Paget disease of the breast - Revision history

Michael: Redirected page to Paget's disease of the breast

2014-09-11T02:11:11Z

Redirected page to Paget's disease of the breast

Michael at 16:10, 6 February 2014

2014-02-06T16:10:49Z

← Older revision		Revision as of 16:10, 6 February 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}

Michael at 03:44, 21 December 2013

2013-12-21T03:44:00Z

← Older revision		Revision as of 03:44, 21 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Extramammary_Paget_disease_-_high_mag.jpg
			\| Width =
			\| Caption = Paget's disease. [[H&E stain]].
			\| Synonyms =
			\| Micro = large epithelioid cells - nested or single - in the epidermis, clear/pale cytoplasm (occasionally eosinophilic), large nucleoli
			\| Subtypes =
			\| LMDDx = benign Toker cell hyperplasia, [[malignant melanoma]], [[Bowen's disease]], [[apocrine carcinoma of the skin]]
			\| Stains =
			\| IHC = CK7 +ve, CEA +ve, S-100 -ve, CK5/6 -ve, HER2 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = erythema, +/-weeping, +/-crusted
			\| Grossing =
			\| Site = [[breast]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usu. associated with invasive breast carcinoma
			\| Other =
			\| ClinDDx = [[nipple adenoma]], contact dermatitis
			\| Tx =
			}}
	'''Paget disease of the breast''', also '''[[Paget's disease]] of the breast''' and '''Paget disease of the nipple''', is a thingy seen in the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>		'''Paget disease of the breast''', also '''[[Paget's disease]] of the breast''' and '''Paget disease of the nipple''', is a thingy seen in the [[breast]]. It is abbreviated '''PDB'''.<ref name=pmid19919588>{{Cite journal \| last1 = Ellis \| first1 = PE. \| last2 = Maclean \| first2 = AB. \| last3 = Crow \| first3 = JC. \| last4 = Wong Te Fong \| first4 = LF. \| last5 = Rolfe \| first5 = KJ. \| last6 = Perrett \| first6 = CW. \| title = Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 cases. \| journal = Histopathology \| volume = 55 \| issue = 6 \| pages = 709-15 \| month = Dec \| year = 2009 \| doi = 10.1111/j.1365-2559.2009.03434.x \| PMID = 19919588 }}</ref>

Rudolf: /* Microscopic */ +images

2013-05-28T20:09:32Z

Microscopic: +images

← Older revision		Revision as of 20:09, 28 May 2013
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	Note:		Note:
	*The neoplastic cells of Paget's disease may contain melanin.<ref name=Ref_APBR306-7>{{Ref APBR\|306-7 Q15}}</ref>		*The neoplastic cells of Paget's disease may contain melanin.<ref name=Ref_APBR306-7>{{Ref APBR\|306-7 Q15}}</ref>

	~~Images:~~
	*[[WC]]:
	**[http://commons.wikimedia.org/wiki/File:Extramammary_Paget_disease_-_low_mag.jpg Paget disease - low mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Extramammary_Paget_disease_-_high_mag.jpg Paget disease - high mag. (WC)].
	*www:
	**[http://path.upmc.edu/cases/case331.html Paget disease of the breast - several good pictures (upmc.edu)].
	**[http://www.webpathology.com/image.asp?case=303&n=3 Paget disease of the nipple (webpathology.com)].

	===DDx===		===DDx===
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	*[[Apocrine carcinoma of the skin]].<ref>URL: [http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687 http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687]. Accessed on: 9 September 2011.</ref>		*[[Apocrine carcinoma of the skin]].<ref>URL: [http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687 http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687]. Accessed on: 9 September 2011.</ref>
	**Images: [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_intermed_mag.jpg apocrine carcinoma - intermed. mag. (WC)], [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_high_mag.jpg apocrine carcinoma - high mag. (WC)].		**Images: [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_intermed_mag.jpg apocrine carcinoma - intermed. mag. (WC)], [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_high_mag.jpg apocrine carcinoma - high mag. (WC)].

			===Images===
			<gallery>
			Image:Extramammary_Paget_disease_-_low_mag.jpg \| Paget disease - low mag. (WC/Nephron)
			Image:Extramammary_Paget_disease_-_high_mag.jpg \| Paget disease - high mag. (WC/Nephron)
			</gallery>
			www:
			*[http://path.upmc.edu/cases/case331.html Paget disease of the breast - several good pictures (upmc.edu)].
			*[http://www.webpathology.com/image.asp?case=303&n=3 Paget disease of the nipple (webpathology.com)].

	==IHC==		==IHC==

Michael: /* Gross */ fix ref.

2012-05-30T16:08:08Z

Gross: fix ref.

← Older revision		Revision as of 16:08, 30 May 2012
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	==Gross==		==Gross==
	Features:<ref>{{Ref ~~ABPR~~\|306}}</ref>		Features:<ref>{{Ref APBR\|294 & 306 Q15}}</ref>
	*Erythematous, i.e. red.		*Erythematous, i.e. red.
	*+/-Crusted.		*+/-Crusted.

Michael: /* Microscopic */ fix ref.

2012-05-30T16:06:47Z

Microscopic: fix ref.

← Older revision		Revision as of 16:06, 30 May 2012
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	Note:		Note:
	*The neoplastic cells of Paget's disease may contain melanin.<ref name=~~Ref_ABPR306~~-7>{{Ref ~~ABPR~~\|306-7}}</ref>		*The neoplastic cells of Paget's disease may contain melanin.<ref name=Ref_APBR306-7>{{Ref APBR\|306-7 Q15}}</ref>

	Images:		Images:

Michael: /* Microscopic */

2012-05-30T15:46:27Z

Microscopic

← Older revision		Revision as of 15:46, 30 May 2012
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	*Clear/pale cytoplasm '''key feature''' - may also be eosinophilic.		*Clear/pale cytoplasm '''key feature''' - may also be eosinophilic.
	*Large nucleoli.		*Large nucleoli.

			Note:
			*The neoplastic cells of Paget's disease may contain melanin.<ref name=Ref_ABPR306-7>{{Ref ABPR\|306-7}}</ref>

	Images:		Images:

Michael: /* Gross */ more

2012-05-30T15:43:59Z

Gross: more

← Older revision		Revision as of 15:43, 30 May 2012
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	==Gross==		==Gross==
	Features:		Features:<ref>{{Ref ABPR\|306}}</ref>
	*Erythematous.		*Erythematous, i.e. red.
	*Crusted.		*+/-Crusted.
			*+/-Weeping (wet).

	DDx - clinical:		DDx - clinical:
	*[[Contact dermatitis]].<ref>URL: [http://www.danderm-pdv.is.kkh.dk/atlas/2-38.html http://www.danderm-pdv.is.kkh.dk/atlas/2-38.html]. Accessed on: 30 May 2012.</ref><ref name=pmid19882019>{{Cite journal \| last1 = Feroze \| first1 = K. \| last2 = Manoj \| first2 = J. \| last3 = Venkitakrishnan \| first3 = S. \| title = Allergic contact dermatitis mimicking mammary paget's disease. \| journal = Indian J Dermatol \| volume = 53 \| issue = 3 \| pages = 154-5 \| month = \| year = 2008 \| doi = 10.4103/0019-5154.43210 \| PMID = 19882019 }}</ref>		*[[Contact dermatitis]].<ref>URL: [http://www.danderm-pdv.is.kkh.dk/atlas/2-38.html http://www.danderm-pdv.is.kkh.dk/atlas/2-38.html]. Accessed on: 30 May 2012.</ref><ref name=pmid19882019>{{Cite journal \| last1 = Feroze \| first1 = K. \| last2 = Manoj \| first2 = J. \| last3 = Venkitakrishnan \| first3 = S. \| title = Allergic contact dermatitis mimicking mammary paget's disease. \| journal = Indian J Dermatol \| volume = 53 \| issue = 3 \| pages = 154-5 \| month = \| year = 2008 \| doi = 10.4103/0019-5154.43210 \| PMID = 19882019 }}</ref>

	~~Image~~:		Images:
	*[http://www.sciencephoto.com/media/252126/enlarge Paget disease of the breast (sciencephoto.com)].		*[http://www.sciencephoto.com/media/252126/enlarge Paget disease of the breast (sciencephoto.com)].
			*[http://img.medscape.com/pi/emed/ckb/dermatology/1048885-1101235-864.jpg Paget disease of breast (medscape.com)].<ref>URL: [http://www.gfmer.ch/selected_images_v2/search_result_list.php?offset=15&param1=Paget%20disease%20of%20breast&param2=and http://www.gfmer.ch/selected_images_v2/search_result_list.php?offset=15&param1=Paget%20disease%20of%20breast&param2=and]. Accessed on: 30 May 2012.</ref>

	==Microscopic==		==Microscopic==

Michael: +gross section, image link

2012-05-30T15:40:04Z

+gross section, image link

← Older revision		Revision as of 15:40, 30 May 2012
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	Note:		Note:
	*[[Extramammary Paget's disease]] is '''not''' usually associated with malignancy.		*[[Extramammary Paget's disease]] is '''not''' usually associated with malignancy.

			==Gross==
			Features:
			*Erythematous.
			*Crusted.

			DDx - clinical:
			*[[Contact dermatitis]].<ref>URL: [http://www.danderm-pdv.is.kkh.dk/atlas/2-38.html http://www.danderm-pdv.is.kkh.dk/atlas/2-38.html]. Accessed on: 30 May 2012.</ref><ref name=pmid19882019>{{Cite journal \| last1 = Feroze \| first1 = K. \| last2 = Manoj \| first2 = J. \| last3 = Venkitakrishnan \| first3 = S. \| title = Allergic contact dermatitis mimicking mammary paget's disease. \| journal = Indian J Dermatol \| volume = 53 \| issue = 3 \| pages = 154-5 \| month = \| year = 2008 \| doi = 10.4103/0019-5154.43210 \| PMID = 19882019 }}</ref>

			Image:
			*[http://www.sciencephoto.com/media/252126/enlarge Paget disease of the breast (sciencephoto.com)].

	==Microscopic==		==Microscopic==

Michael: /* DDx */

2012-02-03T16:56:13Z

DDx

← Older revision		Revision as of 16:56, 3 February 2012
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	*[[Bowen disease]].		*[[Bowen disease]].
	*[[Nipple adenoma\|Nipple (duct) adenoma]] (clinical DDx).		*[[Nipple adenoma\|Nipple (duct) adenoma]] (clinical DDx).
	*[[Apocrine carcinoma]].<ref>URL: [http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687 http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687]. Accessed on: 9 September 2011.</ref>		*[[Apocrine carcinoma of the skin]].<ref>URL: [http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687 http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687]. Accessed on: 9 September 2011.</ref>
	**Images: [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_intermed_mag.jpg apocrine carcinoma - intermed. mag. (WC)], [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_high_mag.jpg apocrine carcinoma - high mag. (WC)].		**Images: [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_intermed_mag.jpg apocrine carcinoma - intermed. mag. (WC)], [http://commons.wikimedia.org/wiki/File:Apocrine_carcinoma_-_high_mag.jpg apocrine carcinoma - high mag. (WC)].