Necrobiotic xanthogranuloma - Revision history

Michael: /* General */

2016-06-17T20:19:05Z

General

← Older revision		Revision as of 20:19, 17 June 2016
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	==General==		==General==
	*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>		*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>
	*Associated with monoclonal gammopathy ~~in most cases~~.<ref name=pmid25566570>{{Cite journal \| last1 = Seastrom \| first1 = S. \| last2 = Bookout \| first2 = A. \| last3 = Hogan \| first3 = DJ. \| title = Necrobiotic xanthogranuloma without a monoclonal gammopathy. \| journal = Cutis \| volume = 94 \| issue = 6 \| pages = 293-6 \| month = Dec \| year = 2014 \| doi = \| PMID = 25566570 }}</ref>		*Associated with monoclonal gammopathy.<ref>{{Cite journal \| last1 = Mehregan \| first1 = DA. \| last2 = Winkelmann \| first2 = RK. \| title = Necrobiotic xanthogranuloma. \| journal = Arch Dermatol \| volume = 128 \| issue = 1 \| pages = 94-100 \| month = Jan \| year = 1992 \| doi = \| PMID = 1739294 }}</ref>
			**There is case report of NXG without a monoclonal gammopathy.<ref name=pmid25566570>{{Cite journal \| last1 = Seastrom \| first1 = S. \| last2 = Bookout \| first2 = A. \| last3 = Hogan \| first3 = DJ. \| title = Necrobiotic xanthogranuloma without a monoclonal gammopathy. \| journal = Cutis \| volume = 94 \| issue = 6 \| pages = 293-6 \| month = Dec \| year = 2014 \| doi = \| PMID = 25566570 }}</ref>

	==Gross==		==Gross==

Michael at 20:16, 17 June 2016

2016-06-17T20:16:03Z

← Older revision		Revision as of 20:16, 17 June 2016
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	'''Necrobiotic xanthogranuloma''', abbreviated '''NXG''', is a rare [[granuloma\|granulomatous]] [[skin]] condition.		'''Necrobiotic xanthogranuloma''', abbreviated '''NXG''', is a rare [[granuloma\|granulomatous]] [[skin]] condition that is typically periorbital.

	==General==		==General==
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	*[[Necrobiosis lipoidica]] - has plasma cells.		*[[Necrobiosis lipoidica]] - has plasma cells.
	*Granuloma-forming infections - positive stains for microorganisms.		*Granuloma-forming infections - positive stains for microorganisms.
			*[[Juvenile xanthogranuloma]].

	===Image===		===Image===
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	==See also==		==See also==
	*[[Inflammatory skin disorders]].		*[[Inflammatory skin disorders]].
			*[[Giant cells]].

	==References==		==References==

Michael: /* Gross */

2016-06-17T20:15:00Z

Gross

← Older revision		Revision as of 20:15, 17 June 2016
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	==Gross==		==Gross==
	Features:		Features:
			*Yellow plaques.
	*Periorbital - classic location.<ref name=pmid17544963>{{Cite journal \| last1 = Fernández-Herrera \| first1 = J. \| last2 = Pedraz \| first2 = J. \| title = Necrobiotic xanthogranuloma. \| journal = Semin Cutan Med Surg \| volume = 26 \| issue = 2 \| pages = 108-13 \| month = Jun \| year = 2007 \| doi = 10.1016/j.sder.2007.02.008 \| PMID = 17544963 }}</ref>		*Periorbital - classic location.<ref name=pmid17544963>{{Cite journal \| last1 = Fernández-Herrera \| first1 = J. \| last2 = Pedraz \| first2 = J. \| title = Necrobiotic xanthogranuloma. \| journal = Semin Cutan Med Surg \| volume = 26 \| issue = 2 \| pages = 108-13 \| month = Jun \| year = 2007 \| doi = 10.1016/j.sder.2007.02.008 \| PMID = 17544963 }}</ref>
			**66% of cases periorbital in one series.<ref name=pmid27238425>{{Cite journal \| last1 = Higgins \| first1 = LS. \| last2 = Go \| first2 = RS. \| last3 = Dingli \| first3 = D. \| last4 = Kumar \| first4 = SK. \| last5 = Rajkumar \| first5 = SV. \| last6 = Dispenzieri \| first6 = A. \| last7 = Buadi \| first7 = FK. \| last8 = Lacy \| first8 = MQ. \| last9 = Lust \| first9 = JA. \| title = Clinical Features and Treatment Outcomes of Patients With Necrobiotic Xanthogranuloma Associated With Monoclonal Gammopathies. \| journal = Clin Lymphoma Myeloma Leuk \| volume = \| issue = \| pages = \| month = May \| year = 2016 \| doi = 10.1016/j.clml.2016.04.009 \| PMID = 27238425 }}</ref>

	==Microscopic==		==Microscopic==

Michael: /* General */

2016-06-17T20:14:16Z

General

← Older revision		Revision as of 20:14, 17 June 2016
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	==General==		==General==
	*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>		*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>
			*Associated with monoclonal gammopathy in most cases.<ref name=pmid25566570>{{Cite journal \| last1 = Seastrom \| first1 = S. \| last2 = Bookout \| first2 = A. \| last3 = Hogan \| first3 = DJ. \| title = Necrobiotic xanthogranuloma without a monoclonal gammopathy. \| journal = Cutis \| volume = 94 \| issue = 6 \| pages = 293-6 \| month = Dec \| year = 2014 \| doi = \| PMID = 25566570 }}</ref>

	==Gross==		==Gross==

Michael at 20:13, 17 June 2016

2016-06-17T20:13:59Z

← Older revision		Revision as of 20:13, 17 June 2016
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	~~#redirect~~ [[~~Inflammatory_skin_disorders#Necrobiotic_xanthogranuloma~~]]		'''Necrobiotic xanthogranuloma''', abbreviated '''NXG''', is a rare [[granuloma\|granulomatous]] [[skin]] condition.

			==General==
			*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>

			==Gross==
			Features:
			*Periorbital - classic location.<ref name=pmid17544963>{{Cite journal \| last1 = Fernández-Herrera \| first1 = J. \| last2 = Pedraz \| first2 = J. \| title = Necrobiotic xanthogranuloma. \| journal = Semin Cutan Med Surg \| volume = 26 \| issue = 2 \| pages = 108-13 \| month = Jun \| year = 2007 \| doi = 10.1016/j.sder.2007.02.008 \| PMID = 17544963 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_Derm629>{{Ref Derm\|629}}</ref>
			*"Necrobiotic granuloma":
			**Palisading granuloma with a core collagen-like material.
			*+/-Cholesterol clefts - common.
			*+/-[[Touton giant cell]]s.
			*+/-Atypical foreign body-type giant cells +/- asteroid bodies.

			DDx:
			*[[Granuloma annulare]].
			*[[Necrobiosis lipoidica]] - has plasma cells.
			*Granuloma-forming infections - positive stains for microorganisms.

			===Image===
			*[http://commons.wikimedia.org/wiki/File:Asteroid_bodies_high_mag_cropped.jpg Asteroid body (WC)].

			==See also==
			*[[Inflammatory skin disorders]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: create

2012-11-23T17:29:58Z

create

New page

#redirect [[Inflammatory_skin_disorders#Necrobiotic_xanthogranuloma]]

[[Category:Diagnosis]]