Myxomatous degeneration - Revision history

Michael: +infobox

2015-04-05T05:58:15Z

+infobox

← Older revision		Revision as of 05:58, 5 April 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Myxomatous_aortic_valve.jpg
			\| Width =
			\| Caption = Myxomatous valve. [[Movat stain]]. (WC)
			\| Synonyms =
			\| Micro = thinning of fibrosa layer, thickening of ''spongiosa layer'' with mucoid (myxomatous) material, +/-secondary changes due to valvular dysfunction (e.g. thrombi, fibrosis)
			\| Subtypes =
			\| LMDDx =
			\| Stains = [[Movat stain]] - to demonstrate mucoid material
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = valve thickened, rubbery consistency, reactive/secondary changes common (fibrosis due to prolapse/abnormal contact of valve with other structures, clots/organized thrombus due to stasis)
			\| Grossing = [[Mitral valve grossing]]
			\| Site = [[heart valve]], typical mitral valve
			\| Assdx =
			\| Syndromes = [[Marfan's syndrome]], [[Turner syndrome]]
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx = surgical replacement
			}}
	'''Myxomatous degeneration''' of [[heart valves]] is rare benign condition that is typically seen in the mitral valve, and may be associated with various genetic conditions.		'''Myxomatous degeneration''' of [[heart valves]] is rare benign condition that is typically seen in the mitral valve, and may be associated with various genetic conditions.

Michael: split out

2015-04-05T05:50:52Z

split out

← Older revision		Revision as of 05:50, 5 April 2015
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	~~#redirect~~ [[~~Heart_valves#Myxomatous_degeneration~~]]		'''Myxomatous degeneration''' of [[heart valves]] is rare benign condition that is typically seen in the mitral valve, and may be associated with various genetic conditions.

			==General==
			*Usually affects the mitral valve.
			*Female > male,<ref>URL: [http://emedicine.medscape.com/article/759004-overview http://emedicine.medscape.com/article/759004-overview]. Accessed on: 8 June 2010.</ref> disputed by Toronto data.<ref name=leong>{{cite journal \|author=Leong SW, Soor GS, Butany J, Henry J, Thangaroopan M, Leask RL \|title=Morphological findings in 192 surgically excised native mitral valves \|journal=Can J Cardiol \|volume=22 \|issue=12 \|pages=1055-61 \|year=2006 \|month=October \|pmid=17036100 \|doi= \|url=}}</ref>
			*Associated with [[Marfan's syndrome]] and [[Turner syndrome]] (Monosomy X).<ref name=pmid779595>{{cite journal \|author=Wigle ED, Rakowski H, Ranganathan N, Silver MC \|title=Mitral valve prolapse \|journal=Annu. Rev. Med. \|volume=27 \|issue= \|pages=165–80 \|year=1976 \|pmid=779595 \|doi=10.1146/annurev.me.27.020176.001121 \|url=}}</ref>

			==Gross==
			Features:<ref name=Ref_PBoD591>{{Ref PBoD\|591}}</ref>
			*No commissural fusion.
			**Commissural fusion typical of rheumatic heart disease.
			*Thickened.
			*Rubbery consistency.
			*Reactive/secondary changes.
			**Fibrosis due to prolapse/abnormal contact of valve with other structures.
			**Clots/organized thrombus - due to stasis.

			==Microscopic==
			*Thinning of ''fibrosa layer''.
			*Thickening of ''spongiosa layer'' with mucoid (myxomatous) material. (key feature).
			*+/-Secondary changes (due to valvular dysfunction): thrombi, fibrosis.

			==Staining==
			*Movat stain.
			**Acid fuchsin, alcian blue, crocein scarlet, elastic hematoxylin, pathology consultation, and saffron.<ref>URL: [http://www.mayomedicallaboratories.com/test-catalog/Overview/9832 http://www.mayomedicallaboratories.com/test-catalog/Overview/9832]. Accessed on: 8 June 2010.</ref><ref name=penn_med>Modified Movat's Pentachrome Stain. University Penn Medicine. URL: [http://www.med.upenn.edu/mcrc/histology_core/movat.shtml http://www.med.upenn.edu/mcrc/histology_core/movat.shtml]. Accessed on: January 29, 2009.</ref>

			Interpretation of Movat stain:<ref name=penn_med/>
			*Black = nuclei and elastic fibers.
			*Yellow = collagen and reticular fibers.
			*Blue = mucin, ground substance.
			*Red (intense) = fibrin.
			*Red = muscle.

			===Image===
			<gallery>
			Image:Myxomatous_aortic_valve.jpg \| Myxomatous valve. [[Movat stain]]. (WC/Nephron)
			</gallery>

			==See also==
			*[[Heart valves]].

			==References==
			{{reflist\|2}}
	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Heart valves]]

Michael: +cat.

2011-10-22T20:23:11Z

+cat.

← Older revision		Revision as of 20:23, 22 October 2011
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	#redirect [[Heart_valves#Myxomatous_degeneration]]		#redirect [[Heart_valves#Myxomatous_degeneration]]

			[[Category:Diagnosis]]

Michael: redirect

2011-05-24T14:16:34Z

redirect

New page

#redirect [[Heart_valves#Myxomatous_degeneration]]