Minimal deviation adenocarcinoma of the uterine cervix - Revision history

Michael: /* IHC */

2016-03-13T23:18:06Z

IHC

← Older revision		Revision as of 23:18, 13 March 2016
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	==IHC==		==IHC==
	Features:		Features:
	*CEA +ve.<ref name=pmid2764221/>		*[[CEA]] +ve.<ref name=pmid2764221/>
	*p16 -ve.<ref name=pmid21497449>{{Cite journal \| last1 = He \| first1 = Y. \| last2 = Li \| first2 = L. \| last3 = Jiang \| first3 = W. \| last4 = Wang \| first4 = DQ. \| last5 = Xu \| first5 = L. \| last6 = Huang \| first6 = Q. \| last7 = Zhang \| first7 = Y. \| last8 = Yang \| first8 = KX. \| title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. \| journal = Pathol Res Pract \| volume = 207 \| issue = 5 \| pages = 295-9 \| month = May \| year = 2011 \| doi = 10.1016/j.prp.2011.02.011 \| PMID = 21497449 }}</ref>		*[[p16]] -ve.<ref name=pmid21497449>{{Cite journal \| last1 = He \| first1 = Y. \| last2 = Li \| first2 = L. \| last3 = Jiang \| first3 = W. \| last4 = Wang \| first4 = DQ. \| last5 = Xu \| first5 = L. \| last6 = Huang \| first6 = Q. \| last7 = Zhang \| first7 = Y. \| last8 = Yang \| first8 = KX. \| title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. \| journal = Pathol Res Pract \| volume = 207 \| issue = 5 \| pages = 295-9 \| month = May \| year = 2011 \| doi = 10.1016/j.prp.2011.02.011 \| PMID = 21497449 }}</ref>

	==See also==		==See also==

Michael: /* Microscopic */

2016-03-13T23:17:23Z

Microscopic

← Older revision		Revision as of 23:17, 13 March 2016
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	DDx:<ref name=pmid12828609/>		DDx:<ref name=pmid12828609/>
	*[[Adenocarcinoma of the uterine cervix]] - has "obvious" nuclear atypia.		*[[Adenocarcinoma of the uterine cervix]] - has "obvious" [[nuclear atypia]].
	*[[Tunnel cluster]].		*[[Tunnel cluster]].

Michael: /* General */

2016-03-13T23:12:21Z

General

← Older revision		Revision as of 23:12, 13 March 2016
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	*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal \| last1 = Riegert-Johnson \| first1 = D. \| last2 = Roberts \| first2 = M. \| last3 = Gleeson \| first3 = FC. \| last4 = Krishna \| first4 = M. \| last5 = Boardman \| first5 = L. \| title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. \| journal = Fam Cancer \| volume = 10 \| issue = 3 \| pages = 463-8 \| month = Sep \| year = 2011 \| doi = 10.1007/s10689-011-9438-x \| PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal \| last1 = Ito \| first1 = M. \| last2 = Minamiguchi \| first2 = S. \| last3 = Mikami \| first3 = Y. \| last4 = Ueda \| first4 = Y. \| last5 = Sekiyama \| first5 = K. \| last6 = Yamamoto \| first6 = T. \| last7 = Takakura \| first7 = K. \| title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. \| journal = Pathol Res Pract \| volume = \| issue = \| pages = \| month = Aug \| year = 2012 \| doi = 10.1016/j.prp.2012.06.008 \| PMID = 22878090 }}</ref>		*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal \| last1 = Riegert-Johnson \| first1 = D. \| last2 = Roberts \| first2 = M. \| last3 = Gleeson \| first3 = FC. \| last4 = Krishna \| first4 = M. \| last5 = Boardman \| first5 = L. \| title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. \| journal = Fam Cancer \| volume = 10 \| issue = 3 \| pages = 463-8 \| month = Sep \| year = 2011 \| doi = 10.1007/s10689-011-9438-x \| PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal \| last1 = Ito \| first1 = M. \| last2 = Minamiguchi \| first2 = S. \| last3 = Mikami \| first3 = Y. \| last4 = Ueda \| first4 = Y. \| last5 = Sekiyama \| first5 = K. \| last6 = Yamamoto \| first6 = T. \| last7 = Takakura \| first7 = K. \| title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. \| journal = Pathol Res Pract \| volume = \| issue = \| pages = \| month = Aug \| year = 2012 \| doi = 10.1016/j.prp.2012.06.008 \| PMID = 22878090 }}</ref>
	*Poor prognosis.<ref name=pmid2764221>{{Cite journal \| last1 = Gilks \| first1 = CB. \| last2 = Young \| first2 = RH. \| last3 = Aguirre \| first3 = P. \| last4 = DeLellis \| first4 = RA. \| last5 = Scully \| first5 = RE. \| title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 9 \| pages = 717-29 \| month = Sep \| year = 1989 \| doi = \| PMID = 2764221 }}</ref>		*Poor prognosis.<ref name=pmid2764221>{{Cite journal \| last1 = Gilks \| first1 = CB. \| last2 = Young \| first2 = RH. \| last3 = Aguirre \| first3 = P. \| last4 = DeLellis \| first4 = RA. \| last5 = Scully \| first5 = RE. \| title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 9 \| pages = 717-29 \| month = Sep \| year = 1989 \| doi = \| PMID = 2764221 }}</ref>
			*Not associated with [[HPV]] - unlike most [[adenocarcinoma of the uterine cervix]].

	Note:		Note:

Michael at 23:11, 13 March 2016

2016-03-13T23:11:19Z

← Older revision		Revision as of 23:11, 13 March 2016
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	It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').		It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').

	It is a subset of ''adenocarcinoma of the uterine cervix'', which is dealt with in the ''[[adenocarcinoma of the uterine cervix]]'' article.		It is a subset of ''adenocarcinoma of the uterine cervix'', which is dealt with in the [[adenocarcinoma of the uterine cervix]] article.

	==General==		==General==

Michael at 23:11, 13 March 2016

2016-03-13T23:11:05Z

← Older revision		Revision as of 23:11, 13 March 2016
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	It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').		It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').

			It is a subset of ''adenocarcinoma of the uterine cervix'', which is dealt with in the ''[[adenocarcinoma of the uterine cervix]]'' article.

	==General==		==General==

Michael at 23:09, 13 March 2016

2016-03-13T23:09:30Z

← Older revision		Revision as of 23:09, 13 March 2016
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	'''Minimal deviation adenocarcinoma of the uterine cervix''' is a very well-differentiated [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]].		'''Minimal deviation adenocarcinoma of the uterine cervix''' is a very well-differentiated [[adenocarcinoma of the uterine cervix]] associated with [[Peutz-Jeghers syndrome]].

	It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').		It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').

Michael: /* General */

2016-03-13T22:58:57Z

General

← Older revision		Revision as of 22:58, 13 March 2016
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	Note:		Note:
	*Very well-differentiated adenocarcinoma may also be seen in the stomach;<ref name=pmid15533229>{{Cite journal \| last1 = Nokubi \| first1 = M. \| last2 = Kawanowa \| first2 = K. \| last3 = Kawata \| first3 = H. \| last4 = Hanatsuka \| first4 = K. \| last5 = Hosoya \| first5 = Y. \| title = Extremely well-differentiated adenocarcinoma of the gastric cardia: a unique case with columnar cells and laminated stones. \| journal = Pathol Int \| volume = 54 \| issue = 11 \| pages = 854-60 \| month = Nov \| year = 2004 \| doi = 10.1111/j.1440-1827.2004.01769.x \| PMID = 15533229 }}</ref> however, ~~these do~~ not appear to be related to the well-differentiated adenocarcinoma in the cervix.		*Very well-differentiated adenocarcinoma may also be seen in the stomach;<ref name=pmid15533229>{{Cite journal \| last1 = Nokubi \| first1 = M. \| last2 = Kawanowa \| first2 = K. \| last3 = Kawata \| first3 = H. \| last4 = Hanatsuka \| first4 = K. \| last5 = Hosoya \| first5 = Y. \| title = Extremely well-differentiated adenocarcinoma of the gastric cardia: a unique case with columnar cells and laminated stones. \| journal = Pathol Int \| volume = 54 \| issue = 11 \| pages = 854-60 \| month = Nov \| year = 2004 \| doi = 10.1111/j.1440-1827.2004.01769.x \| PMID = 15533229 }}</ref> however, this does not appear to be related to the well-differentiated adenocarcinoma in the cervix.

	==Microscopic==		==Microscopic==

Michael at 22:53, 13 March 2016

2016-03-13T22:53:18Z

← Older revision		Revision as of 22:53, 13 March 2016
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	'''Minimal deviation adenocarcinoma of the uterine cervix''' is ~~rare bland form of~~ [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]].		'''Minimal deviation adenocarcinoma of the uterine cervix''' is a very well-differentiated [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]].

	It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').		It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').

	==General==		==General==
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	*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal \| last1 = Riegert-Johnson \| first1 = D. \| last2 = Roberts \| first2 = M. \| last3 = Gleeson \| first3 = FC. \| last4 = Krishna \| first4 = M. \| last5 = Boardman \| first5 = L. \| title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. \| journal = Fam Cancer \| volume = 10 \| issue = 3 \| pages = 463-8 \| month = Sep \| year = 2011 \| doi = 10.1007/s10689-011-9438-x \| PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal \| last1 = Ito \| first1 = M. \| last2 = Minamiguchi \| first2 = S. \| last3 = Mikami \| first3 = Y. \| last4 = Ueda \| first4 = Y. \| last5 = Sekiyama \| first5 = K. \| last6 = Yamamoto \| first6 = T. \| last7 = Takakura \| first7 = K. \| title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. \| journal = Pathol Res Pract \| volume = \| issue = \| pages = \| month = Aug \| year = 2012 \| doi = 10.1016/j.prp.2012.06.008 \| PMID = 22878090 }}</ref>		*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal \| last1 = Riegert-Johnson \| first1 = D. \| last2 = Roberts \| first2 = M. \| last3 = Gleeson \| first3 = FC. \| last4 = Krishna \| first4 = M. \| last5 = Boardman \| first5 = L. \| title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. \| journal = Fam Cancer \| volume = 10 \| issue = 3 \| pages = 463-8 \| month = Sep \| year = 2011 \| doi = 10.1007/s10689-011-9438-x \| PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal \| last1 = Ito \| first1 = M. \| last2 = Minamiguchi \| first2 = S. \| last3 = Mikami \| first3 = Y. \| last4 = Ueda \| first4 = Y. \| last5 = Sekiyama \| first5 = K. \| last6 = Yamamoto \| first6 = T. \| last7 = Takakura \| first7 = K. \| title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. \| journal = Pathol Res Pract \| volume = \| issue = \| pages = \| month = Aug \| year = 2012 \| doi = 10.1016/j.prp.2012.06.008 \| PMID = 22878090 }}</ref>
	*Poor prognosis.<ref name=pmid2764221>{{Cite journal \| last1 = Gilks \| first1 = CB. \| last2 = Young \| first2 = RH. \| last3 = Aguirre \| first3 = P. \| last4 = DeLellis \| first4 = RA. \| last5 = Scully \| first5 = RE. \| title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 9 \| pages = 717-29 \| month = Sep \| year = 1989 \| doi = \| PMID = 2764221 }}</ref>		*Poor prognosis.<ref name=pmid2764221>{{Cite journal \| last1 = Gilks \| first1 = CB. \| last2 = Young \| first2 = RH. \| last3 = Aguirre \| first3 = P. \| last4 = DeLellis \| first4 = RA. \| last5 = Scully \| first5 = RE. \| title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 9 \| pages = 717-29 \| month = Sep \| year = 1989 \| doi = \| PMID = 2764221 }}</ref>

			Note:
			*Very well-differentiated adenocarcinoma may also be seen in the stomach;<ref name=pmid15533229>{{Cite journal \| last1 = Nokubi \| first1 = M. \| last2 = Kawanowa \| first2 = K. \| last3 = Kawata \| first3 = H. \| last4 = Hanatsuka \| first4 = K. \| last5 = Hosoya \| first5 = Y. \| title = Extremely well-differentiated adenocarcinoma of the gastric cardia: a unique case with columnar cells and laminated stones. \| journal = Pathol Int \| volume = 54 \| issue = 11 \| pages = 854-60 \| month = Nov \| year = 2004 \| doi = 10.1111/j.1440-1827.2004.01769.x \| PMID = 15533229 }}</ref> however, these do not appear to be related to the well-differentiated adenocarcinoma in the cervix.

	==Microscopic==		==Microscopic==

Michael at 21:57, 13 March 2016

2016-03-13T21:57:47Z

← Older revision		Revision as of 21:57, 13 March 2016
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	'''Minimal deviation adenocarcinoma of the uterine cervix''' is rare bland form of [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]].		'''Minimal deviation adenocarcinoma of the uterine cervix''' is rare bland form of [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]].

			It is also known as '''adenoma malignum''' and '''minimal deviation adenocarcinoma''' (abbreviated '''MDA''').

	==General==		==General==

Michael: split out

2016-03-13T21:55:54Z

split out

← Older revision		Revision as of 21:55, 13 March 2016
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	~~#redirect~~ [[~~Uterine_cervix#Minimal_deviation_adenocarcinoma_of_the_uterine_cervix~~]]		'''Minimal deviation adenocarcinoma of the uterine cervix''' is rare bland form of [[adenocarcinoma]] of the [[uterine cervix]] associated with [[Peutz-Jeghers syndrome]].

			==General==
			*Rare and difficult diagnosis.<ref name=pmid12828609>{{Cite journal \| last1 = Tsuda \| first1 = H. \| last2 = Mikami \| first2 = Y. \| last3 = Kaku \| first3 = T. \| last4 = Akiyama \| first4 = F. \| last5 = Hasegawa \| first5 = T. \| last6 = Okada \| first6 = S. \| last7 = Hayashi \| first7 = I. \| last8 = Kasamatsu \| first8 = T. \| title = Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. \| journal = Pathol Int \| volume = 53 \| issue = 7 \| pages = 440-9 \| month = Jul \| year = 2003 \| doi = \| PMID = 12828609 }}</ref>
			**Requires a deep sampling;<ref name=pmid22385609>{{Cite journal \| last1 = Lim \| first1 = KT. \| last2 = Lee \| first2 = IH. \| last3 = Kim \| first3 = TJ. \| last4 = Kwon \| first4 = YS. \| last5 = Jeong \| first5 = JG. \| last6 = Shin \| first6 = SJ. \| title = Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases. \| journal = Kaohsiung J Med Sci \| volume = 28 \| issue = 3 \| pages = 161-4 \| month = Mar \| year = 2012 \| doi = 10.1016/j.kjms.2011.10.009 \| PMID = 22385609 }}</ref> thus, usually diagnosed on cone biopsy or hysterectomy.
			*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal \| last1 = Riegert-Johnson \| first1 = D. \| last2 = Roberts \| first2 = M. \| last3 = Gleeson \| first3 = FC. \| last4 = Krishna \| first4 = M. \| last5 = Boardman \| first5 = L. \| title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. \| journal = Fam Cancer \| volume = 10 \| issue = 3 \| pages = 463-8 \| month = Sep \| year = 2011 \| doi = 10.1007/s10689-011-9438-x \| PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal \| last1 = Ito \| first1 = M. \| last2 = Minamiguchi \| first2 = S. \| last3 = Mikami \| first3 = Y. \| last4 = Ueda \| first4 = Y. \| last5 = Sekiyama \| first5 = K. \| last6 = Yamamoto \| first6 = T. \| last7 = Takakura \| first7 = K. \| title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. \| journal = Pathol Res Pract \| volume = \| issue = \| pages = \| month = Aug \| year = 2012 \| doi = 10.1016/j.prp.2012.06.008 \| PMID = 22878090 }}</ref>
			*Poor prognosis.<ref name=pmid2764221>{{Cite journal \| last1 = Gilks \| first1 = CB. \| last2 = Young \| first2 = RH. \| last3 = Aguirre \| first3 = P. \| last4 = DeLellis \| first4 = RA. \| last5 = Scully \| first5 = RE. \| title = Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 9 \| pages = 717-29 \| month = Sep \| year = 1989 \| doi = \| PMID = 2764221 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_WMSP441-2>{{Ref WMSP\|441-2}}</ref>
			*Deep infiltrating glands - '''key feature'''.
			**Desmoplastic stroma - may be subtle.
			**Perivascular and/or perineural location.
			*Minimal nuclear atypia.
			*Abnormal gland morphology<ref name=pmid2764221/> / loss of lobular (gland) architecture. †

			Note:
			*† '''Not''' a criterion required by all pathologists.<ref name=pmid12828609/>

			DDx:<ref name=pmid12828609/>
			*[[Adenocarcinoma of the uterine cervix]] - has "obvious" nuclear atypia.
			*[[Tunnel cluster]].

			==IHC==
			Features:
			*CEA +ve.<ref name=pmid2764221/>
			*p16 -ve.<ref name=pmid21497449>{{Cite journal \| last1 = He \| first1 = Y. \| last2 = Li \| first2 = L. \| last3 = Jiang \| first3 = W. \| last4 = Wang \| first4 = DQ. \| last5 = Xu \| first5 = L. \| last6 = Huang \| first6 = Q. \| last7 = Zhang \| first7 = Y. \| last8 = Yang \| first8 = KX. \| title = Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma. \| journal = Pathol Res Pract \| volume = 207 \| issue = 5 \| pages = 295-9 \| month = May \| year = 2011 \| doi = 10.1016/j.prp.2011.02.011 \| PMID = 21497449 }}</ref>

			==See also==
			*[[Uterine cervix]].
			*[[Peutz-Jeghers polyp]].

			==References==
			{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Uterine cervix]]