Nested urothelial cell carcinoma - Revision history

Michael: redirect

2015-06-19T05:52:04Z

redirect

← Older revision		Revision as of 05:52, 19 June 2015
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	~~'''Nested urothelial cell carcinoma''', also '''nested urothelial carcinoma''', is an aggressive subtype of~~ [[~~urothelial carcinoma]] that has a bland morphology but an aggressive behaviour.~~		#redirect [[Nested urothelial carcinoma]]

	~~It is also known as '''nested variant urothelial cell carcinoma'''.~~

	~~==General==~~
	*Aggressive behaviour despite bland histomorphology.<ref name=pmid14681330>{{Cite journal \| last1 = Lin \| first1 = O. \| last2 = Cardillo \| first2 = M. \| last3 = Dalbagni \| first3 = G. \| last4 = Linkov \| first4 = I. \| last5 = Hutchinson \| first5 = B. \| last6 = Reuter \| first6 = VE. \| title = Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. \| journal = Mod Pathol \| volume = 16 \| issue = 12 \| pages = 1289-98 \| month = Dec \| year = 2003 \| doi = 10.1097/01.MP.0000094091.04541.FC \| PMID = 14681330 }}</ref>

	~~==Microscopic==~~
	Features:<ref name=pmid2712189>{{Cite journal \| last1 = Talbert \| first1 = ML. \| last2 = Young \| first2 = RH. \| title = Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 5 \| pages = 374-81 \| month = May \| year = 1989 \| doi = \| PMID = 2712189 }}</ref>
	*High density of well-circumscribed nests.
	*Mild-to-moderate nuclear atypia.
	*+/-Foci of unequivocal conventional urothelial carcinoma.
	**Focally solid or gland fusion.
	**Moderate-to-severe nuclear atypia +/- abundant mitoses.
	*+/-Extension into the muscularis propria.

	~~DDx:~~
	*[[von Brunn nests]].<ref name=pmid21836490>{{Cite journal \| last1 = Cox \| first1 = R. \| last2 = Epstein \| first2 = JI. \| title = Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 9 \| pages = 1337-42 \| month = Sep \| year = 2011 \| doi = 10.1097/PAS.0b013e318222a653 \| PMID = 21836490 }}</ref>
	*[[Low grade papillary urothelial carcinoma~~]] with lamina propria invasion.~~

	~~==IHC==~~
	*MIB-1 typically >15%.<ref name=pmid14681330/>

	~~==See also==~~
	*[[Urothelial carcinoma]].
	*[[Urothelium]].

	~~==References==~~
	~~{{Reflist\|2}}~~

	~~[[Category:Diagnosis]]~~
	~~[[Category:Urothelium~~]]

Michael: split out

2015-06-19T05:50:24Z

split out

← Older revision		Revision as of 05:50, 19 June 2015
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	~~#redirect~~ [[Urothelium~~#Nested_urothelial_cell_carcinoma~~]]		'''Nested urothelial cell carcinoma''', also '''nested urothelial carcinoma''', is an aggressive subtype of [[urothelial carcinoma]] that has a bland morphology but an aggressive behaviour.

			It is also known as '''nested variant urothelial cell carcinoma'''.

			==General==
			*Aggressive behaviour despite bland histomorphology.<ref name=pmid14681330>{{Cite journal \| last1 = Lin \| first1 = O. \| last2 = Cardillo \| first2 = M. \| last3 = Dalbagni \| first3 = G. \| last4 = Linkov \| first4 = I. \| last5 = Hutchinson \| first5 = B. \| last6 = Reuter \| first6 = VE. \| title = Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. \| journal = Mod Pathol \| volume = 16 \| issue = 12 \| pages = 1289-98 \| month = Dec \| year = 2003 \| doi = 10.1097/01.MP.0000094091.04541.FC \| PMID = 14681330 }}</ref>

			==Microscopic==
			Features:<ref name=pmid2712189>{{Cite journal \| last1 = Talbert \| first1 = ML. \| last2 = Young \| first2 = RH. \| title = Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. \| journal = Am J Surg Pathol \| volume = 13 \| issue = 5 \| pages = 374-81 \| month = May \| year = 1989 \| doi = \| PMID = 2712189 }}</ref>
			*High density of well-circumscribed nests.
			*Mild-to-moderate nuclear atypia.
			*+/-Foci of unequivocal conventional urothelial carcinoma.
			**Focally solid or gland fusion.
			**Moderate-to-severe nuclear atypia +/- abundant mitoses.
			*+/-Extension into the muscularis propria.

			DDx:
			*[[von Brunn nests]].<ref name=pmid21836490>{{Cite journal \| last1 = Cox \| first1 = R. \| last2 = Epstein \| first2 = JI. \| title = Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma. \| journal = Am J Surg Pathol \| volume = 35 \| issue = 9 \| pages = 1337-42 \| month = Sep \| year = 2011 \| doi = 10.1097/PAS.0b013e318222a653 \| PMID = 21836490 }}</ref>
			*[[Low grade papillary urothelial carcinoma]] with lamina propria invasion.

			==IHC==
			*MIB-1 typically >15%.<ref name=pmid14681330/>

			==See also==
			*[[Urothelial carcinoma]].
			*[[Urothelium]].

			==References==
			{{Reflist\|2}}

			[[Category:Diagnosis]]
			[[Category:Urothelium]]

Michael: +redirect

2012-04-20T14:12:37Z

+redirect

New page

#redirect [[Urothelium#Nested_urothelial_cell_carcinoma]]