Lymphoepithelioma-like carcinoma - Revision history

Michael at 00:37, 30 September 2015

2015-09-30T00:37:01Z

← Older revision		Revision as of 00:37, 30 September 2015
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	'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a ~~very~~ rare, poorly differentiated, malignant epithelial tumour.		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Lymphoepithelioma-like_carcinoma_-_high_mag.jpg
			\| Width =
			\| Caption = Lymphoepithelioma-like carcinoma. [[H&E stain]].
			\| Synonyms =
			\| Micro = clusters of cohesive squamoid cells with abundant dense cytoplasm, central nuclei +/- small/indistinct nucleoli, surrounded by a prominent lymphoid component
			\| Subtypes = (considered a subtype of [[squamous carcinoma]])
			\| LMDDx = [[squamous cell carcinoma of the skin]], [[lymphoma]] (non-Hodgkin), [[medullary carcinoma]], [[nasopharyngeal carcinoma]] (head & neck)
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[skin]] and elsewhere
			\| Assdx = [[EBV]] infection (dependent on anatomical site)
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
			'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a rare, poorly differentiated, malignant epithelial tumour.

	It can be considered a subtype of [[squamous carcinoma]] ([[AKA]] squamous cell carcinoma);<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45]. Accessed on: 26 May 2011.</ref> however, some advocate it be considered a separate entity.<ref name=pmid11147469>{{Cite journal \| last1 = Skinner \| first1 = NE. \| last2 = Horowitz \| first2 = RI. \| last3 = Majmudar \| first3 = B. \| title = Lymphoepithelioma-like carcinoma of the uterine cervix. \| journal = South Med J \| volume = 93 \| issue = 10 \| pages = 1024-7 \| month = Oct \| year = 2000 \| doi = \| PMID = 11147469 }}</ref>		It can be considered a subtype of [[squamous carcinoma]] ([[AKA]] squamous cell carcinoma);<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45]. Accessed on: 26 May 2011.</ref> however, some advocate it be considered a separate entity.<ref name=pmid11147469>{{Cite journal \| last1 = Skinner \| first1 = NE. \| last2 = Horowitz \| first2 = RI. \| last3 = Majmudar \| first3 = B. \| title = Lymphoepithelioma-like carcinoma of the uterine cervix. \| journal = South Med J \| volume = 93 \| issue = 10 \| pages = 1024-7 \| month = Oct \| year = 2000 \| doi = \| PMID = 11147469 }}</ref>
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	Epidemiology:		Epidemiology:
	*Common in Inuit and some Asians.<ref name=pathcon_lymph>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7]. Accessed on: 11 May 2011.</ref>		*Common in Inuit and some Asians.<ref name=pathcon_lymph>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7]. Accessed on: 11 May 2011.</ref>


	Etiology:		Etiology:
	*Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland).		*Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, [[stomach]], lung, thymus, salivary gland).
	**Exceptions:		**Exceptions:
	***Skin and [[uterine cervix]].<ref name=pmid7726142>{{Cite journal \| last1 = Lespagnard \| first1 = L. \| last2 = Cochaux \| first2 = P. \| last3 = Larsimont \| first3 = D. \| last4 = Degeyter \| first4 = M. \| last5 = Velu \| first5 = T. \| last6 = Heimann \| first6 = R. \| title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. \| journal = Am J Clin Pathol \| volume = 103 \| issue = 4 \| pages = 449-52 \| month = Apr \| year = 1995 \| doi = \| PMID = 7726142 }}</ref>		***Skin and [[uterine cervix]].<ref name=pmid7726142>{{Cite journal \| last1 = Lespagnard \| first1 = L. \| last2 = Cochaux \| first2 = P. \| last3 = Larsimont \| first3 = D. \| last4 = Degeyter \| first4 = M. \| last5 = Velu \| first5 = T. \| last6 = Heimann \| first6 = R. \| title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. \| journal = Am J Clin Pathol \| volume = 103 \| issue = 4 \| pages = 449-52 \| month = Apr \| year = 1995 \| doi = \| PMID = 7726142 }}</ref>
	****The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal \| last1 = Aoki \| first1 = R. \| last2 = Mitsui \| first2 = H. \| last3 = Harada \| first3 = K. \| last4 = Kawamura \| first4 = T. \| last5 = Shibagaki \| first5 = N. \| last6 = Tsukamoto \| first6 = K. \| last7 = Murata \| first7 = S. \| last8 = Shimada \| first8 = S. \| title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. \| journal = J Am Acad Dermatol \| volume = 62 \| issue = 4 \| pages = 681-4 \| month = Apr \| year = 2010 \| doi = 10.1016/j.jaad.2008.07.024 \| PMID = 20227583 }}</ref>		****The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal \| last1 = Aoki \| first1 = R. \| last2 = Mitsui \| first2 = H. \| last3 = Harada \| first3 = K. \| last4 = Kawamura \| first4 = T. \| last5 = Shibagaki \| first5 = N. \| last6 = Tsukamoto \| first6 = K. \| last7 = Murata \| first7 = S. \| last8 = Shimada \| first8 = S. \| title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. \| journal = J Am Acad Dermatol \| volume = 62 \| issue = 4 \| pages = 681-4 \| month = Apr \| year = 2010 \| doi = 10.1016/j.jaad.2008.07.024 \| PMID = 20227583 }}</ref>
	***[[Lymphoepithelioma-like carcinoma of the urinary bladder\|Urinary bladder]].<ref name=pmid21383609>{{Cite journal \| last1 = Williamson \| first1 = SR. \| last2 = Zhang \| first2 = S. \| last3 = Lopez-Beltran \| first3 = A. \| last4 = Shah \| first4 = RB. \| last5 = Montironi \| first5 = R. \| last6 = Tan \| first6 = PH. \| last7 = Wang \| first7 = M. \| last8 = Baldridge \| first8 = LA. \| last9 = MacLennan \| first9 = GT. \| title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 4 \| pages = 474-83 \| month = Apr \| year = 2011 \| doi = 10.1097/PAS.0b013e31820f709e \| PMID = 21383609 }}</ref>		***[[Lymphoepithelioma-like carcinoma of the urinary bladder\|Urinary bladder]].<ref name=pmid21383609>{{Cite journal \| last1 = Williamson \| first1 = SR. \| last2 = Zhang \| first2 = S. \| last3 = Lopez-Beltran \| first3 = A. \| last4 = Shah \| first4 = RB. \| last5 = Montironi \| first5 = R. \| last6 = Tan \| first6 = PH. \| last7 = Wang \| first7 = M. \| last8 = Baldridge \| first8 = LA. \| last9 = MacLennan \| first9 = GT. \| title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 4 \| pages = 474-83 \| month = Apr \| year = 2011 \| doi = 10.1097/PAS.0b013e31820f709e \| PMID = 21383609 }}</ref>


	Notes:		Notes:
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	DDx:		DDx:
			*[[Squamous cell carcinoma of the skin]].
	*[[Lymphoma]].		*[[Lymphoma]].
	*[[Medullary carcinoma]].		*[[Medullary carcinoma]].

Michael: /* See also */

2015-06-17T09:05:10Z

Michael: /* General */

2015-01-21T20:27:03Z

General

← Older revision		Revision as of 20:27, 21 January 2015
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	Etiology:		Etiology:
	*Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland)~~; the skin~~ and [[uterine cervix]] ~~appear to be exceptions~~.<ref name=pmid7726142>{{Cite journal \| last1 = Lespagnard \| first1 = L. \| last2 = Cochaux \| first2 = P. \| last3 = Larsimont \| first3 = D. \| last4 = Degeyter \| first4 = M. \| last5 = Velu \| first5 = T. \| last6 = Heimann \| first6 = R. \| title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. \| journal = Am J Clin Pathol \| volume = 103 \| issue = 4 \| pages = 449-52 \| month = Apr \| year = 1995 \| doi = \| PMID = 7726142 }}</ref>		*Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland).
	**The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal \| last1 = Aoki \| first1 = R. \| last2 = Mitsui \| first2 = H. \| last3 = Harada \| first3 = K. \| last4 = Kawamura \| first4 = T. \| last5 = Shibagaki \| first5 = N. \| last6 = Tsukamoto \| first6 = K. \| last7 = Murata \| first7 = S. \| last8 = Shimada \| first8 = S. \| title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. \| journal = J Am Acad Dermatol \| volume = 62 \| issue = 4 \| pages = 681-4 \| month = Apr \| year = 2010 \| doi = 10.1016/j.jaad.2008.07.024 \| PMID = 20227583 }}</ref>		**Exceptions:
			***Skin and [[uterine cervix]].<ref name=pmid7726142>{{Cite journal \| last1 = Lespagnard \| first1 = L. \| last2 = Cochaux \| first2 = P. \| last3 = Larsimont \| first3 = D. \| last4 = Degeyter \| first4 = M. \| last5 = Velu \| first5 = T. \| last6 = Heimann \| first6 = R. \| title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. \| journal = Am J Clin Pathol \| volume = 103 \| issue = 4 \| pages = 449-52 \| month = Apr \| year = 1995 \| doi = \| PMID = 7726142 }}</ref>
			****The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal \| last1 = Aoki \| first1 = R. \| last2 = Mitsui \| first2 = H. \| last3 = Harada \| first3 = K. \| last4 = Kawamura \| first4 = T. \| last5 = Shibagaki \| first5 = N. \| last6 = Tsukamoto \| first6 = K. \| last7 = Murata \| first7 = S. \| last8 = Shimada \| first8 = S. \| title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. \| journal = J Am Acad Dermatol \| volume = 62 \| issue = 4 \| pages = 681-4 \| month = Apr \| year = 2010 \| doi = 10.1016/j.jaad.2008.07.024 \| PMID = 20227583 }}</ref>
			***[[Lymphoepithelioma-like carcinoma of the urinary bladder\|Urinary bladder]].<ref name=pmid21383609>{{Cite journal \| last1 = Williamson \| first1 = SR. \| last2 = Zhang \| first2 = S. \| last3 = Lopez-Beltran \| first3 = A. \| last4 = Shah \| first4 = RB. \| last5 = Montironi \| first5 = R. \| last6 = Tan \| first6 = PH. \| last7 = Wang \| first7 = M. \| last8 = Baldridge \| first8 = LA. \| last9 = MacLennan \| first9 = GT. \| title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 4 \| pages = 474-83 \| month = Apr \| year = 2011 \| doi = 10.1097/PAS.0b013e31820f709e \| PMID = 21383609 }}</ref>

Michael: /* Images */

2013-07-16T07:56:28Z

Images

← Older revision		Revision as of 07:56, 16 July 2013
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	===Images===		===Images===
	<gallery>		<gallery>
			Image: Lymphoepithelioma-like carcinoma - very low mag.jpg \| LELC - very low mag.
	Image:Lymphoepithelioma-like_carcinoma_-_low_mag.jpg \| LELC - low mag. (WC)		Image:Lymphoepithelioma-like_carcinoma_-_low_mag.jpg \| LELC - low mag. (WC)
			Image: Lymphoepithelioma-like carcinoma - intermed mag.jpg \| LELC - intermed. mag.
	Image:Lymphoepithelioma-like_carcinoma_-_high_mag.jpg \| LELC - high mag. (WC)		Image:Lymphoepithelioma-like_carcinoma_-_high_mag.jpg \| LELC - high mag. (WC)
	</gallery>		</gallery>

Michael: /* Microscopic */ +images

2013-07-16T07:54:55Z

Microscopic: +images

← Older revision		Revision as of 07:54, 16 July 2013
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	*[[Nasopharyngeal carcinoma]] - H&N lesion.		*[[Nasopharyngeal carcinoma]] - H&N lesion.

	Images:		===Images===
	*[http://commons.wikimedia.org/wiki/File:Lymphoepithelioma-like_carcinoma_-_low_mag.jpg LELC - low mag. (WC)].		<gallery>
	*[http://commons.wikimedia.org/wiki/File:Lymphoepithelioma-like_carcinoma_-_high_mag.jpg LELC - high mag. (WC)].		Image:Lymphoepithelioma-like_carcinoma_-_low_mag.jpg \| LELC - low mag. (WC)
			Image:Lymphoepithelioma-like_carcinoma_-_high_mag.jpg \| LELC - high mag. (WC)
			</gallery>
			www:
	*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/>		*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/>

Michael: /* Microscopic */

2013-02-03T16:19:49Z

Microscopic

← Older revision		Revision as of 16:19, 3 February 2013
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	*[[Lymphoma]].		*[[Lymphoma]].
	*[[Medullary carcinoma]].		*[[Medullary carcinoma]].
			*[[Nasopharyngeal carcinoma]] - H&N lesion.

	Images:		Images:

Michael: /* Microscopic */ fix image links

2011-05-26T17:30:42Z

Microscopic: fix image links

← Older revision		Revision as of 17:30, 26 May 2011
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	Images:		Images:
	*[http://~~upload~~.wikimedia.org/~~wikipedia/commons/b/b7~~/Lymphoepithelioma-like_carcinoma_-_low_mag.jpg LELC - low mag. (WC)].		*[http://commons.wikimedia.org/wiki/File:Lymphoepithelioma-like_carcinoma_-_low_mag.jpg LELC - low mag. (WC)].
	*[http://~~upload~~.wikimedia.org/~~wikipedia/commons/e/e2~~/Lymphoepithelioma-like_carcinoma_-_high_mag.jpg LELC - high mag. (WC)].		*[http://commons.wikimedia.org/wiki/File:Lymphoepithelioma-like_carcinoma_-_high_mag.jpg LELC - high mag. (WC)].
	*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/>		*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/>

Michael: link to SCC

2011-05-26T17:20:36Z

link to SCC

← Older revision		Revision as of 17:20, 26 May 2011
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	'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a very rare, poorly differentiated, malignant epithelial tumour.		'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a very rare, poorly differentiated, malignant epithelial tumour.

			It can be considered a subtype of [[squamous carcinoma]] ([[AKA]] squamous cell carcinoma);<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45]. Accessed on: 26 May 2011.</ref> however, some advocate it be considered a separate entity.<ref name=pmid11147469>{{Cite journal \| last1 = Skinner \| first1 = NE. \| last2 = Horowitz \| first2 = RI. \| last3 = Majmudar \| first3 = B. \| title = Lymphoepithelioma-like carcinoma of the uterine cervix. \| journal = South Med J \| volume = 93 \| issue = 10 \| pages = 1024-7 \| month = Oct \| year = 2000 \| doi = \| PMID = 11147469 }}</ref>

	==General==		==General==
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	*[[Nasopharyngeal carcinoma]].		*[[Nasopharyngeal carcinoma]].
	*[[EBV]].		*[[EBV]].
			*[[Squamous cell carcinoma]].

	==References==		==References==

Michael: +images

2011-05-20T16:04:36Z

+images

← Older revision		Revision as of 16:04, 20 May 2011
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	Images:		Images:
			*[http://upload.wikimedia.org/wikipedia/commons/b/b7/Lymphoepithelioma-like_carcinoma_-_low_mag.jpg LELC - low mag. (WC)].
			*[http://upload.wikimedia.org/wikipedia/commons/e/e2/Lymphoepithelioma-like_carcinoma_-_high_mag.jpg LELC - high mag. (WC)].
	*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/>		*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/>

Michael: /* Microscopic */

2011-05-12T13:50:20Z

Microscopic

← Older revision		Revision as of 13:50, 12 May 2011
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	Features:		Features:
	* Clusters of cohesive squamoid cells with:		* Clusters of cohesive squamoid cells with:
	**~~Aundant~~ dense ~~eosinophilic~~ cytoplasm.		**Abundant dense cytoplasm.
	**Central nuclei +/- small/indistinct nucleoli.		**Central nuclei +/- small/indistinct nucleoli.
	**Surrounded by a prominent lymphoid component - '''key feature'''.		**Surrounded by a prominent lymphoid component - '''key feature'''.

← Older revision		Revision as of 09:05, 17 June 2015
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	*[[EBV]].		*[[EBV]].
	*[[Squamous cell carcinoma]].		*[[Squamous cell carcinoma]].
			*[[Lymphoepithelioma-like carcinoma of the urinary bladder]].

	==References==		==References==