Mesenchymal chondrosarcoma - Revision history

Michael: vauthors

2020-05-24T20:30:38Z

vauthors

← Older revision		Revision as of 20:30, 24 May 2020
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	==Molecular==		==Molecular==
	*t(8;8)(q21.1;q13.3) HEY1-NCOA2.<ref name=pmid24839999>{{Cite journal \| last1 = Panagopoulos \| first1 = I. \| last2 = Gorunova \| first2 = L. \| last3 = Bjerkehagen \| first3 = B. \| last4 = Boye \| first4 = K. \| last5 = Heim \| first5 = S. \| title = Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. \| journal = Oncol Rep \| volume = 32 \| issue = 1 \| pages = 40-4 \| month = Jul \| year = 2014 \| doi = 10.3892/or.2014.3180 \| PMID = 24839999 }}</ref>		*t(8;8)(q21.1;q13.3) HEY1-NCOA2.<ref name=pmid24839999>{{Cite journal \| last1 = Panagopoulos \| first1 = I. \| last2 = Gorunova \| first2 = L. \| last3 = Bjerkehagen \| first3 = B. \| last4 = Boye \| first4 = K. \| last5 = Heim \| first5 = S. \| title = Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. \| journal = Oncol Rep \| volume = 32 \| issue = 1 \| pages = 40-4 \| month = Jul \| year = 2014 \| doi = 10.3892/or.2014.3180 \| PMID = 24839999 }}</ref>
	*Less commonly t(1;5)(q42;q32) IRF2BP2-CDX1<ref>{{cite journal \|~~vauthors~~=Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F \|title=Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma \|journal=PLoS ONE \|volume=7 \|issue=11 \|pages=e49705 \|date=2012 \|pmid=23185413 \|pmc=3504151 \|doi=10.1371/journal.pone.0049705 \|url=}}</ref>		*Less commonly t(1;5)(q42;q32) IRF2BP2-CDX1<ref>{{cite journal \|authors=Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F \|title=Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma \|journal=PLoS ONE \|volume=7 \|issue=11 \|pages=e49705 \|date=2012 \|pmid=23185413 \|pmc=3504151 \|doi=10.1371/journal.pone.0049705 \|url=}}</ref>

	==See also==		==See also==

Mark: /* Molecular */

2020-01-11T22:12:26Z

Molecular

← Older revision		Revision as of 22:12, 11 January 2020
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	==Molecular==		==Molecular==
	t(8;8)(q21.1;q13.3) HEY1-NCOA2.<ref name=pmid24839999>{{Cite journal \| last1 = Panagopoulos \| first1 = I. \| last2 = Gorunova \| first2 = L. \| last3 = Bjerkehagen \| first3 = B. \| last4 = Boye \| first4 = K. \| last5 = Heim \| first5 = S. \| title = Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. \| journal = Oncol Rep \| volume = 32 \| issue = 1 \| pages = 40-4 \| month = Jul \| year = 2014 \| doi = 10.3892/or.2014.3180 \| PMID = 24839999 }}</ref>		*t(8;8)(q21.1;q13.3) HEY1-NCOA2.<ref name=pmid24839999>{{Cite journal \| last1 = Panagopoulos \| first1 = I. \| last2 = Gorunova \| first2 = L. \| last3 = Bjerkehagen \| first3 = B. \| last4 = Boye \| first4 = K. \| last5 = Heim \| first5 = S. \| title = Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. \| journal = Oncol Rep \| volume = 32 \| issue = 1 \| pages = 40-4 \| month = Jul \| year = 2014 \| doi = 10.3892/or.2014.3180 \| PMID = 24839999 }}</ref>
			*Less commonly t(1;5)(q42;q32) IRF2BP2-CDX1<ref>{{cite journal \|vauthors=Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F \|title=Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma \|journal=PLoS ONE \|volume=7 \|issue=11 \|pages=e49705 \|date=2012 \|pmid=23185413 \|pmc=3504151 \|doi=10.1371/journal.pone.0049705 \|url=}}</ref>

	==See also==		==See also==

Michael: /* External links */

2014-11-21T06:22:21Z

External links

← Older revision		Revision as of 06:22, 21 November 2014
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	==External links==		==External links==
	*[http://www.webpathology.com/image.asp?case=332&n=41 ~~Web Pathology~~ images (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=332&n=41 Mesenchymal chondrosarcoma - images (webpathology.com)].
	*[http://www.pathologyoutlines.com/topic/bonemesenchymalchondrosarcoma.html Mesenchymal chondrosarcoma (pathologyoutlines.com)].		*[http://www.pathologyoutlines.com/topic/bonemesenchymalchondrosarcoma.html Mesenchymal chondrosarcoma (pathologyoutlines.com)].

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Chondro-osseous tumours]]		[[Category:Chondro-osseous tumours]]

Michael at 06:21, 21 November 2014

2014-11-21T06:21:49Z

← Older revision		Revision as of 06:21, 21 November 2014
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	*[[Cartilage]].		*[[Cartilage]].
	*[[Chondrosarcoma]].		*[[Chondrosarcoma]].
	*Web Pathology[http://www.webpathology.com/image.asp?case=332&n=41]
	*Pathology Oulines [http://www.pathologyoutlines.com/topic/bonemesenchymalchondrosarcoma.html]
	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}

			==External links==
			*[http://www.webpathology.com/image.asp?case=332&n=41 Web Pathology images (webpathology.com)].
			*[http://www.pathologyoutlines.com/topic/bonemesenchymalchondrosarcoma.html Mesenchymal chondrosarcoma (pathologyoutlines.com)].

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Chondro-osseous tumours]]		[[Category:Chondro-osseous tumours]]

Michael: wikify

2014-11-21T06:20:22Z

wikify

← Older revision		Revision as of 06:20, 21 November 2014
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	'''Mesenchymal chondrosarcoma''' is a rare type of [[chondrosarcoma]] found in the soft tissue.		'''Mesenchymal chondrosarcoma''' is a rare type of [[chondrosarcoma]] that is found in the [[soft tissue lesions\|soft tissue]].

	==General==		==General==
			*Rare variant of [[chondrosarcoma]].
	*Rare variant of chondrosarcoma.		*2–10% of primary chondrosarcomas.
	*2–10% of primary chondrosarcomas		*Adolescents and young adults.
	*Adolescents and young adults		*Female predilection.
	*Female predilection		*Most commonly intraosseous but can occur in extraskeletal sites especially the central nervous system (from the meninges).
	*Most commonly intraosseous but can occur in extraskeletal sites especially the central nervous system (from the ~~meminges~~)		*The ''mesenchymal'' in the name refers to the ability to arise in soft tissues.<ref name=pmid14161087>{{cite journal \|author=Dowling EA \|title=Mesenchymal chondrosarcoma \|journal=J Bone Joint Surg Am \|volume=46 \|issue= \|pages=747–54 \|year=1964 \|month=June \|pmid=14161087 \|doi= \|url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref>
	*The 'mesenchymal' in the name refers to the ability to arise in soft tissues.<ref name=pmid14161087>{{cite journal \|author=Dowling EA \|title=Mesenchymal chondrosarcoma \|journal=J Bone Joint Surg Am \|volume=46 \|issue= \|pages=747–54 \|year=1964 \|month=June \|pmid=14161087 \|doi= \|url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref>
	*Conceptualized as originating from a pleuripotential mesenchymal cell with foci recapitulating enchondral ossification.		*Conceptualized as originating from a pleuripotential mesenchymal cell with foci recapitulating enchondral ossification.
	*The small cells appear to be an undifferentiated cartilage stem cell which “differentiate” into benign cartilage <ref>{{Cite journal \| last1 = Fanburg-Smith \| first1 = JC. \| last2 = Auerbach \| first2 = A. \| last3 = Marwaha \| first3 = JS. \| last4 = Wang \| first4 = Z. \| last5 = Rushing \| first5 = EJ. \| title = Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. \| journal = Hum Pathol \| volume = 41 \| issue = 5 \| pages = 653-62 \| month = May \| year = 2010 \| doi = 10.1016/j.humpath.2009.11.006 \| PMID = 20138330 }}		*The small cells appear to be an undifferentiated cartilage stem cell which “differentiate” into benign cartilage.<ref name=pmid20138330>{{Cite journal \| last1 = Fanburg-Smith \| first1 = JC. \| last2 = Auerbach \| first2 = A. \| last3 = Marwaha \| first3 = JS. \| last4 = Wang \| first4 = Z. \| last5 = Rushing \| first5 = EJ. \| title = Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. \| journal = Hum Pathol \| volume = 41 \| issue = 5 \| pages = 653-62 \| month = May \| year = 2010 \| doi = 10.1016/j.humpath.2009.11.006 \| PMID = 20138330 }}</ref>
	</ref>.

	==Gross==		==Gross==
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	==Microscopic==		==Microscopic==
	~~'White clouds in~~ a ~~dark~~ blue ~~sky'~~		Features:
			*Malignant tumour with a characteristic biphasic pattern.
			**Cellular poorly differentiated [[small round blue cell tumours\|small round blue cells]].
			**Islands of well-differentiated hyaline [[cartilage]].
			***Progressive maturation of cartilage towards the center.
			***Central calcification or [[bone]] formation.
			**Can have a [[staghorn vessels\|hemangiopericytomatous vascular pattern]].

	*~~Malignant tumor with~~ a ~~characteristic biphasic pattern~~		Notes:
	**~~Cellular poorly differentiated small round blue cells~~		*May be described as ''white clouds in a dark blue sky''.
	**Can have a hemangiopericytomatous vascular pattern
	**Islands of well-~~differentiated~~ hyaline cartilage		===DDX===
	***~~Progressive maturation of cartilage towards~~ the ~~center~~		*[[Hemangiopericytoma]] - no cartilage.
	***Central calcification or bone formation		*[[Lymphoma]] - Sox9 negative, CD45 positive.
			*Metaplastic [[glioblastoma]] - usually older adults - GFAP positive.
			*[[Chondrosarcoma]] (NOS) - usually older adults - hyaline cartilage is malignant.
			*[[Small cell osteosarcoma]] - Sox10 negative, no cartilage.
			*[[Ewing sarcoma]] - both are CD99 positive but ES is Sox9 negative, no cartilage.
			*Monophasic [[synovial sarcoma]] - also can have the hemangiopericytomatous vasculature.

			Note:
			*Depends a bit on where the tumour is located and how much cartilage is readily visible.

	===Images===		===Images===
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	*Osteocalcin (negative in small cells).		*Osteocalcin (negative in small cells).
	*CD99 - (positive in small cells)		*CD99 - (positive in small cells)

	~~==DDX==~~
	~~Depends a bit on where the tumor is located and how much cartilage is readily visible.~~
	**Hemangiopericytoma - no cartilage
	**Lymphoma - Sox9 negative, CD45 positive
	**Metaplastic Glioblastoma - usually older adults - GFAP positive
	**Chondrosarcoma - usually older adults - hyaline cartilage is malignant
	**Small cell osteosarcoma - Sox10 negative, no cartilage
	**Ewing sarcoma - Both are CD99 positive but ES is Sox9 negative, no cartilage
	**Monophasic synovial sarcoma - also can have the hemangiopericytomatous vasculature

	==Molecular==		==Molecular==

Sarah: /* Images */

2014-11-20T11:35:59Z

Images

← Older revision		Revision as of 11:35, 20 November 2014
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	www:		www:
	*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].		*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].
	*Web Pathology - This example evokes hemangiopericytoma [http://www.webpathology.com/images/noimage.gif].		*Pathology Outlines - Hemangiopericytomatous example [http://pathologyoutlines.com/wick/chondrosarcoma%20mesenchymal%20type%20micro0007.jpg]
	*Pathology Outlines - ~~Another hemangiopericytomatous~~ example [http://pathologyoutlines.com/wick/chondrosarcoma%20mesenchymal%20type%20micro0007.jpg]
	*Sarcoma Images - [http://www.sarcomaimages.com/index.php?v=Mesenchymal-Chondrosarcoma]		*Sarcoma Images - [http://www.sarcomaimages.com/index.php?v=Mesenchymal-Chondrosarcoma]
	*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_poIB6FYZQ73wh.jpg]		*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_poIB6FYZQ73wh.jpg]
	*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_9oJtTQXXxaEB3.jpg]		*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_9oJtTQXXxaEB3.jpg]
	*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_8h2C7upeOj3EB.jpg]		*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_8h2C7upeOj3EB.jpg]


	==IHC==		==IHC==

Sarah: /* DDX */

2014-11-20T11:31:25Z

DDX

← Older revision		Revision as of 11:31, 20 November 2014
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	**Small cell osteosarcoma - Sox10 negative, no cartilage		**Small cell osteosarcoma - Sox10 negative, no cartilage
	**Ewing sarcoma - Both are CD99 positive but ES is Sox9 negative, no cartilage		**Ewing sarcoma - Both are CD99 positive but ES is Sox9 negative, no cartilage
			**Monophasic synovial sarcoma - also can have the hemangiopericytomatous vasculature

	==Molecular==		==Molecular==

Sarah at 11:27, 20 November 2014

2014-11-20T11:27:45Z

← Older revision		Revision as of 11:27, 20 November 2014
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	*S100 (positive in chondrocytes not in small cells).		*S100 (positive in chondrocytes not in small cells).
	*Osteocalcin (negative in small cells).		*Osteocalcin (negative in small cells).
			*CD99 - (positive in small cells)

	==DDX==		==DDX==

Sarah at 11:26, 20 November 2014

2014-11-20T11:26:11Z

← Older revision		Revision as of 11:26, 20 November 2014
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	==Microscopic==		==Microscopic==
	*"White clouds in a blue sky".		'White clouds in a dark blue sky'

	*Malignant tumor with a characteristic biphasic pattern		*Malignant tumor with a characteristic biphasic pattern
	**Cellular poorly differentiated small round blue cells		**Cellular poorly differentiated small round blue cells
			**Can have a hemangiopericytomatous vascular pattern
	**Islands of well-differentiated hyaline cartilage		**Islands of well-differentiated hyaline cartilage
	***Progressive maturation of cartilage towards the center		***Progressive maturation of cartilage towards the center
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	*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].		*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].
	*Web Pathology - This example evokes hemangiopericytoma [http://www.webpathology.com/images/noimage.gif].		*Web Pathology - This example evokes hemangiopericytoma [http://www.webpathology.com/images/noimage.gif].
	*~~Web~~ Pathology - ~~close up of small cells~~ [http://www.~~webpathology~~.com/images/~~noimage~~.~~gif~~]		*Pathology Outlines - Another hemangiopericytomatous example [http://pathologyoutlines.com/wick/chondrosarcoma%20mesenchymal%20type%20micro0007.jpg]
			*Sarcoma Images - [http://www.sarcomaimages.com/index.php?v=Mesenchymal-Chondrosarcoma]
			*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_poIB6FYZQ73wh.jpg]
			*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_9oJtTQXXxaEB3.jpg]
			*CNS Atlas - [http://www.cnsatlas.com/medicalatlas/images/370/800_8h2C7upeOj3EB.jpg]


	==IHC==		==IHC==
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	*S100 (positive in chondrocytes not in small cells).		*S100 (positive in chondrocytes not in small cells).
	*Osteocalcin (negative in small cells).		*Osteocalcin (negative in small cells).

			==DDX==
			Depends a bit on where the tumor is located and how much cartilage is readily visible.
			**Hemangiopericytoma - no cartilage
			**Lymphoma - Sox9 negative, CD45 positive
			**Metaplastic Glioblastoma - usually older adults - GFAP positive
			**Chondrosarcoma - usually older adults - hyaline cartilage is malignant
			**Small cell osteosarcoma - Sox10 negative, no cartilage
			**Ewing sarcoma - Both are CD99 positive but ES is Sox9 negative, no cartilage

	==Molecular==		==Molecular==
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	*[[Cartilage]].		*[[Cartilage]].
	*[[Chondrosarcoma]].		*[[Chondrosarcoma]].
			*Web Pathology[http://www.webpathology.com/image.asp?case=332&n=41]
			*Pathology Oulines [http://www.pathologyoutlines.com/topic/bonemesenchymalchondrosarcoma.html]
	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}

Sarah: /* Images */

2014-11-20T11:01:46Z

Images

← Older revision		Revision as of 11:01, 20 November 2014
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	www:		www:
	*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].		*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].
			*Web Pathology - This example evokes hemangiopericytoma [http://www.webpathology.com/images/noimage.gif].
			*Web Pathology - close up of small cells [http://www.webpathology.com/images/noimage.gif]

	==IHC==		==IHC==