Liver transplantation pathology - Revision history

Michael: wikify

2012-03-31T23:01:07Z

wikify

← Older revision		Revision as of 23:01, 31 March 2012
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	==Donor liver suitability==		==Donor liver suitability==
	Donor livers are assessed using [[frozen section]]:		Donor livers are assessed using [[frozen section]]:
	*Donor liver ''~~macrovesicular~~ [[steatosis]]'' should ''not'' exceed 30% - as it is associated poor transplant outcome.<ref name=pmid22121403>{{Cite journal \| last1 = Heller \| first1 = B. \| last2 = Peters \| first2 = S. \| title = Assessment of liver transplant donor biopsies for steatosis using frozen section: accuracy and possible impact on transplantation. \| journal = J Clin Med Res \| volume = 3 \| issue = 4 \| pages = 191-4 \| month = Jul \| year = 2011 \| doi = 10.4021/jocmr629w \| PMID = 22121403 }}</ref>		*Donor liver ''[[macrovesicular steatosis]]'' should ''not'' exceed 30% - as it is associated poor transplant outcome.<ref name=pmid22121403>{{Cite journal \| last1 = Heller \| first1 = B. \| last2 = Peters \| first2 = S. \| title = Assessment of liver transplant donor biopsies for steatosis using frozen section: accuracy and possible impact on transplantation. \| journal = J Clin Med Res \| volume = 3 \| issue = 4 \| pages = 191-4 \| month = Jul \| year = 2011 \| doi = 10.4021/jocmr629w \| PMID = 22121403 }}</ref>

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Michael: /* Donor liver suitability */

2012-03-31T22:59:27Z

Donor liver suitability

← Older revision		Revision as of 22:59, 31 March 2012
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	==Donor liver suitability==		==Donor liver suitability==
	Donor livers are assessed using [[frozen section]]:		Donor livers are assessed using [[frozen section]]:
	*Donor liver ''macrovesicular [[steatosis]]'' should ''not'' exceed 30% - as it associated poor transplant outcome.<ref name=pmid22121403>{{Cite journal \| last1 = Heller \| first1 = B. \| last2 = Peters \| first2 = S. \| title = Assessment of liver transplant donor biopsies for steatosis using frozen section: accuracy and possible impact on transplantation. \| journal = J Clin Med Res \| volume = 3 \| issue = 4 \| pages = 191-4 \| month = Jul \| year = 2011 \| doi = 10.4021/jocmr629w \| PMID = 22121403 }}</ref>		*Donor liver ''macrovesicular [[steatosis]]'' should ''not'' exceed 30% - as it is associated poor transplant outcome.<ref name=pmid22121403>{{Cite journal \| last1 = Heller \| first1 = B. \| last2 = Peters \| first2 = S. \| title = Assessment of liver transplant donor biopsies for steatosis using frozen section: accuracy and possible impact on transplantation. \| journal = J Clin Med Res \| volume = 3 \| issue = 4 \| pages = 191-4 \| month = Jul \| year = 2011 \| doi = 10.4021/jocmr629w \| PMID = 22121403 }}</ref>

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Michael: more

2012-03-31T22:53:49Z

← Older revision		Revision as of 22:53, 31 March 2012
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	'''Liver transplantation pathology''' is a niche within a niche. It deals with question: "Is it rejection or something else?".		'''Liver transplantation pathology''' is a niche within a niche. It deals with question: "Is it rejection or something else?".

			==Donor liver suitability==
			Donor livers are assessed using [[frozen section]]:
			*Donor liver ''macrovesicular [[steatosis]]'' should ''not'' exceed 30% - as it associated poor transplant outcome.<ref name=pmid22121403>{{Cite journal \| last1 = Heller \| first1 = B. \| last2 = Peters \| first2 = S. \| title = Assessment of liver transplant donor biopsies for steatosis using frozen section: accuracy and possible impact on transplantation. \| journal = J Clin Med Res \| volume = 3 \| issue = 4 \| pages = 191-4 \| month = Jul \| year = 2011 \| doi = 10.4021/jocmr629w \| PMID = 22121403 }}</ref>

			Note:
			*Microvesicular steatosis does ''not'' appear to affect graft function.<ref name=pmid11070113>{{Cite journal \| last1 = Crowley \| first1 = H. \| last2 = Lewis \| first2 = WD. \| last3 = Gordon \| first3 = F. \| last4 = Jenkins \| first4 = R. \| last5 = Khettry \| first5 = U. \| title = Steatosis in donor and transplant liver biopsies. \| journal = Hum Pathol \| volume = 31 \| issue = 10 \| pages = 1209-13 \| month = Oct \| year = 2000 \| doi = 10.1053/hupa.2000.18473 \| PMID = 11070113 }}</ref>

	==Rejection==		==Rejection==

Michael: +cat

2011-01-17T17:42:47Z

+cat

← Older revision		Revision as of 17:42, 17 January 2011
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	{{Reflist\|1}}		{{Reflist\|1}}

	[[Category:]]		[[Category:Gastrointestinal pathology]]
			[[Category:Liver pathology]]

Michael: create

2011-01-17T17:42:06Z

create

New page

'''Liver transplantation pathology''' is a niche within a niche. It deals with question: "Is it rejection or something else?".

==Rejection==
Tx: more immunosuppression.

===Grading===
RAI (rejection activity index):<ref name=pmid16799959>{{cite journal |author=Höroldt BS, Burattin M, Gunson BK, ''et al.'' |title=Does the Banff rejection activity index predict outcome in patients with early acute cellular rejection following liver transplantation? |journal=Liver Transpl. |volume=12 |issue=7 |pages=1144–51 |year=2006 |month=July |pmid=16799959 |doi=10.1002/lt.20779 |url=}}</ref>
*Based on three components:
*#Endothelial inflammation - scored 0-3.
*#Bile duct damage - scored 0-3.
*#Portal inflammation - scored 0-3.
*The three components are added to give a score with a range of 0 to 9.

==See also==
*[[Liver pathology]].
*[[Medical liver disease]].

==References==
{{Reflist|1}}

[[Category:]]