Ochronosis - Revision history

Michael at 15:02, 9 June 2016

2016-06-09T15:02:49Z

← Older revision		Revision as of 15:02, 9 June 2016
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	==Gross==		==Gross==
	*Tissue with blue-grey discolourization.<ref name=pmid21768245>{{Cite journal \| last1 = Baeva \| first1 = M. \| last2 = Bueno \| first2 = A. \| last3 = Dhimes \| first3 = P. \| title = AIRP best cases in radiologic-pathologic correlation: ochronosis. \| journal = Radiographics \| volume = 31 \| issue = 4 \| pages = 1163-7 \| month = \| year = \| doi = 10.1148/rg.314105175 \| PMID = 21768245 }}</ref>		*Tissue with blue-grey discolourization.<ref name=pmid21768245>{{Cite journal \| last1 = Baeva \| first1 = M. \| last2 = Bueno \| first2 = A. \| last3 = Dhimes \| first3 = P. \| title = AIRP best cases in radiologic-pathologic correlation: ochronosis. \| journal = Radiographics \| volume = 31 \| issue = 4 \| pages = 1163-7 \| month = \| year = \| doi = 10.1148/rg.314105175 \| PMID = 21768245 }}</ref>
	**Affected tissues: articular and auricular [[cartilage]], tendons, ligaments [[heart valves]], sclera, cornea.		**Affected tissues: articular and auricular [[cartilage]], tendons, ligaments [[heart valves]], [[sclera]], cornea.
	*Dark urine (after exposure to sunlight).		*Dark urine (after exposure to sunlight).

Michael: redirect

2013-02-01T15:05:45Z

redirect

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	[[Category:Weird stuff]]		[[Category:Weird stuff]]
			[[Category:Diagnosis]]

Michael: +general

2013-02-01T13:59:45Z

+general

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	'''Ochronosis''' is a disease characterized by the accumulation of homogentisic acid~~. It is subclassified as ''endogenous'' and ''exogenous''~~.		'''Ochronosis''' is a disease characterized by the accumulation of homogentisic acid.

	The endogenous form is genetic and autosomal recessive.<ref name=pmid20055850>{{Cite journal \| last1 = Turgay \| first1 = E. \| last2 = Canat \| first2 = D. \| last3 = Gurel \| first3 = MS. \| last4 = Yuksel \| first4 = T. \| last5 = Baran \| first5 = MF. \| last6 = Demirkesen \| first6 = C. \| title = Endogenous ochronosis. \| journal = Clin Exp Dermatol \| volume = 34 \| issue = 8 \| pages = e865-8 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2230.2009.03618.x \| PMID = 20055850 ~~}}</ref> '''Alcaptonuria''' is a specific genetic defect that causes ochronosis.<ref>{{OMIM\|203500~~}}</ref>		'''Alcaptonuria''' is a specific genetic defect that causes ochronosis.<ref>{{OMIM\|203500}}</ref>

			==General==
			It is subclassified as:
			*Endogenous (genetic).
			*Exogenous.

			The endogenous form is genetic and autosomal recessive.<ref name=pmid20055850>{{Cite journal \| last1 = Turgay \| first1 = E. \| last2 = Canat \| first2 = D. \| last3 = Gurel \| first3 = MS. \| last4 = Yuksel \| first4 = T. \| last5 = Baran \| first5 = MF. \| last6 = Demirkesen \| first6 = C. \| title = Endogenous ochronosis. \| journal = Clin Exp Dermatol \| volume = 34 \| issue = 8 \| pages = e865-8 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2230.2009.03618.x \| PMID = 20055850 }}</ref>

	==Gross==		==Gross==

Michael: /* Microscopic */ more

2013-02-01T13:57:55Z

Microscopic: more

← Older revision		Revision as of 13:57, 1 February 2013
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	==Microscopic==		==Microscopic==
	Features ~~- cartilage~~:		Features:
	*Deposits of (acellular) brown pigment (H&E sections) - '''key feature'''.		*Deposits of (acellular) brown pigment (H&E sections) - '''key feature'''.
	**May be dark magenta.		**May be dark magenta.
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	*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>		*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>
	*[http://www.clinmedres.org/content/2/4/209/F1.expansion.html Ochronosis - aortic valve (clinmedres.org)].<ref name=pmid15931360>{{Cite journal \| last1 = Fisher \| first1 = AA. \| last2 = Davis \| first2 = MW. \| title = Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. \| journal = Clin Med Res \| volume = 2 \| issue = 4 \| pages = 209-15 \| month = Nov \| year = 2004 \| doi = \| PMID = 15931360 }}</ref>		*[http://www.clinmedres.org/content/2/4/209/F1.expansion.html Ochronosis - aortic valve (clinmedres.org)].<ref name=pmid15931360>{{Cite journal \| last1 = Fisher \| first1 = AA. \| last2 = Davis \| first2 = MW. \| title = Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. \| journal = Clin Med Res \| volume = 2 \| issue = 4 \| pages = 209-15 \| month = Nov \| year = 2004 \| doi = \| PMID = 15931360 }}</ref>
			*[http://www.dermpedia.org/conference/wwwdermatopathologyconsultationscom?page=40 Ochronosis - skin (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/conference/wwwdermatopathologyconsultationscom?page=40 http://www.dermpedia.org/conference/wwwdermatopathologyconsultationscom?page=40]. Accessed on: 1 February 2013.</ref>

	==See also==		==See also==

Michael at 13:56, 1 February 2013

2013-02-01T13:56:05Z

← Older revision		Revision as of 13:56, 1 February 2013
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	*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>		*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>
	*[http://www.clinmedres.org/content/2/4/209/F1.expansion.html Ochronosis - aortic valve (clinmedres.org)].<ref name=pmid15931360>{{Cite journal \| last1 = Fisher \| first1 = AA. \| last2 = Davis \| first2 = MW. \| title = Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. \| journal = Clin Med Res \| volume = 2 \| issue = 4 \| pages = 209-15 \| month = Nov \| year = 2004 \| doi = \| PMID = 15931360 }}</ref>		*[http://www.clinmedres.org/content/2/4/209/F1.expansion.html Ochronosis - aortic valve (clinmedres.org)].<ref name=pmid15931360>{{Cite journal \| last1 = Fisher \| first1 = AA. \| last2 = Davis \| first2 = MW. \| title = Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. \| journal = Clin Med Res \| volume = 2 \| issue = 4 \| pages = 209-15 \| month = Nov \| year = 2004 \| doi = \| PMID = 15931360 }}</ref>

			==See also==
			*[[Heart valves]].
			*[[Joints]].

	==References==		==References==

Michael at 13:55, 1 February 2013

2013-02-01T13:55:24Z

← Older revision		Revision as of 13:55, 1 February 2013
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	*[http://radiographics.rsna.org/content/31/4/1163/F11.expansion.html Ochronosis - cartilage (rsna.org)].<ref name=pmid21768245/>		*[http://radiographics.rsna.org/content/31/4/1163/F11.expansion.html Ochronosis - cartilage (rsna.org)].<ref name=pmid21768245/>
	*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>		*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>
			*[http://www.clinmedres.org/content/2/4/209/F1.expansion.html Ochronosis - aortic valve (clinmedres.org)].<ref name=pmid15931360>{{Cite journal \| last1 = Fisher \| first1 = AA. \| last2 = Davis \| first2 = MW. \| title = Alkaptonuric ochronosis with aortic valve and joint replacements and femoral fracture: a case report and literature review. \| journal = Clin Med Res \| volume = 2 \| issue = 4 \| pages = 209-15 \| month = Nov \| year = 2004 \| doi = \| PMID = 15931360 }}</ref>

	==References==		==References==

Michael: tweak

2013-02-01T13:35:36Z

tweak

← Older revision		Revision as of 13:35, 1 February 2013
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	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470624/figure/f2-1841600/ Ochronosis - hip (nih.gov/CMAJ)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470624/figure/f2-1841600/ Ochronosis - hip (nih.gov/CMAJ)].

	===Microscopic===		==Microscopic==
	Features - cartilage:		Features - cartilage:
	*Deposits of (acellular) brown pigment (H&E sections) - '''key feature'''.		*Deposits of (acellular) brown pigment (H&E sections) - '''key feature'''.
			**May be dark magenta.

	~~Image~~:		Images:
	*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis (rsna.org)].<ref name=pmid21768245/>		*[http://radiographics.rsna.org/content/31/4/1163/F11.expansion.html Ochronosis - cartilage (rsna.org)].<ref name=pmid21768245/>
			*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis - soft tissue (rsna.org)].<ref name=pmid21768245/>

	==References==		==References==

Michael: +micro

2013-02-01T13:33:46Z

+micro

← Older revision		Revision as of 13:33, 1 February 2013
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	*[http://www.nejm.org/doi/full/10.1056/NEJMicm1111515 Ochronosis - eye (nejm.org)].		*[http://www.nejm.org/doi/full/10.1056/NEJMicm1111515 Ochronosis - eye (nejm.org)].
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470624/figure/f2-1841600/ Ochronosis - hip (nih.gov/CMAJ)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470624/figure/f2-1841600/ Ochronosis - hip (nih.gov/CMAJ)].

			===Microscopic===
			Features - cartilage:
			*Deposits of (acellular) brown pigment (H&E sections) - '''key feature'''.

			Image:
			*[http://radiographics.rsna.org/content/31/4/1163/F12.expansion.html Ochronosis (rsna.org)].<ref name=pmid21768245/>

	==References==		==References==

Michael: tweak

2013-02-01T13:30:27Z

tweak

← Older revision		Revision as of 13:30, 1 February 2013
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	**Affected tissues: articular and auricular [[cartilage]], tendons, ligaments [[heart valves]], sclera, cornea.		**Affected tissues: articular and auricular [[cartilage]], tendons, ligaments [[heart valves]], sclera, cornea.
	*Dark urine (after exposure to sunlight).		*Dark urine (after exposure to sunlight).

			Images:
			*[http://www.nejm.org/doi/full/10.1056/NEJMicm1111515 Ochronosis - eye (nejm.org)].
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470624/figure/f2-1841600/ Ochronosis - hip (nih.gov/CMAJ)].

	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Weird stuff]]		[[Category:Weird stuff]]

Michael: create

2013-02-01T13:26:50Z

create

← Older revision		Revision as of 13:26, 1 February 2013
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	'''Ochronosis''' is a disease characterized by the accumulation of homogentisic acid. It is subclassified as ''endogenous'' and ''exogenous''.		'''Ochronosis''' is a disease characterized by the accumulation of homogentisic acid. It is subclassified as ''endogenous'' and ''exogenous''.

	The ~~exogenous~~ form is genetic and autosomal recessive.<ref name=pmid20055850>{{Cite journal \| last1 = Turgay \| first1 = E. \| last2 = Canat \| first2 = D. \| last3 = Gurel \| first3 = MS. \| last4 = Yuksel \| first4 = T. \| last5 = Baran \| first5 = MF. \| last6 = Demirkesen \| first6 = C. \| title = Endogenous ochronosis. \| journal = Clin Exp Dermatol \| volume = 34 \| issue = 8 \| pages = e865-8 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2230.2009.03618.x \| PMID = 20055850 }}		The endogenous form is genetic and autosomal recessive.<ref name=pmid20055850>{{Cite journal \| last1 = Turgay \| first1 = E. \| last2 = Canat \| first2 = D. \| last3 = Gurel \| first3 = MS. \| last4 = Yuksel \| first4 = T. \| last5 = Baran \| first5 = MF. \| last6 = Demirkesen \| first6 = C. \| title = Endogenous ochronosis. \| journal = Clin Exp Dermatol \| volume = 34 \| issue = 8 \| pages = e865-8 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2230.2009.03618.x \| PMID = 20055850 }}</ref> '''Alcaptonuria''' is a specific genetic defect that causes ochronosis.<ref>{{OMIM\|203500}}</ref>
	</ref>

	==Gross==		==Gross==
	*~~Blue~~-grey discolourization ~~of tissue~~.		*Tissue with blue-grey discolourization.<ref name=pmid21768245>{{Cite journal \| last1 = Baeva \| first1 = M. \| last2 = Bueno \| first2 = A. \| last3 = Dhimes \| first3 = P. \| title = AIRP best cases in radiologic-pathologic correlation: ochronosis. \| journal = Radiographics \| volume = 31 \| issue = 4 \| pages = 1163-7 \| month = \| year = \| doi = 10.1148/rg.314105175 \| PMID = 21768245 }}</ref>
			**Affected tissues: articular and auricular [[cartilage]], tendons, ligaments [[heart valves]], sclera, cornea.
			*Dark urine (after exposure to sunlight).

	==References==		==References==