Keratins - Revision history

Abraham at 09:59, 22 August 2018

2018-08-22T09:59:22Z

← Older revision		Revision as of 09:59, 22 August 2018
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	In pathology, '''keratins''', also '''cytokeratins''', refers to a set of [[immunostain]]s that mark filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells ([[carcinoma]]s).		In pathology, '''keratins''', also '''cytokeratins''', refers to a set of [[immunostain]]s that mark intermediate filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells ([[carcinoma]]s).

	''Keratin'' when used in singular may refer to ''[[pankeratin]]''.		''Keratin'' when used in singular may refer to ''[[pankeratin]]''.

Michael at 03:19, 2 August 2016

2016-08-02T03:19:03Z

← Older revision		Revision as of 03:19, 2 August 2016
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	'''~~Keratins~~''' refers to a set of ~~immunostains~~ that mark filaments that are characteristic of epithelial cells and ~~cancer~~ derived from epithelial cells ([[carcinoma]]s).		In pathology, '''keratins''', also '''cytokeratins''', refers to a set of [[immunostain]]s that mark filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells ([[carcinoma]]s).

	''Keratin'' when used in singular may refer to ''[[pankeratin]]''.		''Keratin'' when used in singular may refer to ''[[pankeratin]]''.

Michael at 03:17, 2 August 2016

2016-08-02T03:17:17Z

← Older revision		Revision as of 03:17, 2 August 2016
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	*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal \|author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H \|title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma \|journal=Pathol. Res. Pract. \|volume=189 \|issue=8 \|pages=888–93 \|year=1993 \|month=September \|pmid=7508102 \|doi= \|url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes.		*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal \|author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H \|title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma \|journal=Pathol. Res. Pract. \|volume=189 \|issue=8 \|pages=888–93 \|year=1993 \|month=September \|pmid=7508102 \|doi= \|url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes.
	*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]].		*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]].

			==Sarcomas and keratins==
			*Most sarcomas are cytokeratin negative.

			Classic exceptions:
			*[[Angiosarcoma]], epithelioid.
			*[[Synovial sarcoma]].
			*[[Chordoma]].
			*[[Desmoplastic small round cell tumour]].
			*[[Epithelioid sarcoma]].

			Others:
			*[[Leiomyosarcoma]].

	==See also==		==See also==

Michael at 03:13, 2 August 2016

2016-08-02T03:13:18Z

← Older revision		Revision as of 03:13, 2 August 2016
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	''Keratin'' when used in singular may refer to ''[[pankeratin]]''.		''Keratin'' when used in singular may refer to ''[[pankeratin]]''.

			==Classification==
			Divided by molecular weight:<ref>[http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]</ref>
			*Low molecular weight keratins (LMWK): [[CK7\|7]], 8/18, [[CK19\|19]], [[CK20\|20]].
			*High molecular weight keratins (HWMK): 4, 10, 13, 14, 17.

			==Uses==
			*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal \|author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H \|title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma \|journal=Pathol. Res. Pract. \|volume=189 \|issue=8 \|pages=888–93 \|year=1993 \|month=September \|pmid=7508102 \|doi= \|url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes.
			*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]].

	==See also==		==See also==
	*[[Immunohistochemistry]].		*[[Immunohistochemistry]].
	*[[Pankeratin]].		*[[Pankeratin]].

			==References==
			{{Reflist\|1}}

	[[Category:Immunohistochemistry]]		[[Category:Immunohistochemistry]]

Michael: create

2016-08-02T03:09:23Z

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'''Keratins''' refers to a set of immunostains that mark filaments that are characteristic of epithelial cells and cancer derived from epithelial cells ([[carcinoma]]s).

''Keratin'' when used in singular may refer to ''[[pankeratin]]''.

==See also==
*[[Immunohistochemistry]].
*[[Pankeratin]].

[[Category:Immunohistochemistry]]