Hyalinizing clear cell carcinoma - Revision history

Michael: /* Microscopic */

2016-03-13T16:00:44Z

Microscopic

← Older revision		Revision as of 16:00, 13 March 2016
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	*Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal \| last1 = Milchgrub \| first1 = S. \| last2 = Gnepp \| first2 = DR. \| last3 = Vuitch \| first3 = F. \| last4 = Delgado \| first4 = R. \| last5 = Albores-Saavedra \| first5 = J. \| title = Hyalinizing clear cell carcinoma of salivary gland. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 1 \| pages = 74-82 \| month = Jan \| year = 1994 \| doi = \| PMID = 7506496 }}</ref>		*Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal \| last1 = Milchgrub \| first1 = S. \| last2 = Gnepp \| first2 = DR. \| last3 = Vuitch \| first3 = F. \| last4 = Delgado \| first4 = R. \| last5 = Albores-Saavedra \| first5 = J. \| title = Hyalinizing clear cell carcinoma of salivary gland. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 1 \| pages = 74-82 \| month = Jan \| year = 1994 \| doi = \| PMID = 7506496 }}</ref>
	*Low mitotic rate.		*Low mitotic rate.
			*Should ''not'' have epidermoid or mucinous differentiation - seen in clear cell variant of mucoepidermoid carcinoma.

	DDx:		DDx:
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/>

	==Stains==		==Stains==
	*PAS +ve.		*PAS +ve.

Michael at 02:48, 1 October 2014

2014-10-01T02:48:48Z

← Older revision		Revision as of 02:48, 1 October 2014
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = usu. palate or tongue		\| Site = usu. palate or [[tongue]]
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =

Michael at 00:25, 6 January 2014

2014-01-06T00:25:37Z

← Older revision		Revision as of 00:25, 6 January 2014
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	\| Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma		\| Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[mucoepidermoid carcinoma]] (clear cell variant), [[acinic cell carcinoma]] (clear cell variant), metastatic [[clear cell renal cell carcinoma]], [[epithelial-myoepithelial carcinoma]], other [[clear cell tumours]]
	\| Stains = PAS +ve		\| Stains = PAS +ve
	\| IHC = AE1/AE3 +ve, EMA +ve.		\| IHC = AE1/AE3 +ve, EMA +ve.

Michael at 00:24, 6 January 2014

2014-01-06T00:24:33Z

← Older revision		Revision as of 00:24, 6 January 2014
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	**Classically have hemorrhage & [[necrosis]].		**Classically have hemorrhage & [[necrosis]].
	*[[Epithelial-myoepithelial carcinoma]].		*[[Epithelial-myoepithelial carcinoma]].
			*Other [[clear cell tumours]].

	===Images===		===Images===

Michael: tweak

2013-07-30T13:36:53Z

tweak

← Older revision		Revision as of 13:36, 30 July 2013
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	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Hyalinizing clear cell carcinoma''', abbreviated ''HCCC'', is a rare malignant [[~~salivary gland~~]] tumour with a good prognosis.		'''Hyalinizing clear cell carcinoma''', abbreviated ''HCCC'', is a rare malignant [[head and neck pathology\|head and neck]] tumour with a good prognosis.

	==General==		==General==

Michael: split out, +infobox

2013-07-30T13:34:59Z

split out, +infobox

← Older revision		Revision as of 13:34, 30 July 2013
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	~~#redirect~~ [[~~Salivary glands#~~Hyalinizing clear cell carcinoma]]		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Hyalinizing_clear_cell_carcinoma_-_very_high_mag.jpg
			\| Width =
			\| Caption = Hyalinizing clear cell carcinoma. [[H&E stain]].
			\| Micro = cells with abundant clear cytoplasm in cords, trabeculae or clusters; minimal [[nuclear pleomorphism]]; hyalinized stroma
			\| Subtypes =
			\| LMDDx =
			\| Stains = PAS +ve
			\| IHC = AE1/AE3 +ve, EMA +ve.
			\| EM =
			\| Molecular = t(12;22) -- EWSR1/ATF1
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = usu. palate or tongue
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good
			\| Other =
			\| ClinDDx =
			}}
			'''Hyalinizing clear cell carcinoma''', abbreviated ''HCCC'', is a rare malignant [[salivary gland]] tumour with a good prognosis.

			==General==
			*Rare.
			*Good prognosis.<ref name=pmid21393908>{{Cite journal \| last1 = Masilamani \| first1 = S. \| last2 = Rao \| first2 = S. \| last3 = Chirakkal \| first3 = P. \| last4 = Kumar \| first4 = AR. \| title = Hyalinizing clear cell carcinoma of the base of tongue: a distinct and rare entity. \| journal = Indian J Pathol Microbiol \| volume = 54 \| issue = 1 \| pages = 167-9 \| month = \| year = \| doi = 10.4103/0377-4929.77393 \| PMID = 21393908 }}</ref>
			*Typically palate or tongue.<ref name=pmid21669357>{{Cite journal \| last1 = Kauzman \| first1 = A. \| last2 = Tabet \| first2 = JC. \| last3 = Stiharu \| first3 = TI. \| title = Hyalinizing clear cell carcinoma: a case report and review of the literature. \| journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod \| volume = 112 \| issue = 1 \| pages = e26-34 \| month = Jul \| year = 2011 \| doi = 10.1016/j.tripleo.2011.02.041 \| PMID = 21669357 }}</ref>

			==Microscopic==
			Features:<ref name=pmid20596970>{{Cite journal \| last1 = O'Sullivan-Mejia \| first1 = ED. \| last2 = Massey \| first2 = HD. \| last3 = Faquin \| first3 = WC. \| last4 = Powers \| first4 = CN. \| title = Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. \| journal = Head Neck Pathol \| volume = 3 \| issue = 3 \| pages = 179-85 \| month = Sep \| year = 2009 \| doi = 10.1007/s12105-009-0124-3 \| PMID = 20596970 }}</ref>
			*Groups of cells with abundant clear cytoplasm.
			**Arranged in cords, trabeculae or clusters.
			**Minimal [[nuclear pleomorphism]].<ref name=pmid7506496/>
			*Hyalinized stroma.

			Notes:
			*Clear cytoplasm due to glycogen.<ref name=pmid7506496>{{Cite journal \| last1 = Milchgrub \| first1 = S. \| last2 = Gnepp \| first2 = DR. \| last3 = Vuitch \| first3 = F. \| last4 = Delgado \| first4 = R. \| last5 = Albores-Saavedra \| first5 = J. \| title = Hyalinizing clear cell carcinoma of salivary gland. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 1 \| pages = 74-82 \| month = Jan \| year = 1994 \| doi = \| PMID = 7506496 }}</ref>
			*Low mitotic rate.

			DDx:
			*[[Mucoepidermoid carcinoma]], clear cell variant.
			*[[Acinic cell carcinoma]], clear cell variant.
			*Metastatic [[clear cell renal cell carcinoma]].
			**Classically have hemorrhage & [[necrosis]].
			*[[Epithelial-myoepithelial carcinoma]].

			===Images===
			<gallery>
			Image:Hyalinizing_clear_cell_carcinoma_-_intermed_mag.jpg \| HCCC - intermed. mag. (WC/Nephron)
			Image:Hyalinizing_clear_cell_carcinoma_-_high_mag.jpg \| HCCC - high mag. (WC/Nephron)
			Image:Hyalinizing_clear_cell_carcinoma_-_very_high_mag.jpg \| HCCC - very high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig2/ HCCC (nlm.nih.gov)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811632/figure/Fig5/ HCCC (nlm.nih.gov)].<ref name=pmid20596970/>
			==Stains==
			*PAS +ve.

			==IHC==
			*AE1/AE3 +ve.
			*EMA +ve.<ref name=pmid7506496/>

			Others:
			*Desmin -ve.
			*SMA -ve.<ref name=pmid7506496/>
			*S-100 -ve.<ref name=pmid7506496>{{Cite journal \| last1 = Milchgrub \| first1 = S. \| last2 = Gnepp \| first2 = DR. \| last3 = Vuitch \| first3 = F. \| last4 = Delgado \| first4 = R. \| last5 = Albores-Saavedra \| first5 = J. \| title = Hyalinizing clear cell carcinoma of salivary gland. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 1 \| pages = 74-82 \| month = Jan \| year = 1994 \| doi = \| PMID = 7506496 }}</ref>

			==Molecular==
			Recurrent [[translocation]]:<ref name=pmid21484932>{{Cite journal \| last1 = Antonescu \| first1 = CR. \| last2 = Katabi \| first2 = N. \| last3 = Zhang \| first3 = L. \| last4 = Sung \| first4 = YS. \| last5 = Seethala \| first5 = RR. \| last6 = Jordan \| first6 = RC. \| last7 = Perez-Ordoñez \| first7 = B. \| last8 = Have \| first8 = C. \| last9 = Asa \| first9 = SL. \| title = EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. \| journal = Genes Chromosomes Cancer \| volume = 50 \| issue = 7 \| pages = 559-70 \| month = Jul \| year = 2011 \| doi = 10.1002/gcc.20881 \| PMID = 21484932 }}</ref>
			*t(12;22) -- EWSR1/ATF1.
			**Same translocation as in ''[[clear cell sarcoma]]''.

			==See also==
			*[[Salivary glands]].
			*[[Head and neck pathology]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Salivary gland]]
			[[Category:Head and neck pathology]]

Michael: redirect /w cat.

2011-11-09T19:36:34Z

redirect /w cat.

New page

#redirect [[Salivary glands#Hyalinizing clear cell carcinoma]]

[[Category:Diagnosis]]