Invasive micropapillary carcinoma of the breast - Revision history

Michael: gross

2016-09-08T11:35:17Z

gross

← Older revision		Revision as of 11:35, 8 September 2016
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing = [[~~mastectomy~~ grossing]]		\| Grossing = [[breast grossing]]
	\| Staging = [[breast cancer staging]]		\| Staging = [[breast cancer staging]]
	\| Site = [[breast]] - see ''[[invasive breast cancer]]''		\| Site = [[breast]] - see ''[[invasive breast cancer]]''

Michael at 04:12, 1 May 2016

2016-05-01T04:12:02Z

← Older revision		Revision as of 04:12, 1 May 2016
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing = [[mastectomy grossing]]
			\| Staging = [[breast cancer staging]]
	\| Site = [[breast]] - see ''[[invasive breast cancer]]''		\| Site = [[breast]] - see ''[[invasive breast cancer]]''
	\| Assdx =		\| Assdx =

Michael: /* Microscopic */ fix link

2015-05-01T21:38:20Z

Microscopic: fix link

← Older revision		Revision as of 21:38, 1 May 2015
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	*Abundant finely granular cytoplasm.		*Abundant finely granular cytoplasm.
	*Mucin cytoplasmic but not in the surrounding clear spaces.		*Mucin cytoplasmic but not in the surrounding clear spaces.
	*Nuclear atypia is moderate or severe.		*[[Nuclear atypia]] is moderate or severe.
	*Mixed(micropapillary + other) histological pattern common.		*Mixed(micropapillary + other) histological pattern common.
	*Can show [[~~psamomma~~ bodies]] or other calcifications.		*Can show [[psammoma bodies]] or other calcifications.

	DDX		DDX

Michael at 07:27, 1 May 2015

2015-05-01T07:27:16Z

← Older revision		Revision as of 07:27, 1 May 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Breast~~ Breast MicropapillaryCarcinoma Invasive PA.JPG		\| Image = Breast MicropapillaryCarcinoma Invasive 2 PA.JPG
	\| Width =		\| Width =
	\| Caption = Invasive micropapillary carcinoma. [[H&E stain]].		\| Caption = Invasive micropapillary carcinoma. [[H&E stain]].

Michael: +infobox

2015-05-01T07:26:32Z

+infobox

← Older revision		Revision as of 07:26, 1 May 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Breast Breast MicropapillaryCarcinoma Invasive PA.JPG
			\| Width =
			\| Caption = Invasive micropapillary carcinoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = small micropapillary tufts of tumour cells or tubuloalveolar structures, central '''avascular''' stromal core, lear spaces/clefting around the small clusters of tumor cells, +/-lymphovascular invasion
			\| Subtypes =
			\| LMDDx = IDC NST with micropapillary features, metastatic [[serous carcinoma]]
			\| Stains =
			\| IHC = [[EMA]] +ve (periphery of nests) - described as inside-out pattern
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[breast]] - see ''[[invasive breast cancer]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx =
			\| Tx = surgical excision
			}}
	'''Invasive micropapillary carcinoma of the breast''', also '''micropapillary carcinoma''', is a rare type of [[invasive breast cancer]].		'''Invasive micropapillary carcinoma of the breast''', also '''micropapillary carcinoma''', is a rare type of [[invasive breast cancer]].

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	*Nuclear atypia is moderate or severe.		*Nuclear atypia is moderate or severe.
	*Mixed(micropapillary + other) histological pattern common.		*Mixed(micropapillary + other) histological pattern common.
	*Can show psamomma bodies or other calcifications.		*Can show [[psamomma bodies]] or other calcifications.

	DDX		DDX

Michael: /* Microscopic */

2015-05-01T07:21:07Z

Microscopic

← Older revision		Revision as of 07:21, 1 May 2015
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	DDX		DDX
	*Invasive mammary carcinoma of no special type with micropapillary features.		*[[Invasive ductal carcinoma of the breast\|Invasive mammary carcinoma of no special type]] with micropapillary features.
	*Metastatic papillary serous carcinoma of the ovary (WT1, PAX8 positive).<ref>{{Cite journal \| last1 = Nonaka \| first1 = D. \| last2 = Chiriboga \| first2 = L. \| last3 = Soslow \| first3 = RA. \| title = Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 10 \| pages = 1566-71 \| month = Oct \| year = 2008 \| doi = 10.1097/PAS.0b013e31816d71ad \| PMID = 18724243 }}		*Metastatic papillary [[serous carcinoma of the ovary]] (WT1, PAX8 positive).<ref>{{Cite journal \| last1 = Nonaka \| first1 = D. \| last2 = Chiriboga \| first2 = L. \| last3 = Soslow \| first3 = RA. \| title = Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 10 \| pages = 1566-71 \| month = Oct \| year = 2008 \| doi = 10.1097/PAS.0b013e31816d71ad \| PMID = 18724243 }}
	</ref>		</ref>

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	*Even a minor component of this tumor type should be identified and reported due to the high rate of associated lymphatic invasion and nodal involvement.		*Even a minor component of this tumor type should be identified and reported due to the high rate of associated lymphatic invasion and nodal involvement.
	*Skin involvement has been reported to be strongly correlated with a poor prognosis for this subtype.		*Skin involvement has been reported to be strongly correlated with a poor prognosis for this subtype.
	*Micropapillary architectural is retained in node metastases, dermal lymphatic invasion, and recurrences.<ref>{{Cite journal \| last1 = Pettinato \| first1 = G. \| last2 = Manivel \| first2 = CJ. \| last3 = Panico \| first3 = L. \| last4 = Sparano \| first4 = L. \| last5 = Petrella \| first5 = G. \| title = Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. \| journal = Am J Clin Pathol \| volume = 121 \| issue = 6 \| pages = 857-66 \| month = Jun \| year = 2004 \| doi = 10.1309/XTJ7-VHB4-9UD7-8X60 \| PMID = 15198358 }}</ref>		*Micropapillary architectural is retained in [[lymph node metastasis\|node metastases]], dermal lymphatic invasion, and recurrences.<ref name=pmid15198358>{{Cite journal \| last1 = Pettinato \| first1 = G. \| last2 = Manivel \| first2 = CJ. \| last3 = Panico \| first3 = L. \| last4 = Sparano \| first4 = L. \| last5 = Petrella \| first5 = G. \| title = Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. \| journal = Am J Clin Pathol \| volume = 121 \| issue = 6 \| pages = 857-66 \| month = Jun \| year = 2004 \| doi = 10.1309/XTJ7-VHB4-9UD7-8X60 \| PMID = 15198358 }}</ref>

	===Images===		===Images===
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	Image:Breast MicropapillaryCarcinoma Invasive 2 PA.JPG\|Breast - Invasive Micropapillary Carcinoma - High power (SKB)		Image:Breast MicropapillaryCarcinoma Invasive 2 PA.JPG\|Breast - Invasive Micropapillary Carcinoma - High power (SKB)
	</gallery>		</gallery>
			www:
	*[http://www.flickr.com/photos/euthman/5300126397/ Invasive micropapillary carcinoma (flickr.com/euthman)].		*[http://www.flickr.com/photos/euthman/5300126397/ Invasive micropapillary carcinoma (flickr.com/euthman)].
	*[http://www.breast-cancer.ca/images/invasive-micropapillary-breast-carcinoma-cells1.jpg Invasive micropapillary carcinoma - poor quality image (breast-cancer.ca)].<ref>URL: [http://www.breast-cancer.ca/type/micropapillary-breast-carcinoma.htm http://www.breast-cancer.ca/type/micropapillary-breast-carcinoma.htm]. Accessed on: 30 May 2012.</ref>		*[http://www.breast-cancer.ca/images/invasive-micropapillary-breast-carcinoma-cells1.jpg Invasive micropapillary carcinoma - poor quality image (breast-cancer.ca)].<ref>URL: [http://www.breast-cancer.ca/type/micropapillary-breast-carcinoma.htm http://www.breast-cancer.ca/type/micropapillary-breast-carcinoma.htm]. Accessed on: 30 May 2012.</ref>

Michael: /* See also */

2015-05-01T07:18:07Z

Michael: create

2015-05-01T07:17:14Z

create

← Older revision		Revision as of 07:17, 1 May 2015
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	~~#redirect~~ [[~~Invasive_breast_cancer#Invasive_micropapillary_carcinoma_of_the_breast~~]]		'''Invasive micropapillary carcinoma of the breast''', also '''micropapillary carcinoma''', is a rare type of [[invasive breast cancer]].

			==General==
			*Poor prognosis.
			*[[Lymphovascular invasion]] common.<ref name=pmid20304650>{{Cite journal \| last1 = Yu \| first1 = JI. \| last2 = Choi \| first2 = DH. \| last3 = Park \| first3 = W. \| last4 = Huh \| first4 = SJ. \| last5 = Cho \| first5 = EY. \| last6 = Lim \| first6 = YH. \| last7 = Ahn \| first7 = JS. \| last8 = Yang \| first8 = JH. \| last9 = Nam \| first9 = SJ. \| title = Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: matched case-control study. \| journal = Breast \| volume = 19 \| issue = 3 \| pages = 231-7 \| month = Jun \| year = 2010 \| doi = 10.1016/j.breast.2010.01.020 \| PMID = 20304650 }}</ref>

			==Microscopic==
			Features:<ref>{{Cite journal \| last1 = Pettinato \| first1 = G. \| last2 = Manivel \| first2 = CJ. \| last3 = Panico \| first3 = L. \| last4 = Sparano \| first4 = L. \| last5 = Petrella \| first5 = G. \| title = Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. \| journal = Am J Clin Pathol \| volume = 121 \| issue = 6 \| pages = 857-66 \| month = Jun \| year = 2004 \| doi = 10.1309/XTJ7-VHB4-9UD7-8X60 \| PMID = 15198358 }}</ref>
			*Small micropapillary tufts of tumour cells or tubuloalveolar structures.
			*Central '''avascular''' stromal core.
			*Clear spaces/clefting around the small clusters of tumor cells - '''diffuse/through-out the tumour''' - '''key feature'''.
			**Described as "small clusters of tumour lying within dilated vascular channel-like spaces".<ref name=pmid20444748>{{Cite journal \| last1 = Yamaguchi \| first1 = R. \| last2 = Tanaka \| first2 = M. \| last3 = Kondo \| first3 = K. \| last4 = Yokoyama \| first4 = T. \| last5 = Kaneko \| first5 = Y. \| last6 = Yamaguchi \| first6 = M. \| last7 = Ogata \| first7 = Y. \| last8 = Nakashima \| first8 = O. \| last9 = Kage \| first9 = M. \| title = Characteristic morphology of invasive micropapillary carcinoma of the breast: an immunohistochemical analysis. \| journal = Jpn J Clin Oncol \| volume = 40 \| issue = 8 \| pages = 781-7 \| month = Aug \| year = 2010 \| doi = 10.1093/jjco/hyq056 \| PMID = 20444748 \| URL = http://jjco.oxfordjournals.org/content/40/8/781.long }}</ref>
			**Can appear sponge like or swiss cheese like.
			*Abundant finely granular cytoplasm.
			*Mucin cytoplasmic but not in the surrounding clear spaces.
			*Nuclear atypia is moderate or severe.
			*Mixed(micropapillary + other) histological pattern common.
			*Can show psamomma bodies or other calcifications.

			DDX
			*Invasive mammary carcinoma of no special type with micropapillary features.
			*Metastatic papillary serous carcinoma of the ovary (WT1, PAX8 positive).<ref>{{Cite journal \| last1 = Nonaka \| first1 = D. \| last2 = Chiriboga \| first2 = L. \| last3 = Soslow \| first3 = RA. \| title = Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 10 \| pages = 1566-71 \| month = Oct \| year = 2008 \| doi = 10.1097/PAS.0b013e31816d71ad \| PMID = 18724243 }}
			</ref>

			Note:
			*[[Invasive ductal carcinoma of the breast\|Ductal carcinoma]] commonly has clefting... but it isn't diffuse.
			*Even a minor component of this tumor type should be identified and reported due to the high rate of associated lymphatic invasion and nodal involvement.
			*Skin involvement has been reported to be strongly correlated with a poor prognosis for this subtype.
			*Micropapillary architectural is retained in node metastases, dermal lymphatic invasion, and recurrences.<ref>{{Cite journal \| last1 = Pettinato \| first1 = G. \| last2 = Manivel \| first2 = CJ. \| last3 = Panico \| first3 = L. \| last4 = Sparano \| first4 = L. \| last5 = Petrella \| first5 = G. \| title = Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. \| journal = Am J Clin Pathol \| volume = 121 \| issue = 6 \| pages = 857-66 \| month = Jun \| year = 2004 \| doi = 10.1309/XTJ7-VHB4-9UD7-8X60 \| PMID = 15198358 }}</ref>

			===Images===
			<gallery>
			Image:Breast Breast MicropapillaryCarcinoma Invasive PA.JPG\|Breast - Invasive Micropapillary Carcinoma - High power (SKB)
			Image:Breast MicropapillaryCarcinoma Invasive 2 PA.JPG\|Breast - Invasive Micropapillary Carcinoma - High power (SKB)
			</gallery>

			*[http://www.flickr.com/photos/euthman/5300126397/ Invasive micropapillary carcinoma (flickr.com/euthman)].
			*[http://www.breast-cancer.ca/images/invasive-micropapillary-breast-carcinoma-cells1.jpg Invasive micropapillary carcinoma - poor quality image (breast-cancer.ca)].<ref>URL: [http://www.breast-cancer.ca/type/micropapillary-breast-carcinoma.htm http://www.breast-cancer.ca/type/micropapillary-breast-carcinoma.htm]. Accessed on: 30 May 2012.</ref>

			==IHC==
			*[[EMA]] +ve (periphery of nests); described as inside-out pattern.<ref name=pmid20444748>{{Cite journal \| last1 = Yamaguchi \| first1 = R. \| last2 = Tanaka \| first2 = M. \| last3 = Kondo \| first3 = K. \| last4 = Yokoyama \| first4 = T. \| last5 = Kaneko \| first5 = Y. \| last6 = Yamaguchi \| first6 = M. \| last7 = Ogata \| first7 = Y. \| last8 = Nakashima \| first8 = O. \| last9 = Kage \| first9 = M. \| title = Characteristic morphology of invasive micropapillary carcinoma of the breast: an immunohistochemical analysis. \| journal = Jpn J Clin Oncol \| volume = 40 \| issue = 8 \| pages = 781-7 \| month = Aug \| year = 2010 \| doi = 10.1093/jjco/hyq056 \| PMID = 20444748 \| URL = http://jjco.oxfordjournals.org/content/40/8/781.long }}</ref>
			*E-cadherin +ve (centre of nests). (???)
			*p63 +ve/-ve.

			EMA limited to the cytoplasmic membrane oriented toward the stroma.
			E-cadherin absent on the cytoplasmic membrane oriented toward the stroma.
			Hypothesized to indicate an inversion of cell polarization and a disturbance in the cell adhesion molecules.<ref>{{Cite journal \| last1 = Pettinato \| first1 = G. \| last2 = Manivel \| first2 = CJ. \| last3 = Panico \| first3 = L. \| last4 = Sparano \| first4 = L. \| last5 = Petrella \| first5 = G. \| title = Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. \| journal = Am J Clin Pathol \| volume = 121 \| issue = 6 \| pages = 857-66 \| month = Jun \| year = 2004 \| doi = 10.1309/XTJ7-VHB4-9UD7-8X60 \| PMID = 15198358 }}</ref>

			==See also==
			*[[Invasive breast cancer]].
			*[[Micropapillary carcinoma]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Invasive breast cancer]]

Michael: redirect w/ cat.

2012-01-08T03:38:47Z

redirect w/ cat.

New page

#redirect [[Invasive_breast_cancer#Invasive_micropapillary_carcinoma_of_the_breast]]

[[Category:Diagnosis]]

← Older revision		Revision as of 07:18, 1 May 2015
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	==See also==		==See also==
	*[[Invasive breast cancer]].		*[[Invasive breast cancer]].
	*[[Micropapillary carcinoma]].

	==References==		==References==