Other CNS embryonal tumours - Revision history

Michael: vauthors --> authors

2020-05-24T20:27:46Z

vauthors --> authors

← Older revision		Revision as of 20:27, 24 May 2020
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	** BCOR-positive IHC: ''HGNET BCOR‐altered neuroepithelial tumours''		** BCOR-positive IHC: ''HGNET BCOR‐altered neuroepithelial tumours''

	Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal \|~~vauthors~~=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>		Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal \|authors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>

	==Histology==		==Histology==
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	* CK may be focally +ve.		* CK may be focally +ve.

	HGNET-BCOR <ref>{{cite journal \|~~vauthors~~=Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA \|title=High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis \|journal=Brain Pathol. \|volume=30 \|issue=1 \|pages=46–62 \|date=January 2020 \|pmid=31104347 \|doi=10.1111/bpa.12747 \|url=}}</ref>		HGNET-BCOR <ref>{{cite journal \|authors=Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA \|title=High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis \|journal=Brain Pathol. \|volume=30 \|issue=1 \|pages=46–62 \|date=January 2020 \|pmid=31104347 \|doi=10.1111/bpa.12747 \|url=}}</ref>
	* OLIG variable +ve.		* OLIG variable +ve.
	* BCOR +ve.		* BCOR +ve.

Jensflorian: Clinics

2020-02-04T11:00:17Z

Clinics

← Older revision		Revision as of 11:00, 4 February 2020
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	Currently it is a exlcusion criteria encompassing four morphological subgroups		Currently it is a exlcusion criteria encompassing four morphological subgroups
	*CNS neuroblastomas		*CNS neuroblastomas
			**often infants.
			**Tumors can be huge.
	*CNS ganglioneuroblastomas.		*CNS ganglioneuroblastomas.
	** often characterized by FOXR2 fusions: ''CNS neuroblastoma with FOXR2 activation (NB‐FOXR2)''		** often characterized by FOXR2 fusions: ''CNS neuroblastoma with FOXR2 activation (NB‐FOXR2)''

Jensflorian: DDx

2020-02-04T10:58:42Z

DDx

← Older revision		Revision as of 10:58, 4 February 2020
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	* NEUN +/-ve.		* NEUN +/-ve.

	DDx:		==DDx:==
	* [[AT/RT]]		* [[AT/RT]]
	* [[ETMR]]		* [[ETMR]]
	* [[Anaplastic ependymoma]]		* [[Anaplastic ependymoma]]
	* H3F3A G34-mutated [[Glioblastoma]]		* H3F3A G34-mutated [[Glioblastoma]]
			* Metastasis of [[Ewing sarcoma]]

	[[Category:Neuropathology]]		[[Category:Neuropathology]]
	[[Category:Neuropathology tumours]]		[[Category:Neuropathology tumours]]

Jensflorian: /* Histology */ CNS neuroblastoma

2020-02-04T10:57:13Z

Histology: CNS neuroblastoma

← Older revision		Revision as of 10:57, 4 February 2020
Line 49:		Line 49:

	==Histology==		==Histology==
			CNS neuroblastoma:
			*Groups of neurocytic cells.
			*Variable neuropil-rich stroma.
			*Small round blue cells.

	HGNET-BCOR:		HGNET-BCOR:
	*Circumscribed growth.		*Circumscribed growth.

Jensflorian: cat

2020-01-29T10:38:00Z

cat

← Older revision		Revision as of 10:38, 29 January 2020
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	[[Category:Neuropathology]]		[[Category:Neuropathology]]
			[[Category:Neuropathology tumours]]

Jensflorian at 10:37, 29 January 2020

2020-01-29T10:37:19Z

← Older revision		Revision as of 10:37, 29 January 2020
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	==Histology==		==Histology==
	*HGNET-BCOR:		HGNET-BCOR:
	**Circumscribed growth.		*Circumscribed growth.
	**Perivascular pesudorosettes.		*Perivascular pesudorosettes.
	**Fibrillary areas resembling glioma.		*Fibrillary areas resembling glioma.
	**Palisading necrosis.		*Palisading necrosis.
			*Absence of microvascular proliferation.

	==IHC==		==IHC==
Line 69:		Line 70:

	HGNET-BCOR <ref>{{cite journal \|vauthors=Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA \|title=High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis \|journal=Brain Pathol. \|volume=30 \|issue=1 \|pages=46–62 \|date=January 2020 \|pmid=31104347 \|doi=10.1111/bpa.12747 \|url=}}</ref>		HGNET-BCOR <ref>{{cite journal \|vauthors=Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA \|title=High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis \|journal=Brain Pathol. \|volume=30 \|issue=1 \|pages=46–62 \|date=January 2020 \|pmid=31104347 \|doi=10.1111/bpa.12747 \|url=}}</ref>
	* OLIG +ve.		* OLIG variable +ve.
	* BCOR +ve.		* BCOR +ve.
	* Syn -ve.		* Syn -ve.

Jensflorian: /* General */ HGNET-BCOR

2020-01-29T10:32:54Z

General: HGNET-BCOR

← Older revision		Revision as of 10:32, 29 January 2020
Line 47:		Line 47:

	Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal \|vauthors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>		Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal \|vauthors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>

			==Histology==
			*HGNET-BCOR:
			**Circumscribed growth.
			**Perivascular pesudorosettes.
			**Fibrillary areas resembling glioma.
			**Palisading necrosis.

	==IHC==		==IHC==

Jensflorian: molecular

2020-01-29T10:28:05Z

molecular

← Older revision		Revision as of 10:28, 29 January 2020
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	** but absence of C19MC alteration, otherwise classified as [[ETMR]]		** but absence of C19MC alteration, otherwise classified as [[ETMR]]
	* CNS embryonal tumour, NOS		* CNS embryonal tumour, NOS
	** Currently four distinct subtypes can be discriminated by molecular analysis.<ref>{{cite journal \|vauthors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>
	** Similarities to astroblastoma: ''High‐grade neuroepithelial tumours with MN1 alteration (HGNET‐MN1)''		** Similarities to astroblastoma: ''High‐grade neuroepithelial tumours with MN1 alteration (HGNET‐MN1)''
	** NUTM1-positive IHC: ''Ewing's sarcoma family tumour with CIC alteration (EFT‐CIC)''		** NUTM1-positive IHC: ''Ewing's sarcoma family tumour with CIC alteration (EFT‐CIC)''
	** BCOR-positive IHC: ''HGNET BCOR‐altered neuroepithelial tumours''		** BCOR-positive IHC: ''HGNET BCOR‐altered neuroepithelial tumours''

			Currently four distinct subtypes can be discriminated by molecular analysis: NB-FOXR2, HGNET-MN1, EFT-CIC and HGNET-BCOR.<ref>{{cite journal \|vauthors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>

	==IHC==		==IHC==

Jensflorian: /* General */ REF

2020-01-29T10:26:48Z

General: REF

← Older revision		Revision as of 10:26, 29 January 2020
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	==General==		==General==
	Other CNS embryonal tumours are a group of primitive neuroeptithelial tumors that are to be classified in distinct molecular groups in the future.		Other CNS embryonal tumours are a group of primitive neuroeptithelial tumors that are to be classified in distinct molecular groups in the future.
	Currently it is a exlcusion criteria encompassing four subgroups		Currently it is a exlcusion criteria encompassing four morphological subgroups
	*CNS neuroblastomas		*CNS neuroblastomas
	*CNS ganglioneuroblastomas.		*CNS ganglioneuroblastomas.
Line 42:		Line 42:
	** but absence of C19MC alteration, otherwise classified as [[ETMR]]		** but absence of C19MC alteration, otherwise classified as [[ETMR]]
	* CNS embryonal tumour, NOS		* CNS embryonal tumour, NOS
			** Currently four distinct subtypes can be discriminated by molecular analysis.<ref>{{cite journal \|vauthors=Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M \|title=New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs \|journal=Cell \|volume=164 \|issue=5 \|pages=1060–1072 \|date=February 2016 \|pmid=26919435 \|pmc=5139621 \|doi=10.1016/j.cell.2016.01.015 \|url=}}</ref>
	** Similarities to astroblastoma: ''High‐grade neuroepithelial tumours with MN1 alteration (HGNET‐MN1)''		** Similarities to astroblastoma: ''High‐grade neuroepithelial tumours with MN1 alteration (HGNET‐MN1)''
	** NUTM1-positive IHC: ''Ewing's sarcoma family tumour with CIC alteration (EFT‐CIC)''		** NUTM1-positive IHC: ''Ewing's sarcoma family tumour with CIC alteration (EFT‐CIC)''

Jensflorian: /* IHC */ BCOR

2020-01-29T10:24:06Z

IHC: BCOR

← Older revision		Revision as of 10:24, 29 January 2020
Line 59:		Line 59:
	* CK may be focally +ve.		* CK may be focally +ve.

			HGNET-BCOR <ref>{{cite journal \|vauthors=Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA \|title=High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis \|journal=Brain Pathol. \|volume=30 \|issue=1 \|pages=46–62 \|date=January 2020 \|pmid=31104347 \|doi=10.1111/bpa.12747 \|url=}}</ref>
			* OLIG +ve.
			* BCOR +ve.
			* Syn -ve.
			* GFAP -ve.
			* EMA: dots +ve.
			* NEUN +/-ve.

	DDx:		DDx: