Mucinous breast carcinoma - Revision history

Michael at 11:37, 8 September 2016

2016-09-08T11:37:50Z

← Older revision		Revision as of 11:37, 8 September 2016
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	\| IF =		\| IF =
	\| Gross = pale, glistening, jelly-like appearance		\| Gross = pale, glistening, jelly-like appearance
	\| Grossing = [[~~mastectomy~~ grossing]]		\| Grossing = [[breast grossing]]
	\| Staging = [[breast cancer staging]]		\| Staging = [[breast cancer staging]]
	\| Site = [[breast]] - see ''[[invasive breast cancer]]''		\| Site = [[breast]] - see ''[[invasive breast cancer]]''

Michael at 04:12, 1 May 2016

2016-05-01T04:12:57Z

← Older revision		Revision as of 04:12, 1 May 2016
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	\| IF =		\| IF =
	\| Gross = pale, glistening, jelly-like appearance		\| Gross = pale, glistening, jelly-like appearance
	\| Grossing =		\| Grossing = [[mastectomy grossing]]
			\| Staging = [[breast cancer staging]]
	\| Site = [[breast]] - see ''[[invasive breast cancer]]''		\| Site = [[breast]] - see ''[[invasive breast cancer]]''
	\| Assdx =		\| Assdx =

Sarah: /* General */

2015-03-27T09:56:42Z

General

← Older revision		Revision as of 09:56, 27 March 2015
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	==General==		==General==
	*Rare.		*Rare.
			*2% of invasive breast carcinomas.
	*Good prognosis.<ref name=pmid18809061>{{Cite journal \| last1 = Barkley \| first1 = CR. \| last2 = Ligibel \| first2 = JA. \| last3 = Wong \| first3 = JS. \| last4 = Lipsitz \| first4 = S. \| last5 = Smith \| first5 = BL. \| last6 = Golshan \| first6 = M. \| title = Mucinous breast carcinoma: a large contemporary series. \| journal = Am J Surg \| volume = 196 \| issue = 4 \| pages = 549-51 \| month = Oct \| year = 2008 \| doi = 10.1016/j.amjsurg.2008.06.013 \| PMID = 18809061 }}</ref>		*Good prognosis.<ref name=pmid18809061>{{Cite journal \| last1 = Barkley \| first1 = CR. \| last2 = Ligibel \| first2 = JA. \| last3 = Wong \| first3 = JS. \| last4 = Lipsitz \| first4 = S. \| last5 = Smith \| first5 = BL. \| last6 = Golshan \| first6 = M. \| title = Mucinous breast carcinoma: a large contemporary series. \| journal = Am J Surg \| volume = 196 \| issue = 4 \| pages = 549-51 \| month = Oct \| year = 2008 \| doi = 10.1016/j.amjsurg.2008.06.013 \| PMID = 18809061 }}</ref>
	*Usually older women.		*Usually older women.

Sarah: /* Microscopic */

2015-03-27T09:55:33Z

Microscopic

← Older revision		Revision as of 09:55, 27 March 2015
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	**Glands typically have irregular edges.		**Glands typically have irregular edges.
	**+/-Vessels within the mucin pools.		**+/-Vessels within the mucin pools.
			*Subtypes <ref>{{Cite journal \| last1 = Weigelt \| first1 = B. \| last2 = Geyer \| first2 = FC. \| last3 = Horlings \| first3 = HM. \| last4 = Kreike \| first4 = B. \| last5 = Halfwerk \| first5 = H. \| last6 = Reis-Filho \| first6 = JS. \| title = Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special type. \| journal = Mod Pathol \| volume = 22 \| issue = 11 \| pages = 1401-14 \| month = Nov \| year = 2009 \| doi = 10.1038/modpathol.2009.112 \| PMID = 19633645 }}</ref>
			**Mucinous A (or paucicellular) - more mucin
			**Mucinous B (or hypercellular) - less mucin and neuroendocrine differentiation and argyrophilia

	DDx:		DDx:

Sarah: /* Microscopic */

2015-03-27T09:48:23Z

Microscopic

← Older revision		Revision as of 09:48, 27 March 2015
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	*[[DCIS]] with a mucinous component.		*[[DCIS]] with a mucinous component.
	**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.		**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.
	*[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. Any 'no special type' component imparts a worse prognosis so the diagnosis 'mucinous carcinoma' is reserved for tumours with pure mucinous features.		*[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. Any 'no special type' component imparts a worse prognosis so the diagnosis 'mucinous carcinoma' is reserved for tumours with close to pure mucinous features.

	Note:		Note:

Sarah: /* Microscopic */

2015-03-27T09:47:11Z

Microscopic

← Older revision		Revision as of 09:47, 27 March 2015
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	*Malignant mucin producing glands.		*Malignant mucin producing glands.
	**Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal \| last1 = Dogan \| first1 = E. \| last2 = Aksoy \| first2 = S. \| last3 = Dizdar \| first3 = O. \| last4 = Arslan \| first4 = C. \| last5 = Dede \| first5 = DS. \| last6 = Ozisik \| first6 = Y. \| last7 = Altundag \| first7 = K. \| title = Pure mucinous carcinoma of the breast: a single center experience. \| journal = J BUON \| volume = 16 \| issue = 3 \| pages = 565-7 \| month = \| year = \| doi = \| PMID = 22006768 }}</ref>		**Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal \| last1 = Dogan \| first1 = E. \| last2 = Aksoy \| first2 = S. \| last3 = Dizdar \| first3 = O. \| last4 = Arslan \| first4 = C. \| last5 = Dede \| first5 = DS. \| last6 = Ozisik \| first6 = Y. \| last7 = Altundag \| first7 = K. \| title = Pure mucinous carcinoma of the breast: a single center experience. \| journal = J BUON \| volume = 16 \| issue = 3 \| pages = 565-7 \| month = \| year = \| doi = \| PMID = 22006768 }}</ref>
	**~~Cells~~ should float in the mucin - '''key feature'''.		**Small clusters of cells should float in the mucin - '''key feature'''.
	**Glands typically have irregular edges.		**Glands typically have irregular edges.
	**+/-Vessels within the mucin pools.		**+/-Vessels within the mucin pools.
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	*[[DCIS]] with a mucinous component.		*[[DCIS]] with a mucinous component.
	**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.		**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.
	*[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''.		*[[Invasive ductal carcinoma of the breast]] with a mucinous component - more common than ''mucinous breast carcinoma''. Any 'no special type' component imparts a worse prognosis so the diagnosis 'mucinous carcinoma' is reserved for tumours with pure mucinous features.

	Note:		Note:
	*The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site.		*The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site.
	*~~All~~ mucinous ~~lesions should be excised~~.<ref name=pmid12218567>{{Cite journal \| last1 = Jacobs \| first1 = TW. \| last2 = Connolly \| first2 = JL. \| last3 = Schnitt \| first3 = SJ. \| title = Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? \| journal = Am J Surg Pathol \| volume = 26 \| issue = 9 \| pages = 1095-110 \| month = Sep \| year = 2002 \| doi = \| PMID = 12218567 }}</ref>		*A breast core biopsy that show any degree of mucinous change is an indication for excision to exclude mucinous carcinoma.<ref name=pmid12218567>{{Cite journal \| last1 = Jacobs \| first1 = TW. \| last2 = Connolly \| first2 = JL. \| last3 = Schnitt \| first3 = SJ. \| title = Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? \| journal = Am J Surg Pathol \| volume = 26 \| issue = 9 \| pages = 1095-110 \| month = Sep \| year = 2002 \| doi = \| PMID = 12218567 }}</ref>
			*Size and margins are assessed from edge of mucin, even if it does not contain epithelial cells
			*These tumors can be very difficult to assess lymphovascular invasion. Look for tumour cells in areas where lymphatics are expected ie. tumour in arc-shape around vascular bundle

	===Images===		===Images===

Sarah: /* Images */

2015-03-27T09:38:14Z

Images

← Older revision		Revision as of 09:38, 27 March 2015
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	Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - high power (SKB)		Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - high power (SKB)
	Image:Breast DCIS Mucinous Extravasation MP2 PA.JPG\|Breast - Mucinous ductal carcinoma in situ with mucin extravasation - low power. Compare the profile of the involved gland to the examples above. (SKB)		Image:Breast DCIS Mucinous Extravasation MP2 PA.JPG\|Breast - Mucinous ductal carcinoma in situ with mucin extravasation - low power. Compare the profile of the involved gland to the examples above. (SKB)
	Image:Breast DCIS Mucinous Extravasation MP3 PA.JPG\|Breast - Mucinous ductal carcinoma in situ with mucin extravasation - medium power. (SKB)		Image:Breast DCIS Mucinous Extravasation MP3 PA.JPG\|Breast - Mucinous ductal carcinoma in situ with mucin extravasation - medium power. Notice the lack of floating tumour nests (SKB)
	</gallery>		</gallery>

Sarah: /* Images */

2015-03-27T09:37:21Z

Images

← Older revision		Revision as of 09:37, 27 March 2015
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	Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - medium power (SKB)		Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - medium power (SKB)
	Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - high power (SKB)		Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - high power (SKB)
			Image:Breast DCIS Mucinous Extravasation MP2 PA.JPG\|Breast - Mucinous ductal carcinoma in situ with mucin extravasation - low power. Compare the profile of the involved gland to the examples above. (SKB)
			Image:Breast DCIS Mucinous Extravasation MP3 PA.JPG\|Breast - Mucinous ductal carcinoma in situ with mucin extravasation - medium power. (SKB)
	</gallery>		</gallery>

Sarah: /* Images */

2015-03-27T09:27:01Z

Images

← Older revision		Revision as of 09:27, 27 March 2015
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	Image:Mucinous Breast Carcinoma (4685032847).jpg \| MBC - high mag. (WC/Uthman)		Image:Mucinous Breast Carcinoma (4685032847).jpg \| MBC - high mag. (WC/Uthman)
	Image:Mucinous Breast Carcinoma (4685664022).jpg \| MBC - low mag. (WC/Uthman)		Image:Mucinous Breast Carcinoma (4685664022).jpg \| MBC - low mag. (WC/Uthman)
			Image:Breast MucinousCarcinoma LP SNP.jpg\|Mucinous Carcinoma - low power (SKB)
			Image:Breast MucinousCarcinoma 2 MP SNP.jpg\|Mucinous Carcinoma - medium power (SKB)
			Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - medium power (SKB)
			Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - high power (SKB)
	</gallery>		</gallery>

Michael: /* Images */ fix

2015-02-16T22:40:26Z

Images: fix

← Older revision		Revision as of 22:40, 16 February 2015
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	<gallery>		<gallery>
	Image:Mucinous Breast Carcinoma (4685032847).jpg \| MBC - high mag. (WC/Uthman)		Image:Mucinous Breast Carcinoma (4685032847).jpg \| MBC - high mag. (WC/Uthman)
	Image:Mucinous Breast Carcinoma (4685664022).jpg \| MBC - low mag.j (WC/Uthman)		Image:Mucinous Breast Carcinoma (4685664022).jpg \| MBC - low mag. (WC/Uthman)
	</gallery>		</gallery>

← Older revision		Revision as of 09:27, 27 March 2015
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	Image:Mucinous Breast Carcinoma (4685032847).jpg \| MBC - high mag. (WC/Uthman)		Image:Mucinous Breast Carcinoma (4685032847).jpg \| MBC - high mag. (WC/Uthman)
	Image:Mucinous Breast Carcinoma (4685664022).jpg \| MBC - low mag. (WC/Uthman)		Image:Mucinous Breast Carcinoma (4685664022).jpg \| MBC - low mag. (WC/Uthman)
			Image:Breast MucinousCarcinoma LP SNP.jpg\|Mucinous Carcinoma - low power (SKB)
			Image:Breast MucinousCarcinoma 2 MP SNP.jpg\|Mucinous Carcinoma - medium power (SKB)
			Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - medium power (SKB)
			Image:Breast MucinousCarcinoma MP SNP.jpg\|Mucinous Carcinoma - high power (SKB)
	</gallery>		</gallery>