Hyalinizing trabecular tumour - Revision history

Michael at 02:00, 19 March 2019

2019-03-19T02:00:58Z

← Older revision		Revision as of 02:00, 19 March 2019
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	*NSE +ve.		*NSE +ve.
	*Ki-67 - [[Ki-67 membranous pattern\|may have membranous pattern]].<ref name=pmid17525638>{{Cite journal \| last1 = Leonardo \| first1 = E. \| last2 = Volante \| first2 = M. \| last3 = Barbareschi \| first3 = M. \| last4 = Cavazza \| first4 = A. \| last5 = Dei Tos \| first5 = AP. \| last6 = Bussolati \| first6 = G. \| last7 = Papotti \| first7 = M. \| title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? \| journal = Appl Immunohistochem Mol Morphol \| volume = 15 \| issue = 2 \| pages = 220-3 \| month = Jun \| year = 2007 \| doi = 10.1097/01.pai.0000213122.66096.f0 \| PMID = 17525638 }}</ref>		*Ki-67 - [[Ki-67 membranous pattern\|may have membranous pattern]].<ref name=pmid17525638>{{Cite journal \| last1 = Leonardo \| first1 = E. \| last2 = Volante \| first2 = M. \| last3 = Barbareschi \| first3 = M. \| last4 = Cavazza \| first4 = A. \| last5 = Dei Tos \| first5 = AP. \| last6 = Bussolati \| first6 = G. \| last7 = Papotti \| first7 = M. \| title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? \| journal = Appl Immunohistochem Mol Morphol \| volume = 15 \| issue = 2 \| pages = 220-3 \| month = Jun \| year = 2007 \| doi = 10.1097/01.pai.0000213122.66096.f0 \| PMID = 17525638 }}</ref>

			==Molecular==
			*GLIS rearrangement (PAX8-GLIS3, PAX8-GLIS1).<ref name=pmid30648929>{{Cite journal \| last1 = Nikiforova \| first1 = MN. \| last2 = Nikitski \| first2 = AV. \| last3 = Panebianco \| first3 = F. \| last4 = Kaya \| first4 = C. \| last5 = Yip \| first5 = L. \| last6 = Williams \| first6 = M. \| last7 = Chiosea \| first7 = SI. \| last8 = Seethala \| first8 = RR. \| last9 = Roy \| first9 = S. \| title = GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland. \| journal = Thyroid \| volume = 29 \| issue = 2 \| pages = 161-173 \| month = Feb \| year = 2019 \| doi = 10.1089/thy.2018.0791 \| PMID = 30648929 }}</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2019-03-19T01:57:27Z

Microscopic

← Older revision		Revision as of 01:57, 19 March 2019
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	*Trabecular arrangement of cells.		*Trabecular arrangement of cells.
	**May have "curved" trabeculae.		**May have "curved" trabeculae.
			**Well defined cell borders.
	*Extracellular space has hyaline material - '''key feature'''.		*Extracellular space has hyaline material - '''key feature'''.
	*Cytoplasm mimics hyaline material in the extracellular space.		*Cytoplasm mimics hyaline material in the extracellular space.

Michael: /* IHC */

2017-07-02T17:14:31Z

IHC

← Older revision		Revision as of 17:14, 2 July 2017
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	*Thyroglobulin +ve.		*Thyroglobulin +ve.
	*NSE +ve.		*NSE +ve.
	*[[Ki-67 membranous pattern]].<ref name=pmid17525638>{{Cite journal \| last1 = Leonardo \| first1 = E. \| last2 = Volante \| first2 = M. \| last3 = Barbareschi \| first3 = M. \| last4 = Cavazza \| first4 = A. \| last5 = Dei Tos \| first5 = AP. \| last6 = Bussolati \| first6 = G. \| last7 = Papotti \| first7 = M. \| title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? \| journal = Appl Immunohistochem Mol Morphol \| volume = 15 \| issue = 2 \| pages = 220-3 \| month = Jun \| year = 2007 \| doi = 10.1097/01.pai.0000213122.66096.f0 \| PMID = 17525638 }}</ref>		*Ki-67 - [[Ki-67 membranous pattern\|may have membranous pattern]].<ref name=pmid17525638>{{Cite journal \| last1 = Leonardo \| first1 = E. \| last2 = Volante \| first2 = M. \| last3 = Barbareschi \| first3 = M. \| last4 = Cavazza \| first4 = A. \| last5 = Dei Tos \| first5 = AP. \| last6 = Bussolati \| first6 = G. \| last7 = Papotti \| first7 = M. \| title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? \| journal = Appl Immunohistochem Mol Morphol \| volume = 15 \| issue = 2 \| pages = 220-3 \| month = Jun \| year = 2007 \| doi = 10.1097/01.pai.0000213122.66096.f0 \| PMID = 17525638 }}</ref>

	==See also==		==See also==

Michael: tweak

2017-07-02T17:02:30Z

tweak

← Older revision		Revision as of 17:02, 2 July 2017
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	'''Hyalinizing trabecular tumour''', abbreviated '''HTT''', is a rare tumour of the [[thyroid ~~glands~~]]. It is also known as '''hyalinizing trabecular adenoma'''.		'''Hyalinizing trabecular tumour''', abbreviated '''HTT''', is a rare tumour of the [[thyroid gland]]. It is also known as '''hyalinizing trabecular adenoma'''.

	==General==		==General==

Michael: split out

2017-07-02T17:01:51Z

split out

← Older revision		Revision as of 17:01, 2 July 2017
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	~~#redirect~~ [[~~Thyroid_gland#Hyalinizing_trabecular_tumour~~]]		'''Hyalinizing trabecular tumour''', abbreviated '''HTT''', is a rare tumour of the [[thyroid glands]]. It is also known as '''hyalinizing trabecular adenoma'''.

			==General==
			*Considered by some to be a variant of [[papillary thyroid carcinoma]].<ref name=pmid11117782>{{cite journal \|author=Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL \|title=Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics \|journal=Am. J. Surg. Pathol. \|volume=24 \|issue=12 \|pages=1622–6 \|year=2000 \|month=December \|pmid=11117782 \|doi= \|url=}}</ref>
			*Behaviour similar to papillary thyroid carcinoma - indolent.

			==Microscopic==
			Features:
			*Trabecular arrangement of cells.
			**May have "curved" trabeculae.
			*Extracellular space has hyaline material - '''key feature'''.
			*Cytoplasm mimics hyaline material in the extracellular space.

			DDx:
			*[[Papillary thyroid carcinoma]] (if one believes this is a separate entity).
			*[[Medullary thyroid carcinoma]] - not trabecular, nuclei not [[PTC]]-like.
			*[[Paraganglioma]].<ref>URL: [http://path.upmc.edu/cases/case465/dx.html http://path.upmc.edu/cases/case465/dx.html]. Accessed on: 17 January 2011.</ref>

			===Images===
			<gallery>
			Image: Hyalinized trabecular tumour - low mag.jpg \| HHT - low mag. (WC)
			Image: Hyalinized trabecular tumour - intermed mag.jpg \| HHT - intermed. mag. (WC)
			Image: Hyalinized trabecular tumour - high mag.jpg \| HHT - high mag. (WC)
			Image: Thyroid gland - high mag.jpg \| Thyroid gland - high mag. (WC)

			Image: Hyalinized trabecular tumour - 2 - intermed mag.jpg \| HHT - intermed. mag. (WC)
			Image: Hyalinized trabecular tumour - 2 - high mag.jpg \| HHT - high mag. (WC)

			Image: Hyalinized trabecular tumour - 3 - intermed mag.jpg \| HHT - intermed. mag. (WC)
			Image: Hyalinized trabecular tumour - 3 - high mag.jpg \| HHT - high mag. (WC)
			Image: Hyalinized trabecular tumour - 3 - very high mag.jpg \| HHT - very high mag. (WC)
			</gallery>
			www:
			*[http://archive.biomedcentral.com/1742-6413/3/17/figure/F2?highres=y HTT (biomedcentral.com)].<ref name=pmid16867191>{{Cite journal \| last1 = Baloch \| first1 = ZW. \| last2 = Puttaswamy \| first2 = K. \| last3 = Brose \| first3 = M. \| last4 = LiVolsi \| first4 = VA. \| title = Lack of BRAF mutations in hyalinizing trabecular neoplasm. \| journal = Cytojournal \| volume = 3 \| issue = \| pages = 17 \| month = \| year = 2006 \| doi = 10.1186/1742-6413-3-17 \| PMID = 16867191 }}</ref>
			*[http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.article-g01.fs.jpg HTT (ispub.com)].<ref>URL: [http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html]. Accessed on: 1 January 2012.</ref>

			==IHC==
			*Thyroglobulin +ve.
			*NSE +ve.
			*[[Ki-67 membranous pattern]].<ref name=pmid17525638>{{Cite journal \| last1 = Leonardo \| first1 = E. \| last2 = Volante \| first2 = M. \| last3 = Barbareschi \| first3 = M. \| last4 = Cavazza \| first4 = A. \| last5 = Dei Tos \| first5 = AP. \| last6 = Bussolati \| first6 = G. \| last7 = Papotti \| first7 = M. \| title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? \| journal = Appl Immunohistochem Mol Morphol \| volume = 15 \| issue = 2 \| pages = 220-3 \| month = Jun \| year = 2007 \| doi = 10.1097/01.pai.0000213122.66096.f0 \| PMID = 17525638 }}</ref>

			==See also==
			*[[Thyroid gland]].

			==References==
			{{Reflist\|2}}

			[[Category:Endocrine pathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect w/ cat.

2011-11-10T13:24:40Z

redirect w/ cat.

New page

#redirect [[Thyroid_gland#Hyalinizing_trabecular_tumour]]

[[Category:Diagnosis]]