Ovarian tumours - Revision history

Michael: /* Elements */

2025-03-17T17:56:44Z

Elements

← Older revision		Revision as of 17:56, 17 March 2025
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	#*Significant findings: multilocular cyst, solid component, bilateral lesions, ascites, suspected intra-abdominal [[metastases]] (one finding=1 point, two or more findings=4 points).		#*Significant findings: multilocular cyst, solid component, bilateral lesions, ascites, suspected intra-abdominal [[metastases]] (one finding=1 point, two or more findings=4 points).
	#Menopause/pre-menopause status (menopausal=4 points, pre-menopausal=1 point).		#Menopause/pre-menopause status (menopausal=4 points, pre-menopausal=1 point).
	#CA-125 (blood test) in ''U/ml''.		#[[CA-125]] (blood test) in ''U/ml''.

	====Interpretation====		====Interpretation====

Michael: /* Classification */

2018-03-01T16:35:23Z

Classification

← Older revision		Revision as of 16:35, 1 March 2018
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	===Classification===		===Classification===
	*Benign. (Dx: mucinous cystadenoma ''or'' mucinous adenofibroma ''or'' mucinous cystadenofibroma)		*Benign. (Dx: [[Mucinous_cystadenoma_of_the_ovary\|mucinous cystadenoma]] ''or'' mucinous adenofibroma ''or'' mucinous cystadenofibroma)
	**Single layer of cells.		**Single layer of cells.
	*Borderline. (Dx: ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour'')		*Borderline. (Dx: ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour'')

Michael: /* Mucinous tumours - overview */

2018-03-01T16:33:21Z

Mucinous tumours - overview

← Older revision		Revision as of 16:33, 1 March 2018
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	{{Main\|Serous borderline tumour}}		{{Main\|Serous borderline tumour}}

	==Mucinous tumours ~~- overview~~==		==Mucinous ovarian tumours==

	==General==		==General==
	*Common.		*Common.

Michael: /* Mucinous borderline tumour of the ovary */ split out

2018-02-15T16:16:14Z

Mucinous borderline tumour of the ovary: split out

← Older revision		Revision as of 16:16, 15 February 2018
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	*[[AKA]] ''ovarian mucinous borderline tumour''.		*[[AKA]] ''ovarian mucinous borderline tumour''.
	*[[AKA]] ''ovarian mucinous tumour of low malignant potential''.<ref name=pmid21464732>{{Cite journal \| last1 = Khunamornpong \| first1 = S. \| last2 = Settakorn \| first2 = J. \| last3 = Sukpan \| first3 = K. \| last4 = Suprasert \| first4 = P. \| last5 = Siriaunkgul \| first5 = S. \| title = Mucinous tumor of low malignant potential (borderline or atypical proliferative tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. \| journal = Int J Gynecol Pathol \| volume = 30 \| issue = 3 \| pages = 218-30 \| month = May \| year = 2011 \| doi = 10.1097/PGP.0b013e3181fcf01a \| PMID = 21464732 }}</ref>		*[[AKA]] ''ovarian mucinous tumour of low malignant potential''.<ref name=pmid21464732>{{Cite journal \| last1 = Khunamornpong \| first1 = S. \| last2 = Settakorn \| first2 = J. \| last3 = Sukpan \| first3 = K. \| last4 = Suprasert \| first4 = P. \| last5 = Siriaunkgul \| first5 = S. \| title = Mucinous tumor of low malignant potential (borderline or atypical proliferative tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. \| journal = Int J Gynecol Pathol \| volume = 30 \| issue = 3 \| pages = 218-30 \| month = May \| year = 2011 \| doi = 10.1097/PGP.0b013e3181fcf01a \| PMID = 21464732 }}</ref>
	~~===General===~~		{{Main\|Mucinous borderline tumour of the ovary}}
	*Requires extensive sampling - to avoid missing an adenocarcinoma.

	~~Note:~~
	*The WHO prefers ''borderline'' over ''low malignant potential'' as the descriptor for these tumours.<ref name=pmid16100867>{{Cite journal \| last1 = Acs \| first1 = G. \| title = Serous and mucinous borderline (low malignant potential) tumors of the ovary. \| journal = Am J Clin Pathol \| volume = 123 Suppl \| issue = \| pages = S13-57 \| month = Jun \| year = 2005 \| doi = \| PMID = 16100867 }}</ref>

	~~====Classification====~~
	Subdivided into:<ref name=pmid15371946>{{Cite journal \| last1 = Rodriguez \| first1 = IM. \| last2 = Irving \| first2 = JA. \| last3 = Prat \| first3 = J. \| title = Endocervical-like mucinous borderline tumors of the ovary: a clinicopathologic analysis of 31 cases. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 10 \| pages = 1311-8 \| month = Oct \| year = 2004 \| doi = \| PMID = 15371946 }}</ref>
	~~# Intestinal type mucinous borderline tumour of the ovary ~ 90% of cases.~~
	~~# Endocervical type mucinous borderline tumour of the ovary ~ 10% of cases.<ref name=Ref_GP419>{{Ref GP\|419}}</ref>~~

	~~===Gross===~~
	~~''Intestinal type mucinous borderline tumour of the ovary'' and ''endocervical type mucinous borderline tumour of the ovary'':~~
	*Complex multiloculated mass with mucin.
	*Often large - may > 30 cm.

	~~===Microscopic===~~
	~~====Intestinal type mucinous borderline tumour of the ovary====~~
	~~Features:~~
	*Mucinous differentiation:
	**Tall [[columnar cell]]s with apical mucin - usu. resembles gastric foveolar epithelium.
	*Layering of epithelial cells (stratification).
	**Must be <= 3 cells.<ref name=Ref_GP416>{{Ref GP\|416}}</ref>
	*+/-Papillary infoldings.
	**Projections into the cystic space.
	*+/-Mild nuclear atypia.
	*+/-Mitoses (focally).

	~~Notes:~~
	~~#Resembles a [[villous adenoma]] of the [[colon]].<ref name=Ref_GP>{{Ref GP\|416}}</ref>~~
	~~#Borderline component must be >= 10% of the tumour.<ref name=Ref_GP>~~{{~~Ref GP~~\|~~416}}</ref>~~
	~~#*Lesions with <10% borderline component are known as ''[[mucinous cystadenoma of the ovary]] with focal proliferation'' or ''[[mucinous cystadenoma of the ovary]] with focal atypia''.~~

	~~DDx:~~
	*[[Mucinous ~~adenocarcinoma of the ovary]].~~
	*[[Mucinous cystadenoma of the ovary]].
	*[[Mucinous cystadenoma of the ovary]] with focal proliferation.

	~~Images:~~
	*[http://www.webpathology.com/image.asp?case=526&n=7 Ovarian MBT (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=6&Case=526 Ovarian mucinous borderline tumour and benign mucinous tumour (webpathology.com)].

	~~====Endocervical type mucinous~~ borderline tumour of the ovary~~====~~
	~~Features:<ref name=Ref_GP420>{{Ref GP\|420~~}}~~</ref>~~
	~~#Cells with mucinous differentiation resembling endocervical epithelium:~~
	~~#*Tall [[columnar cell]]s with grey apical mucin.~~
	~~#Cells with eosinophilic cytoplasm - known as "pink cells".~~
	~~#Ciliated cells.~~
	*Neutrophils associated with the epithelium/mucin - common.<ref>URL: [http://www.webpathology.com/image.asp?n=12&Case=526 http://www.webpathology.com/image.asp?n=12&Case=526]. Accessed on: 9 January 2013.</ref>

	~~Images:~~
	*[http://www.webpathology.com/image.asp?n=13&Case=526 Endocervical type mucinous borderline tumour - low mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=12&Case=526 Endocervical type mucinous borderline tumour - high mag. (webpathology.com)].

	~~====Comparing intestinal versus endocervical====~~
	~~{\| class="wikitable sortable"~~
	~~! Feature~~
	~~! Intestinal~~
	~~! Endocervical~~
	\|-
	~~\| Primary mucin producing cell~~
	~~\| clear - well-diff. component, eosinophilic (pink)~~
	~~\| eosinophilic (pink), grey or clear~~
	\|-
	~~\| Size~~
	~~\| tall columnar (height:width >3:1) "champagne flute"~~
	~~\| stubby columnar (height:width <3:1)~~
	\|-
	~~\| Accompanying epithelial cells~~
	~~\| +/-goblet cells~~
	~~\| pink cells, ciliated cells~~
	\|-
	~~\| Other cells~~
	~~\| none~~
	~~\| neutrophils (intraepithelial) - common~~
	\|-
	~~\| Images~~
	~~\| [http://www.webpathology.com/image.asp?case=526&n=7 high mag. (webpathology.com)]~~
	~~\| [http://www.webpathology.com/image.asp?n=13&Case=526 low mag. (webpathology.com)], [http://www.webpathology.com/image.asp?n=12&Case=526 high mag. (webpathology.com)]~~
	\|}

	~~===Sign out===~~
	~~<pre>~~
	~~OVARY AND CYST, LEFT, OOPHORECTOMY:~~
	~~- MUCINOUS BORDERLINE TUMOUR, INTESTINAL TYPE, ARISING FROM A MUCINOUS CYSTADENOMA (INTESTINAL TYPE).~~
	~~- OVARIAN PARENCHYMA.~~
	~~</pre>~~

	==Mucinous adenocarcinoma of the ovary==		==Mucinous adenocarcinoma of the ovary==

Michael: /* Ovarian serous borderline tumour */ split out

2016-03-29T02:07:28Z

Ovarian serous borderline tumour: split out

← Older revision		Revision as of 02:07, 29 March 2016
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	*[[AKA]] ''serous borderline tumour of the ovary''.		*[[AKA]] ''serous borderline tumour of the ovary''.
	*[[AKA]] ''serous tumour of low malignant potential of the ovary'', abbreviated ''SLMP''.<ref name=pmid10836293>{{Cite journal \| last1 = Seidman \| first1 = JD. \| last2 = Kurman \| first2 = RJ. \| title = Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. \| journal = Hum Pathol \| volume = 31 \| issue = 5 \| pages = 539-57 \| month = May \| year = 2000 \| doi = \| PMID = 10836293 }}</ref><ref name=pmid10881733>{{Cite journal \| last1 = Dietel \| first1 = M. \| last2 = Hauptmann \| first2 = S. \| title = Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology. \| journal = Virchows Arch \| volume = 436 \| issue = 5 \| pages = 403-12 \| month = May \| year = 2000 \| doi = \| PMID = 10881733 }}</ref>		*[[AKA]] ''serous tumour of low malignant potential of the ovary'', abbreviated ''SLMP''.<ref name=pmid10836293>{{Cite journal \| last1 = Seidman \| first1 = JD. \| last2 = Kurman \| first2 = RJ. \| title = Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. \| journal = Hum Pathol \| volume = 31 \| issue = 5 \| pages = 539-57 \| month = May \| year = 2000 \| doi = \| PMID = 10836293 }}</ref><ref name=pmid10881733>{{Cite journal \| last1 = Dietel \| first1 = M. \| last2 = Hauptmann \| first2 = S. \| title = Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology. \| journal = Virchows Arch \| volume = 436 \| issue = 5 \| pages = 403-12 \| month = May \| year = 2000 \| doi = \| PMID = 10881733 }}</ref>
	*[[AKA]] ''serous ovarian tumour of low malignant potential''.<ref name=pmid10881733/>		{{Main\|Serous borderline tumour}}
	~~===General===~~
	*Usually benign.
	*Require long term follow-up.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_GP399>~~{{~~Ref GP~~\|~~399}}</ref>~~
	*Cuboidal to columnar epithelium with mild to moderate atypia.
	*No invasive.
	*"Sparse" mitoses.
	*+/-[[Psammoma bodies]].
	*+/-Micropapillary architecture - often described as a ''medusa head'' pattern.

	~~DDx:~~
	*[[Serous ~~carcinoma of the ovary]] - focus a with stromal invasion >5mm (linear measurement) ''or'' > 10 mm<sup>2</sup> (area).<ref name=Ref_GP399>{{Ref GP\|399}}</ref>~~
	**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
	*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.

	~~Images:~~
	*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal \| last1 = Burkholz \| first1 = KJ. \| last2 = Wood \| first2 = BP. \| last3 = Zuppan \| first3 = C. \| title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. \| journal = Radiographics \| volume = 25 \| issue = 6 \| pages = 1689-92 \| month = \| year = \| doi = 10.1148/rg.256055015 \| PMID = 16284143 }}~~</ref>~~

	~~====Subclassification====~~
	Typical subdivided into:<ref name=pmid21917305>{{Cite journal \| last1 = Park \| first1 = JY. \| last2 = Kim \| first2 = DY. \| last3 = Kim \| first3 = JH. \| last4 = Kim \| first4 = YM. \| last5 = Kim \| first5 = KR. \| last6 = Kim \| first6 = YT. \| last7 = Nam \| first7 = JH. \| title = Micropapillary pattern in serous borderline ovarian tumors: does it matter? \| journal = Gynecol Oncol \| volume = 123 \| issue = 3 \| pages = 511-6 \| month = Dec \| year = 2011 \| doi = 10.1016/j.ygyno.2011.08.008 \| PMID = 21917305 }}</ref>
	*Micropapillary serous borderline tumour.
	*Typical serous borderline tumour (SBOT).

	~~===Sign out===~~
	~~<pre>~~
	~~Cyst and Right Fallopian Tube, Excision:~~
	~~- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.~~
	~~- Fallopian tube within normal limits.~~
	~~- NEGATIVE for evidence of invasion.~~

	~~Comment:~~
	~~The lesion appears to be confined to a cystic structure.~~
	~~</pre>~~

	==Mucinous tumours - overview==		==Mucinous tumours - overview==

Michael: /* Microscopic */

2016-03-02T16:16:06Z

Microscopic

← Older revision		Revision as of 16:16, 2 March 2016
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	**Columnar.		**Columnar.
	*Papillae.		*Papillae.
	*[[Psammoma bodies]] (concentric ~~calcifications~~).		*[[Psammoma bodies]] (concentric [[calcification]]s).

	Note:		Note:

Michael at 16:28, 18 February 2016

2016-02-18T16:28:07Z

← Older revision		Revision as of 16:28, 18 February 2016
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	*Micropapillary serous borderline tumour.		*Micropapillary serous borderline tumour.
	*Typical serous borderline tumour (SBOT).		*Typical serous borderline tumour (SBOT).

			===Sign out===
			<pre>
			Cyst and Right Fallopian Tube, Excision:
			- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
			- Fallopian tube within normal limits.
			- NEGATIVE for evidence of invasion.

			Comment:
			The lesion appears to be confined to a cystic structure.
			</pre>

	==Mucinous tumours - overview==		==Mucinous tumours - overview==

Michael: /* Grading of ovarian cancer */

2016-02-02T13:43:01Z

Grading of ovarian cancer

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	*Silverberg grading system,<ref>{{cite journal \|author=Silverberg SG \|title=Histopathologic grading of ovarian carcinoma: a review and proposal \|journal=Int. J. Gynecol. Pathol. \|volume=19 \|issue=1 \|pages=7-15 \|year=2000 \|month=January \|pmid=10638449 \|doi= \|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0277-1691&volume=19&issue=1&spage=7}}</ref> aka ''universal grading system''.		*Silverberg grading system,<ref>{{cite journal \|author=Silverberg SG \|title=Histopathologic grading of ovarian carcinoma: a review and proposal \|journal=Int. J. Gynecol. Pathol. \|volume=19 \|issue=1 \|pages=7-15 \|year=2000 \|month=January \|pmid=10638449 \|doi= \|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0277-1691&volume=19&issue=1&spage=7}}</ref> aka ''universal grading system''.
	*Based on ''pattern'', ''cytologic atypia'' and ''mitotic rate''.		*Based on ''pattern'', ''cytologic atypia'' and ''mitotic rate''.
	*System somewhat similar to [[breast]] grading, which can be remembered as: ''~~TMN~~'' (tubular formation, mitotic rate~~, nuclear atypia~~).		*System somewhat similar to [[breast]] grading, which can be remembered as: ''TNM'' (tubular formation, [[nuclear atypia]], mitotic rate).

	===Silverberg system===		===Silverberg system===

Michael: /* Metastatic ovarian tumours */

2016-01-28T05:21:23Z

Metastatic ovarian tumours

← Older revision		Revision as of 05:21, 28 January 2016
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	=Metastatic ovarian tumours=		=Metastatic ovarian tumours=
	{{Main\|~~Metastases}}~~		{{Main\|Ovarian metastasis}}
	~~==Generally==~~
	* Mostly Muellerian origin (uterus, [[fallopian tube]]) or pelvic [[peritoneum]].

	~~==Extramuellerian metastatic tumours==~~
	~~DDx:~~
	* [[Breast]].
	* [[Gastrointestinal pathology\|Gastrointestinal (GI) tract]].
	** Pseudomyxoma peritonei, usu. [[appendix\|appendiceal]] origin.
	** Krukenberg tumour = [[signet ring cell]] cancer with mucin production of GI origin.

	~~===Microscopic===~~
	~~Features:~~
	*Predominantly surface involvement and nodular at low power.
	*[[Signet ring cell]]s (suggestive of GI or breast primary).
	*[[Lymphovascular invasion]].

	~~Image:~~
	*[http://commons.wikimedia.org/wiki/File:Adenocarcinoma_of_the_breast_metastatic_to_the_ovary_-_low_mag.jpg Ovarian metastasis ~~- low mag. (WC/Nephron)].~~

	~~===Mucinous carcinoma - [[GI tract]] metastasis vs. primary ovarian===~~
	~~====Gross====~~
	Features favouring metastatic disease:<ref name=pmid18162780>{{Cite journal \| last1 = Yemelyanova \| first1 = AV. \| last2 = Vang \| first2 = R. \| last3 = Judson \| first3 = K. \| last4 = Wu \| first4 = LS. \| last5 = Ronnett \| first5 = BM. \| title = Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. \| journal = Am J Surg Pathol \| volume = 32 \| issue = 1 \| pages = 128-38 \| month = Jan \| year = 2008 \| doi = 10.1097/PAS.0b013e3180690d2d \| PMID = 18162780 }}</ref>
	*Bilaterality -- both ovaries involved.
	*Small unilateral tumour size -- <10 cm = metastatic.
	**>13 cm = primary ovarian.

	~~====IHC====~~
	~~Ovarian tumours:~~
	*Dipeptidase 1 (DPEP1) +ve.<ref name=pmid21076463>{{Cite journal \| last1 = Okamoto \| first1 = T. \| last2 = Matsumura \| first2 = N. \| last3 = Mandai \| first3 = M. \| last4 = Oura \| first4 = T. \| last5 = Yamanishi \| first5 = Y. \| last6 = Horiuchi \| first6 = A. \| last7 = Hamanishi \| first7 = J. \| last8 = Baba \| first8 = T. \| last9 = Koshiyama \| first9 = M. \| title = Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1. \| journal = Mod Pathol \| volume = 24 \| issue = 2 \| pages = 267-76 \| month = Feb \| year = 2011 \| doi = 10.1038/modpathol.2010.204 \| PMID = 21076463 }}~~</ref>~~
	*CK7 +ve.

	=Sex cord stromal tumours=		=Sex cord stromal tumours=

Michael: /* Mucinous adenocarcinoma of the ovary */ split out

2015-05-02T06:06:21Z

Mucinous adenocarcinoma of the ovary: split out

← Older revision		Revision as of 06:06, 2 May 2015
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	*[[AKA]] ''ovarian mucinous adenocarcinoma''.		*[[AKA]] ''ovarian mucinous adenocarcinoma''.
	*[[AKA]] ''ovarian mucinous carcinoma''.		*[[AKA]] ''ovarian mucinous carcinoma''.
	~~===General===~~		{{Main\|Mucinous adenocarcinoma of the ovary}}
	*Malignant.
	*May arise in [[endometriosis]].<ref name=Ref_PBoD1097>{{~~Ref PBoD~~ \|~~1097}}</ref>~~
	*Poor response to chemotherapy vis-à-vis serous carcinoma.<ref name=pmid19275957>{{Cite journal \| last1 = Shimada \| first1 = M. \| last2 = Kigawa \| first2 = J. \| last3 = Ohishi \| first3 = Y. \| last4 = Yasuda \| first4 = M. \| last5 = Suzuki \| first5 = M. \| last6 = Hiura \| first6 = M. \| last7 = Nishimura \| first7 = R. \| last8 = Tabata \| first8 = T. \| last9 = Sugiyama \| first9 = T. \| title = Clinicopathological characteristics of mucinous adenocarcinoma of the ovary~~. \| journal = Gynecol Oncol \| volume = 113 \| issue = 3 \| pages = 331-4 \| month = Jun \| year = 2009 \| doi = 10.1016/j.ygyno.2009.02.010 \| PMID = 19275957~~ }}~~</ref>~~

	~~===Gross===~~
	~~Features:~~
	*Multiloculated.
	*Sticky, gelatinous fluid (glycoprotein).
	*+/-[[Necrosis]].
	*Typically unilateral.<ref name=pmid22885379>{{Cite journal \| last1 = Offman \| first1 = SL. \| last2 = Longacre \| first2 = TA. \| title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). \| journal = Adv Anat Pathol \| volume = 19 \| issue = 5 \| pages = 296-312 \| month = Sep \| year = 2012 \| doi = 10.1097/PAP.0b013e31826663b1 \| PMID = 22885379 }}</ref>

	~~===Microscopic===~~
	~~Features:~~
	*Mucinous differentiation.
	**Tall [[columnar cell]]s in glands with apical mucin.
	***May have an endocervical-like ''or'' intestinal-like appearance - see ''subtypes''.
	*Invasive morphology - one of the following:
	*#Back-to-back glands/confluent growth pattern.
	*#Desmoplastic stromal response.
	*#Cribriforming of glands.
	*Malignant characteristics:
	**+/-Nuclear atypia.
	**+/-Necrosis.
	**No cilia.

	~~DDx:~~
	*[[Mucinous borderline tumour of the ovary]].
	*[[Metastatic]] [[mucinous carcinoma]].

	~~====Subtypes====~~
	~~#''Endocervical type''.~~
	~~#*Less likely to be malignant.~~
	~~#*More common than malignant type.~~
	~~#''Intestinal type''.~~
	~~#*More likely to be malignant.~~
	~~#*+/-[[Goblet cell]]s.~~
	~~#**One large clear apical vacuole.~~
	~~#*If it doesn't look like intestine to you... it probably isn't.~~
	~~#*May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism).~~
	~~#**Image: [http://www.ispub.com/xml/journals/ijgo/vol9n1/papillary-fig4.jpg]~~

	~~Comparison of mucosa:~~
	*Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa (duke.edu)].
	*Normal colonic mucosa: [http://commons.wikimedia.org/wiki/File:Rectal_prolapse_-_intermed_mag.jpg colonic type mucosa (WC)].

	~~===IHC===~~
	*CK7 +ve.
	*[[CK20]] +ve.

	==Endometrioid carcinoma of the ovary==		==Endometrioid carcinoma of the ovary==