Multiple endocrine neoplasia - Revision history

Michael: /* MEN 1 */

2022-04-06T21:18:31Z

MEN 1

← Older revision		Revision as of 21:18, 6 April 2022
Line 4:		Line 4:
	==Simple==		==Simple==
	===MEN 1===		===MEN 1===
	* [[Parathyroid adenoma]].<ref name=omim131100>{{OMIM\|131100}}</ref><ref name=pmid15490065>{{cite journal \|authors=Doherty GM, Lairmore TC, DeBenedetti MK \|title=Multiple endocrine neoplasia type 1 parathyroid adenoma development over time \|journal=World J Surg \|volume=28 \|issue=11 \|pages=1139–42 \|date=November 2004 \|pmid=15490065 \|doi=10.1007/s00268-004-7560-8 \|url=}}</ref>		* [[Parathyroid adenoma]].<ref name=omim131100>{{OMIM\|131100}}</ref> ‡
	* [[Pancreatic neuroendocrine tumour]]s.		* [[Pancreatic neuroendocrine tumour]]s.
	* [[Pituitary adenoma]].		* [[Pituitary adenoma]].

	Memory device: '''3 Ps'''.		Memory device: '''3 Ps'''.

			Note:<br>
			‡ May be mislabeled as ''[[parathyroid hyperplasia]]''.<ref name=pmid15490065>{{cite journal \|authors=Doherty GM, Lairmore TC, DeBenedetti MK \|title=Multiple endocrine neoplasia type 1 parathyroid adenoma development over time \|journal=World J Surg \|volume=28 \|issue=11 \|pages=1139–42 \|date=November 2004 \|pmid=15490065 \|doi=10.1007/s00268-004-7560-8 \|url=}}</ref>

	===MEN 2A (II)===		===MEN 2A (II)===

Michael: /* Simple */

2022-04-06T21:16:47Z

Simple

← Older revision		Revision as of 21:16, 6 April 2022
Line 4:		Line 4:
	==Simple==		==Simple==
	===MEN 1===		===MEN 1===
	* [[Parathyroid adenoma]].<ref name=omim131100>{{OMIM\|131100}}</ref>		* [[Parathyroid adenoma]].<ref name=omim131100>{{OMIM\|131100}}</ref><ref name=pmid15490065>{{cite journal \|authors=Doherty GM, Lairmore TC, DeBenedetti MK \|title=Multiple endocrine neoplasia type 1 parathyroid adenoma development over time \|journal=World J Surg \|volume=28 \|issue=11 \|pages=1139–42 \|date=November 2004 \|pmid=15490065 \|doi=10.1007/s00268-004-7560-8 \|url=}}</ref>
	* [[Pancreatic neuroendocrine tumour]]s.		* [[Pancreatic neuroendocrine tumour]]s.
	* [[Pituitary adenoma]].		* [[Pituitary adenoma]].

Michael: /* MEN 1 */ write out

2018-09-11T07:08:38Z

MEN 1: write out

← Older revision		Revision as of 07:08, 11 September 2018
Line 33:		Line 33:
	**Usually arise in the [[duodenum]].		**Usually arise in the [[duodenum]].
	**May present as [[Zollinger-Ellison syndrome]] - triad of pancreatic gastrinoma, gastric hypersecretion, small bowel peptic ulcers.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>		**May present as [[Zollinger-Ellison syndrome]] - triad of pancreatic gastrinoma, gastric hypersecretion, small bowel peptic ulcers.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>
	*[[~~DIPNECH~~]] has been described in the context of ''multiple endocrine neoplasia 1''.<ref name=pmid17099078>{{Cite journal \| last1 = Davies \| first1 = SJ. \| last2 = Gosney \| first2 = JR. \| last3 = Hansell \| first3 = DM. \| last4 = Wells \| first4 = AU. \| last5 = du Bois \| first5 = RM. \| last6 = Burke \| first6 = MM. \| last7 = Sheppard \| first7 = MN. \| last8 = Nicholson \| first8 = AG. \| title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. \| journal = Thorax \| volume = 62 \| issue = 3 \| pages = 248-52 \| month = Mar \| year = 2007 \| doi = 10.1136/thx.2006.063065 \| PMID = 17099078 }}</ref>		*[[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]] (DIPNECH) has been described in the context of ''multiple endocrine neoplasia 1''.<ref name=pmid17099078>{{Cite journal \| last1 = Davies \| first1 = SJ. \| last2 = Gosney \| first2 = JR. \| last3 = Hansell \| first3 = DM. \| last4 = Wells \| first4 = AU. \| last5 = du Bois \| first5 = RM. \| last6 = Burke \| first6 = MM. \| last7 = Sheppard \| first7 = MN. \| last8 = Nicholson \| first8 = AG. \| title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. \| journal = Thorax \| volume = 62 \| issue = 3 \| pages = 248-52 \| month = Mar \| year = 2007 \| doi = 10.1136/thx.2006.063065 \| PMID = 17099078 }}</ref>

	===MEN 2A===		===MEN 2A===

Michael: /* MEN 1 */

2018-09-11T07:07:59Z

MEN 1

← Older revision		Revision as of 07:07, 11 September 2018
Line 33:		Line 33:
	**Usually arise in the [[duodenum]].		**Usually arise in the [[duodenum]].
	**May present as [[Zollinger-Ellison syndrome]] - triad of pancreatic gastrinoma, gastric hypersecretion, small bowel peptic ulcers.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>		**May present as [[Zollinger-Ellison syndrome]] - triad of pancreatic gastrinoma, gastric hypersecretion, small bowel peptic ulcers.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>
			*[[DIPNECH]] has been described in the context of ''multiple endocrine neoplasia 1''.<ref name=pmid17099078>{{Cite journal \| last1 = Davies \| first1 = SJ. \| last2 = Gosney \| first2 = JR. \| last3 = Hansell \| first3 = DM. \| last4 = Wells \| first4 = AU. \| last5 = du Bois \| first5 = RM. \| last6 = Burke \| first6 = MM. \| last7 = Sheppard \| first7 = MN. \| last8 = Nicholson \| first8 = AG. \| title = Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. \| journal = Thorax \| volume = 62 \| issue = 3 \| pages = 248-52 \| month = Mar \| year = 2007 \| doi = 10.1136/thx.2006.063065 \| PMID = 17099078 }}</ref>

	===MEN 2A===		===MEN 2A===

Michael at 05:25, 2 January 2016

2016-01-02T05:25:31Z

← Older revision		Revision as of 05:25, 2 January 2016
Line 1:		Line 1:
	[[Image:C-cell hyperplasia in MEN 2 -- low mag.jpg\|thumb\|right\|350px\|C-cell hyperplasia, as may be seen in the context of MEN 2A or MEN 2B. [[H&E stain]].]]		[[Image:C-cell hyperplasia in MEN 2 -- low mag.jpg\|thumb\|right\|350px\|[[C-cell hyperplasia]], as may be seen in the context of MEN 2A or MEN 2B. [[H&E stain]].]]
	'''Multiple endocrine neoplasia''', abbreviated ''MEN'', refers to collection of different genetic abnormalities that lead to endocrine neoplasms.		'''Multiple endocrine neoplasia''', abbreviated '''MEN''', refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

	==Simple==		==Simple==
Line 12:		Line 12:
	===MEN 2A (II)===		===MEN 2A (II)===
	* [[Parathyroid adenoma]].		* [[Parathyroid adenoma]].
	* [[Medullary thyroid carcinoma]] (~~usu.~~ preceded by [[C-cell hyperplasia]]<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>).		* [[Medullary thyroid carcinoma]] (usually preceded by [[C-cell hyperplasia]]<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>).
	* [[Pheochromocytoma]].		* [[Pheochromocytoma]].

Line 21:		Line 21:
	===MEN 2B (III)===		===MEN 2B (III)===
	* Neuromas/[[ganglioneuroma]]s.		* Neuromas/[[ganglioneuroma]]s.
	* [[Medullary thyroid carcinoma]] (~~usu.~~ preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>).		* [[Medullary thyroid carcinoma]] (usually preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>).
	* [[Pheochromocytoma]].		* [[Pheochromocytoma]].

Michael at 17:03, 31 December 2015

2015-12-31T17:03:11Z

← Older revision		Revision as of 17:03, 31 December 2015
Line 1:		Line 1:
			[[Image:C-cell hyperplasia in MEN 2 -- low mag.jpg\|thumb\|right\|350px\|C-cell hyperplasia, as may be seen in the context of MEN 2A or MEN 2B. [[H&E stain]].]]
	'''Multiple endocrine neoplasia''', abbreviated ''MEN'', refers to collection of different genetic abnormalities that lead to endocrine neoplasms.		'''Multiple endocrine neoplasia''', abbreviated ''MEN'', refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Michael: /* MEN 2A (II) */

2015-03-04T06:24:01Z

MEN 2A (II)

← Older revision		Revision as of 06:24, 4 March 2015
Line 11:		Line 11:
	===MEN 2A (II)===		===MEN 2A (II)===
	* [[Parathyroid adenoma]].		* [[Parathyroid adenoma]].
	* [[Medullary thyroid carcinoma]] (usu. preceded by C cell hyperplasia<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>).		* [[Medullary thyroid carcinoma]] (usu. preceded by [[C-cell hyperplasia]]<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>).
	* [[Pheochromocytoma]].		* [[Pheochromocytoma]].

Michael: /* MEN 2B */ rm extra '}}'

2015-03-04T06:23:19Z

MEN 2B: rm extra '}}'

← Older revision		Revision as of 06:23, 4 March 2015
Line 54:		Line 54:

	Characteristics:		Characteristics:
	*[[Marfan syndrome\|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8\|1160}}}}</ref>		*[[Marfan syndrome\|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8\|1160}}</ref>
	*[[Neuroma]]s.		*[[Neuroma]]s.
	*Multiple ganglioneuromas ([[ganglioneuromatosis]]) of the alimentary tract.<ref name=omim162300>{{OMIM\|162300}}</ref><ref name=pmid17306015>{{cite journal \|author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' \|title=Multiple rectal carcinoids with diffuse ganglioneuromatosis \|journal=World J Surg Oncol \|volume=5 \|issue= \|pages=19 \|year=2007 \|pmid=17306015 \|pmc=1805501 \|doi=10.1186/1477-7819-5-19 \|url=}}</ref>		*Multiple ganglioneuromas ([[ganglioneuromatosis]]) of the alimentary tract.<ref name=omim162300>{{OMIM\|162300}}</ref><ref name=pmid17306015>{{cite journal \|author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' \|title=Multiple rectal carcinoids with diffuse ganglioneuromatosis \|journal=World J Surg Oncol \|volume=5 \|issue= \|pages=19 \|year=2007 \|pmid=17306015 \|pmc=1805501 \|doi=10.1186/1477-7819-5-19 \|url=}}</ref>

Michael: /* Details */ tweak

2012-04-07T14:40:31Z

Details: tweak

← Older revision		Revision as of 14:40, 7 April 2012
Line 29:		Line 29:

	Characteristics:<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>		Characteristics:<ref name=Ref_PBoD8_1162>{{Ref PBoD8\|1162}}}}</ref>
	*Endocrine tumours ~~usu.~~ lead to most of the morbidity.		*Endocrine tumours usually lead to most of the morbidity.
	**~~Usu.~~ arise in the duodenum.		**Usually arise in the [[duodenum]].
	**May present as [[Zollinger-Ellison syndrome]] - triad of pancreatic gastrinoma, gastric hypersecretion, small bowel peptic ulcers.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>		**May present as [[Zollinger-Ellison syndrome]] - triad of pancreatic gastrinoma, gastric hypersecretion, small bowel peptic ulcers.<ref name=pmid13259432>{{cite journal \|author=Zollinger RM, Ellison EH \|title=Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas \|journal=Ann. Surg. \|volume=142 \|issue=4 \|pages=709–23; discussion, 724–8 \|year=1955 \|pmid=13259432\|doi=10.1097/00000658-195510000-00015 \|PMC = 1465210 \|URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/?page=1 }}</ref>

Michael: /* MEN 2B */ +gene

2012-04-07T14:39:40Z

MEN 2B: +gene

← Older revision		Revision as of 14:39, 7 April 2012
Line 50:		Line 50:

	===MEN 2B===		===MEN 2B===
			Gene:
			*RET.<ref name=omim162300>{{OMIM\|162300}}</ref>

	Characteristics:		Characteristics:
	*[[Marfan syndrome\|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8\|1160}}}}</ref>		*[[Marfan syndrome\|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8\|1160}}}}</ref>