NUT carcinoma - Revision history

Michael at 09:43, 10 September 2024

2024-09-10T09:43:04Z

← Older revision		Revision as of 09:43, 10 September 2024
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	*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal \| last1 = Stelow \| first1 = EB. \| title = A review of NUT midline carcinoma. \| journal = Head Neck Pathol \| volume = 5 \| issue = 1 \| pages = 31-5 \| month = Mar \| year = 2011 \| doi = 10.1007/s12105-010-0235-x \| PMID = 21221870 }}</ref>		*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal \| last1 = Stelow \| first1 = EB. \| title = A review of NUT midline carcinoma. \| journal = Head Neck Pathol \| volume = 5 \| issue = 1 \| pages = 31-5 \| month = Mar \| year = 2011 \| doi = 10.1007/s12105-010-0235-x \| PMID = 21221870 }}</ref>
	*p63 +ve.<ref name=pmid22534723>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Westra \| first2 = WH. \| title = NUT midline carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 8 \| pages = 1216-21 \| month = Aug \| year = 2012 \| doi = 10.1097/PAS.0b013e318254ce54 \| PMID = 22534723 }}</ref>		*p63 +ve.<ref name=pmid22534723>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Westra \| first2 = WH. \| title = NUT midline carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 8 \| pages = 1216-21 \| month = Aug \| year = 2012 \| doi = 10.1097/PAS.0b013e318254ce54 \| PMID = 22534723 }}</ref>
			**Rarely negative - case report.<ref name=pmid33176817>{{cite journal \|authors=Numakura S, Saito K, Motoi N, Mori T, Saito Y, Yokote F, Kanamoto Y, Asami M, Sakai T, Yamauchi Y, Sakao Y, Uozaki H, Kawamura M \|title=P63-negative pulmonary NUT carcinoma arising in the elderly: a case report \|journal=Diagn Pathol \|volume=15 \|issue=1 \|pages=134 \|date=November 2020 \|pmid=33176817 \|pmc=7657348 \|doi=10.1186/s13000-020-01053-4 \|url=}}</ref>
	*EMA +ve.		*EMA +ve.
	*p16 +ve (4 of 4 cases).<ref name=pmid24185123>{{Cite journal \| last1 = Salles \| first1 = PG. \| last2 = Moura \| first2 = Rde D. \| last3 = Menezes \| first3 = LM. \| last4 = Bacchi \| first4 = CE. \| title = Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV). \| journal = Appl Immunohistochem Mol Morphol \| volume = 22 \| issue = 4 \| pages = 262-5 \| month = Apr \| year = 2014 \| doi = 10.1097/PAI.0b013e3182a4ef2e \| PMID = 24185123 }}</ref>		*p16 +ve (4 of 4 cases).<ref name=pmid24185123>{{Cite journal \| last1 = Salles \| first1 = PG. \| last2 = Moura \| first2 = Rde D. \| last3 = Menezes \| first3 = LM. \| last4 = Bacchi \| first4 = CE. \| title = Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV). \| journal = Appl Immunohistochem Mol Morphol \| volume = 22 \| issue = 4 \| pages = 262-5 \| month = Apr \| year = 2014 \| doi = 10.1097/PAI.0b013e3182a4ef2e \| PMID = 24185123 }}</ref>
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	*CK7 +ve.<ref name=pmid25549144>{{Cite journal \| last1 = Zhu \| first1 = S. \| last2 = Schuerch \| first2 = C. \| last3 = Hunt \| first3 = J. \| title = Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. \| journal = Arch Pathol Lab Med \| volume = 139 \| issue = 1 \| pages = 55-66 \| month = Jan \| year = 2015 \| doi = 10.5858/arpa.2014-0167-RA \| PMID = 25549144 }}</ref>		*CK7 +ve.<ref name=pmid25549144>{{Cite journal \| last1 = Zhu \| first1 = S. \| last2 = Schuerch \| first2 = C. \| last3 = Hunt \| first3 = J. \| title = Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. \| journal = Arch Pathol Lab Med \| volume = 139 \| issue = 1 \| pages = 55-66 \| month = Jan \| year = 2015 \| doi = 10.5858/arpa.2014-0167-RA \| PMID = 25549144 }}</ref>

			Note:
			*p63 +ve with p40 -ve may be suggestive.{{fact}}
	==See also==		==See also==
	*[[Head and neck pathology]].		*[[Head and neck pathology]].

Michael: tweak

2021-06-25T13:49:30Z

tweak

← Older revision		Revision as of 13:49, 25 June 2021
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	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''NUT carcinoma''' is a rare tumour of the [[head and neck pathology\|head and neck]]. The [[World Health Organization\|WHO]] calls this tumour '''carcinoma with t(15;19) translocation'''.<ref name=Ref_WMSP145>{{Ref WMSP\|145}}</ref> It is also known as '''NUT midline carcinoma''', abbreviated '''NMC'''.		'''NUT carcinoma''' is a rare malignant tumour classically of the [[head and neck pathology\|head and neck]]. The [[World Health Organization\|WHO]] calls this tumour '''carcinoma with t(15;19) translocation'''.<ref name=Ref_WMSP145>{{Ref WMSP\|145}}</ref> It is also known as '''NUT midline carcinoma''', abbreviated '''NMC'''.

	==General==		==General==

Michael at 13:12, 25 June 2021

2021-06-25T13:12:49Z

← Older revision		Revision as of 13:12, 25 June 2021
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	\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], acute leukemia, poorly differentiated carcinoma,		\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], acute leukemia, poorly differentiated carcinoma,
	\| Stains =		\| Stains =
	\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve		\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve, NUT +ve
	\| EM =		\| EM =
	\| Molecular = t(15;19)		\| Molecular = t(15;19)
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	==IHC==		==IHC==
			*NUT +ve ('''key immunostain''').
	*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal \| last1 = Stelow \| first1 = EB. \| title = A review of NUT midline carcinoma. \| journal = Head Neck Pathol \| volume = 5 \| issue = 1 \| pages = 31-5 \| month = Mar \| year = 2011 \| doi = 10.1007/s12105-010-0235-x \| PMID = 21221870 }}</ref>		*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal \| last1 = Stelow \| first1 = EB. \| title = A review of NUT midline carcinoma. \| journal = Head Neck Pathol \| volume = 5 \| issue = 1 \| pages = 31-5 \| month = Mar \| year = 2011 \| doi = 10.1007/s12105-010-0235-x \| PMID = 21221870 }}</ref>
	*p63 +ve.<ref name=pmid22534723>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Westra \| first2 = WH. \| title = NUT midline carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 8 \| pages = 1216-21 \| month = Aug \| year = 2012 \| doi = 10.1097/PAS.0b013e318254ce54 \| PMID = 22534723 }}</ref>		*p63 +ve.<ref name=pmid22534723>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Westra \| first2 = WH. \| title = NUT midline carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 8 \| pages = 1216-21 \| month = Aug \| year = 2012 \| doi = 10.1097/PAS.0b013e318254ce54 \| PMID = 22534723 }}</ref>

Michael: /* Microscopic */ tweak

2021-06-25T13:10:47Z

Microscopic: tweak

← Older revision		Revision as of 13:10, 25 June 2021
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	*Poorly differentiated carcinoma.		*Poorly differentiated carcinoma.
	*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>		*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>
	*Acute leukemia - especially as ''NUT ~~midline~~ carcinoma'' may be CD34 positive.<ref name=pmid>{{Cite journal \| last1 = Li \| first1 = W. \| last2 = Chastain \| first2 = K. \| title = NUT midline carcinoma with leukemic presentation mimicking CD34-positive acute leukemia. \| journal = Blood \| volume = 132 \| issue = 4 \| pages = 456 \| month = Jul \| year = 2018 \| doi = 10.1182/blood-2017-07-796268 \| PMID = 30049733 }}</ref>		*Acute leukemia - especially as ''NUT carcinoma'' may be CD34 positive.<ref name=pmid>{{Cite journal \| last1 = Li \| first1 = W. \| last2 = Chastain \| first2 = K. \| title = NUT midline carcinoma with leukemic presentation mimicking CD34-positive acute leukemia. \| journal = Blood \| volume = 132 \| issue = 4 \| pages = 456 \| month = Jul \| year = 2018 \| doi = 10.1182/blood-2017-07-796268 \| PMID = 30049733 }}</ref>

	===Images===		===Images===

Michael at 13:10, 25 June 2021

2021-06-25T13:10:01Z

← Older revision		Revision as of 13:10, 25 June 2021
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	\| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium		\| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Carcinoma ex pleomorphic adenoma]]~~, poorly differentiated carcinoma~~, [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], ~~[[Acute~~ leukemia]]		\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], acute leukemia, poorly differentiated carcinoma,
	\| Stains =		\| Stains =
	\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve		\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve

Michael at 13:09, 25 June 2021

2021-06-25T13:09:33Z

← Older revision		Revision as of 13:09, 25 June 2021
Line 7:		Line 7:
	\| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium		\| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], poorly differentiated carcinoma, [[squamous cell carcinoma]]		\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], poorly differentiated carcinoma, [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], [[Acute leukemia]]
	\| Stains =		\| Stains =
	\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve		\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve

Michael: +SqCC in ddx

2021-06-25T13:08:25Z

+SqCC in ddx

← Older revision		Revision as of 13:08, 25 June 2021
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	\| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium		\| Micro = cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], poorly differentiated carcinoma		\| LMDDx = [[Carcinoma ex pleomorphic adenoma]], poorly differentiated carcinoma, [[squamous cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve		\| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve
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	DDx:		DDx:
			*[[Squamous cell carcinoma]].
	*[[Carcinoma ex pleomorphic adenoma]].		*[[Carcinoma ex pleomorphic adenoma]].
	*Poorly differentiated carcinoma.		*Poorly differentiated carcinoma.

Michael: /* Microscopic */

2019-04-09T20:48:01Z

Microscopic

← Older revision		Revision as of 20:48, 9 April 2019
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	*[[Carcinoma ex pleomorphic adenoma]].		*[[Carcinoma ex pleomorphic adenoma]].
	*Poorly differentiated carcinoma.		*Poorly differentiated carcinoma.
	*SMARCB1-deficient sinonasal carcinoma.<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>		*[[SMARCB1-deficient sinonasal carcinoma]].<ref name=pmid25007146>{{Cite journal \| last1 = Bishop \| first1 = JA. \| last2 = Antonescu \| first2 = CR. \| last3 = Westra \| first3 = WH. \| title = SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract. \| journal = Am J Surg Pathol \| volume = 38 \| issue = 9 \| pages = 1282-9 \| month = Sep \| year = 2014 \| doi = 10.1097/PAS.0000000000000285 \| PMID = 25007146 }}</ref>
	*Acute leukemia - especially as ''NUT midline carcinoma'' may be CD34 positive.<ref name=pmid>{{Cite journal \| last1 = Li \| first1 = W. \| last2 = Chastain \| first2 = K. \| title = NUT midline carcinoma with leukemic presentation mimicking CD34-positive acute leukemia. \| journal = Blood \| volume = 132 \| issue = 4 \| pages = 456 \| month = Jul \| year = 2018 \| doi = 10.1182/blood-2017-07-796268 \| PMID = 30049733 }}</ref>		*Acute leukemia - especially as ''NUT midline carcinoma'' may be CD34 positive.<ref name=pmid>{{Cite journal \| last1 = Li \| first1 = W. \| last2 = Chastain \| first2 = K. \| title = NUT midline carcinoma with leukemic presentation mimicking CD34-positive acute leukemia. \| journal = Blood \| volume = 132 \| issue = 4 \| pages = 456 \| month = Jul \| year = 2018 \| doi = 10.1182/blood-2017-07-796268 \| PMID = 30049733 }}</ref>

Michael: /* IHC */

2019-04-05T14:59:02Z

IHC

← Older revision		Revision as of 14:59, 5 April 2019
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	*p16 +ve (4 of 4 cases).<ref name=pmid24185123>{{Cite journal \| last1 = Salles \| first1 = PG. \| last2 = Moura \| first2 = Rde D. \| last3 = Menezes \| first3 = LM. \| last4 = Bacchi \| first4 = CE. \| title = Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV). \| journal = Appl Immunohistochem Mol Morphol \| volume = 22 \| issue = 4 \| pages = 262-5 \| month = Apr \| year = 2014 \| doi = 10.1097/PAI.0b013e3182a4ef2e \| PMID = 24185123 }}</ref>		*p16 +ve (4 of 4 cases).<ref name=pmid24185123>{{Cite journal \| last1 = Salles \| first1 = PG. \| last2 = Moura \| first2 = Rde D. \| last3 = Menezes \| first3 = LM. \| last4 = Bacchi \| first4 = CE. \| title = Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV). \| journal = Appl Immunohistochem Mol Morphol \| volume = 22 \| issue = 4 \| pages = 262-5 \| month = Apr \| year = 2014 \| doi = 10.1097/PAI.0b013e3182a4ef2e \| PMID = 24185123 }}</ref>
	*Ki-67 >80% of tumour cells.{{fact}}		*Ki-67 >80% of tumour cells.{{fact}}
			*CK7 +ve.<ref name=pmid25549144>{{Cite journal \| last1 = Zhu \| first1 = S. \| last2 = Schuerch \| first2 = C. \| last3 = Hunt \| first3 = J. \| title = Review and updates of immunohistochemistry in selected salivary gland and head and neck tumors. \| journal = Arch Pathol Lab Med \| volume = 139 \| issue = 1 \| pages = 55-66 \| month = Jan \| year = 2015 \| doi = 10.5858/arpa.2014-0167-RA \| PMID = 25549144 }}</ref>

	==See also==		==See also==

Michael: /* IHC */

2019-03-18T00:47:08Z

IHC

← Older revision		Revision as of 00:47, 18 March 2019
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	*EMA +ve.		*EMA +ve.
	*p16 +ve (4 of 4 cases).<ref name=pmid24185123>{{Cite journal \| last1 = Salles \| first1 = PG. \| last2 = Moura \| first2 = Rde D. \| last3 = Menezes \| first3 = LM. \| last4 = Bacchi \| first4 = CE. \| title = Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV). \| journal = Appl Immunohistochem Mol Morphol \| volume = 22 \| issue = 4 \| pages = 262-5 \| month = Apr \| year = 2014 \| doi = 10.1097/PAI.0b013e3182a4ef2e \| PMID = 24185123 }}</ref>		*p16 +ve (4 of 4 cases).<ref name=pmid24185123>{{Cite journal \| last1 = Salles \| first1 = PG. \| last2 = Moura \| first2 = Rde D. \| last3 = Menezes \| first3 = LM. \| last4 = Bacchi \| first4 = CE. \| title = Expression of P16 in NUT carcinomas with no association with human papillomavirus (HPV). \| journal = Appl Immunohistochem Mol Morphol \| volume = 22 \| issue = 4 \| pages = 262-5 \| month = Apr \| year = 2014 \| doi = 10.1097/PAI.0b013e3182a4ef2e \| PMID = 24185123 }}</ref>
			*Ki-67 >80% of tumour cells.{{fact}}

	==See also==		==See also==