P53 - Revision history

Jensflorian: /* Interpretation */ +neuropathology

2018-03-21T09:09:24Z

Interpretation: +neuropathology

← Older revision		Revision as of 09:09, 21 March 2018
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	*p53 may be one of the most misinterpreted stains.		*p53 may be one of the most misinterpreted stains.
	**TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).<ref name=pmid21552211 >{{Cite journal \| last1 = Yemelyanova \| first1 = A. \| last2 = Vang \| first2 = R. \| last3 = Kshirsagar \| first3 = M. \| last4 = Lu \| first4 = D. \| last5 = Marks \| first5 = MA. \| last6 = Shih \| first6 = IeM. \| last7 = Kurman \| first7 = RJ. \| title = Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. \| journal = Mod Pathol \| volume = 24 \| issue = 9 \| pages = 1248-53 \| month = Sep \| year = 2011 \| doi = 10.1038/modpathol.2011.85 \| PMID = 21552211 }}</ref>		**TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).<ref name=pmid21552211 >{{Cite journal \| last1 = Yemelyanova \| first1 = A. \| last2 = Vang \| first2 = R. \| last3 = Kshirsagar \| first3 = M. \| last4 = Lu \| first4 = D. \| last5 = Marks \| first5 = MA. \| last6 = Shih \| first6 = IeM. \| last7 = Kurman \| first7 = RJ. \| title = Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. \| journal = Mod Pathol \| volume = 24 \| issue = 9 \| pages = 1248-53 \| month = Sep \| year = 2011 \| doi = 10.1038/modpathol.2011.85 \| PMID = 21552211 }}</ref>
			*Reliable interpretation of p53 may require co-assesment of other markers.
			**In neuropathology strong p53 expression in combination with loss of [[ATRX]] nuclear expression may allow one to skip the otherwise needed LOH 1p/19q testing in diffuse gliomas.<ref>{{Cite journal \| last1 = Louis \| first1 = DN. \| last2 = Giannini \| first2 = C. \| last3 = Capper \| first3 = D. \| last4 = Paulus \| first4 = W. \| last5 = Figarella-Branger \| first5 = D. \| last6 = Lopes \| first6 = MB. \| last7 = Batchelor \| first7 = TT. \| last8 = Cairncross \| first8 = JG. \| last9 = van den Bent \| first9 = M. \| title = cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant. \| journal = Acta Neuropathol \| volume = \| issue = \| pages = \| month = Mar \| year = 2018 \| doi = 10.1007/s00401-018-1826-y \| PMID = 29497819 }}</ref>

	==See also==		==See also==

Michael: tweak

2018-03-19T15:29:56Z

tweak

← Older revision		Revision as of 15:29, 19 March 2018
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	\| Subspecial =		\| Subspecial =
	\| Pattern =		\| Pattern =
	\| Positive = nuclear staining		\| Positive = nuclear staining (>60% or completely negative - see ''interpretation'')
	\| Negative =		\| Negative =
	\| Other =		\| Other =

Michael at 15:28, 19 March 2018

2018-03-19T15:28:59Z

← Older revision		Revision as of 15:28, 19 March 2018
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	\| Other =		\| Other =
	}}		}}
	'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]].		'''p53''' marks a [[tumour suppressor]] protein commonly implicated in [[cancer]] and a common [[immunostain]].

	==Interpretation==		==Interpretation==

Michael at 15:27, 19 March 2018

2018-03-19T15:27:21Z

← Older revision		Revision as of 15:27, 19 March 2018
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	\| Subspecial =		\| Subspecial =
	\| Pattern =		\| Pattern =
	\| Positive = nuclear staining		\| Positive = nuclear staining
	\| Negative =		\| Negative =
	\| Other =		\| Other =
	}}		}}
	'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]].		'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]].

			==Interpretation==
			*p53 may be one of the most misinterpreted stains.
			**TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).<ref name=pmid21552211 >{{Cite journal \| last1 = Yemelyanova \| first1 = A. \| last2 = Vang \| first2 = R. \| last3 = Kshirsagar \| first3 = M. \| last4 = Lu \| first4 = D. \| last5 = Marks \| first5 = MA. \| last6 = Shih \| first6 = IeM. \| last7 = Kurman \| first7 = RJ. \| title = Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. \| journal = Mod Pathol \| volume = 24 \| issue = 9 \| pages = 1248-53 \| month = Sep \| year = 2011 \| doi = 10.1038/modpathol.2011.85 \| PMID = 21552211 }}</ref>

	==See also==		==See also==

Michael at 15:22, 19 March 2018

2018-03-19T15:22:06Z

← Older revision		Revision as of 15:22, 19 March 2018
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	\| Use = cancer versus benign, prognostication		\| Use = cancer versus benign, prognostication
	\| Subspecial =		\| Subspecial =
	\| Pattern = ~~nuclear staining~~		\| Pattern =
	\| Positive =		\| Positive = nuclear staining
	\| Negative =		\| Negative =
	\| Other =		\| Other =
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	==See also==		==See also==
	*[[Molecular pathology]].		*[[Molecular pathology]].
			*[[Li-Fraumeni syndrome]].

	==References==		==References==

Michael: +infobox

2018-03-19T15:21:28Z

+infobox

← Older revision		Revision as of 15:21, 19 March 2018
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			{{ Infobox immunostain
			\| Name = {{PAGENAME}}
			\| Image = Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg
			\| Width =
			\| Caption = p53 staining in an [[anaplastic astrocytoma]].
			\| Abbrev =
			\| Synonyms =
			\| Similar =
			\| Clones =
			\| Use = cancer versus benign, prognostication
			\| Subspecial =
			\| Pattern = nuclear staining
			\| Positive =
			\| Negative =
			\| Other =
			}}
	'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]].		'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]].


	==See also==		==See also==

Michael: create

2018-03-19T15:19:11Z

create

New page

'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]].

==See also==
*[[Molecular pathology]].

==References==
{{Reflist|1}}

[[Category:Molecular pathology]]
[[Category:Immunohistochemistry]]