Lymphangioleiomyomatosis - Revision history

Michael: /* See also */

2016-03-08T02:07:25Z

Michael at 22:13, 24 October 2015

2015-10-24T22:13:04Z

← Older revision		Revision as of 22:13, 24 October 2015
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	\| Assdx =		\| Assdx =
	\| Syndromes = [[tuberous sclerosis]]		\| Syndromes = [[tuberous sclerosis]]
	\| Clinicalhx = almost always women of childbearing age, recurrent pneumothorax		\| Clinicalhx = almost always women of childbearing age, recurrent [[pneumothorax]]
	\| Signs =		\| Signs =
	\| Symptoms = dyspnea		\| Symptoms = dyspnea
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	==General==		==General==
	*Clinical: [[dyspnea]], recurrent pneumothorax.		*Clinical: [[dyspnea]], recurrent [[pneumothorax]].
	*May be an indication for lung transplantation.		*May be an indication for lung transplantation.
	*Non-neoplastic muscle proliferation versus tumour that can metastasize.<ref name=pmid20235883>{{Cite journal \| last1 = Taveira-DaSilva \| first1 = AM. \| last2 = Pacheco-Rodriguez \| first2 = G. \| last3 = Moss \| first3 = J. \| title = The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. \| journal = Lymphat Res Biol \| volume = 8 \| issue = 1 \| pages = 9-19 \| month = Mar \| year = 2010 \| doi = 10.1089/lrb.2009.0024 \| PMID = 20235883 }}</ref>		*Non-neoplastic muscle proliferation versus tumour that can metastasize.<ref name=pmid20235883>{{Cite journal \| last1 = Taveira-DaSilva \| first1 = AM. \| last2 = Pacheco-Rodriguez \| first2 = G. \| last3 = Moss \| first3 = J. \| title = The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. \| journal = Lymphat Res Biol \| volume = 8 \| issue = 1 \| pages = 9-19 \| month = Mar \| year = 2010 \| doi = 10.1089/lrb.2009.0024 \| PMID = 20235883 }}</ref>

Michael: +hypothesis

2014-12-10T17:55:44Z

+hypothesis

← Older revision		Revision as of 17:55, 10 December 2014
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	*May be an indication for lung transplantation.		*May be an indication for lung transplantation.
	*Non-neoplastic muscle proliferation versus tumour that can metastasize.<ref name=pmid20235883>{{Cite journal \| last1 = Taveira-DaSilva \| first1 = AM. \| last2 = Pacheco-Rodriguez \| first2 = G. \| last3 = Moss \| first3 = J. \| title = The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. \| journal = Lymphat Res Biol \| volume = 8 \| issue = 1 \| pages = 9-19 \| month = Mar \| year = 2010 \| doi = 10.1089/lrb.2009.0024 \| PMID = 20235883 }}</ref>		*Non-neoplastic muscle proliferation versus tumour that can metastasize.<ref name=pmid20235883>{{Cite journal \| last1 = Taveira-DaSilva \| first1 = AM. \| last2 = Pacheco-Rodriguez \| first2 = G. \| last3 = Moss \| first3 = J. \| title = The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. \| journal = Lymphat Res Biol \| volume = 8 \| issue = 1 \| pages = 9-19 \| month = Mar \| year = 2010 \| doi = 10.1089/lrb.2009.0024 \| PMID = 20235883 }}</ref>
			**It has been hypothesized that LAM represent a non-malignant [[metastasis]] of a renal [[angiomyolipoma]].<ref name=pmid17003820/>

	Notes:		Notes:

Michael: /* Epidemiology */

2014-12-10T17:51:21Z

Epidemiology

← Older revision		Revision as of 17:51, 10 December 2014
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	*Associated with [[angiomyolipoma]]s.		*Associated with [[angiomyolipoma]]s.
	**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>		**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>
	*Associated with [[tuberous sclerosis]]~~<ref name=emedicine299545/>~~ - esp. TSC2 mutations.		*Associated with [[tuberous sclerosis]] - esp. TSC2 mutations.
	**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref>		**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref>

Michael: /* Epidemiology */

2014-12-10T17:50:33Z

Epidemiology

← Older revision		Revision as of 17:50, 10 December 2014
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	===Epidemiology===		===Epidemiology===
	*Rare.		*Rare.
	*Usually affects women - primarily in childbearing years~~; case~~ reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>		*Usually affects women - primarily in childbearing years.
			**Case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>
	*Associated with [[angiomyolipoma]]s.		*Associated with [[angiomyolipoma]]s.
	**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>		**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>

Michael: /* Epidemiology */

2014-12-10T17:50:09Z

Epidemiology

← Older revision		Revision as of 17:50, 10 December 2014
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	===Epidemiology===		===Epidemiology===
			*Rare.
			*Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>
	*Associated with [[angiomyolipoma]]s.		*Associated with [[angiomyolipoma]]s.
	**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>		**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>
	*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - esp. TSC2 mutations.		*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - esp. TSC2 mutations.
	*In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref> Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>		**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref>
	*Rare.

	==Gross/Radiology==		==Gross/Radiology==

Michael: /* Epidemiology */

2014-12-10T17:49:24Z

Epidemiology

← Older revision		Revision as of 17:49, 10 December 2014
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	*Associated with [[angiomyolipoma]]s.		*Associated with [[angiomyolipoma]]s.
	**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>		**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>
	~~<ref name=pmid17003820/>~~
	*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - esp. TSC2 mutations.		*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - esp. TSC2 mutations.
	*In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref> Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>		*In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref> Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>

Michael: /* Epidemiology */

2014-12-10T17:49:02Z

Epidemiology

← Older revision		Revision as of 17:49, 10 December 2014
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	===Epidemiology===		===Epidemiology===
	*Associated with [[angiomyolipoma]]s.		*Associated with [[angiomyolipoma]]s.
	**Seen in ~30% of sporadic cases.<ref name=pmid17003820/>		**Seen in ~30% of sporadic cases, and in ~90% of cases with tuberous sclerosis.<ref name=pmid17003820/>
	*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - ~~abnormality in same gene (~~TSC2).		<ref name=pmid17003820/>
	**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref> ~~In this context, AML is seen in ~90% of cases.<ref name=pmid17003820/>~~		*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - esp. TSC2 mutations.
	*Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>		*In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref> Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>
	*Rare.		*Rare.

Michael: /* Epidemiology */

2014-12-10T17:46:48Z

Epidemiology

← Older revision		Revision as of 17:46, 10 December 2014
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	===Epidemiology===		===Epidemiology===
	*Associated with [[angiomyolipoma]]s.<ref name=~~emedicine299545>[http://emedicine.medscape.com/article/299545-overview http:~~/~~/emedicine.medscape.com/article/299545-overview]</ref~~>		*Associated with [[angiomyolipoma]]s.
			**Seen in ~30% of sporadic cases.<ref name=pmid17003820/>
	*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - abnormality in same gene (TSC2).		*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - abnormality in same gene (TSC2).
	**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref>		**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref> In this context, AML is seen in ~90% of cases.<ref name=pmid17003820/>
	*Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>		*Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>
	*Rare.		*Rare.

Michael: /* General */

2014-12-10T17:08:17Z

General

← Older revision		Revision as of 17:08, 10 December 2014
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	*May be an indication for lung transplantation.		*May be an indication for lung transplantation.
	*Non-neoplastic muscle proliferation versus tumour that can metastasize.<ref name=pmid20235883>{{Cite journal \| last1 = Taveira-DaSilva \| first1 = AM. \| last2 = Pacheco-Rodriguez \| first2 = G. \| last3 = Moss \| first3 = J. \| title = The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. \| journal = Lymphat Res Biol \| volume = 8 \| issue = 1 \| pages = 9-19 \| month = Mar \| year = 2010 \| doi = 10.1089/lrb.2009.0024 \| PMID = 20235883 }}</ref>		*Non-neoplastic muscle proliferation versus tumour that can metastasize.<ref name=pmid20235883>{{Cite journal \| last1 = Taveira-DaSilva \| first1 = AM. \| last2 = Pacheco-Rodriguez \| first2 = G. \| last3 = Moss \| first3 = J. \| title = The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis. \| journal = Lymphat Res Biol \| volume = 8 \| issue = 1 \| pages = 9-19 \| month = Mar \| year = 2010 \| doi = 10.1089/lrb.2009.0024 \| PMID = 20235883 }}</ref>
	*In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref>

	Notes:		Notes:
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	*Associated with [[angiomyolipoma]]s.<ref name=emedicine299545>[http://emedicine.medscape.com/article/299545-overview http://emedicine.medscape.com/article/299545-overview]</ref>		*Associated with [[angiomyolipoma]]s.<ref name=emedicine299545>[http://emedicine.medscape.com/article/299545-overview http://emedicine.medscape.com/article/299545-overview]</ref>
	*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - abnormality in same gene (TSC2).		*Associated with [[tuberous sclerosis]]<ref name=emedicine299545/> - abnormality in same gene (TSC2).
			**In the context of [[tuberous sclerosis]], [[angiomyolipoma]] of the kidney often preceeds LAM.<ref name=pmid17003820>{{cite journal \|author=Rakowski SK, Winterkorn EB, Paul E, Steele DJ, Halpern EF, Thiele EA \|title=Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors \|journal=Kidney Int. \|volume=70 \|issue=10 \|pages=1777–82 \|year=2006 \|month=November \|pmid=17003820 \|doi=10.1038/sj.ki.5001853 \|url=}}</ref>
	*Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>		*Usually affects women - primarily in childbearing years; case reports of LAM in men - usu. with [[TSC]].<ref name=pmid17431222>{{Cite journal \| last1 = Schiavina \| first1 = M. \| last2 = Di Scioscio \| first2 = V. \| last3 = Contini \| first3 = P. \| last4 = Cavazza \| first4 = A. \| last5 = Fabiani \| first5 = A. \| last6 = Barberis \| first6 = M. \| last7 = Bini \| first7 = A. \| last8 = Altimari \| first8 = A. \| last9 = Cooke \| first9 = RM. \| title = Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. \| journal = Am J Respir Crit Care Med \| volume = 176 \| issue = 1 \| pages = 96-8 \| month = Jul \| year = 2007 \| doi = 10.1164/rccm.200610-1408CR \| PMID = 17431222 }}</ref>
	*Rare.		*Rare.

← Older revision		Revision as of 02:07, 8 March 2016
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	*[[Medical lung diseases]].		*[[Medical lung diseases]].
	*[[PEComa]].		*[[PEComa]].
			*[[Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis]].

	==References==		==References==