Kikuchi disease - Revision history

Michael at 14:31, 11 January 2014

2014-01-11T14:31:11Z

← Older revision		Revision as of 14:31, 11 January 2014
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	*Rare disease that may mimic [[cancer]], esp. [[lymphoma]].		*Rare disease that may mimic [[cancer]], esp. [[lymphoma]].
	**May cause fever & systemic symptoms.<ref name=pmid20121621>{{cite journal \|author=Hutchinson CB, Wang E \|title=Kikuchi-Fujimoto disease \|journal=Arch. Pathol. Lab. Med. \|volume=134 \|issue=2 \|pages=289–93 \|year=2010 \|month=February \|pmid=20121621 \|doi= \|url=}}</ref>		**May cause fever & systemic symptoms.<ref name=pmid20121621>{{cite journal \|author=Hutchinson CB, Wang E \|title=Kikuchi-Fujimoto disease \|journal=Arch. Pathol. Lab. Med. \|volume=134 \|issue=2 \|pages=289–93 \|year=2010 \|month=February \|pmid=20121621 \|doi= \|url=}}</ref>
			*Associated with the subsequent diagnosis of [[systemic lupus erythematosus]].<ref name=pmid24157995>{{Cite journal \| last1 = Scully \| first1 = DF. \| last2 = Walsh \| first2 = C. \| last3 = Eskander \| first3 = HF. \| last4 = Kane \| first4 = D. \| title = Kikuchi-Fujimoto disease--an unusual mimicker? \| journal = N Z Med J \| volume = 126 \| issue = 1383 \| pages = 85-8 \| month = Sep \| year = 2013 \| doi = \| PMID = 24157995 }}</ref>

	Epidemiology:<ref name=pmid20121621/>		Epidemiology:<ref name=pmid20121621/>
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	DDx:		DDx:
	*Non-Hodgkin lymphoma.		*[[Non-Hodgkin lymphoma]].
	*[[Systemic lupus erythematosus]].		*[[Systemic lupus erythematosus]].
	**Have ''hematoxyphil bodies'' in necrotic foci.		**Have ''hematoxyphil bodies'' in necrotic foci.

Michael at 03:22, 10 December 2013

2013-12-10T03:22:56Z

← Older revision		Revision as of 03:22, 10 December 2013
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	\| ClinDDx = [[lymphoma]], other causes of lymphadenopathy		\| ClinDDx = [[lymphoma]], other causes of lymphadenopathy
	}}		}}
	'''Kikuchi disease''', is a rare [[lymph node pathology]].		'''Kikuchi disease''', is a rare [[lymph node pathology\|pathology of the lymph nodes]].

	It is also known as '''histiocytic necrotising lymphadenitis''',<ref name="pmid15570824">{{cite journal \|author=Kaushik V, Malik TH, Bishop PW, Jones PH \|title=Histiocytic necrotising lymphadenitis (Kikuchi's disease): a rare cause of cervical lymphadenopathy \|journal=Surgeon \|volume=2 \|issue=3 \|pages=179–82 \|year=2004 \|month=June \|pmid=15570824 \|doi= \|url=}}</ref> abbreviated '''HNL''', and '''Kikuchi-Fujimoto disease'''.		It is also known as '''histiocytic necrotising lymphadenitis''',<ref name="pmid15570824">{{cite journal \|author=Kaushik V, Malik TH, Bishop PW, Jones PH \|title=Histiocytic necrotising lymphadenitis (Kikuchi's disease): a rare cause of cervical lymphadenopathy \|journal=Surgeon \|volume=2 \|issue=3 \|pages=179–82 \|year=2004 \|month=June \|pmid=15570824 \|doi= \|url=}}</ref> abbreviated '''HNL''', and '''Kikuchi-Fujimoto disease'''.

Michael: +infobox

2013-12-10T03:19:33Z

+infobox

← Older revision		Revision as of 03:19, 10 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg
			\| Width =
			\| Caption = Kikuchi disease. [[H&E stain]].
			\| Micro = histiocytes, necrosis (paracortical areas) without neutrophils, bland lymphocytes, plasmacytoid dendritic cells
			\| Subtypes =
			\| LMDDx = [[systemic lupus erythematosus lymphadenopathy]]
			\| Stains =
			\| IHC = done to exclude lymphoma
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lymph node]] - see ''[[lymph node pathology]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs = +/-fever
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usu. good - self-limited
			\| Other =
			\| ClinDDx = [[lymphoma]], other causes of lymphadenopathy
			}}
	'''Kikuchi disease''', is a rare [[lymph node pathology]].		'''Kikuchi disease''', is a rare [[lymph node pathology]].

Michael: split-out

2013-12-10T03:14:25Z

split-out

← Older revision		Revision as of 03:14, 10 December 2013
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	~~#redirect~~ [[~~Lymph_node_pathology#Kikuchi_disease~~]]		'''Kikuchi disease''', is a rare [[lymph node pathology]].

			It is also known as '''histiocytic necrotising lymphadenitis''',<ref name="pmid15570824">{{cite journal \|author=Kaushik V, Malik TH, Bishop PW, Jones PH \|title=Histiocytic necrotising lymphadenitis (Kikuchi's disease): a rare cause of cervical lymphadenopathy \|journal=Surgeon \|volume=2 \|issue=3 \|pages=179–82 \|year=2004 \|month=June \|pmid=15570824 \|doi= \|url=}}</ref> abbreviated '''HNL''', and '''Kikuchi-Fujimoto disease'''.

			==General==
			*Rare disease that may mimic [[cancer]], esp. [[lymphoma]].
			**May cause fever & systemic symptoms.<ref name=pmid20121621>{{cite journal \|author=Hutchinson CB, Wang E \|title=Kikuchi-Fujimoto disease \|journal=Arch. Pathol. Lab. Med. \|volume=134 \|issue=2 \|pages=289–93 \|year=2010 \|month=February \|pmid=20121621 \|doi= \|url=}}</ref>

			Epidemiology:<ref name=pmid20121621/>
			*Usually <40 years old.
			*Asian.
			*Female:Male = 3:1.<ref>URL: [http://emedicine.medscape.com/article/210752-overview http://emedicine.medscape.com/article/210752-overview]. Accessed on: 3 June 2010.</ref>

			Treatment:
			*Usually self-limited.<ref name=pmid20121621/>
			*Oral corticosteroids.

			DDx:
			*Non-Hodgkin lymphoma.
			*[[Systemic lupus erythematosus]].
			**Have ''hematoxyphil bodies'' in necrotic foci.
			***Dark blue irregular bodies on H&E.

			==Micrograph==
			Features (the three main features - just as the name suggests):<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_head_and_neck_surgery/volume_1_number_1_30/article_printable/kikuchi_s_lymphadenitis_in_a_young_male.html http://www.ispub.com/journal/the_internet_journal_of_head_and_neck_surgery/volume_1_number_1_30/article_printable/kikuchi_s_lymphadenitis_in_a_young_male.html]. Accessed on: 1 June 2010.</ref>
			*Histiocytes.
			**May be crescentic.
			*Necrosis (due to [[apoptosis]]) - paracortical areas.<ref name=pmid20121621/>
			**[[Necrosis]] without neutrophils - '''key feature'''.
			*Lymphocytes (CD8 +ve).
			*Plasmacytoid dendritic cells.

			Notes:
			*Dendritic cell - vaguely resembles a macrophage:<ref>URL: [http://www.healthsystem.virginia.edu/internet/hematology/hessedd/benignhematologicdisorders/normal-hematopoietic-cells/dendritic-cell.cfm?drid=214 http://www.healthsystem.virginia.edu/internet/hematology/hessedd/benignhematologicdisorders/normal-hematopoietic-cells/dendritic-cell.cfm?drid=214]. Accessed on: 3 June 2010.</ref>
			**Long membrane projections - '''key feature'''.
			**Abundant blue-grey cytoplasm, +/- ground-glass appearance.
			**Nucleus: small, ovoid, usu. single nucleolus.

			===Images===
			<gallery>
			Image:Histiocytic_necrotizing_lymphadenitis_-_intermed_mag.jpg \| Kikuchi disease - intermed. mag. (WC)
			Image:Histiocytic_necrotizing_lymphadenitis_-_high_mag.jpg \| Kikuchi disease - high mag. (WC)
			Image:Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg \| Kikuchi disease - very high mag. (WC)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case200.html Kikuchi disease - several crappy images (upmc.edu)].

			==IHC==
			*CD68 +ve.
			*CD8 +ve - usu. predominant.
			*CD4, CD20, CD3, and CD30 - mixed.
			**Done to excluded lymphoma; esp. large cell lymphomas;<ref name=pmid19577167>{{cite journal \|author=Good DJ, Gascoyne RD \|title=Atypical lymphoid hyperplasia mimicking lymphoma \|journal=Hematol. Oncol. Clin. North Am. \|volume=23 \|issue=4 \|pages=729–45 \|year=2009 \|month=August \|pmid=19577167 \|doi=10.1016/j.hoc.2009.04.005 \|url=}}</ref> should show a mixed population of lymphocytes.
			*Others:
			**CD56 -ve.

			==See also==
			*[[Lymph node pathology]].
			*[[Necrosis]].

			==References==
			{{Reflist\|2}}

			[[Category:Lymph node pathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2011-11-15T05:53:25Z

redirect

New page

#redirect [[Lymph_node_pathology#Kikuchi_disease]]

[[Category:Diagnosis]]