Juvenile granulosa cell tumour - Revision history

Mitchell: /* Images */ added a case

2017-01-02T17:43:50Z

Images: added a case

← Older revision		Revision as of 17:43, 2 January 2017
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	Image:Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg \| Juvenile granulosa cell tumour - very high mag. (WC)		Image:Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg \| Juvenile granulosa cell tumour - very high mag. (WC)
	</gallery>		</gallery>
			[[File:3 13627319654987 sl 1.png\| Juvenile granulosa cell tumor]]
			[[File:3 13627319654987 sl 2.png\| Juvenile granulosa cell tumor]]
			[[File:3 13627319654987 sl 3.png\| Juvenile granulosa cell tumor]]
			[[File:3 13627319654987 sl 4.png\| Juvenile granulosa cell tumor]]
			Juvenile granulosa cell tumor of ovary of child. A. A pink tumor shows cyst-like areas with occasional nodules at low power. B. Tumor cells haphazardly spread without longitudinal grooves, with small nucleoli, in an edematous background. C. The cysts are in fact follicles, some producing, as here, the typical basophilic fluid. D. In some regions, abundant pink cytoplasm is obvious.

	==IHC==		==IHC==

Michael at 14:11, 6 June 2016

2016-06-06T14:11:25Z

← Older revision		Revision as of 14:11, 6 June 2016
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	\| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm		\| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Brenner tumour]], [[~~Small~~ cell carcinoma of hypercalcemic type]]		\| LMDDx = [[Brenner tumour]], [[small cell carcinoma of hypercalcemic type]]
	\| Stains =		\| Stains =
	\| IHC = inhibin +ve, calretinin +ve		\| IHC = inhibin +ve, calretinin +ve

Michael at 14:05, 6 June 2016

2016-06-06T14:05:16Z

← Older revision		Revision as of 14:05, 6 June 2016
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	\| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm		\| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Brenner tumour]]		\| LMDDx = [[Brenner tumour]], [[Small cell carcinoma of hypercalcemic type]]
	\| Stains =		\| Stains =
	\| IHC = inhibin +ve, calretinin +ve		\| IHC = inhibin +ve, calretinin +ve

Michael: /* Microscopic */

2016-06-06T14:04:41Z

Microscopic

← Older revision		Revision as of 14:04, 6 June 2016
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	*[[Brenner tumour]].		*[[Brenner tumour]].
	*[[Adult granulosa cell tumour]].		*[[Adult granulosa cell tumour]].
			*[[Small cell carcinoma of hypercalcemic type]].<ref name=pmid21993272>{{Cite journal \| last1 = Bárcena \| first1 = C. \| last2 = Oliva \| first2 = E. \| title = WT1 expression in the female genital tract. \| journal = Adv Anat Pathol \| volume = 18 \| issue = 6 \| pages = 454-65 \| month = Nov \| year = 2011 \| doi = 10.1097/PAP.0b013e318234aaed \| PMID = 21993272 }}</ref>

	===Images===		===Images===

Michael: touch

2016-02-02T15:25:44Z

touch

← Older revision		Revision as of 15:25, 2 February 2016
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	\| Image = Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg		\| Image = Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Juvenile granulosa cell tumour. [[H&E stain]].		\| Caption = Juvenile granulosa cell tumour. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm		\| Micro = microcystic spaces, cuboidal-to-polygonal cells in sheets or stands or cords, with moderate-to-marked nuclear atypia, and basophilic cytoplasm

Michael: /* Microscopic */

2014-02-18T04:11:17Z

Microscopic

← Older revision		Revision as of 04:11, 18 February 2014
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	DDx:		DDx:
	*[[Brenner tumour]].		*[[Brenner tumour]].
			*[[Adult granulosa cell tumour]].

	===Images===		===Images===

Michael: /* IHC */

2014-02-18T04:10:59Z

IHC

← Older revision		Revision as of 04:10, 18 February 2014
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	*CD34 -ve (0 +ve/12 cases<ref name=pmid20349790/>).		*CD34 -ve (0 +ve/12 cases<ref name=pmid20349790/>).
	*Vimentin +ve (11 +ve/12 cases<ref name=pmid20349790/>).		*Vimentin +ve (11 +ve/12 cases<ref name=pmid20349790/>).
			*CD99 +ve.<ref name=pmid17387475>{{Cite journal \| last1 = Schmidt \| first1 = D. \| last2 = Kommoss \| first2 = F. \| title = [Diagnosis and differential diagnosis of granulosa cell tumor]. \| journal = Pathologe \| volume = 28 \| issue = 3 \| pages = 195-202 \| month = May \| year = 2007 \| doi = 10.1007/s00292-007-0908-8 \| PMID = 17387475 }}</ref>

	==Molecular==		==Molecular==

Michael at 04:08, 18 February 2014

2014-02-18T04:08:52Z

← Older revision		Revision as of 04:08, 18 February 2014
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	\| IHC = inhibin +ve, calretinin +ve		\| IHC = inhibin +ve, calretinin +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = trisomy 12
	\| IF =		\| IF =
	\| Gross = mass lesion, solid		\| Gross = mass lesion, solid

Michael: /* IHC */

2014-02-18T04:07:40Z

IHC

← Older revision		Revision as of 04:07, 18 February 2014
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	** Inhibin negative in ''[[Brenner tumour]]''.		** Inhibin negative in ''[[Brenner tumour]]''.
	*Calretinin +ve.		*Calretinin +ve.
			*Ki-67 <5% (12/12 cases<ref name=pmid20349790>{{Cite journal \| last1 = Kondi-Pafiti \| first1 = A. \| last2 = Grapsa \| first2 = D. \| last3 = Kairi-Vassilatou \| first3 = E. \| last4 = Carvounis \| first4 = E. \| last5 = Hasiakos \| first5 = D. \| last6 = Kontogianni \| first6 = K. \| last7 = Fotiou \| first7 = S. \| title = Granulosa cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 21 cases. \| journal = Eur J Gynaecol Oncol \| volume = 31 \| issue = 1 \| pages = 94-8 \| month = \| year = 2010 \| doi = \| PMID = 20349790 }}</ref>).
			*CD34 -ve (0 +ve/12 cases<ref name=pmid20349790/>).
			*Vimentin +ve (11 +ve/12 cases<ref name=pmid20349790/>).

	==Molecular==		==Molecular==

Michael: /* General */

2014-02-18T04:05:07Z

General

← Older revision		Revision as of 04:05, 18 February 2014
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	==General==		==General==
	*~~May secrete estrogen.~~		*Uncommon.<ref name=pmid23033282>{{Cite journal \| last1 = Oztekin \| first1 = D. \| last2 = Kurt \| first2 = S. \| last3 = Camuzcuoglu \| first3 = H. \| last4 = Balsak \| first4 = D. \| last5 = Dicle \| first5 = N. \| last6 = Tinar \| first6 = S. \| title = Granulosa cell tumors of the ovary: review of 43 cases. \| journal = J BUON \| volume = 17 \| issue = 3 \| pages = 461-4 \| month = \| year = \| doi = \| PMID = 23033282 }}</ref>
	**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]].
	**May present as precocious puberty.<ref name=~~pmid21526089~~>{{Cite journal \| last1 = ~~Hashemipour~~ \| first1 = M. \| last2 = ~~Moaddab~~ \| first2 = MH. \| last3 = ~~Nazem~~ \| first3 = M. \| last4 = ~~Mahzouni~~ \| first4 = P. \| last5 = ~~Salek~~ \| first5 = M. \| title = Granulosa cell ~~tumor in a six-year-old girl presented as precocious puberty~~. \| journal = J ~~Res Med Sci~~ \| volume = 15 \| issue = 4 \| pages = ~~240~~-2 \| month = ~~Jul~~ \| year = ~~2010~~ \| doi = \| PMID = ~~21526089~~ }}</ref>
	*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref>		*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref>
	*~~Uncommon~~.<ref name=~~pmid23033282~~>{{Cite journal \| last1 = ~~Oztekin~~ \| first1 = D. \| last2 = ~~Kurt~~ \| first2 = S. \| last3 = ~~Camuzcuoglu~~ \| first3 = H. \| last4 = ~~Balsak~~ \| first4 = D. \| last5 = ~~Dicle~~ \| first5 = ~~N. \| last6 = Tinar \| first6 = S~~. \| title = Granulosa cell ~~tumors of the ovary: review of 43 cases~~. \| journal = J ~~BUON~~ \| volume = 17 \| issue = 3 \| pages = ~~461~~-4 \| month = \| year = \| doi = \| PMID = ~~23033282~~ }}</ref>
			May secrete estrogen - can present with:
			*Endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]].
			*Precocious puberty.<ref name=pmid21526089>{{Cite journal \| last1 = Hashemipour \| first1 = M. \| last2 = Moaddab \| first2 = MH. \| last3 = Nazem \| first3 = M. \| last4 = Mahzouni \| first4 = P. \| last5 = Salek \| first5 = M. \| title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. \| journal = J Res Med Sci \| volume = 15 \| issue = 4 \| pages = 240-2 \| month = Jul \| year = 2010 \| doi = \| PMID = 21526089 }}</ref>

			Prognosis - granulosa cell tumours (adult and juvenile):<ref name=pmid23033282/>
			*Low-stage: 97% five year survival.
			*High-stage: 67% five year survival.

	==Gross==		==Gross==