Medical kidney diseases - Revision history

Michael: /* Normal */

2017-02-22T03:21:16Z

Normal

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	*[[Membranoproliferative glomerulonephritis]] (MPGN).		*[[Membranoproliferative glomerulonephritis]] (MPGN).

	=Normal=		=Normal kidney=
	===Cells of the glomerulus===		===Cells of the glomerulus===
	*Podocytes.		*Podocytes.

Michael: /* ANCA */

2016-11-25T11:53:06Z

ANCA

← Older revision		Revision as of 11:53, 25 November 2016
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	*PR3-ANCA (proteinase 3 antineutrophil cytoplasmic autoantibody).		*PR3-ANCA (proteinase 3 antineutrophil cytoplasmic autoantibody).
	**Previously c-ANCA.		**Previously c-ANCA.
	**Seen in ANCA-[[vasculitides]], esp. [[~~Granulomatosis~~ with polyangiitis]] (Wegener granulomatosis).		**Seen in ANCA-[[vasculitides]], esp. [[granulomatosis with polyangiitis]] (Wegener granulomatosis).

	===C4d===		===C4d===

Michael: /* ANCA */

2016-11-25T11:52:55Z

ANCA

← Older revision		Revision as of 11:52, 25 November 2016
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	*PR3-ANCA (proteinase 3 antineutrophil cytoplasmic autoantibody).		*PR3-ANCA (proteinase 3 antineutrophil cytoplasmic autoantibody).
	**Previously c-ANCA.		**Previously c-ANCA.
	**Seen in ANCA-[[vasculitides]], esp. [[Wegener granulomatosis]].		**Seen in ANCA-[[vasculitides]], esp. [[Granulomatosis with polyangiitis]] (Wegener granulomatosis).

	===C4d===		===C4d===

Michael at 16:58, 19 February 2016

2016-02-19T16:58:15Z

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	Note:		Note:
	*[[Amyloid]] between 8 and 15 nm (diameter), most often 8-12 nm.<ref name=pmid18045849>{{Cite journal \| last1 = Alpers \| first1 = CE. \| last2 = Kowalewska \| first2 = J. \| title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. \| journal = J Am Soc Nephrol \| volume = 19 \| issue = 1 \| pages = 34-7 \| month = Jan \| year = 2008 \| doi = 10.1681/ASN.2007070757 \| PMID = 18045849 \| URL = http://jasn.asnjournals.org/content/19/1/34.~~long~~ }}</ref>		*[[Amyloid]] between 8 and 15 nm (diameter), most often 8-12 nm.<ref name=pmid18045849>{{Cite journal \| last1 = Alpers \| first1 = CE. \| last2 = Kowalewska \| first2 = J. \| title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. \| journal = J Am Soc Nephrol \| volume = 19 \| issue = 1 \| pages = 34-7 \| month = Jan \| year = 2008 \| doi = 10.1681/ASN.2007070757 \| PMID = 18045849 \| URL = http://jasn.asnjournals.org/content/19/1/34.full }}</ref>

	==Aristolochic acid nephropathy==		==Aristolochic acid nephropathy==

Michael at 16:56, 19 February 2016

2016-02-19T16:56:54Z

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	*[[AKA]] ''fibrillary glomerulopathy''.		*[[AKA]] ''fibrillary glomerulopathy''.
	===General===		===General===
	*Rare ~ 1% native kidney biopsies.<ref name=pmid18045849>{{Cite journal \| last1 = Alpers \| first1 = CE. \| last2 = Kowalewska \| first2 = J. \| title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. \| journal = J Am Soc Nephrol \| volume = 19 \| issue = 1 \| pages = 34-7 \| month = Jan \| year = 2008 \| doi = 10.1681/ASN.2007070757 \| PMID = 18045849 \| URL = http://jasn.asnjournals.org/content/19/1/34.~~long~~ }}</ref>		*Rare ~ 1% native kidney biopsies.<ref name=pmid18045849>{{Cite journal \| last1 = Alpers \| first1 = CE. \| last2 = Kowalewska \| first2 = J. \| title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. \| journal = J Am Soc Nephrol \| volume = 19 \| issue = 1 \| pages = 34-7 \| month = Jan \| year = 2008 \| doi = 10.1681/ASN.2007070757 \| PMID = 18045849 \| URL = http://jasn.asnjournals.org/content/19/1/34.full }}</ref>
	*Presents as [[nephrotic syndrome]].		*Presents as [[nephrotic syndrome]].
	*Prognosis poor; large number progress to ESRD.		*Prognosis poor; large number progress to ESRD.

Michael: /* Immunotactoid glomerulopathy */

2016-02-19T16:54:58Z

Immunotactoid glomerulopathy

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	Presentation:		Presentation:
	*Nephrotic range proteinuria ~ 60% of cases.<ref>{{Cite journal \| last1 = Korbet \| first1 = SM. \| last2 = Schwartz \| first2 = MM. \| last3 = Lewis \| first3 = EJ. \| title = Immunotactoid glomerulopathy. \| journal = Am J Kidney Dis \| volume = 17 \| issue = 3 \| pages = 247-57 \| month = Mar \| year = 1991 \| doi = \| PMID = 1996564 }}</ref>		*Nephrotic range proteinuria ~ 60% of cases.<ref name=pmid1996564>{{Cite journal \| last1 = Korbet \| first1 = SM. \| last2 = Schwartz \| first2 = MM. \| last3 = Lewis \| first3 = EJ. \| title = Immunotactoid glomerulopathy. \| journal = Am J Kidney Dis \| volume = 17 \| issue = 3 \| pages = 247-57 \| month = Mar \| year = 1991 \| doi = \| PMID = 1996564 }}</ref>
	*[[Hypertension]].		*[[Hypertension]].

Michael: fix ref

2016-02-19T16:53:51Z

fix ref

← Older revision		Revision as of 16:53, 19 February 2016
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	\|-		\|-
	\| [[Membranoproliferative glomerulonephritis]] (MPGN)		\| [[Membranoproliferative glomerulonephritis]] (MPGN)
	\| mesangial proliferation with thickening of the glomerular capillary loops<ref name=pmid11682680>{{Cite journal \| last1 = Smet \| first1 = AD. \| last2 = Kuypers \| first2 = D. \| last3 = Evenepoel \| first3 = P. \| last4 = Maes \| first4 = B. \| last5 = Messiaen \| first5 = T. \| last6 = Van Damme \| first6 = B. \| last7 = Vanrenterghem \| first7 = Y. \| title = 'Full house' positive immunohistochemical membranoproliferative glomerulonephritis in a patient with portosystemic shunt. \| journal = Nephrol Dial Transplant \| volume = 16 \| issue = 11 \| pages = 2258-62 \| month = Nov \| year = 2001 \| doi = \| PMID = 11682680 }}</ref>		\| mesangial proliferation with thickening of the glomerular capillary loops<ref name=pmid11682680>{{Cite journal \| last1 = Smet \| first1 = AD. \| last2 = Kuypers \| first2 = D. \| last3 = Evenepoel \| first3 = P. \| last4 = Maes \| first4 = B. \| last5 = Messiaen \| first5 = T. \| last6 = Van Damme \| first6 = B. \| last7 = Vanrenterghem \| first7 = Y. \| title = 'Full house' positive immunohistochemical membranoproliferative glomerulonephritis in a patient with portosystemic shunt. \| journal = Nephrol Dial Transplant \| volume = 16 \| issue = 11 \| pages = 2258-62 \| month = Nov \| year = 2001 \| doi = \| PMID = 11682680 \| URL = http://ndt.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11682680 }}</ref>

	\| low C3, normal C4; primary vs. secondary (often hepatitis C)		\| low C3, normal C4; primary vs. secondary (often hepatitis C)
	\|-		\|-

Michael: /* ANCA */

2016-02-19T16:51:11Z

ANCA

← Older revision		Revision as of 16:51, 19 February 2016
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	**Previously p-ANCA.		**Previously p-ANCA.
	**Seen in ANCA-[[vasculitides]], esp. [[microscopic polyangiitis]].		**Seen in ANCA-[[vasculitides]], esp. [[microscopic polyangiitis]].
	*PR3-~~ANPA~~ (proteinase 3 antineutrophil cytoplasmic autoantibody).		*PR3-ANCA (proteinase 3 antineutrophil cytoplasmic autoantibody).
	**Previously c-ANCA.		**Previously c-ANCA.
	**Seen in ANCA-[[vasculitides]], esp. [[Wegener granulomatosis]].		**Seen in ANCA-[[vasculitides]], esp. [[Wegener granulomatosis]].

Michael: /* General */ tweak

2015-08-05T17:00:42Z

General: tweak

← Older revision		Revision as of 17:00, 5 August 2015
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	*Associated with a specific HLA type (HLA-DRB11501) and two gene families.		*Associated with a specific HLA type (HLA-DRB11501) and two gene families.
	**Antibodies directed against COL4A3,<ref>{{OMIM\|120070}}</ref> which is ''not'' mutated.		**Antibodies directed against COL4A3,<ref>{{OMIM\|120070}}</ref> which is ''not'' mutated.
			*Oligouria - poor prognosticator.{{fact}}

	Tx:		Tx:

Michael: /* IF */ tweak

2015-08-05T16:49:53Z

IF: tweak

← Older revision		Revision as of 16:49, 5 August 2015
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	===IF===		===IF===
	*Linear IgG deposits - '''diagnostic'''.		*Linear IgG deposits - '''diagnostic'''.
			*Fibrinogen in crescents.

	DDx:		DDx: