Muscularis propria invasion in the urinary bladder - Revision history

Michael: /* IHC */

2017-01-27T15:35:56Z

IHC

← Older revision		Revision as of 15:35, 27 January 2017
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	Note:		Note:
	*† Overlap between the patterns is described,<ref name=pmid20154589>{{Cite journal \| last1 = Miyamoto \| first1 = H. \| last2 = Sharma \| first2 = RB. \| last3 = Illei \| first3 = PB. \| last4 = Epstein \| first4 = JI. \| title = Pitfalls in the use of smoothelin to identify muscularis propria invasion by urothelial carcinoma. \| journal = Am J Surg Pathol \| volume = 34 \| issue = 3 \| pages = 418-22 \| month = Mar \| year = 2010 \| doi = 10.1097/PAS.0b013e3181ce5066 \| PMID = 20154589 }}</ref> this limits the utility of the immunostain.		*† Overlap between the patterns is described;<ref name=pmid20154589>{{Cite journal \| last1 = Miyamoto \| first1 = H. \| last2 = Sharma \| first2 = RB. \| last3 = Illei \| first3 = PB. \| last4 = Epstein \| first4 = JI. \| title = Pitfalls in the use of smoothelin to identify muscularis propria invasion by urothelial carcinoma. \| journal = Am J Surg Pathol \| volume = 34 \| issue = 3 \| pages = 418-22 \| month = Mar \| year = 2010 \| doi = 10.1097/PAS.0b013e3181ce5066 \| PMID = 20154589 }}</ref> this limits the utility of the immunostain.
			**Immunostain '''not''' used in many practice environments.

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Michael: +IHC section

2017-01-27T15:34:37Z

+IHC section

← Older revision		Revision as of 15:34, 27 January 2017
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	Image: Muscle invasive urothelial carcinoma -- high mag.jpg \| MIUC - high mag.		Image: Muscle invasive urothelial carcinoma -- high mag.jpg \| MIUC - high mag.
	</gallery>		</gallery>

			==IHC==
			''Smoothelin'' [[immunostain]]:<ref name=pmid18936687>{{Cite journal \| last1 = Paner \| first1 = GP. \| last2 = Shen \| first2 = SS. \| last3 = Lapetino \| first3 = S. \| last4 = Venkataraman \| first4 = G. \| last5 = Barkan \| first5 = GA. \| last6 = Quek \| first6 = ML. \| last7 = Ro \| first7 = JY. \| last8 = Amin \| first8 = MB. \| title = Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinoma. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 1 \| pages = 91-8 \| month = Jan \| year = 2009 \| doi = 10.1097/PAS.0b013e3181804727 \| PMID = 18936687 }}</ref>
			*Muscularis propria - usu. strong. †
			*Muscularis mucosae - negative/weak. †

			Note:
			*† Overlap between the patterns is described,<ref name=pmid20154589>{{Cite journal \| last1 = Miyamoto \| first1 = H. \| last2 = Sharma \| first2 = RB. \| last3 = Illei \| first3 = PB. \| last4 = Epstein \| first4 = JI. \| title = Pitfalls in the use of smoothelin to identify muscularis propria invasion by urothelial carcinoma. \| journal = Am J Surg Pathol \| volume = 34 \| issue = 3 \| pages = 418-22 \| month = Mar \| year = 2010 \| doi = 10.1097/PAS.0b013e3181ce5066 \| PMID = 20154589 }}</ref> this limits the utility of the immunostain.

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Michael at 18:27, 23 January 2017

2017-01-23T18:27:20Z

← Older revision		Revision as of 18:27, 23 January 2017
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	Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.		Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.

	'''''Muscle invasive bladder cancer''''' redirects to this article and refers to invasion of the ''muscularis propria''.		'''''Muscle invasive bladder cancer''''' redirects to this article and refers to invasion of the ''muscularis propria''.

			''Bladder muscularis propria invasion'' and ''urinary bladder muscularis propria invasion'' redirect to this article.

	==General==		==General==

Michael at 13:19, 14 December 2016

2016-12-14T13:19:06Z

← Older revision		Revision as of 13:19, 14 December 2016
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	Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.		Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.

	'''''Muscle invasive bladder cancer''''' redirects ~~here~~ and refers to invasion of the ''muscularis propria''.		'''''Muscle invasive bladder cancer''''' redirects to this article and refers to invasion of the ''muscularis propria''.

	==General==		==General==

Michael at 13:18, 14 December 2016

2016-12-14T13:18:52Z

← Older revision		Revision as of 13:18, 14 December 2016
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	Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.		Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.

			'''''Muscle invasive bladder cancer''''' redirects here and refers to invasion of the ''muscularis propria''.

	==General==		==General==

Michael at 12:19, 11 May 2016

2016-05-11T12:19:29Z

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	A thin layer of discontinous muscularis mucuosae (MM) is present and, especially if hypertrophic, may be confused with muscuaris propria (MP).		A thin layer of discontinous muscularis mucuosae (MM) is present and, especially if hypertrophic, may be confused with muscuaris propria (MP).

			Staging of bladder cancer is dealt with in the ''[[bladder cancer staging]]'' article.

	==General==		==General==

Michael: /* See also */

2016-01-28T02:27:12Z

Michael: tweak

2016-01-28T02:26:44Z

tweak

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			[[Image: Muscle invasive urothelial carcinoma -- intermed mag.jpg \|thumb\|350px\|right \| Muscle invasive urothelial carcinoma. [[H&E stain]].]]
	The presence or absence of '''muscularis propria invasion in the urinary bladder''' is a ''very important'' determination, as the clinical management changes between T1 and T2:		The presence or absence of '''muscularis propria invasion in the urinary bladder''' is a ''very important'' determination, as the clinical management changes between T1 and T2:
	*T1: usually conservative treatment (local excision).		*T1: usually conservative treatment (local excision).
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	Image: Muscle invasive urothelial carcinoma -- very low mag.jpg \| MIUC - very low mag.		Image: Muscle invasive urothelial carcinoma -- very low mag.jpg \| MIUC - very low mag.
	Image: Muscle invasive urothelial carcinoma -- low mag.jpg \| MIUC - low mag.		Image: Muscle invasive urothelial carcinoma -- low mag.jpg \| MIUC - low mag.
	~~Image: Muscle invasive urothelial carcinoma -- intermed mag.jpg \| MIUC - intermed. mag.~~
	Image: Muscle invasive urothelial carcinoma - alt -- intermed mag.jpg \| MIUC - intermed. mag.		Image: Muscle invasive urothelial carcinoma - alt -- intermed mag.jpg \| MIUC - intermed. mag.
	Image: Muscle invasive urothelial carcinoma -- high mag.jpg \| MIUC - high mag.		Image: Muscle invasive urothelial carcinoma -- high mag.jpg \| MIUC - high mag.

Michael: /* Rational assessment of muscularis propria invasion */

2016-01-28T02:12:00Z

Rational assessment of muscularis propria invasion

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	DDx:		DDx:
	*Invasion of hypertrophic muscularis ~~mucosa~~.		*Invasion of hypertrophic muscularis mucosae.

	====Images====		====Images====

Michael: /* Microscopic */

2016-01-28T02:11:44Z

Microscopic

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	#Multiple bundles must be adjacent to one another.		#Multiple bundles must be adjacent to one another.
	#Should '''not''' be superficial - surface epithelium if present should be distant.		#Should '''not''' be superficial - surface epithelium if present should be distant.

			DDx:
			*Invasion of hypertrophic muscularis mucosa.

			====Images====
			<gallery>
			Image: Muscle invasive urothelial carcinoma -- very low mag.jpg \| MIUC - very low mag.
			Image: Muscle invasive urothelial carcinoma -- low mag.jpg \| MIUC - low mag.
			Image: Muscle invasive urothelial carcinoma -- intermed mag.jpg \| MIUC - intermed. mag.
			Image: Muscle invasive urothelial carcinoma - alt -- intermed mag.jpg \| MIUC - intermed. mag.
			Image: Muscle invasive urothelial carcinoma -- high mag.jpg \| MIUC - high mag.
			</gallery>

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← Older revision		Revision as of 02:27, 28 January 2016
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	==See also==		==See also==
	*[[Urothelial carcinoma]].		*[[Urothelial carcinoma]].
			*[[Bladder cancer staging]].
	*[[Cancer staging systems]].		*[[Cancer staging systems]].