Keratocystic odontogenic tumour - Revision history

Michael: redirect

2019-03-18T17:29:02Z

redirect

← Older revision		Revision as of 17:29, 18 March 2019
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	~~{{ Infobox diagnosis~~		#redirect [[Odontogenic keratocyst]]
	~~\| Name = {{PAGENAME}}~~
	~~\| Image = Keratocystic_odontogenic_tumour_-_intermed_mag.jpg~~
	~~\| Width =~~
	~~\| Caption = Keratocystic odontogenic tumour. [[H&E stain]].~~
	~~\| Synonyms = odontogenic keratocyst (old term)~~
	~~\| Micro = stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane~~
	~~\| Subtypes =~~
	~~\| LMDDx = odontogenic cyst ([[dentigerous cyst]]), [[squamous cell carcinoma]]~~
	~~\| Stains =~~
	~~\| IHC =~~
	~~\| EM =~~
	~~\| Molecular =~~
	~~\| IF =~~
	~~\| Gross =~~
	~~\| Grossing =~~
	~~\| Site = usually mandible - see ''[[odontogenic tumours and cysts]]''~~
	~~\| Assdx =~~
	~~\| Syndromes = [[nevoid basal cell carcinoma syndrome]]~~
	~~\| Clinicalhx =~~
	~~\| Signs = mass lesion~~
	~~\| Symptoms =~~
	~~\| Prevalence = uncommon~~
	~~\| Bloodwork =~~
	~~\| Rads =~~
	~~\| Endoscopy =~~
	~~\| Prognosis =~~
	~~\| Other =~~
	~~\| ClinDDx = [[ameloblastoma]]~~
	~~\| Tx =~~
	}}
	~~{{ Infobox external links~~
	~~\| Name = {{PAGENAME}}~~
	~~\| EHVSC = 10179~~
	~~\| EHVSC_mult = {{EHVSC2\|10178}}~~
	~~\| pathprotocols =~~
	~~\| wikipedia = keratocystic odontogenic tumour~~
	~~\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}~~
	~~\| rosaicollection = 14023~~
	}}
	~~'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon~~ [[Odontogenic ~~tumours and cysts\|odontogenic tumour]].~~

	~~It was previously known as '''odontogenic~~ keratocyst''', abbreviated '''OKC'''.<ref name=pmid18353202>{{Cite journal \| last1 = Madras \| first1 = J. \| last2 = Lapointe \| first2 = H. \| title = Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. \| journal = J Can Dent Assoc \| volume = 74 \| issue = 2 \| pages = 165-165h \| month = Mar \| year = 2008 \| doi = \| PMID = 18353202 }}</ref>
	~~==General==~~
	*May be associated with ''[[nevoid basal cell carcinoma syndrome]]''.
	*Very rarely transforms to a [[squamous cell carcinoma]].<ref name=pmid21493332>{{Cite journal \| last1 = Lee \| first1 = JW. \| last2 = Gates \| first2 = R. \| last3 = Wignall \| first3 = A. \| title = Squamous cell carcinoma arising from a keratocystic odontogenic tumor. \| journal = Otolaryngol Head Neck Surg \| volume = 145 \| issue = 2 \| pages = 356-7 \| month = Aug \| year = 2011 \| doi = 10.1177/0194599811399270 \| PMID = 21493332 }}</ref><ref name=pmid23374486>{{Cite journal \| last1 = Tan \| first1 = B. \| last2 = Yan \| first2 = TS. \| last3 = Shermin \| first3 = L. \| last4 = Teck \| first4 = KC. \| last5 = Yoke \| first5 = PC. \| last6 = Goh \| first6 = C. \| last7 = Balakrishnan \| first7 = A. \| title = Malignant transformation of keratocystic odontogenic tumor: Two case reports. \| journal = Am J Otolaryngol \| volume = 34 \| issue = 4 \| pages = 357-61 \| month = \| year = \| doi = 10.1016/j.amjoto.2013.01.002 \| PMID = 23374486 }}</ref>

	~~===Clinical===~~
	Features:<ref name=pmid17928730>{{Cite journal \| last1 = Habibi \| first1 = A. \| last2 = Saghravanian \| first2 = N. \| last3 = Habibi \| first3 = M. \| last4 = Mellati \| first4 = E. \| last5 = Habibi \| first5 = M. \| title = Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. \| journal = J Oral Sci \| volume = 49 \| issue = 3 \| pages = 229-35 \| month = Sep \| year = 2007 \| doi = \| PMID = 17928730 }}</ref>
	*Most common presentation: swelling.

	~~==Gross==~~
	*Location: usually mandible.
	*May mimic [[ameloblastoma]] radiologically.

	~~==Microscopic==~~
	~~Features: <ref>Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.</ref>~~
	*Stratified epithelium (resembling squamous epithelium) with:
	**"Ribbon-like appearance" - '''important'''.
	***Typically 8-10 cell layers thick - with relatively uniform thickness.
	***Lacks rete ridges.
	**Palisaded basal cell layer.
	*Parakeratosis (keratinized cells with nuclei) - '''key feature'''.
	*Artefactual separation of epithelium from the basement membrane.

	~~DDx:~~
	*Odontogenic cyst.
	**Orthokeratinized odontogenic cyst<ref name=pmid21062939>{{Cite journal \| last1 = Macdonald-Jankowski \| first1 = DS. \| title = Orthokeratinized odontogenic cyst: a systematic review. \| journal = Dentomaxillofac Radiol \| volume = 39 \| issue = 8 \| pages = 455-67 \| month = Dec \| year = 2010 \| doi = 10.1259/dmfr/19728573 \| PMID = }}</ref> - usu. [[dentigerous cyst]] - has [[orthokeratosis]] instead of [[parakeratosis]].
	***Orthokeratosis = keratinized cells no nuclei; parakeratosis = keratinized cell with nuclei.

	~~===Images===~~
	~~<gallery>~~
	~~Image:Keratocystic_odontogenic_tumour_-_2_-_intermed_mag.jpg \| KOT - intermed. mag. (WC)~~
	~~Image:Keratocystic_odontogenic_tumour_-_2_-_very_high_mag.jpg \| KOT - very high mag. (WC)~~
	~~Image:Keratocystic_odontogenic_tumour_-_intermed_mag.jpg KOT - another case - intermed. mag. (WC)]~~
	~~Image:Keratocystic_odontogenic_tumour1.jpg \| KOT - poor quality. (WC)~~
	~~Image:Keratocystic_odontogenic_tumour2.jpg \| KOT - showing artefactual clefting - poor quality. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://ars.els-cdn.com/content/image/1-s2.0-S0968605305000992-gr5.jpg KOT (els-cdn.com)].<ref>URL: [http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5 http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5]. Accessed on: 11 March 2013.</ref>

	~~==See also==~~
	*[[Odontogenic tumours and cysts]].
	*[[Head and neck pathology]].

	~~==References==~~
	~~{{Reflist\|2}}~~

	~~[[Category:Diagnosis]]~~
	~~[[Category:Odontogenic tumours and cysts~~]]

Michael at 08:33, 8 May 2014

2014-05-08T08:33:06Z

← Older revision		Revision as of 08:33, 8 May 2014
Line 37:		Line 37:
	\| wikipedia = keratocystic odontogenic tumour		\| wikipedia = keratocystic odontogenic tumour
	\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}		\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}
	\| rosaicollection = 2		\| rosaicollection = 14023
	}}		}}
	'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].		'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].

Michael at 08:31, 8 May 2014

2014-05-08T08:31:52Z

← Older revision		Revision as of 08:31, 8 May 2014
Line 37:		Line 37:
	\| wikipedia = keratocystic odontogenic tumour		\| wikipedia = keratocystic odontogenic tumour
	\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}		\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}
	\| rosaicollection = ~~740~~		\| rosaicollection = 2
	}}		}}
	'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].		'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].

Michael at 08:31, 8 May 2014

2014-05-08T08:31:05Z

← Older revision		Revision as of 08:31, 8 May 2014
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	}}		}}
	{{ Infobox external links		{{ Infobox external links
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| EHVSC = 10179		\| EHVSC = 10179
	\| EHVSC_mult = {{EHVSC2\|10178}}		\| EHVSC_mult = {{EHVSC2\|10178}}
	\| pathprotocols =		\| pathprotocols =
	\| wikipedia = keratocystic odontogenic tumour		\| wikipedia = keratocystic odontogenic tumour
	\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}		\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}
			\| rosaicollection = 740
	}}		}}
	'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].		'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].

Michael at 03:22, 23 March 2014

2014-03-23T03:22:06Z

← Older revision		Revision as of 03:22, 23 March 2014
Line 36:		Line 36:
	\| pathprotocols =		\| pathprotocols =
	\| wikipedia = keratocystic odontogenic tumour		\| wikipedia = keratocystic odontogenic tumour
	\| pathoutlines =		\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}
	}}		}}
	'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].		'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon [[Odontogenic tumours and cysts\|odontogenic tumour]].

Michael at 02:25, 17 March 2014

2014-03-17T02:25:25Z

← Older revision		Revision as of 02:25, 17 March 2014
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = usually mandible		\| Site = usually mandible - see ''[[odontogenic tumours and cysts]]''
	\| Assdx =		\| Assdx =
	\| Syndromes = [[nevoid basal cell carcinoma syndrome]]		\| Syndromes = [[nevoid basal cell carcinoma syndrome]]

Michael at 02:22, 17 March 2014

2014-03-17T02:22:19Z

← Older revision		Revision as of 02:22, 17 March 2014
Line 4:		Line 4:
	\| Width =		\| Width =
	\| Caption = Keratocystic odontogenic tumour. [[H&E stain]].		\| Caption = Keratocystic odontogenic tumour. [[H&E stain]].
	\| Synonyms = odontogenic keratocyst		\| Synonyms = odontogenic keratocyst (old term)
	\| Micro = stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane		\| Micro = stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane
	\| Subtypes =		\| Subtypes =

Michael at 13:47, 27 December 2013

2013-12-27T13:47:59Z

← Older revision		Revision as of 13:47, 27 December 2013
Line 4:		Line 4:
	\| Width =		\| Width =
	\| Caption = Keratocystic odontogenic tumour. [[H&E stain]].		\| Caption = Keratocystic odontogenic tumour. [[H&E stain]].
			\| Synonyms = odontogenic keratocyst
	\| Micro = stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane		\| Micro = stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane
	\| Subtypes =		\| Subtypes =
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	\| Other =		\| Other =
	\| ClinDDx = [[ameloblastoma]]		\| ClinDDx = [[ameloblastoma]]
			\| Tx =
	}}		}}
	{{ Infobox external links		{{ Infobox external links

Michael: tweak

2013-07-29T21:03:48Z

tweak

← Older revision		Revision as of 21:03, 29 July 2013
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	{{ Infobox external links		{{ Infobox external links
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| EHVSC = 10179 ~~<!-- 10178 -->~~		\| EHVSC = 10179
	\| EHVSC_mult = {{EHVSC2\|10178}}		\| EHVSC_mult = {{EHVSC2\|10178}}
	\| pathprotocols =		\| pathprotocols =

Michael: fix

2013-07-29T18:05:43Z

fix

← Older revision		Revision as of 18:05, 29 July 2013
Line 31:		Line 31:
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| EHVSC = 10179 <!-- 10178 -->		\| EHVSC = 10179 <!-- 10178 -->
	\| ~~EHVSC_multi~~ = {{EHVSC2\|10178}}		\| EHVSC_mult = {{EHVSC2\|10178}}
	\| pathprotocols =		\| pathprotocols =
	\| wikipedia = keratocystic odontogenic tumour		\| wikipedia = keratocystic odontogenic tumour

← Older revision		Revision as of 17:29, 18 March 2019
Line 1:		Line 1:
	~~{{ Infobox diagnosis~~		#redirect [[Odontogenic keratocyst]]
	~~\| Name = {{PAGENAME}}~~
	~~\| Image = Keratocystic_odontogenic_tumour_-_intermed_mag.jpg~~
	~~\| Width =~~
	~~\| Caption = Keratocystic odontogenic tumour. [[H&E stain]].~~
	~~\| Synonyms = odontogenic keratocyst (old term)~~
	~~\| Micro = stratified epithelium with "ribbon-like appearance" with palisaded basal cell layer, parakeratosis, artefactual separation of epithelium from the basement membrane~~
	~~\| Subtypes =~~
	~~\| LMDDx = odontogenic cyst ([[dentigerous cyst]]), [[squamous cell carcinoma]]~~
	~~\| Stains =~~
	~~\| IHC =~~
	~~\| EM =~~
	~~\| Molecular =~~
	~~\| IF =~~
	~~\| Gross =~~
	~~\| Grossing =~~
	~~\| Site = usually mandible - see ''[[odontogenic tumours and cysts]]''~~
	~~\| Assdx =~~
	~~\| Syndromes = [[nevoid basal cell carcinoma syndrome]]~~
	~~\| Clinicalhx =~~
	~~\| Signs = mass lesion~~
	~~\| Symptoms =~~
	~~\| Prevalence = uncommon~~
	~~\| Bloodwork =~~
	~~\| Rads =~~
	~~\| Endoscopy =~~
	~~\| Prognosis =~~
	~~\| Other =~~
	~~\| ClinDDx = [[ameloblastoma]]~~
	~~\| Tx =~~
	}}
	~~{{ Infobox external links~~
	~~\| Name = {{PAGENAME}}~~
	~~\| EHVSC = 10179~~
	~~\| EHVSC_mult = {{EHVSC2\|10178}}~~
	~~\| pathprotocols =~~
	~~\| wikipedia = keratocystic odontogenic tumour~~
	~~\| pathoutlines = {{Pathologyoutlines\|topic/mandiblemaxillakeratocyst}}~~
	~~\| rosaicollection = 14023~~
	}}
	~~'''Keratocystic odontogenic tumour''', abbreviated '''KOT''', is an uncommon~~ [[Odontogenic ~~tumours and cysts\|odontogenic tumour]].~~

	~~It was previously known as '''odontogenic~~ keratocyst''', abbreviated '''OKC'''.<ref name=pmid18353202>{{Cite journal \| last1 = Madras \| first1 = J. \| last2 = Lapointe \| first2 = H. \| title = Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. \| journal = J Can Dent Assoc \| volume = 74 \| issue = 2 \| pages = 165-165h \| month = Mar \| year = 2008 \| doi = \| PMID = 18353202 }}</ref>
	~~==General==~~
	*May be associated with ''[[nevoid basal cell carcinoma syndrome]]''.
	*Very rarely transforms to a [[squamous cell carcinoma]].<ref name=pmid21493332>{{Cite journal \| last1 = Lee \| first1 = JW. \| last2 = Gates \| first2 = R. \| last3 = Wignall \| first3 = A. \| title = Squamous cell carcinoma arising from a keratocystic odontogenic tumor. \| journal = Otolaryngol Head Neck Surg \| volume = 145 \| issue = 2 \| pages = 356-7 \| month = Aug \| year = 2011 \| doi = 10.1177/0194599811399270 \| PMID = 21493332 }}</ref><ref name=pmid23374486>{{Cite journal \| last1 = Tan \| first1 = B. \| last2 = Yan \| first2 = TS. \| last3 = Shermin \| first3 = L. \| last4 = Teck \| first4 = KC. \| last5 = Yoke \| first5 = PC. \| last6 = Goh \| first6 = C. \| last7 = Balakrishnan \| first7 = A. \| title = Malignant transformation of keratocystic odontogenic tumor: Two case reports. \| journal = Am J Otolaryngol \| volume = 34 \| issue = 4 \| pages = 357-61 \| month = \| year = \| doi = 10.1016/j.amjoto.2013.01.002 \| PMID = 23374486 }}</ref>

	~~===Clinical===~~
	Features:<ref name=pmid17928730>{{Cite journal \| last1 = Habibi \| first1 = A. \| last2 = Saghravanian \| first2 = N. \| last3 = Habibi \| first3 = M. \| last4 = Mellati \| first4 = E. \| last5 = Habibi \| first5 = M. \| title = Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. \| journal = J Oral Sci \| volume = 49 \| issue = 3 \| pages = 229-35 \| month = Sep \| year = 2007 \| doi = \| PMID = 17928730 }}</ref>
	*Most common presentation: swelling.

	~~==Gross==~~
	*Location: usually mandible.
	*May mimic [[ameloblastoma]] radiologically.

	~~==Microscopic==~~
	~~Features: <ref>Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.</ref>~~
	*Stratified epithelium (resembling squamous epithelium) with:
	**"Ribbon-like appearance" - '''important'''.
	***Typically 8-10 cell layers thick - with relatively uniform thickness.
	***Lacks rete ridges.
	**Palisaded basal cell layer.
	*Parakeratosis (keratinized cells with nuclei) - '''key feature'''.
	*Artefactual separation of epithelium from the basement membrane.

	~~DDx:~~
	*Odontogenic cyst.
	**Orthokeratinized odontogenic cyst<ref name=pmid21062939>{{Cite journal \| last1 = Macdonald-Jankowski \| first1 = DS. \| title = Orthokeratinized odontogenic cyst: a systematic review. \| journal = Dentomaxillofac Radiol \| volume = 39 \| issue = 8 \| pages = 455-67 \| month = Dec \| year = 2010 \| doi = 10.1259/dmfr/19728573 \| PMID = }}</ref> - usu. [[dentigerous cyst]] - has [[orthokeratosis]] instead of [[parakeratosis]].
	***Orthokeratosis = keratinized cells no nuclei; parakeratosis = keratinized cell with nuclei.

	~~===Images===~~
	~~<gallery>~~
	~~Image:Keratocystic_odontogenic_tumour_-_2_-_intermed_mag.jpg \| KOT - intermed. mag. (WC)~~
	~~Image:Keratocystic_odontogenic_tumour_-_2_-_very_high_mag.jpg \| KOT - very high mag. (WC)~~
	~~Image:Keratocystic_odontogenic_tumour_-_intermed_mag.jpg KOT - another case - intermed. mag. (WC)]~~
	~~Image:Keratocystic_odontogenic_tumour1.jpg \| KOT - poor quality. (WC)~~
	~~Image:Keratocystic_odontogenic_tumour2.jpg \| KOT - showing artefactual clefting - poor quality. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://ars.els-cdn.com/content/image/1-s2.0-S0968605305000992-gr5.jpg KOT (els-cdn.com)].<ref>URL: [http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5 http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5]. Accessed on: 11 March 2013.</ref>

	~~==See also==~~
	*[[Odontogenic tumours and cysts]].
	*[[Head and neck pathology]].

	~~==References==~~
	~~{{Reflist\|2}}~~

	~~[[Category:Diagnosis]]~~
	~~[[Category:Odontogenic tumours and cysts~~]]