Inflammatory skin disorders - Revision history

Michael: /* Microscopic */

2018-12-05T22:18:21Z

Microscopic

← Older revision		Revision as of 22:18, 5 December 2018
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	DDx ''rips'':		DDx ''rips'':
	*Rheumatoid neutrophilic dermatitis.		*Rheumatoid neutrophilic dermatitis.
	*Bowel-associated dermatosis-arthritis syndrome.		*[[Bowel-associated dermatosis-arthritis syndrome]] (BADAS).
	*[[Pyoderma gangrenosum]].		*[[Pyoderma gangrenosum]].
	*Sweet syndrome.		*Sweet syndrome.

Michael at 21:41, 28 November 2016

2016-11-28T21:41:39Z

← Older revision		Revision as of 21:41, 28 November 2016
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	\| -small vessel <br> -medium vessel <br> -large vessel		\| -small vessel <br> -medium vessel <br> -large vessel
	\| -[[leukocytoclastic vasculitis]]<br>-[[PAN]]<br>-[[giant cell arteritis]]		\| -[[leukocytoclastic vasculitis]]<br>-[[PAN]]<br>-[[giant cell arteritis]]
	\| [[Image:Churg-Strauss_syndrome_-_high_mag.jpg \|thumb\|150px\|[[~~Churg-Strauss syndrome~~\|~~CCS~~]] (WC)]]		\| [[Image:Churg-Strauss_syndrome_-_high_mag.jpg \|thumb\|150px\|[[Eosinophilic granulomatosis with polyangiitis\|EGPA]] (WC)]]
	\|-		\|-
	\| [[Dermatitides_with_perivascular_inflammation\|Perivascular]]		\| [[Dermatitides_with_perivascular_inflammation\|Perivascular]]

Michael at 15:03, 28 June 2016

2016-06-28T15:03:34Z

← Older revision		Revision as of 15:03, 28 June 2016
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	*'''L'''upus erythematosus.		*'''L'''upus erythematosus.
	*'''L'''ymphocytic infiltrate of Jessner / tumid lupus erythematosus.		*'''L'''ymphocytic infiltrate of Jessner / tumid lupus erythematosus.
	*Polymorphous '''l'''ight eruption.		*[[polymorphous light eruption\|Polymorphous '''l'''ight eruption]].
	*'''L'''yme disease.		*'''L'''yme disease.

Michael: /* Necrobiotic xanthogranuloma */ split out

2016-06-17T20:12:32Z

Necrobiotic xanthogranuloma: split out

← Older revision		Revision as of 20:12, 17 June 2016
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	==Necrobiotic xanthogranuloma==		==Necrobiotic xanthogranuloma==
	*Abbreviated ''NXG''.		*Abbreviated ''NXG''.
	~~===General===~~		{{Main\|Necrobiotic xanthogranuloma}}
	*Usually elderly.<ref name=Ref_Derm629>{{~~Ref Derm~~\|~~629}}</ref>~~

	~~===Gross===~~
	~~Features:~~
	*Periorbital - classic location.<ref name=pmid17544963>{{Cite journal \| last1 = Fernández-Herrera \| first1 = J. \| last2 = Pedraz \| first2 = J. \| title = Necrobiotic xanthogranuloma~~. \| journal = Semin Cutan Med Surg \| volume = 26 \| issue = 2 \| pages = 108-13 \| month = Jun \| year = 2007 \| doi = 10.1016/j.sder.2007.02.008 \| PMID = 17544963~~ }}~~</ref>~~

	~~===Microscopic===~~
	~~Features:<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>~~
	*"Necrobiotic granuloma":
	**Palisading granuloma with a core collagen-like material.
	*+/-Cholesterol clefts - common.
	*+/-[[Touton giant cell]]s.
	*+/-Atypical foreign body-type giant cells +/- asteroid bodies.

	~~DDx:~~
	*[[Granuloma annulare]].
	*[[Necrobiosis lipoidica]] - has plasma cells.
	*Granuloma-forming infections - positive stains for microorganisms.

	~~Image:~~
	*[http://commons.wikimedia.org/wiki/File:Asteroid_bodies_high_mag_cropped.jpg Asteroid body (WC)].

	=DDx for pattern=		=DDx for pattern=

Michael: /* Psoriasis */

2016-04-12T18:03:53Z

Psoriasis

← Older revision		Revision as of 18:03, 12 April 2016
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	Common locations:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8\|603}}</ref>		Common locations:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8\|603}}</ref>
	*Knees, elbows, scalp, ~~glands~~ [[penis]].		*Knees, elbows, scalp, glans [[penis]].

	===Microscopic===		===Microscopic===

Michael: /* Neutrophils */

2015-10-21T18:50:18Z

Neutrophils

← Older revision		Revision as of 18:50, 21 October 2015
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	===Neutrophils===		===Neutrophils===
	DDx:<ref name=pmid18418089/>		DDx:<ref name=pmid18418089/>
	*Cellulitis.		*[[Cellulitis]].
	*Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis)		*Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis)

Michael: /* Pyoderma gangrenosum */ split out

2015-10-19T20:12:58Z

Pyoderma gangrenosum: split out

← Older revision		Revision as of 20:12, 19 October 2015
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	==Pyoderma gangrenosum==		==Pyoderma gangrenosum==
	~~===General===~~		{{Main\|Pyoderma gangrenosum}}
	*May be seen in [[IBD]] (UC and CD) - approximately 30% of cases.<ref name=pmid16858047/>

	~~Clinical~~
	*''[[Pathergy]]'' = minor trauma (to the skin) results in a non-healing lesion.<ref name=pmid22202507>{{~~Cite journal~~ \| ~~last1 = Wong \| first1 = WW. \| last2 = Machado \| first2 = GR. \| last3 = Hill \| first3 = ME. \| title =~~ Pyoderma gangrenosum~~: the great pretender and a challenging diagnosis. \| journal = J Cutan Med Surg \| volume = 15 \| issue = 6 \| pages = 322-8 \| month = \| year = \| doi = \| PMID = 22202507~~ }}~~</ref>~~

	~~===Gross===~~
	*Skin ulceration - classically on the legs.<ref name=pmid16858047>{{Cite journal \| last1 = Brooklyn \| first1 = T. \| last2 = Dunnill \| first2 = G. \| last3 = Probert \| first3 = C. \| title = Diagnosis and treatment of pyoderma gangrenosum. \| journal = BMJ \| volume = 333 \| issue = 7560 \| pages = 181-4 \| month = Jul \| year = 2006 \| doi = 10.1136/bmj.333.7560.181 \| PMID = 16858047 \| PMC = 1513476 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/?tool=pubmed }}</ref>

	~~===Microscopic===~~
	~~Features:<ref name=pmid16858047/>~~
	*Early: lymphocytes cells only in the dermis - often perivascular & vascular.
	**+/-Fibrinoid necrosis of vessels at edge of lesion.
	*Late: abscess formation ([[neutrophil]]s).

	~~DDx:~~
	*[[Vasculitis]].
	*[[Sweet syndrome]].

	~~====Image====~~
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)].

	~~===Sign out===~~
	~~<pre>~~
	~~A. Skin, Left Leg from Central Wound, Punch Biopsy:~~
	~~- Necrotic debris with underlying granulation tissue and benign connective tissue~~
	~~with superficial vasculitis, see comment.~~
	~~- NEGATIVE for skin surface.~~

	~~B. Skin, Left Leg from Wound and Normal Skin Junction, Punch Biopsy:~~
	~~- Skin with ulceration, necrotic debris, and superficial vasculitis, see comment.~~
	~~- Fat necrosis and severe atherosclerosis.~~

	~~Comment:~~
	~~The findings are in keeping with pyoderma gangrenosum; however, atherosclerotic disease~~
	~~and vasculitis should be considered clinically.~~

	~~The vasculitis is seen superficially and is likely secondary to the ulceration.~~
	~~</pre>~~

	==Necrobiotic xanthogranuloma==		==Necrobiotic xanthogranuloma==

Michael: /* Pyoderma gangrenosum */

2015-10-19T19:46:48Z

Pyoderma gangrenosum

← Older revision		Revision as of 19:46, 19 October 2015
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	*[[Sweet syndrome]].		*[[Sweet syndrome]].

	Image:		====Image====
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)].

			===Sign out===
			<pre>
			A. Skin, Left Leg from Central Wound, Punch Biopsy:
			- Necrotic debris with underlying granulation tissue and benign connective tissue
			with superficial vasculitis, see comment.
			- NEGATIVE for skin surface.

			B. Skin, Left Leg from Wound and Normal Skin Junction, Punch Biopsy:
			- Skin with ulceration, necrotic debris, and superficial vasculitis, see comment.
			- Fat necrosis and severe atherosclerosis.

			Comment:
			The findings are in keeping with pyoderma gangrenosum; however, atherosclerotic disease
			and vasculitis should be considered clinically.

			The vasculitis is seen superficially and is likely secondary to the ulceration.
			</pre>

	==Necrobiotic xanthogranuloma==		==Necrobiotic xanthogranuloma==

Michael: /* Regular psoriasiform dermatitis */

2014-09-24T06:23:44Z

Regular psoriasiform dermatitis

← Older revision		Revision as of 06:23, 24 September 2014
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	*Psoriasis vulgaris.		*Psoriasis vulgaris.
	*Dermatophyte infection.		*Dermatophyte infection.
	*Pityriasis rubra pilaris.		*[[Pityriasis rubra pilaris]].

	===Irregular psoriasiform dermatitis===		===Irregular psoriasiform dermatitis===

Michael: /* Images */

2014-09-18T04:46:51Z

Images

← Older revision		Revision as of 04:46, 18 September 2014
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	====Images====		====Images====
	<gallery>		<gallery>
			Image:Vacuolar_interface_dermatitis_-_low_mag.jpg \| Vacuolar interface dermatitis with dermal mucin - low mag. (WC)
	Image:Vacuolar_interface_dermatitis_-_intermed_mag.jpg \| Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)		Image:Vacuolar_interface_dermatitis_-_intermed_mag.jpg \| Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)
	Image:Vacuolar_interface_dermatitis_-_high_mag.jpg \| Vacuolar interface dermatitis with dermal mucin - high mag. (WC)		Image:Vacuolar_interface_dermatitis_-_high_mag.jpg \| Vacuolar interface dermatitis with dermal mucin - high mag. (WC)
			Image:Vacuolar_interface_dermatitis_-_very_high_mag.jpg \| Vacuolar interface dermatitis with dermal mucin - very high mag. (WC)
	</gallery>		</gallery>