Melanotic Xp11 translocation renal cancer - Revision history

Michael at 05:16, 2 January 2018

2018-01-02T05:16:04Z

← Older revision		Revision as of 05:16, 2 January 2018
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Melanotic_Xp11.2_translocation_renal_cancer_-_b1_--_high_mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Melanotic Xp11.2 translocation renal cancer. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = melanin-like pigment, clear cells - epithelioid morphology - similar to [[Xp11.2 translocation carcinoma]]
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[PEComa]], [[malignant melanoma]], [[Xp11.2 translocation carcinoma]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = S-100 -ve, TFE3 +ve, keratin -ve
	\| EM =		\| EM =
	\| Molecular = Xp11 translocation		\| Molecular = Xp11 translocation

Michael: more

2018-01-02T05:13:19Z

← Older revision		Revision as of 05:13, 2 January 2018
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular = Xp11 translocation
			\| IF =
			\| Gross =
			\| Grossing = [[partial nephrectomy grossing]], [[Total nephrectomy for tumour grossing]]
			\| Staging =
			\| Site = [[kidney]] - see ''[[kidney tumours]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = case reports
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = unknown
			\| Other =
			\| ClinDDx = other renal tumours
			\| Tx = excision
			}}
	'''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref name=pmid26274027>{{Cite journal \| last1 = Rao \| first1 = Q. \| last2 = Shen \| first2 = Q. \| last3 = Xia \| first3 = QY. \| last4 = Wang \| first4 = ZY. \| last5 = Liu \| first5 = B. \| last6 = Shi \| first6 = SS. \| last7 = Shi \| first7 = QL. \| last8 = Yin \| first8 = HL. \| last9 = Wu \| first9 = B. \| title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 9 \| pages = 1181-96 \| month = Sep \| year = 2015 \| doi = 10.1097/PAS.0000000000000502 \| PMID = 26274027 }}</ref>		'''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref name=pmid26274027>{{Cite journal \| last1 = Rao \| first1 = Q. \| last2 = Shen \| first2 = Q. \| last3 = Xia \| first3 = QY. \| last4 = Wang \| first4 = ZY. \| last5 = Liu \| first5 = B. \| last6 = Shi \| first6 = SS. \| last7 = Shi \| first7 = QL. \| last8 = Yin \| first8 = HL. \| last9 = Wu \| first9 = B. \| title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 9 \| pages = 1181-96 \| month = Sep \| year = 2015 \| doi = 10.1097/PAS.0000000000000502 \| PMID = 26274027 }}</ref>

Michael: +images

2018-01-02T05:11:01Z

+images

← Older revision		Revision as of 05:11, 2 January 2018
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	*[[Malignant melanoma]].		*[[Malignant melanoma]].
	*[[Xp11.2 translocation carcinoma]].		*[[Xp11.2 translocation carcinoma]].

			===Images===
			<gallery>
			Image: Melanotic Xp11.2 translocation renal cancer -- low mag.jpg \| MXTRC - low mag.
			Image: Melanotic Xp11.2 translocation renal cancer -- intermed mag.jpg \| MXTRC - intermed. mag.
			Image: Melanotic Xp11.2 translocation renal cancer -- high mag.jpg \| MXTRC - high mag.
			Image: Melanotic Xp11.2 translocation renal cancer -- very high mag.jpg \| MXTRC - very high mag.

			Image: Melanotic Xp11.2 translocation renal cancer - b -- low mag.jpg \| MXTRC - low mag.
			Image: Melanotic Xp11.2 translocation renal cancer - b -- intermed mag.jpg \| MXTRC - intermed. mag.
			Image: Melanotic Xp11.2 translocation renal cancer - b1 -- high mag.jpg \| MXTRC - high mag.
			Image: Melanotic Xp11.2 translocation renal cancer - b2 -- high mag.jpg \| MXTRC - high mag.
			</gallery>

	==IHC==		==IHC==

Michael: tweak

2017-04-26T15:55:45Z

tweak

← Older revision		Revision as of 15:55, 26 April 2017
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	'''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref>{{Cite journal \| last1 = Rao \| first1 = Q. \| last2 = Shen \| first2 = Q. \| last3 = Xia \| first3 = QY. \| last4 = Wang \| first4 = ZY. \| last5 = Liu \| first5 = B. \| last6 = Shi \| first6 = SS. \| last7 = Shi \| first7 = QL. \| last8 = Yin \| first8 = HL. \| last9 = Wu \| first9 = B. \| title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 9 \| pages = 1181-96 \| month = Sep \| year = 2015 \| doi = 10.1097/PAS.0000000000000502 \| PMID = 26274027 }}</ref>		'''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref name=pmid26274027>{{Cite journal \| last1 = Rao \| first1 = Q. \| last2 = Shen \| first2 = Q. \| last3 = Xia \| first3 = QY. \| last4 = Wang \| first4 = ZY. \| last5 = Liu \| first5 = B. \| last6 = Shi \| first6 = SS. \| last7 = Shi \| first7 = QL. \| last8 = Yin \| first8 = HL. \| last9 = Wu \| first9 = B. \| title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 9 \| pages = 1181-96 \| month = Sep \| year = 2015 \| doi = 10.1097/PAS.0000000000000502 \| PMID = 26274027 }}</ref>

			==General==
			*Evolving entity.<ref name=pmid19065101>{{Cite journal \| last1 = Argani \| first1 = P. \| last2 = Aulmann \| first2 = S. \| last3 = Karanjawala \| first3 = Z. \| last4 = Fraser \| first4 = RB. \| last5 = Ladanyi \| first5 = M. \| last6 = Rodriguez \| first6 = MM. \| title = Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 4 \| pages = 609-19 \| month = Apr \| year = 2009 \| doi = 10.1097/PAS.0b013e31818fbdff \| PMID = 19065101 }}</ref><ref name=pmid26274027/>
			*Very rare.

			==Microscopic==
			Features:
			*Melanin-like pigment.
			*Clear cells, epithelioid morphology - similar to [[Xp11.2 translocation carcinoma]].

			DDx:
			*[[PEComa]] - may have TFE3 rearrangement.
			*[[Malignant melanoma]].
			*[[Xp11.2 translocation carcinoma]].

			==IHC==
			*TFE3 +ve.
			*Keratin -ve.

			==Molecular==
			*TFE3 rearrangement.

	==See also==		==See also==

Michael at 12:27, 26 April 2017

2017-04-26T12:27:51Z

← Older revision		Revision as of 12:27, 26 April 2017
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	'''Melanotic Xp11 translocation renal cancer''' is a very rare kidney tumour that is evolving as an entity.<ref>{{Cite journal \| last1 = Rao \| first1 = Q. \| last2 = Shen \| first2 = Q. \| last3 = Xia \| first3 = QY. \| last4 = Wang \| first4 = ZY. \| last5 = Liu \| first5 = B. \| last6 = Shi \| first6 = SS. \| last7 = Shi \| first7 = QL. \| last8 = Yin \| first8 = HL. \| last9 = Wu \| first9 = B. \| title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 9 \| pages = 1181-96 \| month = Sep \| year = 2015 \| doi = 10.1097/PAS.0000000000000502 \| PMID = 26274027 }}</ref>		'''Melanotic Xp11 translocation renal cancer''' is a very rare [[kidney tumour]] that is evolving as an entity.<ref>{{Cite journal \| last1 = Rao \| first1 = Q. \| last2 = Shen \| first2 = Q. \| last3 = Xia \| first3 = QY. \| last4 = Wang \| first4 = ZY. \| last5 = Liu \| first5 = B. \| last6 = Shi \| first6 = SS. \| last7 = Shi \| first7 = QL. \| last8 = Yin \| first8 = HL. \| last9 = Wu \| first9 = B. \| title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. \| journal = Am J Surg Pathol \| volume = 39 \| issue = 9 \| pages = 1181-96 \| month = Sep \| year = 2015 \| doi = 10.1097/PAS.0000000000000502 \| PMID = 26274027 }}</ref>

	==See also==		==See also==

Michael: Created page with "'''Melanotic Xp11 translocation renal cancer''' is a very rare kidney tumour that is evolving as an entity.{{Cite journal | last1 = Rao | first1 = Q. | last2 = Shen | fi..."

2017-04-26T12:27:39Z

Created page with "'''Melanotic Xp11 translocation renal cancer''' is a very rare kidney tumour that is evolving as an entity.<ref>{{Cite journal | last1 = Rao | first1 = Q. | last2 = Shen | fi..."

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'''Melanotic Xp11 translocation renal cancer''' is a very rare kidney tumour that is evolving as an entity.<ref>{{Cite journal | last1 = Rao | first1 = Q. | last2 = Shen | first2 = Q. | last3 = Xia | first3 = QY. | last4 = Wang | first4 = ZY. | last5 = Liu | first5 = B. | last6 = Shi | first6 = SS. | last7 = Shi | first7 = QL. | last8 = Yin | first8 = HL. | last9 = Wu | first9 = B. | title = PSF/SFPQ is a very common gene fusion partner in TFE3 rearrangement-associated perivascular epithelioid cell tumors (PEComas) and melanotic Xp11 translocation renal cancers: clinicopathologic, immunohistochemical, and molecular characteristics suggesting classification as a distinct entity. | journal = Am J Surg Pathol | volume = 39 | issue = 9 | pages = 1181-96 | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000502 | PMID = 26274027 }}</ref>

==See also==
*[[Chromosomal translocations]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]