Oligoastrocytoma - Revision history

Jensflorian: WHO 2016

2016-05-20T10:38:26Z

WHO 2016

← Older revision		Revision as of 10:38, 20 May 2016
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	'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is ~~suspected~~ '''~~not~~''' ~~to be~~ a distinct entity.<ref name=pmid25143301>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>		'''Oligoastrocytoma, NOS''' is an uncommon [[neuropathology tumour]] that is '''no longer''' a distinct entity.<ref name=pmid25143301>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>

	==General==		==General==
	*Mixed tumour by definition.		*Mixed tumour by definition.
	*~~More sophisticated testing usually allows separation into~~ ''oligodendroglioma'' or ''astrocytoma''.<ref name=pmid25143301/>		*After [[IDH-1]]/2 mutation screening and LOH 1p/19q analysis almost all tumors are either classified as ''oligodendroglioma'' or ''astrocytoma''.<ref name=pmid25143301/>
			*The NOS category is reserved for cases without genetic testing.<ref>{{Cite journal \| last1 = Louis \| first1 = DN. \| last2 = Perry \| first2 = A. \| last3 = Reifenberger \| first3 = G. \| last4 = von Deimling \| first4 = A. \| last5 = Figarella-Branger \| first5 = D. \| last6 = Cavenee \| first6 = WK. \| last7 = Ohgaki \| first7 = H. \| last8 = Wiestler \| first8 = OD. \| last9 = Kleihues \| first9 = P. \| title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. \| journal = Acta Neuropathol \| volume = 131 \| issue = 6 \| pages = 803-20 \| month = Jun \| year = 2016 \| doi = 10.1007/s00401-016-1545-1 \| PMID = 27157931 }}</ref>

			Two types exist:
			*Oligoastrocytoma, NOS (Grade II WHO; ICD-O: 9382/3)
			*Anaplastic Oligoastrocytoma, NOS (Grade III WHO; ICD-O: 9382/3)


	==Microscopic==		==Microscopic==
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	*[[Anaplastic astrocytoma]].		*[[Anaplastic astrocytoma]].
	*[[Oligodendroglioma]].		*[[Oligodendroglioma]].
			*[[Diffuse astrocytoma]].
			*[[Anaplastic oligodendroglioma]]
			*[[Glioblastoma]]

	===IHC===		===IHC===
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	Others:		Others:
	*Ki-67 ~10%. ~~(???)~~		*Ki-67 3-10%.
	*~~p53 - focally +ve.~~ (~~???~~)		*ATRX loss (in cases without LOH1p/19q).
	*[[IDH-1]] +ve. (85%)		*[[IDH-1]] +ve. (85%).

	==See also==		==See also==
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	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]
			[[Category:WHO grade II tumours]]

Jensflorian: wikify

2015-09-30T08:46:34Z

wikify

← Older revision		Revision as of 08:46, 30 September 2015
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	===IHC===		===IHC===
	*Oligodendroglioma-like cells: MAP2 +ve (cytoplasm).		*Oligodendroglioma-like cells: [[MAP2]] +ve (cytoplasm).
	*Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).		*Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).

Jensflorian: /* IHC */ wikify

2015-09-30T06:24:37Z

IHC: wikify

← Older revision		Revision as of 06:24, 30 September 2015
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	*Ki-67 ~10%. (???)		*Ki-67 ~10%. (???)
	*p53 - focally +ve. (???)		*p53 - focally +ve. (???)
	*IDH-1 +ve. (85%)		*[[IDH-1]] +ve. (85%)

	==See also==		==See also==

Jensflorian: /* IHC */ typo

2015-09-30T06:24:11Z

IHC: typo

← Older revision		Revision as of 06:24, 30 September 2015
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	===IHC===		===IHC===
	*Oligodendroglioma-like cells: ~~MAP-2~~ +ve (cytoplasm).		*Oligodendroglioma-like cells: MAP2 +ve (cytoplasm).
	*Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).		*Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).

Michael at 07:52, 10 December 2014

2014-12-10T07:52:18Z

← Older revision		Revision as of 07:52, 10 December 2014
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	'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected ''not'' to be a distinct entity.<ref name=pmid25143301>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>		'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected '''not''' to be a distinct entity.<ref name=pmid25143301>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>

	==General==		==General==

Michael at 07:09, 10 December 2014

2014-12-10T07:09:29Z

← Older revision		Revision as of 07:09, 10 December 2014
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	'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected ''not'' to be a distinct entity.<~~Ref~~>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>		'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected ''not'' to be a distinct entity.<ref name=pmid25143301>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>

	==General==		==General==
	*Mixed tumour.		*Mixed tumour by definition.
			*More sophisticated testing usually allows separation into ''oligodendroglioma'' or ''astrocytoma''.<ref name=pmid25143301/>

	==Microscopic==		==Microscopic==

Michael at 07:04, 10 December 2014

2014-12-10T07:04:55Z

← Older revision		Revision as of 07:04, 10 December 2014
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	'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected not to be a distinct entity.<Ref>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>		'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected ''not'' to be a distinct entity.<Ref>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>

	==General==		==General==

Michael: /* Microscopic */

2014-12-10T07:04:39Z

Microscopic

← Older revision		Revision as of 07:04, 10 December 2014
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	DDx:		DDx:
	*Anaplastic astrocytoma.		*[[Anaplastic astrocytoma]].
	*Oligodendroglioma. ~~(???)~~		*[[Oligodendroglioma]].

	===IHC===		===IHC===

Michael: split, ref

2014-12-10T07:03:24Z

split, ref

← Older revision		Revision as of 07:03, 10 December 2014
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	'''Oligoastrocytoma''' is ~~a rare~~ [[neuropathology tumour]].		'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected not to be a distinct entity.<Ref>{{Cite journal \| last1 = Sahm \| first1 = F. \| last2 = Reuss \| first2 = D. \| last3 = Koelsche \| first3 = C. \| last4 = Capper \| first4 = D. \| last5 = Schittenhelm \| first5 = J. \| last6 = Heim \| first6 = S. \| last7 = Jones \| first7 = DT. \| last8 = Pfister \| first8 = SM. \| last9 = Herold-Mende \| first9 = C. \| title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. \| journal = Acta Neuropathol \| volume = 128 \| issue = 4 \| pages = 551-9 \| month = Oct \| year = 2014 \| doi = 10.1007/s00401-014-1326-7 \| PMID = 25143301 }}</ref>

	==General==		==General==
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	{{Reflist\|1}}		{{Reflist\|1}}

	~~[[Category:Diagnosis]]~~
	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]

Michael: split out

2014-12-10T06:51:56Z

split out

← Older revision		Revision as of 06:51, 10 December 2014
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	#~~redirect~~ [[Neuropathology tumours~~#Oligoastrocytoma~~]]		'''Oligoastrocytoma''' is a rare [[neuropathology tumour]].

			==General==
			*Mixed tumour.

			==Microscopic==
			Features:
			*Astrocytoma-like and oligodendroglioma-like:
			*#Oligodendroglioma-like cells = round nucleus, peri-nuclear clearing.
			*#Astrocytoma-like cells = non-ovoid/elongated nucleus.

			DDx:
			*Anaplastic astrocytoma.
			*Oligodendroglioma. (???)

			===IHC===
			*Oligodendroglioma-like cells: MAP-2 +ve (cytoplasm).
			*Astrocytoma-like cells: GFAP +ve (cytoplasm, nuclear membrane).

			Others:
			*Ki-67 ~10%. (???)
			*p53 - focally +ve. (???)
			*IDH-1 +ve. (85%)

			==See also==
			*[[Neuropathology tumours]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Neuropathology tumours]]