Juvenile xanthogranuloma - Revision history

Michael at 20:37, 17 June 2016

2016-06-17T20:37:22Z

← Older revision		Revision as of 20:37, 17 June 2016
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	*+/-Touton [[giant cell]] - '''key feature'''.		*+/-Touton [[giant cell]] - '''key feature'''.
	**Large multi-nucleated cells where nuclei are distributed at the cell periphery.		**Large multi-nucleated cells where nuclei are distributed at the cell periphery.

			Notes:
			*Must prove they are non-Langerhans cell histiocytes, esp. if no Touton giant cells.

	DDx:		DDx:
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	*[[Erdheim-Chester disease]] - usu. [[BRAF V600E mutated]].<ref name=pmid22879539>{{Cite journal \| last1 = Haroche \| first1 = J. \| last2 = Charlotte \| first2 = F. \| last3 = Arnaud \| first3 = L. \| last4 = von Deimling \| first4 = A. \| last5 = Hélias-Rodzewicz \| first5 = Z. \| last6 = Hervier \| first6 = B. \| last7 = Cohen-Aubart \| first7 = F. \| last8 = Launay \| first8 = D. \| last9 = Lesot \| first9 = A. \| title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. \| journal = Blood \| volume = 120 \| issue = 13 \| pages = 2700-3 \| month = Sep \| year = 2012 \| doi = 10.1182/blood-2012-05-430140 \| PMID = 22879539 }}</ref>		*[[Erdheim-Chester disease]] - usu. [[BRAF V600E mutated]].<ref name=pmid22879539>{{Cite journal \| last1 = Haroche \| first1 = J. \| last2 = Charlotte \| first2 = F. \| last3 = Arnaud \| first3 = L. \| last4 = von Deimling \| first4 = A. \| last5 = Hélias-Rodzewicz \| first5 = Z. \| last6 = Hervier \| first6 = B. \| last7 = Cohen-Aubart \| first7 = F. \| last8 = Launay \| first8 = D. \| last9 = Lesot \| first9 = A. \| title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. \| journal = Blood \| volume = 120 \| issue = 13 \| pages = 2700-3 \| month = Sep \| year = 2012 \| doi = 10.1182/blood-2012-05-430140 \| PMID = 22879539 }}</ref>
	*[[Rosai-Dorfman disease]] - Emperipolesis.		*[[Rosai-Dorfman disease]] - Emperipolesis.
			*[[Necrobiotic xanthogranuloma]] - also may have Touton giant cells.
	~~Notes:~~
	*~~Must prove they are non~~-~~Langerhans cell histiocytes, esp. if no~~ Touton giant cells.

	===Images===		===Images===
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	*[[Dermatopathology]].		*[[Dermatopathology]].
	*[[Pediatric pathology]].		*[[Pediatric pathology]].
	*[[Necrobiotic xanthogranuloma]].

	==References==		==References==

Michael: /* See also */

2016-06-17T20:36:43Z

Michael: /* Microscopic */

2016-06-09T13:56:21Z

Microscopic

← Older revision		Revision as of 13:56, 9 June 2016
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	*[[Spitz nevus]] - uncommon; reported to have Touton cells.<ref name=pmid18312437>{{Cite journal \| last1 = Guitart \| first1 = J. \| last2 = Gerami \| first2 = P. \| title = Touton-like giant cells in a Spitz's nevus. \| journal = J Cutan Pathol \| volume = 35 \| issue = 7 \| pages = 694-5 \| month = Jul \| year = 2008 \| doi = 10.1111/j.1600-0560.2007.00877.x \| PMID = 18312437 }}</ref>		*[[Spitz nevus]] - uncommon; reported to have Touton cells.<ref name=pmid18312437>{{Cite journal \| last1 = Guitart \| first1 = J. \| last2 = Gerami \| first2 = P. \| title = Touton-like giant cells in a Spitz's nevus. \| journal = J Cutan Pathol \| volume = 35 \| issue = 7 \| pages = 694-5 \| month = Jul \| year = 2008 \| doi = 10.1111/j.1600-0560.2007.00877.x \| PMID = 18312437 }}</ref>
	*[[Dermatofibroma]], aneurysmal - has Touton [[giant cell]]s and hemosiderin deposition.		*[[Dermatofibroma]], aneurysmal - has Touton [[giant cell]]s and hemosiderin deposition.
	* [[Tuberculoma]]		*[[Tuberculoma]].
	* Erdheim-Chester disease - usu. BRAF V600E mutated. <ref>{{Cite journal \| last1 = Haroche \| first1 = J. \| last2 = Charlotte \| first2 = F. \| last3 = Arnaud \| first3 = L. \| last4 = von Deimling \| first4 = A. \| last5 = Hélias-Rodzewicz \| first5 = Z. \| last6 = Hervier \| first6 = B. \| last7 = Cohen-Aubart \| first7 = F. \| last8 = Launay \| first8 = D. \| last9 = Lesot \| first9 = A. \| title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. \| journal = Blood \| volume = 120 \| issue = 13 \| pages = 2700-3 \| month = Sep \| year = 2012 \| doi = 10.1182/blood-2012-05-430140 \| PMID = 22879539 }}</ref>		*[[Erdheim-Chester disease]] - usu. [[BRAF V600E mutated]].<ref name=pmid22879539>{{Cite journal \| last1 = Haroche \| first1 = J. \| last2 = Charlotte \| first2 = F. \| last3 = Arnaud \| first3 = L. \| last4 = von Deimling \| first4 = A. \| last5 = Hélias-Rodzewicz \| first5 = Z. \| last6 = Hervier \| first6 = B. \| last7 = Cohen-Aubart \| first7 = F. \| last8 = Launay \| first8 = D. \| last9 = Lesot \| first9 = A. \| title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. \| journal = Blood \| volume = 120 \| issue = 13 \| pages = 2700-3 \| month = Sep \| year = 2012 \| doi = 10.1182/blood-2012-05-430140 \| PMID = 22879539 }}</ref>
	* Rosai-Dorfman disease (Emperipolesis)		*[[Rosai-Dorfman disease]] - Emperipolesis.

	Notes:		Notes:

Jensflorian: more DDx

2016-06-09T13:43:59Z

more DDx

← Older revision		Revision as of 13:43, 9 June 2016
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	*[[Spitz nevus]] - uncommon; reported to have Touton cells.<ref name=pmid18312437>{{Cite journal \| last1 = Guitart \| first1 = J. \| last2 = Gerami \| first2 = P. \| title = Touton-like giant cells in a Spitz's nevus. \| journal = J Cutan Pathol \| volume = 35 \| issue = 7 \| pages = 694-5 \| month = Jul \| year = 2008 \| doi = 10.1111/j.1600-0560.2007.00877.x \| PMID = 18312437 }}</ref>		*[[Spitz nevus]] - uncommon; reported to have Touton cells.<ref name=pmid18312437>{{Cite journal \| last1 = Guitart \| first1 = J. \| last2 = Gerami \| first2 = P. \| title = Touton-like giant cells in a Spitz's nevus. \| journal = J Cutan Pathol \| volume = 35 \| issue = 7 \| pages = 694-5 \| month = Jul \| year = 2008 \| doi = 10.1111/j.1600-0560.2007.00877.x \| PMID = 18312437 }}</ref>
	*[[Dermatofibroma]], aneurysmal - has Touton [[giant cell]]s and hemosiderin deposition.		*[[Dermatofibroma]], aneurysmal - has Touton [[giant cell]]s and hemosiderin deposition.
			* [[Tuberculoma]]
			* Erdheim-Chester disease - usu. BRAF V600E mutated. <ref>{{Cite journal \| last1 = Haroche \| first1 = J. \| last2 = Charlotte \| first2 = F. \| last3 = Arnaud \| first3 = L. \| last4 = von Deimling \| first4 = A. \| last5 = Hélias-Rodzewicz \| first5 = Z. \| last6 = Hervier \| first6 = B. \| last7 = Cohen-Aubart \| first7 = F. \| last8 = Launay \| first8 = D. \| last9 = Lesot \| first9 = A. \| title = High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. \| journal = Blood \| volume = 120 \| issue = 13 \| pages = 2700-3 \| month = Sep \| year = 2012 \| doi = 10.1182/blood-2012-05-430140 \| PMID = 22879539 }}</ref>
			* Rosai-Dorfman disease (Emperipolesis)

	Notes:		Notes:

Michael: /* General */

2016-06-07T17:27:49Z

General

← Older revision		Revision as of 17:27, 7 June 2016
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	==General==		==General==
	*Usually in children and infants, sometimes in adults.<ref name=Ref_Derm622>{{Ref Derm\|622}}</ref>		*Usually in children and infants, sometimes in adults.<ref name=Ref_Derm622>{{Ref Derm\|622}}</ref>
	**In adults, it may be referred to as ''cutaneous xanthogranuloma'',<ref name=pmid24801255>{{Cite journal \| last1 = Chiang \| first1 = E. \| last2 = Lissner \| first2 = G. \| last3 = Bryar \| first3 = PJ. \| title = Unusual presentation of xanthogranuloma on the eyelid of an adult. \| journal = Ophthal Plast Reconstr Surg \| volume = 30 \| issue = 6 \| pages = e155-6 \| month = \| year = \| doi = 10.1097/01.iop.0000440703.67932.37 \| PMID = 24801255 }}</ref> ''adult onset xanthogranuloma'', and ''adult xanthogranuloma''<ref name=pmid24154556>{{Cite journal \| last1 = Tan \| first1 = LC. \| last2 = Tan \| first2 = KB. \| last3 = Aw \| first3 = CW. \| title = Unusual presentation of adult xanthogranuloma: a case report. \| journal = Singapore Med J \| volume = 55 \| issue = 2 \| pages = e25-7 \| month = Feb \| year = 2014 \| doi = 10.11622/smedj.2013207 \| PMID = 24154556 }}</ref>		**In adults, it may be referred to as ''cutaneous xanthogranuloma'',<ref name=pmid24801255>{{Cite journal \| last1 = Chiang \| first1 = E. \| last2 = Lissner \| first2 = G. \| last3 = Bryar \| first3 = PJ. \| title = Unusual presentation of xanthogranuloma on the eyelid of an adult. \| journal = Ophthal Plast Reconstr Surg \| volume = 30 \| issue = 6 \| pages = e155-6 \| month = \| year = \| doi = 10.1097/01.iop.0000440703.67932.37 \| PMID = 24801255 }}</ref> ''adult onset xanthogranuloma'', and ''adult xanthogranuloma''.<ref name=pmid24154556>{{Cite journal \| last1 = Tan \| first1 = LC. \| last2 = Tan \| first2 = KB. \| last3 = Aw \| first3 = CW. \| title = Unusual presentation of adult xanthogranuloma: a case report. \| journal = Singapore Med J \| volume = 55 \| issue = 2 \| pages = e25-7 \| month = Feb \| year = 2014 \| doi = 10.11622/smedj.2013207 \| PMID = 24154556 }}</ref>
	*Most common form of non–Langerhans cell histiocytosis.<ref name=emed_jxg>URL: [http://emedicine.medscape.com/article/1111629-diagnosis http://emedicine.medscape.com/article/1111629-diagnosis]. Accessed on: 3 February 2011.</ref>		*Most common form of non–Langerhans cell histiocytosis.<ref name=emed_jxg>URL: [http://emedicine.medscape.com/article/1111629-diagnosis http://emedicine.medscape.com/article/1111629-diagnosis]. Accessed on: 3 February 2011.</ref>
	*Can rarely be found in the brain.<ref>URL: [http://path.upmc.edu/cases/case245/dx.html http://path.upmc.edu/cases/case245/dx.html]. Accessed on: 13 January 2012.</ref>		*Can rarely be found in the brain.<ref>URL: [http://path.upmc.edu/cases/case245/dx.html http://path.upmc.edu/cases/case245/dx.html]. Accessed on: 13 January 2012.</ref>

Michael: /* General */

2016-06-07T17:24:58Z

General

← Older revision		Revision as of 17:24, 7 June 2016
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	==General==		==General==
	*Usually in children and infants, sometimes in adults.<ref name=Ref_Derm622>{{Ref Derm\|622}}</ref>		*Usually in children and infants, sometimes in adults.<ref name=Ref_Derm622>{{Ref Derm\|622}}</ref>
			**In adults, it may be referred to as ''cutaneous xanthogranuloma'',<ref name=pmid24801255>{{Cite journal \| last1 = Chiang \| first1 = E. \| last2 = Lissner \| first2 = G. \| last3 = Bryar \| first3 = PJ. \| title = Unusual presentation of xanthogranuloma on the eyelid of an adult. \| journal = Ophthal Plast Reconstr Surg \| volume = 30 \| issue = 6 \| pages = e155-6 \| month = \| year = \| doi = 10.1097/01.iop.0000440703.67932.37 \| PMID = 24801255 }}</ref> ''adult onset xanthogranuloma'', and ''adult xanthogranuloma''<ref name=pmid24154556>{{Cite journal \| last1 = Tan \| first1 = LC. \| last2 = Tan \| first2 = KB. \| last3 = Aw \| first3 = CW. \| title = Unusual presentation of adult xanthogranuloma: a case report. \| journal = Singapore Med J \| volume = 55 \| issue = 2 \| pages = e25-7 \| month = Feb \| year = 2014 \| doi = 10.11622/smedj.2013207 \| PMID = 24154556 }}</ref>
	*Most common form of non–Langerhans cell histiocytosis.<ref name=emed_jxg>URL: [http://emedicine.medscape.com/article/1111629-diagnosis http://emedicine.medscape.com/article/1111629-diagnosis]. Accessed on: 3 February 2011.</ref>		*Most common form of non–Langerhans cell histiocytosis.<ref name=emed_jxg>URL: [http://emedicine.medscape.com/article/1111629-diagnosis http://emedicine.medscape.com/article/1111629-diagnosis]. Accessed on: 3 February 2011.</ref>
	*Can rarely be found in the brain.<ref>URL: [http://path.upmc.edu/cases/case245/dx.html http://path.upmc.edu/cases/case245/dx.html]. Accessed on: 13 January 2012.</ref>		*Can rarely be found in the brain.<ref>URL: [http://path.upmc.edu/cases/case245/dx.html http://path.upmc.edu/cases/case245/dx.html]. Accessed on: 13 January 2012.</ref>

Michael: /* Images */ +image

2015-03-01T04:18:11Z

Images: +image

← Older revision		Revision as of 04:18, 1 March 2015
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:Juvenile_xanthogranuloma_-_intermed_mag.jpg \| Juvenile xanthogranuloma - intermed. mag. (WC)		Image:Juvenile_xanthogranuloma_-_intermed_mag.jpg \| JXG - intermed. mag. (WC)
	Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg \| Touton giant cells in a ~~juvenile xanthogranuloma~~ - very high mag. (WC)		Image:Juvenile xanthogranuloma - high mag.jpg \| \| JXG - intermed. mag. (WC)
			Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg \| Touton giant cells in a JXG - very high mag. (WC)
	</gallery>		</gallery>

	===IHC===		===IHC===
	Features:<ref name=emed_jxg/>		Features:<ref name=emed_jxg/>

Michael: touch

2015-03-01T04:16:55Z

touch

← Older revision		Revision as of 04:16, 1 March 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Juvenile_xanthogranuloma_-_very_high_mag.jpg		\| Image = Juvenile_xanthogranuloma_-_very_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Juvenile xanthogranuloma. [[H&E stain]].		\| Caption = Juvenile xanthogranuloma. [[H&E stain]].

Michael: touch

2014-11-04T00:07:08Z

touch

← Older revision		Revision as of 00:07, 4 November 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Juvenile_xanthogranuloma_-_very_high_mag.jpg		\| Image = Juvenile_xanthogranuloma_-_very_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Juvenile xanthogranuloma. [[H&E stain]].		\| Caption = Juvenile xanthogranuloma. [[H&E stain]].

Michael: +infobox

2013-10-31T02:00:58Z

+infobox

← Older revision		Revision as of 02:00, 31 October 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Juvenile_xanthogranuloma_-_very_high_mag.jpg
			\| Width =
			\| Caption = Juvenile xanthogranuloma. [[H&E stain]].
			\| Micro = dermal histiocytes with abundant cytoplasm, +/-Touton [[giant cell]]s (large multi-nucleated cells where nuclei are distributed at the cell periphery)
			\| Subtypes =
			\| LMDDx = [[Langerhans cell histiocytosis]], [[Spitz nevus]] (reported to have Touton cells), [[Dermatofibroma]] - aneurysmal type
			\| Stains =
			\| IHC = CD68 +ve, CD1a -ve, CD207 -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = usually in children and infants, sometimes in adults
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			}}
	'''Juvenile xanthogranuloma''', abbreviated '''JXG''', is a relatively common distinctive diagnosis in dermatopathology. It is also known as '''nevoxanthoendothelioma'''. In adults, it is called ''adult xanthogranuloma''.<ref name=Ref_Derm622>{{Ref Derm\|622}}</ref>		'''Juvenile xanthogranuloma''', abbreviated '''JXG''', is a relatively common distinctive diagnosis in dermatopathology. It is also known as '''nevoxanthoendothelioma'''. In adults, it is called ''adult xanthogranuloma''.<ref name=Ref_Derm622>{{Ref Derm\|622}}</ref>

← Older revision		Revision as of 20:36, 17 June 2016
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	*[[Dermatopathology]].		*[[Dermatopathology]].
	*[[Pediatric pathology]].		*[[Pediatric pathology]].
			*[[Necrobiotic xanthogranuloma]].

	==References==		==References==