Merkel cell carcinoma - Revision history

Mark: many ALK1 +ve

2023-01-10T21:32:37Z

many ALK1 +ve

← Older revision		Revision as of 21:32, 10 January 2023
Line 103:		Line 103:
	*NSE +ve.<ref name=pmid15606676/>		*NSE +ve.<ref name=pmid15606676/>
	*PAX5 +ve.<ref name=pmid25040178>{{Cite journal \| last1 = Jankowski \| first1 = M. \| last2 = Kopinski \| first2 = P. \| last3 = Schwartz \| first3 = R. \| last4 = Czajkowski \| first4 = R. \| title = Merkel cell carcinoma: is this a true carcinoma? \| journal = Exp Dermatol \| volume = 23 \| issue = 11 \| pages = 792-4 \| month = Nov \| year = 2014 \| doi = 10.1111/exd.12490 \| PMID = 25040178 }}</ref>		*PAX5 +ve.<ref name=pmid25040178>{{Cite journal \| last1 = Jankowski \| first1 = M. \| last2 = Kopinski \| first2 = P. \| last3 = Schwartz \| first3 = R. \| last4 = Czajkowski \| first4 = R. \| title = Merkel cell carcinoma: is this a true carcinoma? \| journal = Exp Dermatol \| volume = 23 \| issue = 11 \| pages = 792-4 \| month = Nov \| year = 2014 \| doi = 10.1111/exd.12490 \| PMID = 25040178 }}</ref>
			*ALK1<ref name=pmid23574788>{{cite journal \|vauthors=Filtenborg-Barnkob BE, Bzorek M \|title=Expression of anaplastic lymphoma kinase in Merkel cell carcinomas \|journal=Hum Pathol \|volume=44 \|issue=8 \|pages=1656–64 \|date=August 2013 \|pmid=23574788 \|doi=10.1016/j.humpath.2012.11.021 \|url=}}</ref>

	==EM==		==EM==

Michael: +NF

2023-01-09T19:00:50Z

+NF

← Older revision		Revision as of 19:00, 9 January 2023
Line 8:		Line 8:
	\| LMDDx = [[small cell carcinoma]], cutaneous [[Ewing sarcoma]], [[Burkitt lymphoma]], other [[small round blue cell tumours]]		\| LMDDx = [[small cell carcinoma]], cutaneous [[Ewing sarcoma]], [[Burkitt lymphoma]], other [[small round blue cell tumours]]
	\| Stains =		\| Stains =
	\| IHC = Merkel cell polyomavirus +ve, CK20 +ve (perinuclear dot-like), CD56 +ve, TTF-1 -ve, CK7 -ve		\| IHC = Merkel cell polyomavirus +ve, CK20 +ve (perinuclear dot-like), CD56 +ve, TTF-1 -ve, CK7 -ve, NF +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =
Line 96:		Line 96:
	*AE1/AE3 +ve.		*AE1/AE3 +ve.
	*Merkel cell polyomavirus +ve ~85% of cases.<ref name=pmid21870327>{{Cite journal \| last1 = Jung \| first1 = HS. \| last2 = Choi \| first2 = YL. \| last3 = Choi \| first3 = JS. \| last4 = Roh \| first4 = JH. \| last5 = Pyon \| first5 = JK. \| last6 = Woo \| first6 = KJ. \| last7 = Lee \| first7 = EH. \| last8 = Jang \| first8 = KT. \| last9 = Han \| first9 = J. \| title = Detection of Merkel cell polyomavirus in Merkel cell carcinomas and small cell carcinomas by PCR and immunohistochemistry. \| journal = Histol Histopathol \| volume = 26 \| issue = 10 \| pages = 1231-41 \| month = Oct \| year = 2011 \| doi = \| PMID = 21870327 }}</ref>		*Merkel cell polyomavirus +ve ~85% of cases.<ref name=pmid21870327>{{Cite journal \| last1 = Jung \| first1 = HS. \| last2 = Choi \| first2 = YL. \| last3 = Choi \| first3 = JS. \| last4 = Roh \| first4 = JH. \| last5 = Pyon \| first5 = JK. \| last6 = Woo \| first6 = KJ. \| last7 = Lee \| first7 = EH. \| last8 = Jang \| first8 = KT. \| last9 = Han \| first9 = J. \| title = Detection of Merkel cell polyomavirus in Merkel cell carcinomas and small cell carcinomas by PCR and immunohistochemistry. \| journal = Histol Histopathol \| volume = 26 \| issue = 10 \| pages = 1231-41 \| month = Oct \| year = 2011 \| doi = \| PMID = 21870327 }}</ref>
			*NF +ve (12 of 13 cases).<ref name=pmid16625069>{{cite journal \|authors=Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS \|title=Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung \|journal=Am J Dermatopathol \|volume=28 \|issue=2 \|pages=99–104 \|date=April 2006 \|pmid=16625069 \|doi=10.1097/01.dad.0000183701.67366.c7 \|url=}}</ref>
			**Useful to differentiate from [[small cell carcinoma of lung]].

	Others:		Others:

Michael: /* See also */

2021-12-09T15:09:53Z

Michael: /* IHC */

2016-02-22T17:04:17Z

IHC

← Older revision		Revision as of 17:04, 22 February 2016
Line 100:		Line 100:
	*TTF-1 -ve.		*TTF-1 -ve.
	*NSE +ve.<ref name=pmid15606676/>		*NSE +ve.<ref name=pmid15606676/>
			*PAX5 +ve.<ref name=pmid25040178>{{Cite journal \| last1 = Jankowski \| first1 = M. \| last2 = Kopinski \| first2 = P. \| last3 = Schwartz \| first3 = R. \| last4 = Czajkowski \| first4 = R. \| title = Merkel cell carcinoma: is this a true carcinoma? \| journal = Exp Dermatol \| volume = 23 \| issue = 11 \| pages = 792-4 \| month = Nov \| year = 2014 \| doi = 10.1111/exd.12490 \| PMID = 25040178 }}</ref>

	==EM==		==EM==

Michael: /* See also */

2013-12-30T02:25:16Z

Michael: fix sp

2013-08-21T23:28:58Z

fix sp

← Older revision		Revision as of 23:28, 21 August 2013
Line 6:		Line 6:
	\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets		\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[small cell carcinoma]], cutaneous [[Ewing ~~sarcinoma~~]], [[Burkitt lymphoma]], other [[small round blue cell tumours]]		\| LMDDx = [[small cell carcinoma]], cutaneous [[Ewing sarcoma]], [[Burkitt lymphoma]], other [[small round blue cell tumours]]
	\| Stains =		\| Stains =
	\| IHC = Merkel cell polyomavirus +ve, CK20 +ve (perinuclear dot-like), CD56 +ve, TTF-1 -ve, CK7 -ve		\| IHC = Merkel cell polyomavirus +ve, CK20 +ve (perinuclear dot-like), CD56 +ve, TTF-1 -ve, CK7 -ve

Michael at 23:28, 21 August 2013

2013-08-21T23:28:38Z

← Older revision		Revision as of 23:28, 21 August 2013
Line 6:		Line 6:
	\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets		\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[small cell carcinoma]]		\| LMDDx = [[small cell carcinoma]], cutaneous [[Ewing sarcinoma]], [[Burkitt lymphoma]], other [[small round blue cell tumours]]
	\| Stains =		\| Stains =
	\| IHC = Merkel cell polyomavirus +ve, CK20 +ve (perinuclear dot-like), CD56 +ve, TTF-1 -ve, CK7 -ve		\| IHC = Merkel cell polyomavirus +ve, CK20 +ve (perinuclear dot-like), CD56 +ve, TTF-1 -ve, CK7 -ve

Michael: twk

2013-08-21T23:27:53Z

twk

← Older revision		Revision as of 23:27, 21 August 2013
Line 5:		Line 5:
	\| Caption = Merkel cell carcinoma. [[H&E stain]].		\| Caption = Merkel cell carcinoma. [[H&E stain]].
	\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets		\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets
	\| Subtypes = ~~small cell (common), large cell (uncommon)~~		\| Subtypes =
	\| LMDDx = [[small cell carcinoma]]		\| LMDDx = [[small cell carcinoma]]
	\| Stains =		\| Stains =

Michael: teak

2013-08-21T23:26:31Z

teak

← Older revision		Revision as of 23:26, 21 August 2013
Line 17:		Line 17:
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = +/-immunosuppressed/immunoincompetent
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
Line 27:		Line 27:
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
			}}
			{{ Infobox external links
			\| Name = {{PAGENAME}}
			\| EHVSC =
			\| EHVSC_mult =
			\| pathprotocols =
			\| wikipedia = merkel cell carcinoma
			\| pathoutlines =
	}}		}}
	'''Merkel cell carcinoma''', abbreviated '''MCC''', is an uncommon aggressive form of skin cancer.		'''Merkel cell carcinoma''', abbreviated '''MCC''', is an uncommon aggressive form of skin cancer.

Michael: tweak some more

2013-08-21T23:24:16Z

tweak some more

← Older revision		Revision as of 23:24, 21 August 2013
Line 4:		Line 4:
	\| Width =		\| Width =
	\| Caption = Merkel cell carcinoma. [[H&E stain]].		\| Caption = Merkel cell carcinoma. [[H&E stain]].
	\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually small (~3x resting lymphocyte), often in sheets		\| Micro = neuroendocrine nuclear features (round nucleus, small nucleoli/no nucleolus, stippled chromatin), usually scant cytoplasm, usually small (~3x resting lymphocyte), often in sheets
	\| Subtypes = small cell (common), large cell (uncommon)		\| Subtypes = small cell (common), large cell (uncommon)
	\| LMDDx = [[small cell carcinoma]]		\| LMDDx = [[small cell carcinoma]]

← Older revision		Revision as of 15:09, 9 December 2021
Line 109:		Line 109:
	*[[Small cell carcinoma]].		*[[Small cell carcinoma]].
	*[[Dermatopathology]].		*[[Dermatopathology]].
			*[[Viruses and cancer]].

	==References==		==References==

← Older revision		Revision as of 02:25, 30 December 2013
Line 107:		Line 107:
	*[[Dermatologic neoplasms]].		*[[Dermatologic neoplasms]].
	*[[Small cell carcinoma]].		*[[Small cell carcinoma]].
			*[[Dermatopathology]].

	==References==		==References==