Nodular lymphocyte-predominant Hodgkin lymphoma - Revision history

Michael: /* Images (NLPHL) */

2019-12-26T20:04:02Z

Images (NLPHL)

← Older revision		Revision as of 20:04, 26 December 2019
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	<gallery>		<gallery>
	Image:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg \| Popcorn cell. (WC)		Image:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg \| Popcorn cell. (WC)
	Image:Nodular lymphocyte predominant Hodgkin's lymphoma.jpg \| LP/popcorn cells (WC)]]		Image:Nodular lymphocyte predominant Hodgkin's lymphoma.jpg \| LP/popcorn cells (WC)

	</gallery>		</gallery>

Michael at 20:03, 26 December 2019

2019-12-26T20:03:47Z

← Older revision		Revision as of 20:03, 26 December 2019
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	==See also==		==See also==
	*[[~~Hemtopathology~~]].		*[[Hematopathology]].
	*[[Hodgkin lymphoma]].		*[[Hodgkin lymphoma]].

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	{{Reflist\|2}}		{{Reflist\|2}}

	[[Category:~~Hematopathology~~]]		[[Category:Haematopathology]]

Michael: fix

2019-12-26T20:01:40Z

fix

← Older revision		Revision as of 20:01, 26 December 2019
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	</gallery>		</gallery>

			==See also==
			*[[Hemtopathology]].
			*[[Hodgkin lymphoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Hematopathology]]

Michael: /* A panel */

2019-12-26T20:00:35Z

A panel

← Older revision		Revision as of 20:00, 26 December 2019
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	\|CD57 \|\| rosettes around malign. cells \|\| -		\|CD57 \|\| rosettes around malign. cells \|\| -
	\|-		\|-
	\|EBER \|\| -ve \|\| +ve/-ve		\|[[EBER]] \|\| -ve \|\| +ve/-ve
	\|-		\|-
	\|EMA \|\| +ve/-ve \|\| -ve		\|EMA \|\| +ve/-ve \|\| -ve

Mark: add image

2018-12-05T16:25:36Z

add image

← Older revision		Revision as of 16:25, 5 December 2018
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	<gallery>		<gallery>
	Image:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg \| Popcorn cell. (WC)		Image:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg \| Popcorn cell. (WC)
			Image:Nodular lymphocyte predominant Hodgkin's lymphoma.jpg \| LP/popcorn cells (WC)]]

	</gallery>		</gallery>

Mark: transfer from Hodgkin lymphoma page

2018-06-23T16:20:54Z

transfer from Hodgkin lymphoma page

New page

{{ Infobox diagnosis
| Name = Nodular lymphocyte-predominant Hodgkin lymphoma
| Image = Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg
| Width =
| Caption = Popcorn cell in nodular lymphocyte-predominant Hodgkin lymphoma
| Micro = Popcorn cells (relatively) small (compared to classic RSCs) - have lobulated nucleus (key feature), small nucleoli; subtle nodularity at low power
| Subtypes = none
| LMDDx = [[diffuse large B cell lymphoma]] (esp. ''T-cell/histiocytic-rich LBCL''), [[anaplastic large cell lymphoma]],
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, classical Hodgkin lymphoma
| Stains =
| IHC = LCA (CD45) +ve, CD20 +ve, CD10 +ve, Bcl-6 +ve, EMA +ve, CD30 -ve, CD15 -ve
| EM =
| Molecular =
| IF =
| Gross =
| Grossing =
| Site = usu. [[lymph node]]
| Assdx =
| Syndromes =
| Clinicalhx =
| Signs = lymphadenopathy
| Symptoms =
| Prevalence = uncommon
| Bloodwork =
| Rads =
| Endoscopy =
| Prognosis = good
| Other =
| ClinDDx =
}}
*AKA ''lympho-histiocytic variant''.
*Abbreviated ''NLPHL''.
*Different IHC and morphologic appearance than classic HL.
*Significant risk for transformation into [[diffuse large B cell lymphoma]] (DLBCL); 10-year cumulative transformation rate (to DLBCL) in one study was 12%.<ref name=pmid20029973 >{{cite journal |author=Biasoli I, Stamatoullas A, Meignin V, ''et al.'' |title=Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group |journal=Cancer |volume=116 |issue=3 |pages=631–9 |year=2010 |month=February |pmid=20029973 |doi=10.1002/cncr.24819 |url=}}</ref>

==Microscopy==
Features (nodular lymphocyte-predominant Hodgkin's lymphoma):
*''Popcorn cell'' (previously known as ''Lymphocytic & histiocytic'' cell (L&H cell)<ref name=pmid9499174>{{cite journal |author=Küppers R, Rajewsky K, Braeuninger A, Hansmann ML |title=L&H cells in lymphocyte-predominant Hodgkin's disease |journal=N. Engl. J. Med. |volume=338 |issue=11 |pages=763–4; author reply 764–5 |year=1998 |month=March |pmid=9499174 |doi=10.1056/NEJM199803123381113 |url=}}</ref>) - variant of RSC:
**Cells (relatively) small (compared to classic RSCs).
**Lobulated nucleus - '''key feature'''.
**Small nucleoli.
*Subtle nodularity at low power (2.5x or 5x objective).

==IHC==
Abbreviated panel:<ref name=Ref_WMSP568>{{Ref_WMSP|568}}</ref>
*CD30 Reed-Sternberg cells (RSCs) +ve ~98%
*CD15 Reed-Sternberg cells +ve ~80%, stains neutrophils.
*CD45 '''often negative''' in RSCs.
*CD20 may stain RSCs.
*PAX5 +ve.<ref name=Ref_APBR683>{{Ref APBR|683}}</ref>

Additional - for completeness:
*CD3 (T lymphocytes)

NLPHL IHC '''differs''' from the classical HL:<ref name=Ref_APBR683>{{Ref APBR|683}}</ref>
*LCA +ve.
*CD20 +ve.
*CD10 +ve.
*Bcl-6 +ve.
*[[EMA]] +ve.
*CD30 -ve
*CD15 -ve.

===A panel===
{| class="wikitable"
|Antibody || NLPHL || CHL
|-
|CD45 || +ve || -ve
|-
|CD20 || +ve || -ve
|-
|BCL6 || ||
|-
|MUM1<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/601900 http://www.ncbi.nlm.nih.gov/omim/601900]. Accessed on: 10 August 2010.</ref> || -ve ||
|-
|CD30 || -ve || +ve (most sensitive).
|-
|CD15 || -ve || +ve
|-
|CD21 || networks present || no networks
|-
|[[CD23]] || networks present || no networks
|-
|OCT-2 || +ve || -ve
|-
|PAX5 || +ve || +ve (proves B cell linage)
|-
|CD3 || usu. < benign B cell || usu. > benign B cell component
|-
|CD57 || rosettes around malign. cells || -
|-
|EBER || -ve || +ve/-ve
|-
|EMA || +ve/-ve || -ve
|-
|4 unstained || ||
|}

====Images (NLPHL)====
www:
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)].
<gallery>
Image:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg | Popcorn cell. (WC)
</gallery>