Mantle cell lymphoma - Revision history

Mitchell: /* Images */ added a case

2017-02-24T20:28:31Z

Images: added a case

← Older revision		Revision as of 20:28, 24 February 2017
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	www:		www:
	*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].
			[[File:4 718053471 sl 1.png\|Mantle cell lymphoma]]
			[[File:4 718053471 sl 2.png\|Mantle cell lymphoma]]
			[[File:4 718053471 sl 3.png\|Mantle cell lymphoma]]
			[[File:4 718053471 sl 4.png\|Mantle cell lymphoma]]
			[[File:4 718053471 sl 5.png\|Mantle cell lymphoma]]
			[[File:4 718053471 sl 6.png\|Mantle cell lymphoma]]
			[[File:4 718053471 sl 7.png\|Mantle cell lymphoma]]<br>
			Mantle cell lymphoma in a 56 year old woman. A. A blue sea of cells spares a lymphoid follicle in the upper right corner. B. Small, round to reniform cells contrast with the larger tingible body macrophage (arrow). C-F. Tumor cells are Cyclin D1. CD20, BCL2, and CD5 positive positive. G. About 60% of tumor cells were positive for Ki67. Tumor cells were negative for CD3, CD10, and BCL6.

	==IHC==		==IHC==

Michael: /* See also */

2014-05-22T18:00:20Z

Michael at 17:59, 22 May 2014

2014-05-22T17:59:48Z

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	==Molecular==		==Molecular==
	*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>		*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>

			==Sign out==
			<pre>
			TERMINAL ILEUM, BIOPSY:
			- MANTLE CELL LYMPHOMA.

			COMMENT:
			The tumour consists of small lymphoid cells in sheets.

			The tumour stains as follows:
			POSITIVE: CD20, CD5, BCL2, cyclin D1.
			NEGATIVE: CD23, BCL6, CD10.
			PROLIFERATION (Ki-67): 25%.
			</pre>

	==See also==		==See also==
	*[[Small cell lymphomas]].		*[[Small cell lymphomas]].
			*[[Ileal lymphoid hyperplasia]].

	==References==		==References==

Michael: /* Microscopic */

2014-05-22T17:55:23Z

Microscopic

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	==Microscopic==		==Microscopic==
	Features:<ref>Good, D. 17 August 2010.</ref>		Features:<ref>Good, D. 17 August 2010.</ref>
	*~~Small~~ monomorphic (uniform size, shape and staining) lymphoid population.		*Typically a small monomorphic (uniform size, shape and staining) lymphoid population.
			**May be "large" (blastic variant of mantle cell lymphoma) with 1 or 2 nucleoli.<ref name=pmid17917091>{{cite journal \|author=Todorovic M, Pavlovic M, Balint B, ''et al.'' \|title=Immunophenotypic profile and clinical characteristics in patients with advanced stage mantle cell lymphoma \|journal=Med. Oncol. \|volume=24 \|issue=4 \|pages=413–8 \|year=2007 \|pmid=17917091 \|doi= \|url=}}</ref>
	*Abundant mitoses.		*Abundant mitoses.
	*Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).		*Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).

Michael: /* Microscopic */

2014-05-14T12:01:10Z

Microscopic

← Older revision		Revision as of 12:01, 14 May 2014
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	*Other [[small cell lymphomas]], esp. [[marginal zone lymphoma]].		*Other [[small cell lymphomas]], esp. [[marginal zone lymphoma]].
	*[[Burkitt's lymphoma]].		*[[Burkitt's lymphoma]].
			*Large B-cell lymphoma - for blastic variant of MCL.<ref name=pmid11681422>{{cite journal \|author=Bernard M, Gressin R, Lefrère F, ''et al.'' \|title=Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype \|journal=Leukemia \|volume=15 \|issue=11 \|pages=1785–91 \|year=2001 \|month=November \|pmid=11681422 \|doi= \|url=}}</ref>

	===Images===		===Images===

Michael at 11:56, 14 May 2014

2014-05-14T11:56:52Z

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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = poor		\| Prognosis = moderately aggressive to poor
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
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	==General==		==General==
	*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal \| last1 = Hankin \| first1 = RC. \| last2 = Hunter \| first2 = SV. \| title = Mantle cell lymphoma. \| journal = Arch Pathol Lab Med \| volume = 123 \| issue = 12 \| pages = 1182-8 \| month = Dec \| year = 1999 \| doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 \| PMID = 10583923 }}</ref>		*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal \| last1 = Hankin \| first1 = RC. \| last2 = Hunter \| first2 = SV. \| title = Mantle cell lymphoma. \| journal = Arch Pathol Lab Med \| volume = 123 \| issue = 12 \| pages = 1182-8 \| month = Dec \| year = 1999 \| doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 \| PMID = 10583923 }}</ref>
			*Rare ~ 2% of non-Hogkin's lymphoma in a series of over 4000 patients.<ref name=pmid18723950>{{cite journal \|author=Gujral S, Agarwal A, Gota V, ''et al.'' \|title=A clinicopathologic study of mantle cell lymphoma in a single center study in India \|journal=Indian J Pathol Microbiol \|volume=51 \|issue=3 \|pages=315–22 \|year=2008 \|pmid=18723950 \|doi= \|url=}}</ref>
	GI tract - typically:<ref name=pmid22236942/>		GI tract - typically:<ref name=pmid22236942/>
	*Abdominal pain (~37% of cases) or GI bleeding (~26% of cases).		*Abdominal pain (~37% of cases) or GI bleeding (~26% of cases).

Michael at 18:06, 13 May 2014

2014-05-13T18:06:00Z

← Older revision		Revision as of 18:06, 13 May 2014
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	\| Synonyms =		\| Synonyms =
	\| Micro = small monomorphic (uniform size, shape and staining) lymphoid population with abundant mitoses, +/-scattered epithelioid histiocytes (should not be confused with tingible-body macrophages), +/-sclerosed blood vessels		\| Micro = small monomorphic (uniform size, shape and staining) lymphoid population with abundant mitoses, +/-scattered epithelioid histiocytes (should not be confused with tingible-body macrophages), +/-sclerosed blood vessels
	\| Subtypes =		\| Subtypes = blastic variant
	\| LMDDx = other [[small cell lymphomas]] (esp. [[MALT lymphoma]]), [[Burkitt lymphoma]]		\| LMDDx = other [[small cell lymphomas]] (esp. [[MALT lymphoma]]), [[Burkitt lymphoma]]
	\| Stains =		\| Stains =

Michael: /* IHC */

2014-01-26T17:45:19Z

IHC

← Older revision		Revision as of 17:45, 26 January 2014
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	==IHC==		==IHC==
	*CD5 +ve.		*CD45 +ve.
			*CD20 +ve.
			*CD79a +ve.
			*CD5 +ve -- '''important'''.
	**Negative in case reports.<ref>URL: [http://path.upmc.edu/cases/case308/dx.html http://path.upmc.edu/cases/case308/dx.html]. Accessed on: 14 January 2012.</ref>		**Negative in case reports.<ref>URL: [http://path.upmc.edu/cases/case308/dx.html http://path.upmc.edu/cases/case308/dx.html]. Accessed on: 14 January 2012.</ref>
	*CD43 +ve.		*CD43 +ve.
	*Cyclin D1 +ve.		*Cyclin D1 +ve -- '''key immunostain'''.
	**[[AKA]] BCL1, AKA CCND1.<ref name=omim168461>{{OMIM\|168461}}</ref>		**[[AKA]] BCL1, AKA CCND1.<ref name=omim168461>{{OMIM\|168461}}</ref>

	Others:		Others:
	*CD23 -ve.		*CD23 -ve.
	**Positive in CLL.		**Positive in [[CLL]].

	==Molecular==		==Molecular==

Michael at 17:39, 26 January 2014

2014-01-26T17:39:27Z

← Older revision		Revision as of 17:39, 26 January 2014
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	==General==		==General==
	*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal \| last1 = Hankin \| first1 = RC. \| last2 = Hunter \| first2 = SV. \| title = Mantle cell lymphoma. \| journal = Arch Pathol Lab Med \| volume = 123 \| issue = 12 \| pages = 1182-8 \| month = Dec \| year = 1999 \| doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 \| PMID = 10583923 }}</ref>		*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{Cite journal \| last1 = Hankin \| first1 = RC. \| last2 = Hunter \| first2 = SV. \| title = Mantle cell lymphoma. \| journal = Arch Pathol Lab Med \| volume = 123 \| issue = 12 \| pages = 1182-8 \| month = Dec \| year = 1999 \| doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 \| PMID = 10583923 }}</ref>

			GI tract - typically:<ref name=pmid22236942/>
			*Abdominal pain (~37% of cases) or GI bleeding (~26% of cases).

			==Gross==
			*GI tract: polypoid lesions (~50% of cases).<ref name=pmid22236942>{{Cite journal \| last1 = Kim \| first1 = JH. \| last2 = Jung \| first2 = HW. \| last3 = Kang \| first3 = KJ. \| last4 = Min \| first4 = BH. \| last5 = Lee \| first5 = JH. \| last6 = Chang \| first6 = DK. \| last7 = Kim \| first7 = YH. \| last8 = Son \| first8 = HJ. \| last9 = Rhee \| first9 = PL. \| title = Endoscopic findings in mantle cell lymphoma with gastrointestinal tract involvement. \| journal = Acta Haematol \| volume = 127 \| issue = 3 \| pages = 129-34 \| month = \| year = 2012 \| doi = 10.1159/000333139 \| PMID = 22236942 }}</ref>

	==Microscopic==		==Microscopic==

Michael at 02:21, 30 December 2013

2013-12-30T02:21:21Z

← Older revision		Revision as of 02:21, 30 December 2013
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	\| LMDDx = other [[small cell lymphomas]] (esp. [[MALT lymphoma]]), [[Burkitt lymphoma]]		\| LMDDx = other [[small cell lymphomas]] (esp. [[MALT lymphoma]]), [[Burkitt lymphoma]]
	\| Stains =		\| Stains =
	\| IHC = cyclin D1 +ve, CD5 +ve, CD43 +ve, CD20 +ve		\| IHC = cyclin D1 +ve, CD5 +ve, CD43 +ve, CD20 +ve, CD23 -ve
	\| EM =		\| EM =
	\| Molecular = t(11;14)(q13;q32) / IGH-CCND1		\| Molecular = t(11;14)(q13;q32) / IGH-CCND1

← Older revision		Revision as of 18:00, 22 May 2014
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	==See also==		==See also==
	*[[Small cell lymphomas]].		*[[Small cell lymphomas]].
	*[[Ileal lymphoid hyperplasia]].		*[[Ileal nodular lymphoid hyperplasia]].

	==References==		==References==