Nodular fasciitis - Revision history

Michael at 16:17, 18 June 2017

2017-06-18T16:17:24Z

← Older revision		Revision as of 16:17, 18 June 2017
Line 6:		Line 6:
	\| Micro = usu. well-circumscribed, clusters of (non-pleomorphic) spindle cells, inflammation (lymphocytes), microcysts in cellular regions - uncommon, mitoses - common, [[extravasated RBC]]s.		\| Micro = usu. well-circumscribed, clusters of (non-pleomorphic) spindle cells, inflammation (lymphocytes), microcysts in cellular regions - uncommon, mitoses - common, [[extravasated RBC]]s.
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = myxoid [[dermatofibrosarcoma protuberans]], cellular [[dermatofibroma]], [[desmoid-type fibromatosis]], other [[spindle cell lesions of the skin]]
	\| Stains =		\| Stains =
	\| IHC = CD34 -ve, desmin -ve, SMA -ve, S-100 -ve, AE1/AE3 -ve.		\| IHC = CD34 -ve, desmin -ve, SMA -ve, S-100 -ve, AE1/AE3 -ve.
Line 74:		Line 74:
	*Cellular [[dermatofibroma]].		*Cellular [[dermatofibroma]].
	*[[Desmoid-type fibromatosis]].		*[[Desmoid-type fibromatosis]].
			*Other [[spindle cell lesions of the skin]].

	===Images===		===Images===

Michael: touch

2016-02-08T03:29:40Z

touch

← Older revision		Revision as of 03:29, 8 February 2016
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Nodular_fasciitis_-_intermed_mag.jpg		\| Image = Nodular_fasciitis_-_intermed_mag.jpg
	\| Width =		\| Width =
	\| Caption = Nodular fasciitis. [[H&E stain]].		\| Caption = Nodular fasciitis. [[H&E stain]].

Michael: /* IHC */

2014-06-21T11:54:39Z

IHC

← Older revision		Revision as of 11:54, 21 June 2014
Line 92:		Line 92:
	*CD34 -ve.		*CD34 -ve.
	*Desmin -ve.		*Desmin -ve.
	*SMA -ve.		*SMA +ve -- strong.{{fact}}
	*S-100 -ve.		*S-100 -ve.
	*AE1/AE3 -ve.		*AE1/AE3 -ve.

Michael at 03:41, 30 December 2013

2013-12-30T03:41:37Z

← Older revision		Revision as of 03:41, 30 December 2013
Line 28:		Line 28:
	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Nodular fasciitis''' is a benign [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].		'''Nodular fasciitis''' is a benign [[soft tissue lesion]].

			It should '''not''' to be confused with [[necrotizing fasciitis]].
	==General==		==General==
	*Benign.		*Benign.

Michael at 04:15, 1 December 2013

2013-12-01T04:15:04Z

← Older revision		Revision as of 04:15, 1 December 2013
Line 28:		Line 28:
	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Nodular fasciitis''' is a [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].		'''Nodular fasciitis''' is a benign [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].
	==General==		==General==
	*Benign.		*Benign.

Michael at 04:09, 1 December 2013

2013-12-01T04:09:00Z

← Older revision		Revision as of 04:09, 1 December 2013
Line 28:		Line 28:
	\| ClinDDx =		\| ClinDDx =
	}}		}}
	'''Nodular fasciitis''' is ~~an uncommon~~ [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].		'''Nodular fasciitis''' is a [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].
	==General==		==General==
	*Benign.		*Benign.

Michael at 03:20, 29 September 2013

2013-09-29T03:20:08Z

← Older revision		Revision as of 03:20, 29 September 2013
Line 20:		Line 20:
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence = ~~uncommon~~		\| Prevalence = common soft tissue lesion
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
Line 33:		Line 33:
	*All age groups - though typically 20-40 years old.		*All age groups - though typically 20-40 years old.
	*Associated with trauma.		*Associated with trauma.
	*~~Rapid growth~~ - clinically concerning for malignancy.<ref name=pmid14569327>{{Cite journal \| last1 = Chi \| first1 = CC. \| last2 = Kuo \| first2 = TT. \| last3 = Wang \| first3 = SH. \| title = Nodular fasciitis: clinical characteristics and preoperative diagnosis. \| journal = J Formos Med Assoc \| volume = 102 \| issue = 8 \| pages = 586-9 \| month = Aug \| year = 2003 \| doi = \| PMID = 14569327 }}</ref>		*Often rapidily growing - clinically concerning for malignancy.<ref name=pmid14569327>{{Cite journal \| last1 = Chi \| first1 = CC. \| last2 = Kuo \| first2 = TT. \| last3 = Wang \| first3 = SH. \| title = Nodular fasciitis: clinical characteristics and preoperative diagnosis. \| journal = J Formos Med Assoc \| volume = 102 \| issue = 8 \| pages = 586-9 \| month = Aug \| year = 2003 \| doi = \| PMID = 14569327 }}</ref>
	*Commonly misdiagnosed as malignant.<ref name=pmid17235006 >{{Cite journal \| last1 = Dinauer \| first1 = PA. \| last2 = Brixey \| first2 = CJ. \| last3 = Moncur \| first3 = JT. \| last4 = Fanburg-Smith \| first4 = JC. \| last5 = Murphey \| first5 = MD. \| title = Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults. \| journal = Radiographics \| volume = 27 \| issue = 1 \| pages = 173-87 \| month = \| year = \| doi = 10.1148/rg.271065065 \| PMID = 17235006 \| URL = http://radiographics.rsna.org/content/27/1/173.long }}</ref>		*Commonly misdiagnosed as malignant.<ref name=pmid17235006 >{{Cite journal \| last1 = Dinauer \| first1 = PA. \| last2 = Brixey \| first2 = CJ. \| last3 = Moncur \| first3 = JT. \| last4 = Fanburg-Smith \| first4 = JC. \| last5 = Murphey \| first5 = MD. \| title = Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults. \| journal = Radiographics \| volume = 27 \| issue = 1 \| pages = 173-87 \| month = \| year = \| doi = 10.1148/rg.271065065 \| PMID = 17235006 \| URL = http://radiographics.rsna.org/content/27/1/173.long }}</ref>

Michael: tweak

2013-09-29T03:17:28Z

tweak

← Older revision		Revision as of 03:17, 29 September 2013
Line 12:		Line 12:
	\| Molecular = t(15;15) ?		\| Molecular = t(15;15) ?
	\| IF =		\| IF =
	\| Gross =		\| Gross = usu. upper extremity ~45% of cases
	\| Grossing =		\| Grossing =
	\| Site = [[soft tissue lesions\|soft tissue]] - [[fibroblastic/myofibroblastic tumours]]		\| Site = [[soft tissue lesions\|soft tissue]] - [[fibroblastic/myofibroblastic tumours]]
Line 31:		Line 31:
	==General==		==General==
	*Benign.		*Benign.
	*All age groups.		*All age groups - though typically 20-40 years old.
	*Associated with trauma.		*Associated with trauma.
	*Rapid growth - clinically concerning for malignancy.<ref name=pmid14569327>{{Cite journal \| last1 = Chi \| first1 = CC. \| last2 = Kuo \| first2 = TT. \| last3 = Wang \| first3 = SH. \| title = Nodular fasciitis: clinical characteristics and preoperative diagnosis. \| journal = J Formos Med Assoc \| volume = 102 \| issue = 8 \| pages = 586-9 \| month = Aug \| year = 2003 \| doi = \| PMID = 14569327 }}</ref>		*Rapid growth - clinically concerning for malignancy.<ref name=pmid14569327>{{Cite journal \| last1 = Chi \| first1 = CC. \| last2 = Kuo \| first2 = TT. \| last3 = Wang \| first3 = SH. \| title = Nodular fasciitis: clinical characteristics and preoperative diagnosis. \| journal = J Formos Med Assoc \| volume = 102 \| issue = 8 \| pages = 586-9 \| month = Aug \| year = 2003 \| doi = \| PMID = 14569327 }}</ref>
			*Commonly misdiagnosed as malignant.<ref name=pmid17235006 >{{Cite journal \| last1 = Dinauer \| first1 = PA. \| last2 = Brixey \| first2 = CJ. \| last3 = Moncur \| first3 = JT. \| last4 = Fanburg-Smith \| first4 = JC. \| last5 = Murphey \| first5 = MD. \| title = Pathologic and MR imaging features of benign fibrous soft-tissue tumors in adults. \| journal = Radiographics \| volume = 27 \| issue = 1 \| pages = 173-87 \| month = \| year = \| doi = 10.1148/rg.271065065 \| PMID = 17235006 \| URL = http://radiographics.rsna.org/content/27/1/173.long }}</ref>

			Subtypes - location:<ref name=pmid17235006/>
			*Subcutaneous.
			*Intramuscular.
			*Fascial
			*Dermal - rare.
			*Intravascular - rare.

			==Gross==
			*Usually upper extremity ~45% of cases.<ref name=pmid17235006/>
			**Other locations in order: trunk (~20%), head and neck (~20%), and lower extremities (~15%).

	==Microscopic==		==Microscopic==
Line 57:		Line 69:

	DDx:<ref>URL: [http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html]. Accessed on: 11 November 2011.</ref>		DDx:<ref>URL: [http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html]. Accessed on: 11 November 2011.</ref>
	*Myxoid [[~~DFSP~~]].		*Myxoid [[dermatofibrosarcoma protuberans]].
	*Cellular [[dermatofibroma]].		*Cellular [[dermatofibroma]].
	*[[Desmoid-type fibromatosis]].		*[[Desmoid-type fibromatosis]].

Michael: /* General */

2013-09-29T03:07:07Z

General

← Older revision		Revision as of 03:07, 29 September 2013
Line 33:		Line 33:
	*All age groups.		*All age groups.
	*Associated with trauma.		*Associated with trauma.
			*Rapid growth - clinically concerning for malignancy.<ref name=pmid14569327>{{Cite journal \| last1 = Chi \| first1 = CC. \| last2 = Kuo \| first2 = TT. \| last3 = Wang \| first3 = SH. \| title = Nodular fasciitis: clinical characteristics and preoperative diagnosis. \| journal = J Formos Med Assoc \| volume = 102 \| issue = 8 \| pages = 586-9 \| month = Aug \| year = 2003 \| doi = \| PMID = 14569327 }}</ref>

	==Microscopic==		==Microscopic==

Michael: more

2013-09-29T03:05:12Z

← Older revision		Revision as of 03:05, 29 September 2013
Line 8:		Line 8:
	\| LMDDx =		\| LMDDx =
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CD34 -ve, desmin -ve, SMA -ve, S-100 -ve, AE1/AE3 -ve.
	\| EM =		\| EM =
	\| Molecular =		\| Molecular = t(15;15) ?
	\| IF =		\| IF =
	\| Gross =		\| Gross =
Line 29:		Line 29:
	}}		}}
	'''Nodular fasciitis''' is an uncommon [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].		'''Nodular fasciitis''' is an uncommon [[soft tissue lesion]]. It should '''not''' to be confused with [[necrotizing fasciitis]].
	===General===		==General==
	*Benign.		*Benign.
	*All age groups.		*All age groups.
	*Associated with trauma.		*Associated with trauma.

	===Microscopic===		==Microscopic==
	Features:<ref name=Ref_WMSP606>{{Ref WMSP\|606}}</ref><ref>{{cite journal \|author=de Feraudy S, Fletcher CD \|title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases \|journal=Am. J. Surg. Pathol. \|volume=34 \|issue=9 \|pages=1377–81 \|year=2010 \|month=September \|pmid=20716998 \|doi=10.1097/PAS.0b013e3181ed7374 \|url=}}</ref>		Features:<ref name=Ref_WMSP606>{{Ref WMSP\|606}}</ref><ref>{{cite journal \|author=de Feraudy S, Fletcher CD \|title=Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases \|journal=Am. J. Surg. Pathol. \|volume=34 \|issue=9 \|pages=1377–81 \|year=2010 \|month=September \|pmid=20716998 \|doi=10.1097/PAS.0b013e3181ed7374 \|url=}}</ref>
	*Usu. well-circumscribed.		*Usu. well-circumscribed.
Line 73:		Line 73:
	www:		www:
	*[http://www.humpath.com/nodular-fasciitis NF (humpath.com)].		*[http://www.humpath.com/nodular-fasciitis NF (humpath.com)].
	===IHC===		==IHC==
	Routine spindle cell panel:		Routine spindle cell panel:
	*CD34 -ve.		*CD34 -ve.
	*Desmin -ve.		*Desmin -ve.
	*SMA -ve.		*SMA -ve.
	*~~S100~~ -ve.		*S-100 -ve.
	*AE1/AE3 -ve.		*AE1/AE3 -ve.

Line 86:		Line 86:
	*Vimentin +ve.		*Vimentin +ve.

	===Molecular===		==Molecular==
	*Evolving - case reports.		*Evolving - case reports.
	**t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal \|author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z \|title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region \|journal=Cancer Genet. Cytogenet. \|volume=141 \|issue=2 \|pages=160–3 \|year=2003 \|month=March \|pmid=12606136 \|doi= \|url=}}</ref>		**t(15;15)(q13;q25).<ref name=pmid12606136>{{cite journal \|author=Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z \|title=Cytogenetic findings in a case of nodular fasciitis of subclavicular region \|journal=Cancer Genet. Cytogenet. \|volume=141 \|issue=2 \|pages=160–3 \|year=2003 \|month=March \|pmid=12606136 \|doi= \|url=}}</ref>