| IHC = Ki-67 high (>35% of cells), PAX8 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 22:12, 4 March 2016

2016-03-04T22:12:11Z

← Older revision		Revision as of 22:12, 4 March 2016
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	*[[Low grade papillary urothelial carcinoma]].		*[[Low grade papillary urothelial carcinoma]].
	**Stanford criteria has a 5% rule -- if the high-grade component is <5% it is low-grade.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>		**Stanford criteria has a 5% rule -- if the high-grade component is <5% it is low-grade.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>
			***There is some evidence to suggest low-grade with <5% high-grade behaves similar to low-grade.<ref name=pmid26520419>{{Cite journal \| last1 = Reis \| first1 = LO. \| last2 = Taheri \| first2 = D. \| last3 = Chaux \| first3 = A. \| last4 = Guner \| first4 = G. \| last5 = Mendoza Rodriguez \| first5 = MA. \| last6 = Bivalacqua \| first6 = TJ. \| last7 = Schoenberg \| first7 = MP. \| last8 = Epstein \| first8 = JI. \| last9 = Netto \| first9 = GJ. \| title = Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder. \| journal = Hum Pathol \| volume = 47 \| issue = 1 \| pages = 20-5 \| month = Jan \| year = 2016 \| doi = 10.1016/j.humpath.2015.09.007 \| PMID = 26520419 }}></ref>
	*[[Prostate carcinoma]] with pseudopapillae<ref name=pmid24503758>{{cite journal \|author=Gordetsky J, Epstein JI \|title=Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=7 \|pages=941–5 \|year=2014 \|month=July \|pmid=24503758 \|doi=10.1097/PAS.0000000000000178 \|url=}}</ref> - see ''[[urothelial carcinoma-like prostatic carcinoma]]''.		*[[Prostate carcinoma]] with pseudopapillae<ref name=pmid24503758>{{cite journal \|author=Gordetsky J, Epstein JI \|title=Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=7 \|pages=941–5 \|year=2014 \|month=July \|pmid=24503758 \|doi=10.1097/PAS.0000000000000178 \|url=}}</ref> - see ''[[urothelial carcinoma-like prostatic carcinoma]]''.
	**Should be considered if a [[urethra]]l tumour.		**Should be considered if a [[urethra]]l tumour.

Michael: /* Microscopic */

2016-03-04T22:09:15Z

Microscopic

← Older revision		Revision as of 22:09, 4 March 2016
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	DDx:		DDx:
	*[[Low grade papillary urothelial carcinoma]].		*[[Low grade papillary urothelial carcinoma]].
			**Stanford criteria has a 5% rule -- if the high-grade component is <5% it is low-grade.<ref>URL: [http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/ http://surgpathcriteria.stanford.edu/bladder/tcc-papillary-transitional-urothelial-carcinoma/]. Accessed on: 27 January 2014.</ref>
	*[[Prostate carcinoma]] with pseudopapillae<ref name=pmid24503758>{{cite journal \|author=Gordetsky J, Epstein JI \|title=Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=7 \|pages=941–5 \|year=2014 \|month=July \|pmid=24503758 \|doi=10.1097/PAS.0000000000000178 \|url=}}</ref> - see ''[[urothelial carcinoma-like prostatic carcinoma]]''.		*[[Prostate carcinoma]] with pseudopapillae<ref name=pmid24503758>{{cite journal \|author=Gordetsky J, Epstein JI \|title=Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=7 \|pages=941–5 \|year=2014 \|month=July \|pmid=24503758 \|doi=10.1097/PAS.0000000000000178 \|url=}}</ref> - see ''[[urothelial carcinoma-like prostatic carcinoma]]''.
	**Should be considered if a [[urethra]]l tumour.		**Should be considered if a [[urethra]]l tumour.

Michael: /* Sign out */

2015-12-07T18:56:03Z

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← Older revision		Revision as of 18:56, 7 December 2015
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	-- Please see synoptic report.		-- Please see synoptic report.
	- Muscularis propria present and NEGATIVE for invasion.		- Muscularis propria present and NEGATIVE for invasion.
	- NEGATIVE for carcinoma in situ.		- NEGATIVE for (flat) urothelial carcinoma in situ.
	</pre>		</pre>

Michael: /* Micro */

2015-12-07T18:49:28Z

Micro

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	====Micro====		====Micro====
			The sections show urothelial mucosa with thick papillary structures. Focally, nuclei are large (~3-4x resting lymphocyte), hyperchromatic and have nucleoli. Mitotic activity is present and focally brisk (4 mitoses in 1 HPF, 1 HPF~0.2376 mm*mm). Umbrella cells are seen only focally.

			=====Alternate=====
	The sections show a small fragment of urothelial mucosa with two papillary structures,		The sections show a small fragment of urothelial mucosa with two papillary structures,
	enlarged nuclei (~3-4x resting lymphocyte) and moderate nuclear size variation. Mitotic activity is seen focally. Umbrella		enlarged nuclei (~3-4x resting lymphocyte) and moderate nuclear size variation. Mitotic activity is seen focally. Umbrella

Michael: /* Sign out */

2015-12-07T18:41:38Z

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← Older revision		Revision as of 18:41, 7 December 2015
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	Urinary Bladder Tumour, Transurethral Resection:		Urinary Bladder Tumour, Transurethral Resection:
	- HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA.		- HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA.
	-- NEGATIVE for lamina propria ~~invasion~~		-- NEGATIVE for lamina propria invasion.
	~~-- Muscularis propria present and NEGATIVE for~~ invasion.
	-- NEGATIVE for lymphovascular invasion.		-- NEGATIVE for lymphovascular invasion.
	-- Please see synoptic report.		-- Please see synoptic report.
			- Muscularis propria present and NEGATIVE for invasion.
	- NEGATIVE for carcinoma in situ.		- NEGATIVE for carcinoma in situ.
	</pre>		</pre>

Michael: /* Sign out */

2015-12-07T18:40:35Z

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← Older revision		Revision as of 18:40, 7 December 2015
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	==Sign out==		==Sign out==
			<pre>
			Urinary Bladder Tumour, Transurethral Resection:
			- HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA.
			-- NEGATIVE for lamina propria invasion
			-- Muscularis propria present and NEGATIVE for invasion.
			-- NEGATIVE for lymphovascular invasion.
			-- Please see synoptic report.
			- NEGATIVE for carcinoma in situ.
			</pre>

			====Block letters====
	<pre>		<pre>
	URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION:		URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION:
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	contains a nest with smaller cells, cystic spaces and no appreciable mitoses		contains a nest with smaller cells, cystic spaces and no appreciable mitoses
	(cystitis cystica).		(cystitis cystica).

	==See also==		==See also==
	*[[Urothelium]].		*[[Urothelium]].

Michael: /* Invasion into the lamina propria */

2015-11-08T18:42:40Z

Invasion into the lamina propria

← Older revision		Revision as of 18:42, 8 November 2015
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	Urinary Bladder Tumour, Transurethral Resection:		Urinary Bladder Tumour, Transurethral Resection:
	- INVASIVE HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA with lamina propria invasion.		- INVASIVE HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA with lamina propria invasion.
	-- Muscularis propria present, NEGATIVE for ~~invasive malignancy~~.		-- Muscularis propria present, NEGATIVE for muscularis propria invasion.
	-- NEGATIVE for lymphovascular invasion.		-- NEGATIVE for lymphovascular invasion.
	-- Please see synoptic report.		-- Please see synoptic report.

Michael: /* Invasion into the lamina propria */

2015-11-08T18:35:12Z

Invasion into the lamina propria

← Older revision		Revision as of 18:35, 8 November 2015
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	Urinary Bladder Tumour, Transurethral Resection:		Urinary Bladder Tumour, Transurethral Resection:
	- INVASIVE HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA with lamina propria invasion.		- INVASIVE HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA with lamina propria invasion.
	-- Muscularis propria NEGATIVE for invasive malignancy.		-- Muscularis propria present, NEGATIVE for invasive malignancy.
	-- NEGATIVE lymphovascular invasion.		-- NEGATIVE for lymphovascular invasion.
	-- Please see synoptic report.		-- Please see synoptic report.
	</pre>		</pre>

Michael: /* Invasion into the lamina propria */

2015-11-08T18:32:37Z

Invasion into the lamina propria

← Older revision		Revision as of 18:32, 8 November 2015
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	===Invasion into the lamina propria===		===Invasion into the lamina propria===
			<pre>
			Urinary Bladder Tumour, Transurethral Resection:
			- INVASIVE HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA with lamina propria invasion.
			-- Muscularis propria NEGATIVE for invasive malignancy.
			-- NEGATIVE lymphovascular invasion.
			-- Please see synoptic report.
			</pre>

			====Block letters====
	<pre>		<pre>
	URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION URINARY BLADDER TUMOUR (TURBT):		URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION URINARY BLADDER TUMOUR (TURBT):