Neurofibroma - Revision history

Michael: /* Alternate */ fix typo

2022-01-21T17:19:07Z

Alternate: fix typo

← Older revision		Revision as of 17:19, 21 January 2022
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	====Alternate====		====Alternate====
	The sections show skin with an unencapsulated dermal spindle cell lesion with ~~navy~~ nuclei that have a likeness to shredded carrots. Occasional mast cells are present within the lesion. There is no nuclear atypia. Mitotic activity is not appreciated. No melanocytic nests are identified.		The sections show skin with an unencapsulated dermal spindle cell lesion with wavy nuclei that have a likeness to shredded carrots. Occasional mast cells are present within the lesion. There is no nuclear atypia. Mitotic activity is not appreciated. No melanocytic nests are identified.

	==See also==		==See also==

Michael at 19:03, 23 November 2015

2015-11-23T19:03:45Z

← Older revision		Revision as of 19:03, 23 November 2015
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	\| Width =		\| Width =
	\| Caption = Neurofibroma. [[H&E stain]].		\| Caption = Neurofibroma. [[H&E stain]].
	\| Micro = spindle cells with wavy nuclei without pleomorphism ~~("shredded carrots")~~, +/-arranged in fascicles and intermixed with collagen, moderately increased cellularity, poorly ''or'' well-circumscribed, +/-plexiform growth pattern ("bag of worms"), +/-mast cells (useful)		\| Micro = spindle cells with wavy nuclei without pleomorphism, +/-arranged in fascicles and intermixed with (wire-like) collagen ("shredded carrots"), moderately increased cellularity, poorly ''or'' well-circumscribed, +/-plexiform growth pattern ("bag of worms"), +/-mast cells (useful)
	\| Subtypes = [[plexiform neurofibroma]]		\| Subtypes = [[plexiform neurofibroma]]
	\| LMDDx = [[schwannoma]], [[dermatofibrosarcoma protuberans]], [[ganglioneuroma]], neurotized [[melanocytic nevus]], [[MPNST]]		\| LMDDx = [[schwannoma]], [[dermatofibrosarcoma protuberans]], [[ganglioneuroma]], neurotized [[melanocytic nevus]], [[MPNST]]

Michael: /* Images */ fix

2015-10-26T05:33:26Z

Images: fix

← Older revision		Revision as of 05:33, 26 October 2015
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	File:Neurofibroma_-3.jpg \| Neurofibroma (WC/Netha Hussain)		File:Neurofibroma_-3.jpg \| Neurofibroma (WC/Netha Hussain)
	File:Plexiform_neurofibroma.jpg \| Neurofibroma (WC/Netha Hussain)		File:Plexiform_neurofibroma.jpg \| Neurofibroma (WC/Netha Hussain)
	/File:Plexiform_neurofibroma_-1.jpg \| Plexiform Neurofibroma (WC/Netha Hussain)		File:Plexiform_neurofibroma_-1.jpg \| Plexiform Neurofibroma (WC/Netha Hussain)
	</gallery>		</gallery>
	www:		www:

Jensflorian at 11:55, 18 July 2015

2015-07-18T11:55:38Z

← Older revision		Revision as of 11:55, 18 July 2015
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	[[Category:Peripheral nerve sheath tumours]]		[[Category:Peripheral nerve sheath tumours]]
	[[Category:Neuropathology]]		[[Category:Neuropathology tumours]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Jensflorian: +images

2015-07-18T11:50:37Z

+images

← Older revision		Revision as of 11:50, 18 July 2015
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	Gross features (plexiform NF):<ref name=pmid15486243>{{Cite journal \| last1 = Wilkinson \| first1 = LM. \| last2 = Manson \| first2 = D. \| last3 = Smith \| first3 = CR. \| title = Best cases from the AFIP: plexiform neurofibroma of the bladder. \| journal = Radiographics \| volume = 24 Suppl 1 \| issue = \| pages = S237-42 \| month = Oct \| year = 2004 \| doi = 10.1148/rg.24si035170 \| PMID = 15486243 }}</ref>		Gross features (plexiform NF):<ref name=pmid15486243>{{Cite journal \| last1 = Wilkinson \| first1 = LM. \| last2 = Manson \| first2 = D. \| last3 = Smith \| first3 = CR. \| title = Best cases from the AFIP: plexiform neurofibroma of the bladder. \| journal = Radiographics \| volume = 24 Suppl 1 \| issue = \| pages = S237-42 \| month = Oct \| year = 2004 \| doi = 10.1148/rg.24si035170 \| PMID = 15486243 }}</ref>
	*"Bag of worms" appearance.		*"Bag of worms" appearance.

			<gallery>
			File:Neurofibroma_large_NF1.jpg \|Large neurofibroma in a NF1 case (WC/jensflorian)
			File:Neurofibroma -1.jpg \| Neurofibroma (Calicut College)
			File:Neurofibroma -2.jpg \| Neurofibroma with typical whitish surface (Calicut College)
			</gallery>

	Radiologic:<ref name=pmid15486243/>		Radiologic:<ref name=pmid15486243/>
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	Image:Neurofibroma_(2).jpg \| Neurofibroma - intermed. mag. (WC)		Image:Neurofibroma_(2).jpg \| Neurofibroma - intermed. mag. (WC)
	Image:Neurofibroma_(3).jpg \| Neurofibroma - high mag. (WC)		Image:Neurofibroma_(3).jpg \| Neurofibroma - high mag. (WC)
			File:Neurofibroma_-3.jpg \| Neurofibroma (WC/Netha Hussain)
			File:Plexiform_neurofibroma.jpg \| Neurofibroma (WC/Netha Hussain)
			/File:Plexiform_neurofibroma_-1.jpg \| Plexiform Neurofibroma (WC/Netha Hussain)
	</gallery>		</gallery>
	www:		www:
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	[[Category:Peripheral nerve sheath tumours]]		[[Category:Peripheral nerve sheath tumours]]
			[[Category:Neuropathology]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: touch

2015-07-18T02:45:20Z

touch

← Older revision		Revision as of 02:45, 18 July 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Neurofibroma_(3).jpg		\| Image = Neurofibroma_(3).jpg
	\| Width =		\| Width =
	\| Caption = Neurofibroma. [[H&E stain]].		\| Caption = Neurofibroma. [[H&E stain]].

Michael: /* Microscopic */

2015-03-19T19:40:56Z

Microscopic

← Older revision		Revision as of 19:40, 19 March 2015
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	Features:		Features:
	*Spindle cells with wavy nuclei without pleomorphism - '''key feature'''.		*Spindle cells with wavy nuclei without pleomorphism - '''key feature'''.
	**Often described as "shredded carrots".		*Intermixed with wire-like collagen.
	*May be arranged in fascicles and intermixed with collagen.
	**Often no pattern is apparent.		**Often no pattern is apparent.
			**Often described as "shredded carrots".<ref name=pmid24216989>{{Cite journal \| last1 = Bernthal \| first1 = NM. \| last2 = Jones \| first2 = KB. \| last3 = Monument \| first3 = MJ. \| last4 = Liu \| first4 = T. \| last5 = Viskochil \| first5 = D. \| last6 = Randall \| first6 = RL. \| title = Lost in translation: ambiguity in nerve sheath tumor nomenclature and its resultant treatment effect. \| journal = Cancers (Basel) \| volume = 5 \| issue = 2 \| pages = 519-28 \| month = \| year = 2013 \| doi = 10.3390/cancers5020519 \| PMID = 24216989 }}</ref>
	*Moderate increase of cellularity vis-a-vis normal dermis.		*Moderate increase of cellularity vis-a-vis normal dermis.
	*May be poorly or well-circumscribed.		*May be poorly or well-circumscribed.

Laura: /* General */

2014-11-16T20:19:14Z

General

← Older revision		Revision as of 20:19, 16 November 2014
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	Classification:<ref name=pmid15486243>{{Cite journal \| last1 = Wilkinson \| first1 = LM. \| last2 = Manson \| first2 = D. \| last3 = Smith \| first3 = CR. \| title = Best cases from the AFIP: plexiform neurofibroma of the bladder. \| journal = Radiographics \| volume = 24 Suppl 1 \| issue = \| pages = S237-42 \| month = Oct \| year = 2004 \| doi = 10.1148/rg.24si035170 \| PMID = 15486243 }}</ref>		Classification:<ref name=pmid15486243>{{Cite journal \| last1 = Wilkinson \| first1 = LM. \| last2 = Manson \| first2 = D. \| last3 = Smith \| first3 = CR. \| title = Best cases from the AFIP: plexiform neurofibroma of the bladder. \| journal = Radiographics \| volume = 24 Suppl 1 \| issue = \| pages = S237-42 \| month = Oct \| year = 2004 \| doi = 10.1148/rg.24si035170 \| PMID = 15486243 }}</ref>
	#Localized - ~~sporatic~~.		#Localized - sporadic.
	#Diffuse - usually poorly defined, young adults and children; ~~sporatic~~.		#Diffuse - usually poorly defined, young adults and children; sporadic.
	#Plexiform - associated with NF1.		#Plexiform - associated with NF1.

Michael at 12:08, 27 November 2013

2013-11-27T12:08:46Z

← Older revision		Revision as of 12:08, 27 November 2013
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = benign ~~if isolated~~		\| Prognosis = benign
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =

Michael at 19:23, 25 November 2013

2013-11-25T19:23:10Z

← Older revision		Revision as of 19:23, 25 November 2013
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	DDx:		DDx:
	*[[Plexiform neurofibroma]].		*[[Plexiform neurofibroma]].
	*[[Schwannoma]].		*[[Schwannoma]] - calretinin +ve, CD34 mostly -ve.<ref>URL: [http://www.ihcworld.com/_newsletter/2004/2004-10_NF_vs_schwannoma_v1.pdf http://www.ihcworld.com/_newsletter/2004/2004-10_NF_vs_schwannoma_v1.pdf]. Accessed on: 25 November 2013.</ref>
	*[[Dermatofibrosarcoma protuberans]] (DFSP) - S-100 -ve.		*[[Dermatofibrosarcoma protuberans]] (DFSP) - S-100 -ve.
	*[[Ganglioneuroma]].		*[[Ganglioneuroma]].