Michael: split out

2016-05-21T04:26:46Z

split out

← Older revision		Revision as of 04:26, 21 May 2016
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	~~#redirect~~ [[~~Pancreas#~~Pancreatic intraepithelial neoplasia]]		'''Pancreatic intraepithelial neoplasia''', abbreviated '''PanIN''', is generally believed to be the precursor lesion for [[ductal adenocarcinoma of the pancreas]].

			==General==
			*PanIN is thought to be the precursor lesion for pancreatic carcinoma.<ref name=Ref_PBoD949>{{Ref PBoD\|949}}</ref>

			===Overview===
			Putative preneoplasm-neoplasm-carcinoma sequence:
			*PanIN1a.
			**Not neoplastic, i.e. clonal.
			*PanIN1b.
			**Not neoplastic, i.e. clonal.
			*PanIN2.
			**Can be thought of as ''low-grade dysplasia'', e.g. a ''(colonic) [[tubular adenoma of the gastrointestinal tract\|tubular adenoma]] without high-grade dysplasia''.
			*PanIN3.
			**Can be thought of as ''high-grade dysplasia'', e.g. ''(colonic) villous adenoma''.
			**May be referred to as ''carcinoma in situ''.<ref name=pmid21537863>{{Cite journal \| last1 = Matthaei \| first1 = H. \| last2 = Hong \| first2 = SM. \| last3 = Mayo \| first3 = SC. \| last4 = dal Molin \| first4 = M. \| last5 = Olino \| first5 = K. \| last6 = Venkat \| first6 = R. \| last7 = Goggins \| first7 = M. \| last8 = Herman \| first8 = JM. \| last9 = Edil \| first9 = BH. \| title = Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer. \| journal = Ann Surg Oncol \| volume = 18 \| issue = 12 \| pages = 3493-9 \| month = Nov \| year = 2011 \| doi = 10.1245/s10434-011-1745-9 \| PMID = 21537863 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_PBoD949>{{Ref PBoD\|949}}</ref>
			*PanIN1a - increased amount of cytoplasm.
			**Nuclear size & stratification perserved, arch. perserved.
			*PanIN1b - increased amount of cytoplasm, folding of epithelium/moderated arch. distortion.
			**Nuclear size & stratification perserved.
			*PanIN2 - increased cell size, and nuclear enlargement (increased NC ratio), moderate nuclear atypia with loss of (basal) nuclear polarization.
			*PanIN3 - marked nuclear atypia with increased NC ratio.
			**No invasion identified.
			*Pancreatic carcinoma - cytologic features of PanIN3 with definite invasion.

			===Images===
			<gallery>
			Image:Pancreas_neoplasia_carcinoma_sequence.png \| Normal pancreas, pancreatic intraepithelial neoplasia and pancreatic carcinoma. (WC)
			</gallery>

			====www====
			*[http://www.path.jhu.edu/pancreas/professionals/panin-3.php PanIN III - several images (jhu.edu)].

			==See also==
			*[[Pancreas]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Pancreas]]

Michael: redirect

2014-03-05T10:57:21Z

redirect

← Older revision		Revision as of 10:57, 5 March 2014
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	#redirect [[Pancreas#Pancreatic intraepithelial neoplasia]]		#redirect [[Pancreas#Pancreatic intraepithelial neoplasia]]

			[[Category:Diagnosis]]

Michael: redirect

2014-03-05T10:57:11Z

redirect

New page

#redirect [[Pancreas#Pancreatic intraepithelial neoplasia]]

Pancreatic intraepithelial neoplasia - Revision history

Michael: split out

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Michael: redirect