Microglandular hyperplasia of the uterine cervix - Revision history

Michael at 04:53, 3 March 2014

2014-03-03T04:53:09Z

← Older revision		Revision as of 04:53, 3 March 2014
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	\| Tx =		\| Tx =
	}}		}}
	'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding the [[uterine cervix]] that may be confused with malignancy, especially [[endocervical adenocarcinoma]]. It is usually referred to simply as '''microglandular hyperplasia''', abbreviated '''MGH''', and is also known as '''microglandular change'''.		'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding of the [[uterine cervix]] that may be confused with malignancy, especially [[endocervical adenocarcinoma]]. It is usually referred to simply as '''microglandular hyperplasia''', abbreviated '''MGH''', and is also known as '''microglandular change'''.

	It should '''not''' to be confused with ''[[microglandular adenosis]]''.		It should '''not''' to be confused with ''[[microglandular adenosis]]''.

Michael: /* See also */

2014-02-23T13:49:02Z

Michael: /* Images */

2014-02-04T00:16:11Z

Images

← Older revision		Revision as of 00:16, 4 February 2014
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	===Images===		===Images===
			<gallery>
			Image: Microglandular hyperplasia -- low mag.jpg \| MGH - low mag.
			Image: Microglandular hyperplasia -- intermed mag.jpg \| MGH - intermed. mag.
			Image: Microglandular hyperplasia -- high mag.jpg \| MGH - high mag.
			Image: Microglandular hyperplasia - alt 1 -- high mag.jpg \| MGH - high mag.
			Image: Microglandular hyperplasia - alt 2 -- high mag.jpg \| MGH - high mag.
			</gallery>
	www:		www:
	*[http://www.nature.com/modpathol/journal/v13/n3/fig_tab/3880047f14.html#figure-title MGH (nature.com)].		*[http://www.nature.com/modpathol/journal/v13/n3/fig_tab/3880047f14.html#figure-title MGH (nature.com)].

Michael at 00:10, 4 February 2014

2014-02-04T00:10:31Z

← Older revision		Revision as of 00:10, 4 February 2014
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	\| Caption = Microglandular hyperplasia. [[H&E stain]].		\| Caption = Microglandular hyperplasia. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = crowded small glands (classic), reticular or solid, cytologically benign - usually cuboidal morphology, typically clear cytoplasm
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[Endocervical adenocarcinoma in situ\|adenocarcinoma in situ of the uterine cervix]], endometrial mucinous microglandular adenocarcinoma, [[clear cell carcinoma of the uterine cervix]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

Michael at 00:07, 4 February 2014

2014-02-04T00:07:52Z

← Older revision		Revision as of 00:07, 4 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Microglandular_hyperplasia_--_intermed_mag.jpg
			\| Width =
			\| Caption = Microglandular hyperplasia. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[uterine cervix]]
			\| Assdx = [[OCP]] use
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding the [[uterine cervix]] that may be confused with malignancy, especially [[endocervical adenocarcinoma]]. It is usually referred to simply as '''microglandular hyperplasia''', abbreviated '''MGH''', and is also known as '''microglandular change'''.		'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding the [[uterine cervix]] that may be confused with malignancy, especially [[endocervical adenocarcinoma]]. It is usually referred to simply as '''microglandular hyperplasia''', abbreviated '''MGH''', and is also known as '''microglandular change'''.

Michael at 01:40, 19 December 2013

2013-12-19T01:40:02Z

← Older revision		Revision as of 01:40, 19 December 2013
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	'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding the [[uterine cervix]] that may be confused with malignancy.		'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding the [[uterine cervix]] that may be confused with malignancy, especially [[endocervical adenocarcinoma]]. It is usually referred to simply as '''microglandular hyperplasia''', abbreviated '''MGH''', and is also known as '''microglandular change'''.

	It is ~~also~~ simply ~~known~~ '''microglandular hyperplasia''', abbreviated '''MGH''', is also known as '''microglandular change'''

	It should '''not''' to be confused with ''[[microglandular adenosis]]''.		It should '''not''' to be confused with ''[[microglandular adenosis]]''.

Michael: split out/create

2013-12-19T01:38:00Z

split out/create

New page

'''Microglandular hyperplasia of the uterine cervix''' is a relatively common benign finding the [[uterine cervix]] that may be confused with malignancy.

It is also simply known '''microglandular hyperplasia''', abbreviated '''MGH''', is also known as '''microglandular change'''

It should '''not''' to be confused with ''[[microglandular adenosis]]''.

==General==
*Associated with [[OCP]] use.<ref name=pmid10757337>{{Cite journal | last1 = Zaino | first1 = RJ. | title = Glandular lesions of the uterine cervix. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 261-74 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880047 | PMID = 10757337 | URL = http://www.nature.com/modpathol/journal/v13/n3/full/3880047a.html }}</ref>
*May be confused with adenocarcinoma.<ref name=pmid7234352>{{Cite journal | last1 = Jobo | first1 = T. | last2 = Kuramoto | first2 = H. | last3 = Morisawa | first3 = T. | title = [Microglandular hyperplasia of the cervix: reevaluation of the polyp (author's transl)]. | journal = Acta Obstet Gynaecol Jpn | volume = 33 | issue = 5 | pages = 651-8 | month = May | year = 1981 | doi = | PMID = 7234352 }}</ref>
==Gross==
Features:
*Yellowish polypoid/papillary lesion.<ref name=cxhealth>URL: [http://www.cervicalhealth.com/colposcopy.php http://www.cervicalhealth.com/colposcopy.php]. Accessed on: 18 December 2013.</ref><ref name=pmid7234352/>

Images:
*[http://www.cervicalhealth.com/colposcopy.php MGH at colposcopy (cervicalhealth.com)].<ref name=cxhealth/>

==Microscopic==
Features:<ref name=pmid10757337/>
*Cytologically benign - '''important'''.
**Usually cuboidal morphology.
**Typically clear cytoplasm.
*Crowded small glands (classic), reticular or solid.

Significant negatives:
*Nuclear atypia absent.
*[[NC ratio]] not significantly increased.

DDx:
*[[Endocervical adenocarcinoma in situ|Adenocarcinoma in situ of the uterine cervix]].
*Endometrial mucinous microglandular adenocarcinoma - very rare.<ref name=pmid16306789>{{Cite journal | last1 = Giordano | first1 = G. | last2 = D'Adda | first2 = T. | last3 = Gnetti | first3 = L. | last4 = Merisio | first4 = C. | last5 = Melpignano | first5 = M. | title = Endometrial mucinous microglandular adenocarcinoma: morphologic, immunohistochemical features, and emphasis in the human papillomavirus status. | journal = Int J Gynecol Pathol | volume = 25 | issue = 1 | pages = 77-82 | month = Jan | year = 2006 | doi = | PMID = 16306789 }}</ref><ref name=pmid12808571>{{Cite journal | last1 = Zamecnik | first1 = M. | last2 = Skalova | first2 = A. | last3 = Opatrny | first3 = V. | title = Microglandular adenocarcinoma of the uterus mimicking microglandular cervical hyperplasia. | journal = Ann Diagn Pathol | volume = 7 | issue = 3 | pages = 180-6 | month = Jun | year = 2003 | doi = | PMID = 12808571 }}</ref>
*[[Clear cell carcinoma of the uterine cervix]].<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref>

===Images===
www:
*[http://www.nature.com/modpathol/journal/v13/n3/fig_tab/3880047f14.html#figure-title MGH (nature.com)].
*[http://sunnybrook.ca/uploads/cx_MGH_5_vd.jpg MGH (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro]. Accessed on: 25 February 2012.</ref>

==IHC==
Features:<ref name=pmid12819393>{{Cite journal | last1 = Qiu | first1 = W. | last2 = Mittal | first2 = K. | title = Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometrium. | journal = Int J Gynecol Pathol | volume = 22 | issue = 3 | pages = 261-5 | month = Jul | year = 2003 | doi = 10.1097/01.PGP.0000071043.12278.8D | PMID = 12819393 }}</ref>
*Ki-67 ~ 0.5% cells.
*Vimentin -ve.
*PR +ve ~ 60% of cases.
*ER +ve/-ve.

Others:<ref name=pmid12819393/>
*p53 -ve.
*CEA -ve.
*p16 -ve (scattered cells +ve).{{fact}}

==Sign out==
<pre>
UTERINE ENDOCERVIX, CURETTAGE:
- MICROGLANDULAR HYPERPLASIA.
- SQUAMOUS EPITHELIUM WITH REACTIVE CHANGES AND METAPLASTIC CHANGES.
</pre>

===Micro===
The sections show gland forming epithelium without nuclear atypia (no nuclear membrane
irregularities, no coarse chromatin). The nuclei are less than 2x the size of a neutrophil,
regularly spaced, pale staining and have small regular nucleoli visible with the 20x
objective. No mitotic activity is apparent.

Fragments of reactive squamous epithelium with metaplastic changes are present. Benign
superficial squamous epithelium is identified.

==See also==
*[[Uterine cervix]].

==References==
{{Reflist|2}}

[[Category:Diagnosis]]
[[Category:Uterine cervix]]

← Older revision		Revision as of 13:49, 23 February 2014
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	==See also==		==See also==
	*[[Uterine cervix]].		*[[Uterine cervix]].
			*[[Adenocarcinoma of the uterine cervix]].

	==References==		==References==