Mucinous borderline tumour of the ovary - Revision history

Michael: pictures don't match - remove

2018-03-01T16:39:10Z

pictures don't match - remove

← Older revision		Revision as of 16:39, 1 March 2018
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	*[[Mucinous cystadenoma of the ovary]] with focal proliferation.		*[[Mucinous cystadenoma of the ovary]] with focal proliferation.

	Images:		<!-- Images: -->
	*[http://www.webpathology.com/image.asp?case=526&n=7 Ovarian MBT (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=6&Case=526 Ovarian mucinous borderline tumour and benign mucinous tumour (webpathology.com)].

	===Endocervical type mucinous borderline tumour of the ovary===		===Endocervical type mucinous borderline tumour of the ovary===
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	*Neutrophils associated with the epithelium/mucin - common.<ref>URL: [http://www.webpathology.com/image.asp?n=12&Case=526 http://www.webpathology.com/image.asp?n=12&Case=526]. Accessed on: 9 January 2013.</ref>		*Neutrophils associated with the epithelium/mucin - common.<ref>URL: [http://www.webpathology.com/image.asp?n=12&Case=526 http://www.webpathology.com/image.asp?n=12&Case=526]. Accessed on: 9 January 2013.</ref>

	Images:		<!-- Images: -->
	*[http://www.webpathology.com/image.asp?n=13&Case=526 Endocervical type mucinous borderline tumour - ~~low mag. (webpathology.com)].~~
	*[http://www.webpathology.com/image.asp?n=12&Case=526 Endocervical type mucinous borderline tumour - ~~high mag. (webpathology.com)].~~

	===Comparing intestinal versus endocervical===		===Comparing intestinal versus endocervical===
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	\|-		\|-
	\| Images		\| Images
	\| ~~[http://www.webpathology.com/image.asp?case=526&n=7 high mag. (webpathology.com)]~~		\|
	\| ~~[http://www.webpathology.com/image.asp?n=13&Case=526 low mag. (webpathology.com)], [http://www.webpathology.com/image.asp?n=12&Case=526 high mag. (webpathology.com)]~~		\|
	\|}		\|}

Michael at 16:32, 1 March 2018

2018-03-01T16:32:22Z

← Older revision		Revision as of 16:32, 1 March 2018
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	\| [http://www.webpathology.com/image.asp?n=13&Case=526 low mag. (webpathology.com)], [http://www.webpathology.com/image.asp?n=12&Case=526 high mag. (webpathology.com)]		\| [http://www.webpathology.com/image.asp?n=13&Case=526 low mag. (webpathology.com)], [http://www.webpathology.com/image.asp?n=12&Case=526 high mag. (webpathology.com)]
	\|}		\|}

			==Molecular==
			*[[KRAS mutation]]s common ~ 73% of mucinous borderline tumours in one series.<ref name=pmid9118042>{{Cite journal \| last1 = Cuatrecasas \| first1 = M. \| last2 = Villanueva \| first2 = A. \| last3 = Matias-Guiu \| first3 = X. \| last4 = Prat \| first4 = J. \| title = K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases. \| journal = Cancer \| volume = 79 \| issue = 8 \| pages = 1581-6 \| month = Apr \| year = 1997 \| doi = \| PMID = 9118042 }}</ref>

	==Sign out==		==Sign out==

Michael: split out

2018-02-15T16:18:24Z

split out

← Older revision		Revision as of 16:18, 15 February 2018
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	~~#redirect[[Ovarian tumours#~~Mucinous borderline tumour of the ovary]]		'''Mucinous borderline tumour of the ovary''' is an [[ovarian tumour]] with a low malignant potential.

			It is also known as '''ovarian mucinous borderline tumour''' and '''ovarian mucinous tumour of low malignant potential'''.<ref name=pmid21464732>{{Cite journal \| last1 = Khunamornpong \| first1 = S. \| last2 = Settakorn \| first2 = J. \| last3 = Sukpan \| first3 = K. \| last4 = Suprasert \| first4 = P. \| last5 = Siriaunkgul \| first5 = S. \| title = Mucinous tumor of low malignant potential (borderline or atypical proliferative tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. \| journal = Int J Gynecol Pathol \| volume = 30 \| issue = 3 \| pages = 218-30 \| month = May \| year = 2011 \| doi = 10.1097/PGP.0b013e3181fcf01a \| PMID = 21464732 }}</ref>

			==General==
			*Requires extensive sampling - to avoid missing an adenocarcinoma.

			Note:
			*The WHO prefers ''borderline'' over ''low malignant potential'' as the descriptor for these tumours.<ref name=pmid16100867>{{Cite journal \| last1 = Acs \| first1 = G. \| title = Serous and mucinous borderline (low malignant potential) tumors of the ovary. \| journal = Am J Clin Pathol \| volume = 123 Suppl \| issue = \| pages = S13-57 \| month = Jun \| year = 2005 \| doi = \| PMID = 16100867 }}</ref>

			===Classification===
			Subdivided into:<ref name=pmid15371946>{{Cite journal \| last1 = Rodriguez \| first1 = IM. \| last2 = Irving \| first2 = JA. \| last3 = Prat \| first3 = J. \| title = Endocervical-like mucinous borderline tumors of the ovary: a clinicopathologic analysis of 31 cases. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 10 \| pages = 1311-8 \| month = Oct \| year = 2004 \| doi = \| PMID = 15371946 }}</ref>
			# Intestinal type mucinous borderline tumour of the ovary ~ 90% of cases.
			# Endocervical type mucinous borderline tumour of the ovary ~ 10% of cases.<ref name=Ref_GP419>{{Ref GP\|419}}</ref>

			==Gross==
			''Intestinal type mucinous borderline tumour of the ovary'' and ''endocervical type mucinous borderline tumour of the ovary'':
			*Complex multiloculated mass with mucin.
			*Often large - may > 30 cm.

			==Microscopic==
			===Intestinal type mucinous borderline tumour of the ovary===
			Features:
			*Mucinous differentiation:
			**Tall [[columnar cell]]s with apical mucin - usu. resembles gastric foveolar epithelium.
			*Layering of epithelial cells (stratification).
			**Must be <= 3 cells.<ref name=Ref_GP416>{{Ref GP\|416}}</ref>
			*+/-Papillary infoldings.
			**Projections into the cystic space.
			*+/-Mild nuclear atypia.
			*+/-Mitoses (focally).

			Notes:
			#Resembles a [[villous adenoma]] of the [[colon]].<ref name=Ref_GP>{{Ref GP\|416}}</ref>
			#Borderline component must be >= 10% of the tumour.<ref name=Ref_GP>{{Ref GP\|416}}</ref>
			#*Lesions with <10% borderline component are known as ''[[mucinous cystadenoma of the ovary]] with focal proliferation'' or ''[[mucinous cystadenoma of the ovary]] with focal atypia''.

			DDx:
			*[[Mucinous adenocarcinoma of the ovary]].
			*[[Mucinous cystadenoma of the ovary]].
			*[[Mucinous cystadenoma of the ovary]] with focal proliferation.

			Images:
			*[http://www.webpathology.com/image.asp?case=526&n=7 Ovarian MBT (webpathology.com)].
			*[http://www.webpathology.com/image.asp?n=6&Case=526 Ovarian mucinous borderline tumour and benign mucinous tumour (webpathology.com)].

			===Endocervical type mucinous borderline tumour of the ovary===
			Features:<ref name=Ref_GP420>{{Ref GP\|420}}</ref>
			#Cells with mucinous differentiation resembling endocervical epithelium:
			#*Tall [[columnar cell]]s with grey apical mucin.
			#Cells with eosinophilic cytoplasm - known as "pink cells".
			#Ciliated cells.
			*Neutrophils associated with the epithelium/mucin - common.<ref>URL: [http://www.webpathology.com/image.asp?n=12&Case=526 http://www.webpathology.com/image.asp?n=12&Case=526]. Accessed on: 9 January 2013.</ref>

			Images:
			*[http://www.webpathology.com/image.asp?n=13&Case=526 Endocervical type mucinous borderline tumour - low mag. (webpathology.com)].
			*[http://www.webpathology.com/image.asp?n=12&Case=526 Endocervical type mucinous borderline tumour - high mag. (webpathology.com)].

			===Comparing intestinal versus endocervical===
			{\| class="wikitable sortable"
			! Feature
			! Intestinal
			! Endocervical
			\|-
			\| Primary mucin producing cell
			\| clear - well-diff. component, eosinophilic (pink)
			\| eosinophilic (pink), grey or clear
			\|-
			\| Size
			\| tall columnar (height:width >3:1) "champagne flute"
			\| stubby columnar (height:width <3:1)
			\|-
			\| Accompanying epithelial cells
			\| +/-goblet cells
			\| pink cells, ciliated cells
			\|-
			\| Other cells
			\| none
			\| neutrophils (intraepithelial) - common
			\|-
			\| Images
			\| [http://www.webpathology.com/image.asp?case=526&n=7 high mag. (webpathology.com)]
			\| [http://www.webpathology.com/image.asp?n=13&Case=526 low mag. (webpathology.com)], [http://www.webpathology.com/image.asp?n=12&Case=526 high mag. (webpathology.com)]
			\|}

			==Sign out==
			<pre>
			OVARY AND CYST, LEFT, OOPHORECTOMY:
			- MUCINOUS BORDERLINE TUMOUR, INTESTINAL TYPE, ARISING FROM A MUCINOUS CYSTADENOMA (INTESTINAL TYPE).
			- OVARIAN PARENCHYMA.
			</pre>

			==See also==
			*[[Ovarian tumours]].

			==References==
			{{Reflist\|1}}

			[[Category:Gynecologic pathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: fix redirect

2012-12-24T19:27:12Z

fix redirect

← Older revision		Revision as of 19:27, 24 December 2012
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	#redirect[[Ovarian tumours#Mucinous ~~adenocarcinoma~~ of the ovary]]		#redirect[[Ovarian tumours#Mucinous borderline tumour of the ovary]]

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2012-12-24T19:26:25Z

redirect

New page

#redirect[[Ovarian tumours#Mucinous adenocarcinoma of the ovary]]

[[Category:Diagnosis]]