Lymph nodes - Revision history

Michael at 19:03, 15 October 2023

2023-10-15T19:03:59Z

← Older revision		Revision as of 19:03, 15 October 2023
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	'''Lymph nodes''', abbreviated '''LNs''', are very important in pathology. They are the site of [[metastases]] and/or may be the site of a primary tumour, i.e. [[lymphoma]].		'''Lymph nodes''', abbreviated '''LNs''', are very important in pathology. They are the site of [[metastases]] and/or may be the site of a primary tumour, i.e. [[lymphoma]].

	Haematopathology and lymphoma is dealt with in the ''[[haematopathology]]'' article. This article covers the basics of lymph nodes. Lymph node pathology is dealt with in the ''[[lymph node pathology]]'' article.		Haematopathology and lymphoma is dealt with in the ''[[haematopathology]]'' article. This article covers the basics of lymph nodes. Lymph node pathology is dealt with in the ''[[lymph node pathology]]'' article. [[Grossing]] is covered in ''[[lymph node grossing]]''.

	=Clinical=		=Clinical=

Michael at 18:31, 15 October 2023

2023-10-15T18:31:25Z

← Older revision		Revision as of 18:31, 15 October 2023
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	=Gross pathologic exam=		=Gross pathologic exam=
			{{Main\|Lymph node grossing}}
	Normal:		Normal:
	*Firm (relative to adipose tissue).		*Firm (relative to adipose tissue).

Michael: /* Pathology */

2019-10-31T20:01:40Z

Pathology

← Older revision		Revision as of 20:01, 31 October 2019
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	*[[Sentinel lymph node sampling in breast cancer\|Breast cancer]] - very common.		*[[Sentinel lymph node sampling in breast cancer\|Breast cancer]] - very common.
	*[[Malignant melanoma#Sentinel lymph node panel\|Malignant melanoma]] - first context in which SLN sampling was done.		*[[Malignant melanoma#Sentinel lymph node panel\|Malignant melanoma]] - first context in which SLN sampling was done.

			===Lymph node metastasis===
			{{Main\|Lymph node metastasis}}
			*Cancer that has spread to a lymph node.

	=See also=		=See also=

Michael: /* Sentinel lymph nodes */

2019-02-22T21:07:15Z

Sentinel lymph nodes

← Older revision		Revision as of 21:07, 22 February 2019
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	*LN sampling is associated with morbidity; thus, selective LN sampling is preferred.		*LN sampling is associated with morbidity; thus, selective LN sampling is preferred.
	*The most important LNs in a LN chain, in the context of [[cancer]], are the ones that are adjacent to the tumour; these are known as '''sentinel lymph nodes'''.		*The most important LNs in a LN chain, in the context of [[cancer]], are the ones that are adjacent to the tumour; these are known as '''sentinel lymph nodes'''.
			*In lymph node positive disease, the most radioactive lymph node may be negative; this happens ~13% of the time in melanoma.<ref name=pmid11314933>{{Cite journal \| last1 = McMasters \| first1 = KM. \| last2 = Reintgen \| first2 = DS. \| last3 = Ross \| first3 = MI. \| last4 = Wong \| first4 = SL. \| last5 = Gershenwald \| first5 = JE. \| last6 = Krag \| first6 = DN. \| last7 = Noyes \| first7 = RD. \| last8 = Viar \| first8 = V. \| last9 = Cerrito \| first9 = PB. \| title = Sentinel lymph node biopsy for melanoma: how many radioactive nodes should be removed? \| journal = Ann Surg Oncol \| volume = 8 \| issue = 3 \| pages = 192-7 \| month = Apr \| year = 2001 \| doi = \| PMID = 11314933 }}</ref>

	Use:		Use:

Michael at 20:13, 27 December 2013

2013-12-27T20:13:10Z

← Older revision		Revision as of 20:13, 27 December 2013
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	\| mesh-like chromatin, usu. beside another one		\| mesh-like chromatin, usu. beside another one
	\| large cell, unremarkable/small nucleolus		\| large cell, unremarkable/small nucleolus
	\| CD21+, CD23+		\| CD21+, [[CD23]]+
	\| other ?		\| other ?
	\| image ?		\| image ?

Michael: /* Gross pathologic exam */ w

2013-03-21T12:15:39Z

Gross pathologic exam: w

← Older revision		Revision as of 12:15, 21 March 2013
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	*White lesions, especially irregular = suggestive of carcinoma.		*White lesions, especially irregular = suggestive of carcinoma.
	*White, glistening, with lobulated surface - "fish flesh" = suggestive of lymphoma.		*White, glistening, with lobulated surface - "fish flesh" = suggestive of lymphoma.
	**Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref>Bailey, D. 5 August 2010.</ref>		**Subtle lobulation (~1 mm) on section suggestive of ''[[follicular lymphoma]]''.<ref>Bailey, D. 5 August 2010.</ref>

	=Microscopic=		=Microscopic=

Michael: tweak

2013-03-21T12:15:21Z

tweak

← Older revision		Revision as of 12:15, 21 March 2013
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	*White lesions, especially irregular = suggestive of carcinoma.		*White lesions, especially irregular = suggestive of carcinoma.
	*White, glistening, with lobulated surface - "fish flesh" = suggestive of lymphoma.		*White, glistening, with lobulated surface - "fish flesh" = suggestive of lymphoma.
	**Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref>DB. 5 August 2010.</ref>		**Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref>Bailey, D. 5 August 2010.</ref>

	=Microscopic=		=Microscopic=
	==LN architecture==		==Lymph node architecture==
	Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4\|206-8}}</ref>		Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4\|206-8}}</ref>
	*Capsule.		*Capsule.
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	*[[Trabeculae]] - segment the LN radially, i.e. are spoke-like structures.		*[[Trabeculae]] - segment the LN radially, i.e. are spoke-like structures.

	==LN follicles==		==Lymph node follicles==
	Types of follicles:<ref name=Ref_WFH4_208>{{Ref WFH4\|208}}</ref>		Types of follicles:<ref name=Ref_WFH4_208>{{Ref WFH4\|208}}</ref>
	#Primary follicle - no germinal center (pale area).		#Primary follicle - no germinal center (pale area).
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	*Usually asymmetrical; thicker, i.e. more mantle cells, at capsular aspect.<ref>DG. 17 August 2010.</ref>		*Usually asymmetrical; thicker, i.e. more mantle cells, at capsular aspect.<ref>DG. 17 August 2010.</ref>

	==B ~~cell cycle~~==		==Cell types==
			Follicular dendritic cells:<ref name=pmid9258622>{{cite journal \|author=Wright CA, Nayler SJ, Leiman G \|title=Cytopathology of follicular dendritic cell tumors \|journal=Diagn. Cytopathol. \|volume=17 \|issue=2 \|pages=138–42 \|year=1997 \|month=August \|pmid=9258622 \|doi= \|url=http://www3.interscience.wiley.com/journal/57062/abstract?CRETRY=1&SRETRY=0}}</ref>
			*Classically found in pairs.
			*Large nucleus with:
			**Basketweave chromatin pattern.
			**Small central nucleolus.

			Lymphocytes:
			*See ''B lymphocytes'' section.

			===B lymphocytes===
			*B cells are best understood in the context of their maturation.

	B cell cycle/maturation:<ref name=Ref_WFH4_210>{{Ref WFH4\|210}}</ref>		B cell cycle/maturation:<ref name=Ref_WFH4_210>{{Ref WFH4\|210}}</ref>
	#Centroblast (CB):		#Centroblast (CB):
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	*[http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm Lymphoid organs (healthsystem.virginia.edu)].		*[http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm Lymphoid organs (healthsystem.virginia.edu)].

	=~~=Cell types==~~		===Cell types - table===
	Follicular dendritic cells:<ref name=pmid9258622>{{cite journal \|author=Wright CA, Nayler SJ, Leiman G \|title=Cytopathology of follicular dendritic cell tumors \|journal=Diagn. Cytopathol. \|volume=17 \|issue=2 \|pages=138–42 \|year=1997 \|month=August \|pmid=9258622 \|doi= \|url=http://www3.interscience.wiley.com/journal/57062/abstract?CRETRY=1&SRETRY=0}}</ref>
	*Classically found in pairs.
	*Large nucleus with:
	**Basketweave chromatin pattern.
	**Small central nucleolus.

	~~Lymphocytes~~
	*See ''B cell cycle'' section.

	==Cell types - table==

	{\| class="wikitable"		{\| class="wikitable"
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	*[[Basics]].		*[[Basics]].

	==References==		=References=
	{{reflist\|2}}		{{reflist\|2}}

	==External links==		=External links=
	*[http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Lymph node architecture (umdnj.edu)].		*[http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Lymph node architecture (umdnj.edu)].

	[[Category:Haematopathology]]		[[Category:Haematopathology]]

Michael: re-org

2013-03-21T12:06:35Z

re-org

← Older revision		Revision as of 12:06, 21 March 2013
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	Haematopathology and lymphoma is dealt with in the ''[[haematopathology]]'' article. This article covers the basics of lymph nodes. Lymph node pathology is dealt with in the ''[[lymph node pathology]]'' article.		Haematopathology and lymphoma is dealt with in the ''[[haematopathology]]'' article. This article covers the basics of lymph nodes. Lymph node pathology is dealt with in the ''[[lymph node pathology]]'' article.

	==Clinical==		=Clinical=
	===Normal (clinical)===		===Normal (clinical)===
	*Round.		*Round.
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	**What qualifies for "large" depends on the location in the body.		**What qualifies for "large" depends on the location in the body.

	==Gross pathologic exam==		=Gross pathologic exam=
	Normal:		Normal:
	*Firm (relative to adipose tissue).		*Firm (relative to adipose tissue).
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	**Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref>DB. 5 August 2010.</ref>		**Subtle lobulation (~1 mm) on section suggestive of ''follicular lymphoma''.<ref>DB. 5 August 2010.</ref>

			=Microscopic=
	==LN architecture==		==LN architecture==
	Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4\|206-8}}</ref>		Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4\|206-8}}</ref>
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	==Pathology==		=Pathology=
	{{Main\|Lymph node pathology}}		{{Main\|Lymph node pathology}}
	LNs are very important in [[cancer staging]] and are, in many contexts, sampled routinely.		LNs are very important in [[cancer staging]] and are, in many contexts, sampled routinely.
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	*[[Malignant melanoma#Sentinel lymph node panel\|Malignant melanoma]] - first context in which SLN sampling was done.		*[[Malignant melanoma#Sentinel lymph node panel\|Malignant melanoma]] - first context in which SLN sampling was done.

	==See also==		=See also=
	*[[Haematopathology]].		*[[Haematopathology]].
	*[[Lymph node pathology]].		*[[Lymph node pathology]].

Michael: /* Sentinel lymph nodes */ fix

2012-12-18T13:26:52Z

Sentinel lymph nodes: fix

← Older revision		Revision as of 13:26, 18 December 2012
Line 189:		Line 189:
	Use:		Use:
	*[[Sentinel lymph node sampling in breast cancer\|Breast cancer]] - very common.		*[[Sentinel lymph node sampling in breast cancer\|Breast cancer]] - very common.
	*[[Malignant melanoma#Sentinel lymph node panel]] - first context in which SLN sampling was done.		*[[Malignant melanoma#Sentinel lymph node panel\|Malignant melanoma]] - first context in which SLN sampling was done.

	==See also==		==See also==

Michael: /* Sentinel lymph nodes */

2012-12-18T13:26:37Z

Sentinel lymph nodes

← Older revision		Revision as of 13:26, 18 December 2012
Line 189:		Line 189:
	Use:		Use:
	*[[Sentinel lymph node sampling in breast cancer\|Breast cancer]] - very common.		*[[Sentinel lymph node sampling in breast cancer\|Breast cancer]] - very common.
	*[[Malignant melanoma]] - first context in which SLN sampling was done.		*[[Malignant melanoma#Sentinel lymph node panel]] - first context in which SLN sampling was done.

	==See also==		==See also==