Nipple adenoma - Revision history

Michael at 21:17, 9 May 2016

2016-05-09T21:17:24Z

← Older revision		Revision as of 21:17, 9 May 2016
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	\| Micro = proliferation of epithelial and myoepithelial elements that extends into the breast stroma; not encapsulated; lacks true fibrovascular cores, +/-focal necrosis		\| Micro = proliferation of epithelial and myoepithelial elements that extends into the breast stroma; not encapsulated; lacks true fibrovascular cores, +/-focal necrosis
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[intraductal papilloma]]		\| LMDDx = [[intraductal papilloma of the breast]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
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	DDx:		DDx:
	*[[Intraductal papilloma]].		*[[Intraductal papilloma of the breast]].
	**Found within the duct '''not''' the stroma.		**Found within the duct '''not''' the stroma.
	**Often deeper - one should '''not''' see skin in the histologic section.		**Often deeper - one should '''not''' see skin in the histologic section.
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	==See also==		==See also==
	*[[Breast pathology]].		*[[Breast pathology]].
	*[[Intraductal papilloma]].		*[[Intraductal papilloma of the breast]].

	==References==		==References==

Sarah: /* Microscopic */

2015-03-26T10:47:30Z

Microscopic

← Older revision		Revision as of 10:47, 26 March 2015
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	==Microscopic==		==Microscopic==
	Features:		Features:
			*Not encapsulated.<ref name=pmid2123505/>
	*Proliferation of epithelial and myoepithelial elements that extends into the breast stroma.<ref name=pmid2123505>{{Cite journal \| title = Adenoma of Nipple. \| journal = Br Med J \| volume = 1 \| issue = 5330 \| pages = 563 \| month = Mar \| year = 1963 \| doi = \| PMID = 20789667 \| PMC = 2123505 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2123505/?page=1 }}</ref>		*Proliferation of epithelial and myoepithelial elements that extends into the breast stroma.<ref name=pmid2123505>{{Cite journal \| title = Adenoma of Nipple. \| journal = Br Med J \| volume = 1 \| issue = 5330 \| pages = 563 \| month = Mar \| year = 1963 \| doi = \| PMID = 20789667 \| PMC = 2123505 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2123505/?page=1 }}</ref>
	*Arborising papillomatous epithelial proliferation within duct		*Arborising papillomatous epithelial proliferation within duct
	*Papillae have fibrovascular cores.		*(Papillae have fibrovascular cores) at least as far as I can see but not according to Stanford.
	*Florid epithelial hyperplasia can be seen		*Florid epithelial hyperplasia can be seen
	*Can see haphazard arrangement of proliferating tubular structures		*Can see haphazard arrangement of proliferating tubular structures
	~~• Differential diagnosis: syringomatous adenoma and tubular carcinoma~~

	Notes:		Notes:
	*Not encapsulated.<ref name=pmid2123505/>
	*Lacks true fibrovascular cores.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html]. Accessed on: 6 August 2011.</ref>		*Lacks true fibrovascular cores.<ref>URL: [http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html]. Accessed on: 6 August 2011.</ref>
	*Focal necrosis may be present.<ref name=Ref_APBR307>{{Ref APBR\|307 Q16}}</ref>		*Focal necrosis may be present.<ref name=Ref_APBR307>{{Ref APBR\|307 Q16}}</ref>
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	**Often deeper - one should '''not''' see skin in the histologic section.		**Often deeper - one should '''not''' see skin in the histologic section.
	*Syringomatous adenoma		*Syringomatous adenoma
	*Intraductal carcinoma - ~~cribriforming~~ glands should be absent		*Intraductal carcinoma - the proliferation in nipple adenoma should be no more atypical than that seen with usual intraductal hyperplasia or intraductal papillomatosis. Cribriforming glands should be absent
	*Invasive ductal carcinoma - IHC is useful (see below) the ducts should all be lined by myoepithelium.		*Invasive ductal carcinoma - IHC is useful (see below) the ducts should all be lined by myoepithelium.

Sarah: /* Microscopic */

2015-03-26T10:31:20Z

Microscopic

← Older revision		Revision as of 10:31, 26 March 2015
Line 61:		Line 61:
	**Often deeper - one should '''not''' see skin in the histologic section.		**Often deeper - one should '''not''' see skin in the histologic section.
	*Syringomatous adenoma		*Syringomatous adenoma
	*Intraductal carcinoma		*Intraductal carcinoma - cribriforming glands should be absent
			*Invasive ductal carcinoma - IHC is useful (see below) the ducts should all be lined by myoepithelium.

	===Images===		===Images===

Sarah: /* Images */

2015-03-26T10:27:44Z

Images

Sarah: /* Microscopic */

2015-03-26T10:26:39Z

Microscopic

← Older revision		Revision as of 10:26, 26 March 2015
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	Features:		Features:
	*Proliferation of epithelial and myoepithelial elements that extends into the breast stroma.<ref name=pmid2123505>{{Cite journal \| title = Adenoma of Nipple. \| journal = Br Med J \| volume = 1 \| issue = 5330 \| pages = 563 \| month = Mar \| year = 1963 \| doi = \| PMID = 20789667 \| PMC = 2123505 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2123505/?page=1 }}</ref>		*Proliferation of epithelial and myoepithelial elements that extends into the breast stroma.<ref name=pmid2123505>{{Cite journal \| title = Adenoma of Nipple. \| journal = Br Med J \| volume = 1 \| issue = 5330 \| pages = 563 \| month = Mar \| year = 1963 \| doi = \| PMID = 20789667 \| PMC = 2123505 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2123505/?page=1 }}</ref>
			*Arborising papillomatous epithelial proliferation within duct
			*Papillae have fibrovascular cores.
			*Florid epithelial hyperplasia can be seen
			*Can see haphazard arrangement of proliferating tubular structures
			• Differential diagnosis: syringomatous adenoma and tubular carcinoma

	Notes:		Notes:
Line 55:		Line 60:
	**Found within the duct '''not''' the stroma.		**Found within the duct '''not''' the stroma.
	**Often deeper - one should '''not''' see skin in the histologic section.		**Often deeper - one should '''not''' see skin in the histologic section.
			*Syringomatous adenoma
			*Intraductal carcinoma

	===Images===		===Images===
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	Image:Nipple_adenoma_-_intermed mag.jpg \| Nipple adenoma - intermed. mag. (WC/Nephron)		Image:Nipple_adenoma_-_intermed mag.jpg \| Nipple adenoma - intermed. mag. (WC/Nephron)
	Image:Nipple_adenoma_-_very_high_mag.jpg \| Nipple adenoma - very high mag. (WC/Nephron)		Image:Nipple_adenoma_-_very_high_mag.jpg \| Nipple adenoma - very high mag. (WC/Nephron)
			Image:Breast NippleAdenoma LP SNP.jpg\|thumb\|Breast Nipple Adenoma - low power (SKB)
			Image:Breast NippleAdenoma MP SNP.jpg\|thumb\|Breast Nipple Adenoma - medium power (SKB)
			Image:Breast NippleAdenoma MP2 SNP.jpg\|thumb\|Breast Nipple Adenoma - medium power (SKB)
			Image:Breast NippleAdenoma LP2 14BR***.jpg\|thumb\|Breast Nipple Adenoma - low power (SKB)
			Image:Breast NippleAdenoma LP 14BR***.jpg\|thumb\|Breast Nipple Adenoma - low power (SKB)
			Image:Breast NippleAdenoma MP 14BR***.jpg\|thumb\|Breast Nipple Adenoma - medium power (SKB)
			Image:Breast NippleAdenoma CK5 14BR***.jpg\|thumb\|Breast Nipple Adenoma - CK5 (SKB)
			Image:Breast NippleAdenoma CK14 14BR***.jpg\|thumb\|Breast Nipple Adenoma CK14 (SKB)
			Image:Breast NippleAdenoma SMA 14BR***.jpg\|thumb\|Breast Nipple Adenoma - SMA (SKB)
			Image:Breast NippleAdenoma p63 14BR***.jpg\|thumb\|Breast Nipple Adenoma - p63 (SKB)
	</gallery>		</gallery>
	www:		www:

Sarah: /* General */

2015-03-26T10:03:41Z

General

← Older revision		Revision as of 10:03, 26 March 2015
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	==General==		==General==
			*A benign lesion with papillary architecture arising at the nipple.
	*Rare.<ref>{{Cite journal \| last1 = Shinn \| first1 = L. \| last2 = Woodward \| first2 = C. \| last3 = Boddu \| first3 = S. \| last4 = Jha \| first4 = P. \| last5 = Fouroutan \| first5 = H. \| last6 = Péley \| first6 = G. \| title = Nipple adenoma arising in a supernumerary mammary gland: a case report. \| journal = Tumori \| volume = 97 \| issue = 6 \| pages = 812-4 \| month = \| year = \| doi = 10.1700/1018.11102 \| PMID = 22322852 }}</ref>		*Rare.<ref>{{Cite journal \| last1 = Shinn \| first1 = L. \| last2 = Woodward \| first2 = C. \| last3 = Boddu \| first3 = S. \| last4 = Jha \| first4 = P. \| last5 = Fouroutan \| first5 = H. \| last6 = Péley \| first6 = G. \| title = Nipple adenoma arising in a supernumerary mammary gland: a case report. \| journal = Tumori \| volume = 97 \| issue = 6 \| pages = 812-4 \| month = \| year = \| doi = 10.1700/1018.11102 \| PMID = 22322852 }}</ref>
	*Reported in men.<ref name=pmid22342578/>		*Reported in men.<ref name=pmid22342578/>

Michael at 18:26, 16 February 2014

2014-02-16T18:26:35Z

← Older revision		Revision as of 18:26, 16 February 2014
Line 35:		Line 35:

	==General==		==General==
	*Rare.<ref><{{Cite journal \| last1 = Shinn \| first1 = L. \| last2 = Woodward \| first2 = C. \| last3 = Boddu \| first3 = S. \| last4 = Jha \| first4 = P. \| last5 = Fouroutan \| first5 = H. \| last6 = Péley \| first6 = G. \| title = Nipple adenoma arising in a supernumerary mammary gland: a case report. \| journal = Tumori \| volume = 97 \| issue = 6 \| pages = 812-4 \| month = \| year = \| doi = 10.1700/1018.11102 \| PMID = 22322852 }}/ref>		*Rare.<ref>{{Cite journal \| last1 = Shinn \| first1 = L. \| last2 = Woodward \| first2 = C. \| last3 = Boddu \| first3 = S. \| last4 = Jha \| first4 = P. \| last5 = Fouroutan \| first5 = H. \| last6 = Péley \| first6 = G. \| title = Nipple adenoma arising in a supernumerary mammary gland: a case report. \| journal = Tumori \| volume = 97 \| issue = 6 \| pages = 812-4 \| month = \| year = \| doi = 10.1700/1018.11102 \| PMID = 22322852 }}</ref>
	*Reported in men.<ref name=pmid22342578/>		*Reported in men.<ref name=pmid22342578/>

Michael at 18:26, 16 February 2014

2014-02-16T18:26:16Z

← Older revision		Revision as of 18:26, 16 February 2014
Line 35:		Line 35:

	==General==		==General==
	*Rare.		*Rare.<ref><{{Cite journal \| last1 = Shinn \| first1 = L. \| last2 = Woodward \| first2 = C. \| last3 = Boddu \| first3 = S. \| last4 = Jha \| first4 = P. \| last5 = Fouroutan \| first5 = H. \| last6 = Péley \| first6 = G. \| title = Nipple adenoma arising in a supernumerary mammary gland: a case report. \| journal = Tumori \| volume = 97 \| issue = 6 \| pages = 812-4 \| month = \| year = \| doi = 10.1700/1018.11102 \| PMID = 22322852 }}/ref>
	*Reported in men.<ref name=pmid22342578/>		*Reported in men.<ref name=pmid22342578/>

Michael at 18:14, 16 February 2014

2014-02-16T18:14:08Z

← Older revision		Revision as of 18:14, 16 February 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Nipple_adenoma_-_very_high_mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Nipple adenoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = proliferation of epithelial and myoepithelial elements that extends into the breast stroma; not encapsulated; lacks true fibrovascular cores, +/-focal necrosis		\| Micro = proliferation of epithelial and myoepithelial elements that extends into the breast stroma; not encapsulated; lacks true fibrovascular cores, +/-focal necrosis

Michael: /* Images */

2014-02-16T18:13:20Z

Images

← Older revision		Revision as of 18:13, 16 February 2014
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	<gallery>		<gallery>
	Image:Nipple_adenoma_-_low_mag.jpg \| Nipple adenoma - low mag. (WC/Nephron)		Image:Nipple_adenoma_-_low_mag.jpg \| Nipple adenoma - low mag. (WC/Nephron)
			Image:Nipple_adenoma_-_intermed mag.jpg \| Nipple adenoma - intermed. mag. (WC/Nephron)
	Image:Nipple_adenoma_-_very_high_mag.jpg \| Nipple adenoma - very high mag. (WC/Nephron)		Image:Nipple_adenoma_-_very_high_mag.jpg \| Nipple adenoma - very high mag. (WC/Nephron)
	</gallery>		</gallery>

← Older revision		Revision as of 10:27, 26 March 2015
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	Image:Nipple_adenoma_-_intermed mag.jpg \| Nipple adenoma - intermed. mag. (WC/Nephron)		Image:Nipple_adenoma_-_intermed mag.jpg \| Nipple adenoma - intermed. mag. (WC/Nephron)
	Image:Nipple_adenoma_-_very_high_mag.jpg \| Nipple adenoma - very high mag. (WC/Nephron)		Image:Nipple_adenoma_-_very_high_mag.jpg \| Nipple adenoma - very high mag. (WC/Nephron)
	Image:Breast NippleAdenoma LP SNP.jpg~~\|thumb~~\|Breast Nipple Adenoma - low power (SKB)		Image:Breast NippleAdenoma LP SNP.jpg\|Breast Nipple Adenoma - low power (SKB)
	Image:Breast NippleAdenoma MP SNP.jpg~~\|thumb~~\|Breast Nipple Adenoma - medium power (SKB)		Image:Breast NippleAdenoma MP SNP.jpg\|Breast Nipple Adenoma - medium power (SKB)
	Image:Breast NippleAdenoma MP2 SNP.jpg~~\|thumb~~\|Breast Nipple Adenoma - medium power (SKB)		Image:Breast NippleAdenoma MP2 SNP.jpg\|Breast Nipple Adenoma - medium power (SKB)
	Image:Breast NippleAdenoma LP2 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma - low power (SKB)		Image:Breast NippleAdenoma LP2 14BR***.jpg\|Breast Nipple Adenoma - low power (SKB)
	Image:Breast NippleAdenoma LP 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma - low power (SKB)		Image:Breast NippleAdenoma LP 14BR***.jpg\|Breast Nipple Adenoma - low power (SKB)
	Image:Breast NippleAdenoma MP 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma - medium power (SKB)		Image:Breast NippleAdenoma MP 14BR***.jpg\|Breast Nipple Adenoma - medium power (SKB)
	Image:Breast NippleAdenoma CK5 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma - CK5 (SKB)		Image:Breast NippleAdenoma CK5 14BR***.jpg\|Breast Nipple Adenoma - CK5 (SKB)
	Image:Breast NippleAdenoma CK14 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma CK14 (SKB)		Image:Breast NippleAdenoma CK14 14BR***.jpg\|Breast Nipple Adenoma CK14 (SKB)
	Image:Breast NippleAdenoma SMA 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma - SMA (SKB)		Image:Breast NippleAdenoma SMA 14BR***.jpg\|Breast Nipple Adenoma - SMA (SKB)
	Image:Breast NippleAdenoma p63 14BR***.jpg~~\|thumb~~\|Breast Nipple Adenoma - p63 (SKB)		Image:Breast NippleAdenoma p63 14BR***.jpg\|Breast Nipple Adenoma - p63 (SKB)
	</gallery>		</gallery>
	www:		www: