Nasopharyngeal carcinoma - Revision history

Michael: ddx snuc

2021-10-04T17:10:09Z

ddx snuc

← Older revision		Revision as of 17:10, 4 October 2021
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	\| Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component		\| Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component
	\| Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC		\| Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC
	\| LMDDx = [[HPV-associated head and neck squamous cell carcinoma]], [[squamous cell carcinoma of the head and neck]]		\| LMDDx = [[HPV-associated head and neck squamous cell carcinoma]], [[squamous cell carcinoma of the head and neck]], [[sinonasal undifferentiated carcinoma]] (SNUC)
	\| Stains =		\| Stains =
	\| IHC = p16 -ve, LMP-1 -ve/+ve		\| IHC = p16 -ve, LMP-1 -ve/+ve
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	*[[HPV-associated head and neck squamous cell carcinoma]].		*[[HPV-associated head and neck squamous cell carcinoma]].
	*[[Squamous cell carcinoma of the head and neck]].		*[[Squamous cell carcinoma of the head and neck]].
			*[[Sinonasal undifferentiated carcinoma]] (SNUC).

	===Images===		===Images===

Michael: synonyms

2021-10-04T16:47:50Z

synonyms

← Older revision		Revision as of 16:47, 4 October 2021
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	\| Width =		\| Width =
	\| Caption = Nasopharyngeal carcinoma. [[H&E stain]].		\| Caption = Nasopharyngeal carcinoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms = nasopharyngeal-type undifferentiated carcinoma, non-keratining nasopharyngeal carcinoma undifferentiated type
	\| Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component		\| Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component
	\| Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC		\| Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC

Michael at 19:57, 26 December 2019

2019-12-26T19:57:25Z

← Older revision		Revision as of 19:57, 26 December 2019
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	\| IHC = p16 -ve, LMP-1 -ve/+ve		\| IHC = p16 -ve, LMP-1 -ve/+ve
	\| EM =		\| EM =
	\| Molecular = EBER +ve		\| Molecular = [[EBER]] +ve
	\| IF =		\| IF =
	\| Gross =		\| Gross =
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	==Molecular==		==Molecular==
	*EBER +ve.<ref name=pmid11913680/>		*[[EBER]] +ve.<ref name=pmid11913680/>

	===Images===		===Images===

Michael: /* Molecular */ tweak

2019-12-26T19:39:22Z

Molecular: tweak

← Older revision		Revision as of 19:39, 26 December 2019
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	===Images===		===Images===
	<gallery>		<gallery>
	Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg \| NC - EBER - very low mag. (WC)		Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg \| NPC - EBER - very low mag. (WC)
	Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg \| NC - EBER - low mag. (WC)		Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg \| NPC - EBER - low mag. (WC)
	Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg \| NC - EBER - high mag. (WC)		Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg \| NPC - EBER - high mag. (WC)
	</gallery>		</gallery>

Michael: /* Case 1 */ tweak

2019-12-26T19:39:05Z

Case 1: tweak

← Older revision		Revision as of 19:39, 26 December 2019
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	====Case 1====		====Case 1====
	<gallery>		<gallery>
	Image: Nasopharyngeal carcinoma -- extremely low mag.jpg \| NC - very low mag. (WC)		Image: Nasopharyngeal carcinoma -- extremely low mag.jpg \| NPC - very low mag. (WC)
	Image: Nasopharyngeal carcinoma -- very low mag.jpg \| NC - very low mag. (WC)		Image: Nasopharyngeal carcinoma -- very low mag.jpg \| NPC - very low mag. (WC)
	Image: Nasopharyngeal carcinoma -- low mag.jpg \| NC - low mag. (WC)		Image: Nasopharyngeal carcinoma -- low mag.jpg \| NPC - low mag. (WC)
	Image: Nasopharyngeal carcinoma -- intermed mag.jpg \| NC - intermed. mag. (WC)		Image: Nasopharyngeal carcinoma -- intermed mag.jpg \| NPC - intermed. mag. (WC)
	Image: Nasopharyngeal carcinoma -- high mag.jpg \| NC - high mag. (WC)		Image: Nasopharyngeal carcinoma -- high mag.jpg \| NPC - high mag. (WC)
	Image: Nasopharyngeal carcinoma - alt -- high mag.jpg \| NC - high mag. (WC)		Image: Nasopharyngeal carcinoma - alt -- high mag.jpg \| NPC - high mag. (WC)
	Image: Nasopharyngeal carcinoma -- very high mag.jpg \| NC - very high mag. (WC)		Image: Nasopharyngeal carcinoma -- very high mag.jpg \| NPC - very high mag. (WC)
	</gallery>		</gallery>

	====Case 2====		====Case 2====
	<gallery>		<gallery>

Michael: /* Images */ fi

2019-12-26T19:38:23Z

Images: fi

← Older revision		Revision as of 19:38, 26 December 2019
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	===Images===		===Images===
	<~~gallary~~>		<gallery>
	Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg \| NC - EBER - very low mag. (WC)		Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg \| NC - EBER - very low mag. (WC)
	Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg \| NC - EBER - low mag. (WC)		Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg \| NC - EBER - low mag. (WC)
	Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg \| NC - EBER - high mag. (WC)		Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg \| NC - EBER - high mag. (WC)
	</gallery>		</gallery>

	==See also==		==See also==
	*[[Head and neck pathology]].		*[[Head and neck pathology]].

Michael: tweak

2019-12-26T19:37:51Z

tweak

← Older revision		Revision as of 19:37, 26 December 2019
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Lymphoepithelioma_met_to_LN_6~~.jpg		\| Image = Nasopharyngeal carcinoma - alt -- high mag.jpg
	\| Width =		\| Width =
	\| Caption = Nasopharyngeal carcinoma. [[H&E stain]].		\| Caption = Nasopharyngeal carcinoma. [[H&E stain]].
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	Image:Lymphoepithelioma_met_to_LN_6.jpg \| Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)		Image:Lymphoepithelioma_met_to_LN_6.jpg \| Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)
	</gallery>		</gallery>
	www:		====www====
	*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)].		*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)].
	*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)].		*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)].

Michael at 19:36, 26 December 2019

2019-12-26T19:36:16Z

← Older revision		Revision as of 19:36, 26 December 2019
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	===Images===		===Images===
			====Case 1====
			<gallery>
			Image: Nasopharyngeal carcinoma -- extremely low mag.jpg \| NC - very low mag. (WC)
			Image: Nasopharyngeal carcinoma -- very low mag.jpg \| NC - very low mag. (WC)
			Image: Nasopharyngeal carcinoma -- low mag.jpg \| NC - low mag. (WC)
			Image: Nasopharyngeal carcinoma -- intermed mag.jpg \| NC - intermed. mag. (WC)
			Image: Nasopharyngeal carcinoma -- high mag.jpg \| NC - high mag. (WC)
			Image: Nasopharyngeal carcinoma - alt -- high mag.jpg \| NC - high mag. (WC)
			Image: Nasopharyngeal carcinoma -- very high mag.jpg \| NC - very high mag. (WC)
			</gallery>
			====Case 2====
	<gallery>		<gallery>
	Image:Lymphoepithelioma_met_to_LN_6.jpg \| Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)		Image:Lymphoepithelioma_met_to_LN_6.jpg \| Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC)
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	*EBER +ve.<ref name=pmid11913680/>		*EBER +ve.<ref name=pmid11913680/>

			===Images===
			<gallary>
			Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg \| NC - EBER - very low mag. (WC)
			Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg \| NC - EBER - low mag. (WC)
			Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg \| NC - EBER - high mag. (WC)
			</gallery>
	==See also==		==See also==
	*[[Head and neck pathology]].		*[[Head and neck pathology]].

Michael: /* IHC */

2019-07-30T19:40:27Z

IHC

← Older revision		Revision as of 19:40, 30 July 2019
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	*p16 -ve.<ref name=pmid9546345>{{cite journal \|author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J \|title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product \|journal=Am. J. Pathol. \|volume=152 \|issue=4 \|pages=865–9 \|year=1998 \|month=April \|pmid=9546345 \|pmc=1858242 \|doi= \|url=}}</ref>		*p16 -ve.<ref name=pmid9546345>{{cite journal \|author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J \|title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product \|journal=Am. J. Pathol. \|volume=152 \|issue=4 \|pages=865–9 \|year=1998 \|month=April \|pmid=9546345 \|pmc=1858242 \|doi= \|url=}}</ref>
	*LMP-1 (EBV-LMP) +ve/-ve.		*LMP-1 (EBV-LMP) +ve/-ve.
	**~~Specific but not~~ sensitive; positive in 40-45% of cases in a series of 30 cases.<ref name=pmid11913680>{{Cite journal \| last1 = Plaza \| first1 = G. \| last2 = Manzanal \| first2 = AI. \| last3 = Fogué \| first3 = L. \| last4 = Santón \| first4 = A. \| last5 = Martínez-Montero \| first5 = JC. \| last6 = Bellas \| first6 = C. \| title = Association of Epstein-Barr virus and nasopharyngeal carcinoma in Caucasian patients. \| journal = Ann Otol Rhinol Laryngol \| volume = 111 \| issue = 3 Pt 1 \| pages = 210-6 \| month = Mar \| year = 2002 \| doi = 10.1177/000348940211100304 \| PMID = 11913680 }}</ref>		**''Not'' [[Sensitivity\|sensitive]]; only positive in 40-45% of cases in a series of 30 cases.<ref name=pmid11913680>{{Cite journal \| last1 = Plaza \| first1 = G. \| last2 = Manzanal \| first2 = AI. \| last3 = Fogué \| first3 = L. \| last4 = Santón \| first4 = A. \| last5 = Martínez-Montero \| first5 = JC. \| last6 = Bellas \| first6 = C. \| title = Association of Epstein-Barr virus and nasopharyngeal carcinoma in Caucasian patients. \| journal = Ann Otol Rhinol Laryngol \| volume = 111 \| issue = 3 Pt 1 \| pages = 210-6 \| month = Mar \| year = 2002 \| doi = 10.1177/000348940211100304 \| PMID = 11913680 }}</ref>

	Notes:		Notes:

Michael: /* IHC */

2019-07-30T19:39:10Z

IHC

← Older revision		Revision as of 19:39, 30 July 2019
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	==IHC==		==IHC==
	*p16 -ve.<ref name=pmid9546345>{{cite journal \|author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J \|title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product \|journal=Am. J. Pathol. \|volume=152 \|issue=4 \|pages=865–9 \|year=1998 \|month=April \|pmid=9546345 \|pmc=1858242 \|doi= \|url=}}</ref>		*p16 -ve.<ref name=pmid9546345>{{cite journal \|author=Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J \|title=Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product \|journal=Am. J. Pathol. \|volume=152 \|issue=4 \|pages=865–9 \|year=1998 \|month=April \|pmid=9546345 \|pmc=1858242 \|doi= \|url=}}</ref>
	*LMP-1 (EBV-LMP) +ve/-ve.<ref name=pmid11913680>{{Cite journal \| last1 = Plaza \| first1 = G. \| last2 = Manzanal \| first2 = AI. \| last3 = Fogué \| first3 = L. \| last4 = Santón \| first4 = A. \| last5 = Martínez-Montero \| first5 = JC. \| last6 = Bellas \| first6 = C. \| title = Association of Epstein-Barr virus and nasopharyngeal carcinoma in Caucasian patients. \| journal = Ann Otol Rhinol Laryngol \| volume = 111 \| issue = 3 Pt 1 \| pages = 210-6 \| month = Mar \| year = 2002 \| doi = 10.1177/000348940211100304 \| PMID = 11913680 }}</ref>		*LMP-1 (EBV-LMP) +ve/-ve.
			**Specific but not sensitive; positive in 40-45% of cases in a series of 30 cases.<ref name=pmid11913680>{{Cite journal \| last1 = Plaza \| first1 = G. \| last2 = Manzanal \| first2 = AI. \| last3 = Fogué \| first3 = L. \| last4 = Santón \| first4 = A. \| last5 = Martínez-Montero \| first5 = JC. \| last6 = Bellas \| first6 = C. \| title = Association of Epstein-Barr virus and nasopharyngeal carcinoma in Caucasian patients. \| journal = Ann Otol Rhinol Laryngol \| volume = 111 \| issue = 3 Pt 1 \| pages = 210-6 \| month = Mar \| year = 2002 \| doi = 10.1177/000348940211100304 \| PMID = 11913680 }}</ref>

	Notes:		Notes: