Lhermitte-Duclos disease - Revision history

Jensflorian: update +pics

2015-10-13T09:54:06Z

update +pics

← Older revision		Revision as of 09:54, 13 October 2015
Line 6:		Line 6:
	*[[Cerebellum\|Cerebellar]] lesion.		*[[Cerebellum\|Cerebellar]] lesion.
	*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM\|158350}}</ref>		*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM\|158350}}</ref>
			*Rarely bilateral.<ref>{{Cite journal \| last1 = Bozbuga \| first1 = M. \| last2 = Gulec \| first2 = I. \| last3 = Suslu \| first3 = HT. \| last4 = Bayindir \| first4 = C. \| title = Bilateral Lhermitte-Duclos disease. \| journal = Neurol India \| volume = 58 \| issue = 2 \| pages = 309-11 \| month = \| year = \| doi = 10.4103/0028-3886.63799 \| PMID = 20508358 }}</ref>
			*ICD-O code: 9493/0

	==Microscopic==		==Microscopic==
Line 13:		Line 15:
	*Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - '''key feature'''.		*Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - '''key feature'''.
	*+/-Microcalcifications.		*+/-Microcalcifications.

			==IHC==
			*Synapto+ve.
			*Calbindin+ve.
			*PTEN-ve.
			*MIB-1 almost absent.

	===Images===		===Images===
	<gallery>		<gallery>
			File:Dysplastic cerebellar gangliocytoma.jpg \| LDD in cerebellar cross section (AFIP)
	Image:Dysplastic gangliocytoma lhermitte duclos.jpg \| LDD. (WC/Jensflorian)		Image:Dysplastic gangliocytoma lhermitte duclos.jpg \| LDD. (WC/Jensflorian)
			File:Lhermitte Duclos Luxol.jpg \| LDD, Luxol fast blue stain. (WC/Sbrandner)
			File:Lhermitte Duclos Calbindin.jpg \| LDD, Calbindin. (WC/Sbrandner)
	</gallery>		</gallery>
	www:		www:
	*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].

			==Molecular==
			*PTEN inactivation. <ref>{{Cite journal \| last1 = Chen \| first1 = XY. \| last2 = Lu \| first2 = F. \| last3 = Wang \| first3 = YM. \| last4 = Yang \| first4 = Y. \| last5 = Wei \| first5 = GQ. \| last6 = Wu \| first6 = D. \| last7 = Wang \| first7 = LF. \| last8 = Wu \| first8 = YM. \| title = PTEN inactivation by germline/somatic c.950_953delTACT mutation in patients with Lhermitte-Duclos disease manifesting progressive phenotypes. \| journal = Clin Genet \| volume = 86 \| issue = 4 \| pages = 349-54 \| month = Oct \| year = 2014 \| doi = 10.1111/cge.12282 \| PMID = 24102544 }}</ref>
			**Mosaic forms reported.<ref>{{Cite journal \| last1 = Pritchard \| first1 = CC. \| last2 = Smith \| first2 = C. \| last3 = Marushchak \| first3 = T. \| last4 = Koehler \| first4 = K. \| last5 = Holmes \| first5 = H. \| last6 = Raskind \| first6 = W. \| last7 = Walsh \| first7 = T. \| last8 = Bennett \| first8 = RL. \| title = A mosaic PTEN mutation causing Cowden syndrome identified by deep sequencing. \| journal = Genet Med \| volume = 15 \| issue = 12 \| pages = 1004-7 \| month = Dec \| year = 2013 \| doi = 10.1038/gim.2013.51 \| PMID = 23619277 }}</ref>



			==DDx:==
			(Usually on imaging):
			*Arachnoid vascular malformation <ref>{{Cite journal \| last1 = Huang \| first1 = S. \| last2 = Zhang \| first2 = G. \| last3 = Zhang \| first3 = J. \| title = Similar MR imaging characteristics but different pathological changes: a misdiagnosis for Lhermitte-Duclos disease and review of the literature. \| journal = Int J Clin Exp Pathol \| volume = 8 \| issue = 6 \| pages = 7583-7 \| month = \| year = 2015 \| doi = \| PMID = 26261673 }}</ref>
			*Cerebellar [[Pleomorphic xanthoastrocytoma]]<ref>{{Cite journal \| last1 = Takei \| first1 = H. \| last2 = Rouah \| first2 = E. \| last3 = Bhattacharjee \| first3 = MB. \| title = Cerebellar pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1: a case report and literature review. \| journal = Int J Clin Exp Pathol \| volume = 8 \| issue = 6 \| pages = 7570-4 \| month = \| year = 2015 \| doi = \| PMID = 26261671 }}</ref>
			*[[Medulloblastoma]]<ref>{{Cite journal \| last1 = Douglas-Akinwande \| first1 = AC. \| last2 = Payner \| first2 = TD. \| last3 = Hattab \| first3 = EM. \| title = Medulloblastoma mimicking Lhermitte-Duclos disease on MRI and CT. \| journal = Clin Neurol Neurosurg \| volume = 111 \| issue = 6 \| pages = 536-9 \| month = Jul \| year = 2009 \| doi = 10.1016/j.clineuro.2009.01.008 \| PMID = 19233547 }}</ref>

	==See also==		==See also==
Line 29:		Line 52:
	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:WHO grade I tumours]]

Michael: /* General */

2014-10-17T14:51:55Z

General

← Older revision		Revision as of 14:51, 17 October 2014
Line 4:		Line 4:

	==General==		==General==
	*Cerebellar lesion.		*[[Cerebellum\|Cerebellar]] lesion.
	*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM\|158350}}</ref>		*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM\|158350}}</ref>

Michael at 14:51, 17 October 2014

2014-10-17T14:51:22Z

← Older revision		Revision as of 14:51, 17 October 2014
Line 1:		Line 1:
	'''Lhermitte-~~Duclos_disease~~''', abbreviated '''LDD''', is a rare [[neuropathology]].		'''Lhermitte-Duclos disease''', abbreviated '''LDD''', is a rare [[neuropathology]].

	It is also known as '''dysplastic cerebellar gangliocytoma'''<ref name=pmid20060133>{{Cite journal \| last1 = Yağci-Küpeli \| first1 = B. \| last2 = Oguz \| first2 = KK. \| last3 = Bilen \| first3 = MA. \| last4 = Yalçin \| first4 = B. \| last5 = Akalan \| first5 = N. \| last6 = Büyükpamukçu \| first6 = M. \| title = An unusual cause of posterior fossa mass: Lhermitte-Duclos disease. \| journal = J Neurol Sci \| volume = 290 \| issue = 1-2 \| pages = 138-41 \| month = Mar \| year = 2010 \| doi = 10.1016/j.jns.2009.12.010 \| PMID = 20060133 }}</ref> and '''dysplastic gangliocytoma of the cerebellum'''.		It is also known as '''dysplastic cerebellar gangliocytoma'''<ref name=pmid20060133>{{Cite journal \| last1 = Yağci-Küpeli \| first1 = B. \| last2 = Oguz \| first2 = KK. \| last3 = Bilen \| first3 = MA. \| last4 = Yalçin \| first4 = B. \| last5 = Akalan \| first5 = N. \| last6 = Büyükpamukçu \| first6 = M. \| title = An unusual cause of posterior fossa mass: Lhermitte-Duclos disease. \| journal = J Neurol Sci \| volume = 290 \| issue = 1-2 \| pages = 138-41 \| month = Mar \| year = 2010 \| doi = 10.1016/j.jns.2009.12.010 \| PMID = 20060133 }}</ref> and '''dysplastic gangliocytoma of the cerebellum'''.

Michael at 14:51, 17 October 2014

2014-10-17T14:51:10Z

← Older revision		Revision as of 14:51, 17 October 2014
Line 14:		Line 14:
	*+/-Microcalcifications.		*+/-Microcalcifications.

	Images:		===Images===
			<gallery>
			Image:Dysplastic gangliocytoma lhermitte duclos.jpg \| LDD. (WC/Jensflorian)
			</gallery>
			www:
	*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].

Michael: split out

2014-02-17T03:52:25Z

split out

← Older revision		Revision as of 03:52, 17 February 2014
Line 1:		Line 1:
	~~#redirect [[Neuropathology_tumours#~~Lhermitte-Duclos_disease]]		'''Lhermitte-Duclos_disease''', abbreviated '''LDD''', is a rare [[neuropathology]].

			It is also known as '''dysplastic cerebellar gangliocytoma'''<ref name=pmid20060133>{{Cite journal \| last1 = Yağci-Küpeli \| first1 = B. \| last2 = Oguz \| first2 = KK. \| last3 = Bilen \| first3 = MA. \| last4 = Yalçin \| first4 = B. \| last5 = Akalan \| first5 = N. \| last6 = Büyükpamukçu \| first6 = M. \| title = An unusual cause of posterior fossa mass: Lhermitte-Duclos disease. \| journal = J Neurol Sci \| volume = 290 \| issue = 1-2 \| pages = 138-41 \| month = Mar \| year = 2010 \| doi = 10.1016/j.jns.2009.12.010 \| PMID = 20060133 }}</ref> and '''dysplastic gangliocytoma of the cerebellum'''.

			==General==
			*Cerebellar lesion.
			*May be associated with [[Cowden syndrome]].<ref name=omim158350>{{OMIM\|158350}}</ref>

			==Microscopic==
			Features:<ref>URL: [http://path.upmc.edu/cases/case472.html http://path.upmc.edu/cases/case472.html]. Accessed on: 21 January 2012.</ref>
			*The outer (molecular) layer has increased cellularity.
			*Purkinje cells absent.<ref name=pmid20060133/>
			*Large (polygonal) cells with round nuclei and prominent nucleoli in the inner (granular) layer - '''key feature'''.
			*+/-Microcalcifications.

			Images:
			*[http://path.upmc.edu/cases/case472.html LDD - several images (upmc.edu)].

			==See also==
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|2}}

			[[Category:Neuropathology tumours]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2012-01-21T17:31:19Z

redirect

New page

#redirect [[Neuropathology_tumours#Lhermitte-Duclos_disease]]

[[Category:Diagnosis]]